Gene Page: SNRNP200

Summary ?
GeneID23020
SymbolSNRNP200
SynonymsASCC3L1|BRR2|HELIC2|RP33|U5-200KD
Descriptionsmall nuclear ribonucleoprotein U5 subunit 200
ReferenceMIM:601664|HGNC:HGNC:30859|Ensembl:ENSG00000144028|HPRD:03391|Vega:OTTHUMG00000130455
Gene typeprotein-coding
Map location2q11.2
Pascal p-value7.534E-5
Sherlock p-value0.504
eGeneCaudate basal ganglia
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0454 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
YTHDF10.950.96
KIAA19670.950.95
VPS390.950.96
ZNF2630.950.95
USP220.940.96
ZFYVE10.940.95
FBXO420.940.95
USP190.940.94
RNF2160.940.95
QRICH10.940.95
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.82-0.87
MT-CO2-0.81-0.87
AF347015.21-0.80-0.91
AF347015.27-0.80-0.86
AF347015.8-0.79-0.85
MT-CYB-0.78-0.83
AF347015.33-0.77-0.81
HIGD1B-0.75-0.82
AF347015.15-0.74-0.82
AF347015.2-0.74-0.81

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003676nucleic acid bindingIEA-
GO:0005515protein bindingIPI9774689 |17353931 
GO:0005524ATP bindingIC9539711 
GO:0016787hydrolase activityIEA-
GO:0008026ATP-dependent helicase activityIDA9539711 
GO:0017111nucleoside-triphosphatase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000354cis assembly of pre-catalytic spliceosomeIC9539711 
GO:0000398nuclear mRNA splicing, via spliceosomeEXP12226669 
GO:0008380RNA splicingIDA8670905 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005681spliceosomeIDA8670905 
GO:0005682snRNP U5IDA9539711 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD2BP2FWP010 | LIN1 | Snu40 | U5-52KCD2 (cytoplasmic tail) binding protein 2Affinity Capture-MSBioGRID17353931 
MCCDKFZp762O1615 | FLJ38893 | FLJ46755 | MCC1mutated in colorectal cancersAffinity Capture-MSBioGRID17353931 
MEGF10DKFZp781K1852 | FLJ41574 | KIAA1780multiple EGF-like-domains 10-HPRD12421765 
MYCbHLHe39 | c-Mycv-myc myelocytomatosis viral oncogene homolog (avian)Affinity Capture-MSBioGRID17353931 
PRKAB1AMPK | HAMPKb | MGC17785protein kinase, AMP-activated, beta 1 non-catalytic subunitAffinity Capture-MSBioGRID17353931 
RNPS1E5.1 | MGC117332RNA binding protein S1, serine-rich domainAffinity Capture-MSBioGRID17353931 
RNU11U11RNA, U11 small nuclearAffinity Capture-MSBioGRID15146077 
RNU12U12RNA, U12 small nuclearAffinity Capture-MSBioGRID15146077 
SMNDC1SMNR | SPF30survival motor neuron domain containing 1-HPRD,BioGRID11331595 
SNRNP4040K | FLJ41108 | HPRP8BP | MGC1910 | PRP8BP | PRPF8BP | RP11-490K7.3 | SPF38 | WDR57small nuclear ribonucleoprotein 40kDa (U5)Affinity Capture-MSBioGRID17353931 
SNRPBCOD | SNRPB1 | SmB/SmB' | snRNP-Bsmall nuclear ribonucleoprotein polypeptides B and B1Affinity Capture-MSBioGRID17353931 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideAffinity Capture-MSBioGRID17353931 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG SPLICEOSOME 12872All SZGR 2.0 genes in this pathway
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA 14077All SZGR 2.0 genes in this pathway
REACTOME MRNA PROCESSING 16186All SZGR 2.0 genes in this pathway
REACTOME MRNA SPLICING 11158All SZGR 2.0 genes in this pathway
REACTOME MRNA SPLICING MINOR PATHWAY 4519All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406230All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
BARIS THYROID CANCER UP 239All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479299All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP 236139All SZGR 2.0 genes in this pathway
COLLIS PRKDC SUBSTRATES 2015All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425253All SZGR 2.0 genes in this pathway
WHITEFORD PEDIATRIC CANCER MARKERS 11663All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN 18197All SZGR 2.0 genes in this pathway
YAGI AML WITH T 9 11 TRANSLOCATION 13087All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway