Summary ?
GeneID3065
SymbolHDAC1
SynonymsGON-10|HD1|RPD3|RPD3L1
Descriptionhistone deacetylase 1
ReferenceMIM:601241|HGNC:HGNC:4852|Ensembl:ENSG00000116478|HPRD:03143|Vega:OTTHUMG00000007529
Gene typeprotein-coding
Map location1p34
Pascal p-value0.59
Fetal beta0.69
eGeneMyers' cis & trans
SupportAscano FMRP targets
Chromatin Remodeling Genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenics,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs4501739chrX35960848HDAC130650.03trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MAMDC40.900.78
AC135050.20.890.76
CNKSR10.890.78
ZNF6920.890.81
VWCE0.890.77
MST10.880.77
MYO190.880.76
VARS20.880.70
CTRL0.880.78
GAL3ST40.880.67
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ABCG2-0.51-0.64
HLA-C-0.49-0.51
FBXO2-0.47-0.50
PLA2G4A-0.46-0.58
ITM2B-0.46-0.53
AIFM3-0.45-0.46
ALDOC-0.45-0.45
RGS5-0.45-0.57
SLC39A8-0.45-0.54
HLA-F-0.45-0.40

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityTAS8646880 
GO:0004407histone deacetylase activityTAS12711221 
GO:0016787hydrolase activityIEA-
GO:0008134transcription factor bindingIPI15509593 
GO:0008134transcription factor bindingTAS12711221 
GO:0042802identical protein bindingIPI9150135 
GO:0019899enzyme bindingIPI11062478 |11136718 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0006916anti-apoptosisTAS10777477 
GO:0016568chromatin modificationTAS12711221 
GO:0016575histone deacetylationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000118histone deacetylase complexTAS12711221 
GO:0005634nucleusIDA10846170 
GO:0005634nucleusTAS12711221 
GO:0005737cytoplasmTAS12711221 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AOF2BHC110 | KDM1 | KIAA0601 | LSD1amine oxidase (flavin containing) domain 2-HPRD,BioGRID12493763 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptor-HPRD,BioGRID11994312 
ARID4ARBBP1 | RBP-1 | RBP1AT rich interactive domain 4A (RBP1-like)-HPRD10490602 
ARID4BBCAA | BRCAA1 | DKFZp313M2420 | MGC163290 | RBBP1L1 | RBP1L1 | SAP180AT rich interactive domain 4B (RBP1-like)Affinity Capture-WesternBioGRID12724404 
ATRFRP1 | MEC1 | SCKL | SCKL1ataxia telangiectasia and Rad3 relatedAffinity Capture-WesternBioGRID10545197 
ATRXATR2 | MGC2094 | MRXHF1 | RAD54 | RAD54L | SFM1 | SHS | XH2 | XNP | ZNF-HXalpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)-HPRD14645126 
BAZ2ADKFZp781B109 | FLJ13768 | FLJ13780 | FLJ45876 | KIAA0314 | TIP5 | WALp3bromodomain adjacent to zinc finger domain, 2A-HPRD12198165 
BCL3BCL4 | D19S37B-cell CLL/lymphoma 3HDAC1 interacts with BCL-3.BIND15469820 
BCL6BCL5 | BCL6A | LAZ3 | ZBTB27 | ZNF51B-cell CLL/lymphoma 6Affinity Capture-WesternBioGRID9627120 
BCORANOP2 | FLJ20285 | FLJ38041 | KIAA1575 | MAA2 | MCOPS2 | MGC131961 | MGC71031BCL6 co-repressor-HPRD,BioGRID10898795 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetBRCA1 interacts with HDAC1BIND10220405 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD,BioGRID10220405 
BUB1BUB1A | BUB1L | hBUB1budding uninhibited by benzimidazoles 1 homolog (yeast)Affinity Capture-Western
Co-purification
BioGRID15388328 
BUB1BBUB1beta | BUBR1 | Bub1A | MAD3L | SSK1 | hBUBR1budding uninhibited by benzimidazoles 1 homolog beta (yeast)Affinity Capture-Western
Co-purification
BioGRID15388328 
BUB3BUB3L | hBUB3budding uninhibited by benzimidazoles 3 homolog (yeast)Affinity Capture-Western
Co-purification
BioGRID15388328 
CABIN1CAIN | KIAA0330 | PPP3INcalcineurin binding protein 1-HPRD,BioGRID10933397 
CBFA2T3ETO2 | MTG16 | MTGR2 | ZMYND4core-binding factor, runt domain, alpha subunit 2; translocated to, 3-HPRD,BioGRID12242670 
CBX5HP1 | HP1Achromobox homolog 5 (HP1 alpha homolog, Drosophila)Affinity Capture-WesternBioGRID12242305 
CDC20CDC20A | MGC102824 | bA276H19.3 | p55CDCcell division cycle 20 homolog (S. cerevisiae)Affinity Capture-Western
Co-purification
BioGRID15388328 
CDH1Arc-1 | CD324 | CDHE | ECAD | LCAM | UVOcadherin 1, type 1, E-cadherin (epithelial)Affinity Capture-Western
Co-purification
BioGRID15388328 
CDKN1ACAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1cyclin-dependent kinase inhibitor 1A (p21, Cip1)HDAC1 interacts with the p21 promoter.BIND15710329 
CDKN1ACAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1cyclin-dependent kinase inhibitor 1A (p21, Cip1)HDAC1 interacts with the CDKN1A (p21) promoter.BIND15674334 
CDYLCDYL1 | DKFZp586C1622 | MGC131936chromodomain protein, Y-like-HPRD,BioGRID12947414 
CHD1DKFZp686E2337chromodomain helicase DNA binding protein 1-HPRD,BioGRID12890497 
CHD3Mi-2a | Mi2-ALPHA | ZFHchromodomain helicase DNA binding protein 3-HPRD,BioGRID9804427 
CHD4DKFZp686E06161 | Mi-2b | Mi2-BETAchromodomain helicase DNA binding protein 4Affinity Capture-MS
Affinity Capture-Western
BioGRID9804427 |10220385 
|12920132 
CTBP1BARS | MGC104684C-terminal binding protein 1-HPRD,BioGRID9650586 
DAXXBING2 | DAP6 | EAP1 | MGC126245 | MGC126246death-domain associated protein-HPRD,BioGRID10669754 
DDB2DDBB | FLJ34321 | UV-DDB2damage-specific DNA binding protein 2, 48kDa-HPRD8602529 
DDX17DKFZp761H2016 | P72 | RH70DEAD (Asp-Glu-Ala-Asp) box polypeptide 17-HPRD,BioGRID15298701 
DDX5DKFZp686J01190 | G17P1 | HLR1 | HUMP68 | p68DEAD (Asp-Glu-Ala-Asp) box polypeptide 5Affinity Capture-WesternBioGRID15298701 
DNMT1AIM | CXXC9 | DNMT | FLJ16293 | MCMT | MGC104992DNA (cytosine-5-)-methyltransferase 1Co-fractionationBioGRID10888886 
DNMT1AIM | CXXC9 | DNMT | FLJ16293 | MCMT | MGC104992DNA (cytosine-5-)-methyltransferase 1-HPRD10615135 
DNMT3ADNMT3A2 | M.HsaIIIADNA (cytosine-5-)-methyltransferase 3 alpha-HPRD,BioGRID11350943 
DNMT3BICF | M.HsaIIIBDNA (cytosine-5-)-methyltransferase 3 betaCo-purificationBioGRID15148359 
DNMT3BICF | M.HsaIIIBDNA (cytosine-5-)-methyltransferase 3 beta-HPRD12202768 
DNMT3BICF | M.HsaIIIBDNA (cytosine-5-)-methyltransferase 3 betaDNMT3B interacts with HDAC1.BIND15120635 
DNMT3LMGC1090DNA (cytosine-5-)-methyltransferase 3-like-HPRD,BioGRID12177302 |12202768 
E2F1E2F-1 | RBAP1 | RBBP3 | RBP3E2F transcription factor 1Affinity Capture-WesternBioGRID10734134 
E2F4E2F-4E2F transcription factor 4, p107/p130-binding-HPRD,BioGRID9724731 
EEDHEED | WAIT1embryonic ectoderm development-HPRD,BioGRID10581039 
EFCAB6DJBP | FLJ23588 | HSCBCIP1 | KIAA1672 | dJ185D5.1EF-hand calcium binding domain 6Affinity Capture-WesternBioGRID12612053 
EID2CRI2 | EID-2 | MGC20452EP300 interacting inhibitor of differentiation 2-HPRD12586827 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1ER-alpha interacts with HDAC1.BIND14506733 
EVI1AML1-EVI-1 | EVI-1 | MDS1-EVI1 | MGC163392 | PRDM3ecotropic viral integration site 1-HPRD,BioGRID11568182 
EZH2ENX-1 | EZH1 | KMT6 | MGC9169enhancer of zeste homolog 2 (Drosophila)-HPRD,BioGRID10581039 
FKBP3FKBP-25 | PPIaseFK506 binding protein 3, 25kDa-HPRD,BioGRID11532945 
FOXG1BF1 | BF2 | FHKL3 | FKH2 | FKHL1 | FKHL2 | FKHL3 | FKHL4 | FOXG1A | FOXG1B | FOXG1C | HBF-1 | HBF-2 | HBF-3 | HBF-G2 | HBF2 | HFK1 | HFK2 | HFK3 | KHL2 | QINforkhead box G1-HPRD11238932 
GATA1ERYF1 | GF-1 | GF1 | NFE1GATA binding protein 1 (globin transcription factor 1)Affinity Capture-WesternBioGRID14668799 
GATAD2BFLJ37346 | KIAA1150 | MGC138257 | MGC138285 | P66beta | RP11-216N14.6GATA zinc finger domain containing 2BAffinity Capture-WesternBioGRID11756549 
GTF2IBAP-135 | BAP135 | BTKAP1 | DIWS | FLJ38776 | FLJ56355 | IB291 | SPIN | TFII-I | WBS | WBSCR6general transcription factor II, iAffinity Capture-WesternBioGRID12393887 
HBP1FLJ16340HMG-box transcription factor 1-HPRD,BioGRID15235594 
HCFC1CFF | HCF-1 | HCF1 | HFC1 | MGC70925 | VCAFhost cell factor C1 (VP16-accessory protein)Affinity Capture-MS
Affinity Capture-Western
BioGRID12670868 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1Affinity Capture-MSBioGRID12920132 
HDAC2RPD3 | YAF1histone deacetylase 2-HPRD,BioGRID9520398 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3-HPRD10944117 |11302704 
HDAC9DKFZp779K1053 | HD7 | HDAC | HDAC7 | HDAC7B | HDAC9B | HDAC9FL | HDRP | KIAA0744 | MITRhistone deacetylase 9Affinity Capture-WesternBioGRID10655483 
HDAC9DKFZp779K1053 | HD7 | HDAC | HDAC7 | HDAC7B | HDAC9B | HDAC9FL | HDRP | KIAA0744 | MITRhistone deacetylase 9An unspecified isoform of HDAC9 (MITR) interacts with HDAC1. This interaction was modelled on a demonstrated interaction between an unspecified isoform of human HDAC9 and HDAC1 from an unspecified species.BIND15711539 
HDAC9DKFZp779K1053 | HD7 | HDAC | HDAC7 | HDAC7B | HDAC9B | HDAC9FL | HDRP | KIAA0744 | MITRhistone deacetylase 9-HPRD12590135 
HEY2CHF1 | GRIDLOCK | GRL | HERP1 | HESR2 | HRT2 | MGC10720 | bHLHb32hairy/enhancer-of-split related with YRPW motif 2-HPRD,BioGRID11486045 
HIC1ZBTB29 | hic-1hypermethylated in cancer 1-HPRD12052894 
HIF1AHIF-1alpha | HIF1 | HIF1-ALPHA | MOP1 | PASD8hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)Reconstituted ComplexBioGRID11641274 
HIF1ANDKFZp762F1811 | FIH1 | FLJ20615 | FLJ22027hypoxia-inducible factor 1, alpha subunit inhibitor-HPRD,BioGRID11641274 
HMG20BBRAF25 | BRAF35 | FLJ26127 | HMGX2 | PP7706 | SMARCE1r | SOXL | pp8857high-mobility group 20BAffinity Capture-Western
Co-purification
BioGRID12032298 
HRALUNC | AU | HSA277165hairless homolog (mouse)-HPRD,BioGRID11641275 
HSPA4APG-2 | HS24/P52 | MGC131852 | RY | hsp70 | hsp70RYheat shock 70kDa protein 4Affinity Capture-WesternBioGRID11777905 
HSPD1CPN60 | GROEL | HSP60 | HSP65 | HuCHA60 | SPG13heat shock 60kDa protein 1 (chaperonin)Affinity Capture-WesternBioGRID11777905 
HUS1-HUS1 checkpoint homolog (S. pombe)-HPRD,BioGRID10846170 
IFRD1PC4 | TIS7interferon-related developmental regulator 1Affinity Capture-WesternBioGRID12198164 
IKZF1Hs.54452 | IK1 | IKAROS | LYF1 | PRO0758 | ZNFN1A1 | hIk-1IKAROS family zinc finger 1 (Ikaros)Affinity Capture-WesternBioGRID10357820 |12015313 
ING1p24ING1c | p33 | p33ING1 | p33ING1b | p47 | p47ING1ainhibitor of growth family, member 1Affinity Capture-MS
Affinity Capture-Western
BioGRID11784859 |12015309 
KAT5ESA1 | HTATIP | HTATIP1 | PLIP | TIP | TIP60 | cPLA2K(lysine) acetyltransferase 5-HPRD11994312 
KLF11FKLF | FKLF1 | MODY7 | TIEG2 | Tieg3Kruppel-like factor 11-HPRD,BioGRID11438660 
MAD1L1HsMAD1 | MAD1 | PIG9 | TP53I9 | TXBP181MAD1 mitotic arrest deficient-like 1 (yeast)Affinity Capture-Western
Co-purification
BioGRID15388328 
MAP3K7IP2FLJ21885 | KIAA0733 | TAB2mitogen-activated protein kinase kinase kinase 7 interacting protein 2Reconstituted ComplexBioGRID12150997 
MBD2DKFZp586O0821 | DMTase | NY-CO-41methyl-CpG binding domain protein 2-HPRD,BioGRID10471499 
MBD3-methyl-CpG binding domain protein 3-HPRD,BioGRID12124384 
MBD3-methyl-CpG binding domain protein 3MBD3 interacts with HDAC1.BIND12124384 
MBD3L1MBD3L | MGC138263 | MGC138269methyl-CpG binding domain protein 3-like 1Affinity Capture-WesternBioGRID15456747 
MDM2HDMX | MGC71221 | hdm2Mdm2 p53 binding protein homolog (mouse)-HPRD,BioGRID12426395 
MDS1MDS1-EVI1 | PRDM3myelodysplasia syndrome 1-HPRD,BioGRID11552981 
MIER1DKFZp781G0451 | ER1 | KIAA1610 | MGC131940 | MGC150640 | MGC150641 | MI-ER1 | RP5-944N15.1 | hMI-ER1mesoderm induction early response 1 homolog (Xenopus laevis)-HPRD,BioGRID12482978 
MIZFDKFZp434F162 | HiNF-P | ZNF743MBD2-interacting zinc fingerAffinity Capture-WesternBioGRID12665568 
MLLALL-1 | CXXC7 | FLJ11783 | HRX | HTRX1 | KMT2A | MLL/GAS7 | MLL1A | TET1-MLL | TRX1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)Affinity Capture-Western
Reconstituted Complex
BioGRID12829790 
MORF4L2KIAA0026 | MORFL2 | MRGXmortality factor 4 like 2-HPRD14506250 
MT1GMGC12386 | MT1 | MT1Kmetallothionein 1GHDAC1 interacts with the MT1G promoter.BIND15735762 
MTA1-metastasis associated 1-HPRD,BioGRID10840944 |11146623 
MTA2DKFZp686F2281 | MTA1L1 | PIDmetastasis associated 1 family, member 2Affinity Capture-MS
Affinity Capture-Western
Co-purification
BioGRID10444591 |11171972 
|12374985 |12920132 
MXD1MAD | MAD1 | MGC104659MAX dimerization protein 1-HPRD9150133 |9150134 
MXD1MAD | MAD1 | MGC104659MAX dimerization protein 1Reconstituted ComplexBioGRID11101889 
MYOD1MYF3 | MYOD | PUM | bHLHc1myogenic differentiation 1-HPRD,BioGRID11285237 |11684023 
NCOR2CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1nuclear receptor co-repressor 2Affinity Capture-Western
Co-purification
BioGRID11013263 |11739383 
NFIXNF1Anuclear factor I/X (CCAAT-binding transcription factor)Affinity Capture-WesternBioGRID11896613 
NFKB1DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105nuclear factor of kappa light polypeptide gene enhancer in B-cells 1-HPRD,BioGRID11931769 
NFKBIAIKBA | MAD-3 | NFKBInuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alphaHDAC1 interacts with I-kappa-B-alpha.BIND12972430 
NR2F2ARP1 | COUP-TFII | COUPTFB | MGC117452 | SVP40 | TFCOUP2nuclear receptor subfamily 2, group F, member 2-HPRD,BioGRID10704340 
NRIP1FLJ77253 | RIP140nuclear receptor interacting protein 1-HPRD11006275|11285237 
PCNAMGC8367proliferating cell nuclear antigen-HPRD,BioGRID11929879 
PEX14MGC12767 | NAPP2 | Pex14p | dJ734G22.2peroxisomal biogenesis factor 14-HPRD11909966 
PHBPHB1prohibitin-HPRD,BioGRID12466959 
PHF12FLJ34122 | KIAA1523 | MGC131914 | PF1PHD finger protein 12-HPRD,BioGRID11390640 
PHF21ABHC80 | BM-006 | KIAA1696PHD finger protein 21A-HPRD,BioGRID15325272 
PIAS3FLJ14651 | ZMIZ5protein inhibitor of activated STAT, 3-HPRD14691252 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemia-HPRD,BioGRID11259576 |11430826 
PPARDFAAR | MGC3931 | NR1C2 | NUC1 | NUCI | NUCII | PPAR-beta | PPARBperoxisome proliferator-activated receptor delta-HPRD,BioGRID11867749 
PTMAMGC104802 | TMSAprothymosin, alpha-HPRD,BioGRID12634383 
RAD9ARAD9RAD9 homolog A (S. pombe)-HPRD,BioGRID10846170 
RARBHAP | NR1B2 | RRB2retinoic acid receptor, betaHDAC1 interacts with RARB (RAR-beta-2) gene promoter sequences.BIND15688037 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1RB interacts with HDAC1.BIND11447271 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1-HPRD9491888 |10888886 
|11896613 |11909966 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1The Retinoblastoma protein interacts with Histone Deacetylase 1.BIND10734134 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1Affinity Capture-Western
Reconstituted Complex
BioGRID9491888 |9724731 
|10490602 |10615135 
|10779361 |11684023 
|12466959 
RBBP4NURF55 | RBAP48retinoblastoma binding protein 4RbAp48 interacts with HDAC1BIND10734134 
RBBP4NURF55 | RBAP48retinoblastoma binding protein 4-HPRD10734134 |11302704 
|12091390 |12943729 
RBBP4NURF55 | RBAP48retinoblastoma binding protein 4Affinity Capture-Western
Co-purification
Reconstituted Complex
BioGRID9150133 |9150135 
|9520398 |10220385 
|10444591 |10471499 
|11171972 |11470869 
|12091390 |12920132 
|12943729 
RBBP7MGC138867 | MGC138868 | RbAp46retinoblastoma binding protein 7Affinity Capture-Western
Co-purification
BioGRID9150135 |10444591 
|10471499 |12920132 
RBL1CP107 | MGC40006 | PRB1 | p107retinoblastoma-like 1 (p107)-HPRD,BioGRID9724731 
RBL2FLJ26459 | P130 | Rb2retinoblastoma-like 2 (p130)-HPRD,BioGRID10969803 
RCOR1COREST | KIAA0071 | RCORREST corepressor 1Affinity Capture-MS
Affinity Capture-Western
Co-purification
BioGRID11171972 |12032298 
RECQL4RECQ4RecQ protein-like 4HDAC1 interacts with the RECQL4 (RECQ4) promoter.BIND15674334 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)-HPRD,BioGRID11564889 
RFC1A1 | MGC51786 | MHCBFB | PO-GA | RECC1 | RFC | RFC140replication factor C (activator 1) 1, 145kDa-HPRD,BioGRID12045192 
RFC4A1 | MGC27291 | RFC37replication factor C (activator 1) 4, 37kDa-HPRD12045192 
RUNX1T1AML1T1 | CBFA2T1 | CDR | ETO | MGC2796 | MTG8 | MTG8b | ZMYND2runt-related transcription factor 1; translocated to, 1 (cyclin D-related)Affinity Capture-WesternBioGRID11533236 
RUNX1T1AML1T1 | CBFA2T1 | CDR | ETO | MGC2796 | MTG8 | MTG8b | ZMYND2runt-related transcription factor 1; translocated to, 1 (cyclin D-related)ETO interacts with HDAC1.BIND15333839 
RUNX3AML2 | CBFA3 | FLJ34510 | MGC16070 | PEBP2aCrunt-related transcription factor 3-HPRD15138260 
RUVBL2CGI-46 | ECP51 | INO80J | REPTIN | RVB2 | TIH2 | TIP48 | TIP49BRuvB-like 2 (E. coli)RUVBL2 (reptin) interacts with HDAC1.BIND15829968 
SALL1HSAL1 | TBS | ZNF794sal-like 1 (Drosophila)-HPRD11836251 
SAP130FLJ12761Sin3A-associated protein, 130kDaAffinity Capture-WesternBioGRID12724404 
SAP182HOR0202 | MGC27131 | SAP18pSin3A-associated protein, 18kDa-HPRD9150135 
SAP30-Sin3A-associated protein, 30kDa-HPRD,BioGRID9651585 
SATB1-SATB homeobox 1-HPRD,BioGRID12374985 
SETDB1ESET | KG1T | KIAA0067 | KMT1ESET domain, bifurcated 1-HPRD12398767 
SIN3ADKFZp434K2235 | FLJ90319 | KIAA0700SIN3 homolog A, transcription regulator (yeast)The transcriptional repressor mSin3A interacts with the histone deacetylase 1 protein.BIND9150133 |9150134 
SIN3ADKFZp434K2235 | FLJ90319 | KIAA0700SIN3 homolog A, transcription regulator (yeast)Affinity Capture-MS
Affinity Capture-Western
Co-fractionation
Co-purification
BioGRID9520398 |9804427 
|10220385 |10444591 
|10640275 |11171972 
|11784859 |11931768 
|12091390 |12374985 
|12398767 |12724404 
|12920132 |12943729 
SIN3ADKFZp434K2235 | FLJ90319 | KIAA0700SIN3 homolog A, transcription regulator (yeast)-HPRD11013263 
SIN3BKIAA0700SIN3 homolog B, transcription regulator (yeast)-HPRD11959842 
SIN3BKIAA0700SIN3 homolog B, transcription regulator (yeast)Affinity Capture-Western
Co-purification
BioGRID10357820 |10444591 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2-HPRD,BioGRID10199400 
SMARCA2BAF190 | BRM | FLJ36757 | MGC74511 | SNF2 | SNF2L2 | SNF2LA | SWI2 | Sth1p | hBRM | hSNF2aSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2Co-purificationBioGRID11238380 
SMARCB1BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFSSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1Co-purificationBioGRID11238380 
SP1-Sp1 transcription factorAffinity Capture-WesternBioGRID11896613 |12091390 
|12176973 |12847090 
SP1-Sp1 transcription factor-HPRD11896613 |11909966 
SP3DKFZp686O1631 | SPR-2Sp3 transcription factor-HPRD,BioGRID12176973 
SPENKIAA0929 | MINT | RP1-134O19.1 | SHARPspen homolog, transcriptional regulator (Drosophila)-HPRD,BioGRID11331609 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)Stat3 interacts with HDAC1.BIND15653507 
SUDS3FLJ00052 | MGC104711 | SAP45 | SDS3suppressor of defective silencing 3 homolog (S. cerevisiae)Affinity Capture-WesternBioGRID11909966 |12724404 
SUV39H1KMT1A | MG44 | SUV39Hsuppressor of variegation 3-9 homolog 1 (Drosophila)-HPRD,BioGRID11788710 
TAL1SCL | TCL5 | bHLHa17 | tal-1T-cell acute lymphocytic leukemia 1-HPRD10688671 
TAL1SCL | TCL5 | bHLHa17 | tal-1T-cell acute lymphocytic leukemia 1Affinity Capture-MSBioGRID16407974 
TGIF1HPE4 | MGC39747 | MGC5066 | TGIFTGFB-induced factor homeobox 1Affinity Capture-WesternBioGRID10995736 |11427533 
TGIF2-TGFB-induced factor homeobox 2-HPRD,BioGRID11427533 
TLE4BCE-1 | BCE1 | E(spI) | ESG | ESG4 | GRG4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)Affinity Capture-WesternBioGRID11266540 
TNFSF10APO2L | Apo-2L | CD253 | TL2 | TRAILtumor necrosis factor (ligand) superfamily, member 10HDAC1 interacts with the TNFSF10 promoter.BIND15619633 
TOP2ATOP2 | TP2Atopoisomerase (DNA) II alpha 170kDa-HPRD,BioGRID11136718 
TOP2BTOPIIB | top2betatopoisomerase (DNA) II beta 180kDaAffinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID11062478 |11136718 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53Affinity Capture-WesternBioGRID12426395 
TPD52L1D53 | MGC8556 | TPD52L2 | hD53tumor protein D52-like 1Two-hybridBioGRID16169070 
TRIM27RFP | RNF76tripartite motif-containing 27-HPRD14530259 
TXNIPEST01027 | HHCPA78 | THIF | VDUP1thioredoxin interacting protein-HPRD,BioGRID12821938 
VHLHRCA1 | RCA1 | VHL1von Hippel-Lindau tumor suppressorReconstituted ComplexBioGRID11641274 
YY1DELTA | INO80S | NF-E1 | UCRBP | YIN-YANG-1YY1 transcription factorReconstituted ComplexBioGRID9346952 
ZBTB16PLZF | ZNF145zinc finger and BTB domain containing 16-HPRD9627120 |15467736 
ZBTB16PLZF | ZNF145zinc finger and BTB domain containing 16Affinity Capture-Western
Reconstituted Complex
BioGRID9627120 |9765306 
|15467736 
ZBTB16PLZF | ZNF145zinc finger and BTB domain containing 16HDAC1 interacts with PLZF. This interaction was modelled on a demonstrated interaction between HDAC1 and PLZF from unspecified species.BIND9486654 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CELL CYCLE 12884All SZGR 2.0 genes in this pathway
KEGG NOTCH SIGNALING PATHWAY 4735All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE 185109All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA 7359All SZGR 2.0 genes in this pathway
BIOCARTA CARM ER PATHWAY 3527All SZGR 2.0 genes in this pathway
BIOCARTA G1 PATHWAY 2821All SZGR 2.0 genes in this pathway
BIOCARTA VDR PATHWAY 127All SZGR 2.0 genes in this pathway
BIOCARTA MTA3 PATHWAY 1910All SZGR 2.0 genes in this pathway
BIOCARTA PITX2 PATHWAY 1515All SZGR 2.0 genes in this pathway
BIOCARTA MEF2D PATHWAY 2316All SZGR 2.0 genes in this pathway
BIOCARTA WNT PATHWAY 2624All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY 8263All SZGR 2.0 genes in this pathway
PID NOTCH PATHWAY 5949All SZGR 2.0 genes in this pathway
PID E2F PATHWAY 7448All SZGR 2.0 genes in this pathway
PID PS1 PATHWAY 4639All SZGR 2.0 genes in this pathway
PID HDAC CLASSI PATHWAY 6650All SZGR 2.0 genes in this pathway
PID TELOMERASE PATHWAY 6848All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY 8260All SZGR 2.0 genes in this pathway
PID RANBP2 PATHWAY 1111All SZGR 2.0 genes in this pathway
PID AR TF PATHWAY 5338All SZGR 2.0 genes in this pathway
PID IL3 PATHWAY 2719All SZGR 2.0 genes in this pathway
PID ERA GENOMIC PATHWAY 6537All SZGR 2.0 genes in this pathway
PID RETINOIC ACID PATHWAY 3023All SZGR 2.0 genes in this pathway
PID HEDGEHOG GLI PATHWAY 4835All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY 8060All SZGR 2.0 genes in this pathway
PID MYC REPRESS PATHWAY 6352All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY 6546All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY 4839All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217167All SZGR 2.0 genes in this pathway
REACTOME G0 AND EARLY G1 2513All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421253All SZGR 2.0 genes in this pathway
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 4628All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH1 7046All SZGR 2.0 genes in this pathway
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION 2717All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 3826All SZGR 2.0 genes in this pathway
REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 2014All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY 352181All SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING 8161All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325185All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES 13779All SZGR 2.0 genes in this pathway
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 132101All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH 10364All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX 6342All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 UP 201125All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS DN 260143All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS DN 232139All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265158All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR DN 6439All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR DN 7550All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP 293179All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479299All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 10173All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539324All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 8 3628All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 UP 6440All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA 176122All SZGR 2.0 genes in this pathway
XU RESPONSE TO TRETINOIN AND NSC682994 UP 1713All SZGR 2.0 genes in this pathway
NGUYEN NOTCH1 TARGETS UP 2923All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY TBH AND H2O2 3624All SZGR 2.0 genes in this pathway
LEE AGING NEOCORTEX DN 8049All SZGR 2.0 genes in this pathway
RHODES CANCER META SIGNATURE 6447All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198132All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C1 7245All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294199All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342220All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE 242168All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299189All SZGR 2.0 genes in this pathway
GU PDEF TARGETS UP 7149All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368247All SZGR 2.0 genes in this pathway
SETLUR PROSTATE CANCER TMPRSS2 ERG FUSION UP 6748All SZGR 2.0 genes in this pathway
KESHELAVA MULTIPLE DRUG RESISTANCE 8856All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335193All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP 295155All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN 336211All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-41090961Ahsa-miR-410AAUAUAACACAGAUGGCCUGU