SZGR2

Summary ?

GeneID	2764
Symbol	GMFB
Synonyms	GMF
Description	glia maturation factor beta
Reference	MIM:601713\|HGNC:HGNC:4373\|Ensembl:ENSG00000197045\|Vega:OTTHUMG00000140307
Gene type	protein-coding
Map location	14q22.2
Pascal p-value	0.199
Sherlock p-value	0.274
Fetal beta	-0.572
DMG	1 (# studies)
Support	G2Cdb.human_Synaptosome G2Cdb.humanPSD

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:vanEijk_2014	Genome-wide DNA methylation analysis	This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250).	1
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg24256211	14	55035215	GMFB	0.003	5.855		DMG:vanEijk_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MAST1	0.91	0.94
PACS1	0.90	0.95
GPRIN1	0.90	0.93
KIFC3	0.90	0.89
RASGEF1C	0.90	0.90
PIK3R2	0.89	0.93
MAPKBP1	0.89	0.93
AC079061.1	0.89	0.86
TMEM63B	0.89	0.94
RUSC1	0.88	0.94

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.70	-0.82
MT-CO2	-0.70	-0.82
AF347015.27	-0.70	-0.81
AF347015.33	-0.68	-0.79
MT-CYB	-0.68	-0.80
S100B	-0.68	-0.78
AF347015.8	-0.67	-0.82
AC021016.1	-0.67	-0.82
COPZ2	-0.67	-0.76
FXYD1	-0.67	-0.77

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003779	actin binding	IEA		-
GO:0004871	signal transducer activity	TAS		7598724 \|8798479
GO:0004860	protein kinase inhibitor activity	TAS		8639570
GO:0008083	growth factor activity	IEA		-
GO:0008047	enzyme activator activity	TAS		8798479
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007399	nervous system development	TAS	neurite (GO term level: 5)	1712830
GO:0006468	protein amino acid phosphorylation	TAS		7598724
GO:0007165	signal transduction	TAS		8798479
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005622	intracellular	IEA		-
GO:0005634	nucleus	IDA		18029348
GO:0005730	nucleolus	IDA		18029348
GO:0005739	mitochondrion	IDA		18029348

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
WINTER HYPOXIA UP	92	57	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL DN	74	42	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN	431	263	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
GRABARCZYK BCL11B TARGETS UP	81	40	All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN	310	188	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP	557	331	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP	633	376	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
OUELLET CULTURED OVARIAN CANCER INVASIVE VS LMP UP	69	40	All SZGR 2.0 genes in this pathway
CHOI ATL STAGE PREDICTOR	44	24	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
CALVET IRINOTECAN SENSITIVE VS REVERTED UP	5	5	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP	769	437	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
WEI MIR34A TARGETS	148	97	All SZGR 2.0 genes in this pathway
BALDWIN PRKCI TARGETS UP	35	26	All SZGR 2.0 genes in this pathway
GOLDRATH HOMEOSTATIC PROLIFERATION	171	102	All SZGR 2.0 genes in this pathway
DER IFN BETA RESPONSE UP	102	67	All SZGR 2.0 genes in this pathway
JIANG VHL TARGETS	138	91	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP	120	89	All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION DN	98	67	All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR UP	93	65	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5	482	296	All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS	90	71	All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS	92	68	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP	863	514	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP	518	299	All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 UP	188	121	All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS LATE UP	104	67	All SZGR 2.0 genes in this pathway
JIANG HYPOXIA VIA VHL	34	24	All SZGR 2.0 genes in this pathway
BAE BRCA1 TARGETS UP	75	47	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP	548	370	All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN	315	215	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D	658	397	All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN	784	464	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124/506	791	797	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	791	797	m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-132/212	88	94	1A	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	88	94	1A	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-135	2760	2766	1A	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	2760	2766	1A	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-145	3068	3074	1A	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-145	3068	3074	1A	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-148/152	85	91	m8	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-181	3157	3163	1A	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-182	2820	2827	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-194	89	95	m8	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-203.1	3121	3127	m8	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-217	111	117	1A	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU
miR-26	3329	3336	1A,m8	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	3329	3336	1A,m8	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-29	3562	3568	m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-320	807	813	1A	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-34/449	834	841	1A,m8	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-375	147	153	1A	hsa-miR-375	UUUGUUCGUUCGGCUCGCGUGA
miR-382	3095	3101	m8	hsa-miR-382^brain	GAAGUUGUUCGUGGUGGAUUCG
miR-384	2540	2546	1A	hsa-miR-384	AUUCCUAGAAAUUGUUCAUA
miR-490	2462	2468	1A	hsa-miR-490	CAACCUGGAGGACUCCAUGCUG
miR-495	101	107	m8	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-96	2821	2827	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: GMFB