SZGR2

Summary ?

GeneID	3065
Symbol	HDAC1
Synonyms	GON-10\|HD1\|RPD3\|RPD3L1
Description	histone deacetylase 1
Reference	MIM:601241\|HGNC:HGNC:4852\|Ensembl:ENSG00000116478\|HPRD:03143\|Vega:OTTHUMG00000007529
Gene type	protein-coding
Map location	1p34
Pascal p-value	0.59
Fetal beta	0.69
eGene	Myers' cis & trans
Support	Ascano FMRP targets Chromatin Remodeling Genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenics,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs4501739	chrX	35960848	HDAC1	3065		0.03		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MAMDC4	0.90	0.78
AC135050.2	0.89	0.76
CNKSR1	0.89	0.78
ZNF692	0.89	0.81
VWCE	0.89	0.77
MST1	0.88	0.77
MYO19	0.88	0.76
VARS2	0.88	0.70
CTRL	0.88	0.78
GAL3ST4	0.88	0.67

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ABCG2	-0.51	-0.64
HLA-C	-0.49	-0.51
FBXO2	-0.47	-0.50
PLA2G4A	-0.46	-0.58
ITM2B	-0.46	-0.53
AIFM3	-0.45	-0.46
ALDOC	-0.45	-0.45
RGS5	-0.45	-0.57
SLC39A8	-0.45	-0.54
HLA-F	-0.45	-0.40

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003700	transcription factor activity	TAS		8646880
GO:0004407	histone deacetylase activity	TAS		12711221
GO:0016787	hydrolase activity	IEA		-
GO:0008134	transcription factor binding	IPI		15509593
GO:0008134	transcription factor binding	TAS		12711221
GO:0042802	identical protein binding	IPI		9150135
GO:0019899	enzyme binding	IPI		11062478 \|11136718
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0006350	transcription	IEA		-
GO:0006916	anti-apoptosis	TAS		10777477
GO:0016568	chromatin modification	TAS		12711221
GO:0016575	histone deacetylation	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000118	histone deacetylase complex	TAS		12711221
GO:0005634	nucleus	IDA		10846170
GO:0005634	nucleus	TAS		12711221
GO:0005737	cytoplasm	TAS		12711221

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AOF2	BHC110 \| KDM1 \| KIAA0601 \| LSD1	amine oxidase (flavin containing) domain 2	-	HPRD,BioGRID	12493763
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	-	HPRD,BioGRID	11994312
ARID4A	RBBP1 \| RBP-1 \| RBP1	AT rich interactive domain 4A (RBP1-like)	-	HPRD	10490602
ARID4B	BCAA \| BRCAA1 \| DKFZp313M2420 \| MGC163290 \| RBBP1L1 \| RBP1L1 \| SAP180	AT rich interactive domain 4B (RBP1-like)	Affinity Capture-Western	BioGRID	12724404
ATR	FRP1 \| MEC1 \| SCKL \| SCKL1	ataxia telangiectasia and Rad3 related	Affinity Capture-Western	BioGRID	10545197
ATRX	ATR2 \| MGC2094 \| MRXHF1 \| RAD54 \| RAD54L \| SFM1 \| SHS \| XH2 \| XNP \| ZNF-HX	alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)	-	HPRD	14645126
BAZ2A	DKFZp781B109 \| FLJ13768 \| FLJ13780 \| FLJ45876 \| KIAA0314 \| TIP5 \| WALp3	bromodomain adjacent to zinc finger domain, 2A	-	HPRD	12198165
BCL3	BCL4 \| D19S37	B-cell CLL/lymphoma 3	HDAC1 interacts with BCL-3.	BIND	15469820
BCL6	BCL5 \| BCL6A \| LAZ3 \| ZBTB27 \| ZNF51	B-cell CLL/lymphoma 6	Affinity Capture-Western	BioGRID	9627120
BCOR	ANOP2 \| FLJ20285 \| FLJ38041 \| KIAA1575 \| MAA2 \| MCOPS2 \| MGC131961 \| MGC71031	BCL6 co-repressor	-	HPRD,BioGRID	10898795
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	BRCA1 interacts with HDAC1	BIND	10220405
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	-	HPRD,BioGRID	10220405
BUB1	BUB1A \| BUB1L \| hBUB1	budding uninhibited by benzimidazoles 1 homolog (yeast)	Affinity Capture-Western Co-purification	BioGRID	15388328
BUB1B	BUB1beta \| BUBR1 \| Bub1A \| MAD3L \| SSK1 \| hBUBR1	budding uninhibited by benzimidazoles 1 homolog beta (yeast)	Affinity Capture-Western Co-purification	BioGRID	15388328
BUB3	BUB3L \| hBUB3	budding uninhibited by benzimidazoles 3 homolog (yeast)	Affinity Capture-Western Co-purification	BioGRID	15388328
CABIN1	CAIN \| KIAA0330 \| PPP3IN	calcineurin binding protein 1	-	HPRD,BioGRID	10933397
CBFA2T3	ETO2 \| MTG16 \| MTGR2 \| ZMYND4	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	-	HPRD,BioGRID	12242670
CBX5	HP1 \| HP1A	chromobox homolog 5 (HP1 alpha homolog, Drosophila)	Affinity Capture-Western	BioGRID	12242305
CDC20	CDC20A \| MGC102824 \| bA276H19.3 \| p55CDC	cell division cycle 20 homolog (S. cerevisiae)	Affinity Capture-Western Co-purification	BioGRID	15388328
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	Affinity Capture-Western Co-purification	BioGRID	15388328
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	HDAC1 interacts with the p21 promoter.	BIND	15710329
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	HDAC1 interacts with the CDKN1A (p21) promoter.	BIND	15674334
CDYL	CDYL1 \| DKFZp586C1622 \| MGC131936	chromodomain protein, Y-like	-	HPRD,BioGRID	12947414
CHD1	DKFZp686E2337	chromodomain helicase DNA binding protein 1	-	HPRD,BioGRID	12890497
CHD3	Mi-2a \| Mi2-ALPHA \| ZFH	chromodomain helicase DNA binding protein 3	-	HPRD,BioGRID	9804427
CHD4	DKFZp686E06161 \| Mi-2b \| Mi2-BETA	chromodomain helicase DNA binding protein 4	Affinity Capture-MS Affinity Capture-Western	BioGRID	9804427 \|10220385 \|12920132
CTBP1	BARS \| MGC104684	C-terminal binding protein 1	-	HPRD,BioGRID	9650586
DAXX	BING2 \| DAP6 \| EAP1 \| MGC126245 \| MGC126246	death-domain associated protein	-	HPRD,BioGRID	10669754
DDB2	DDBB \| FLJ34321 \| UV-DDB2	damage-specific DNA binding protein 2, 48kDa	-	HPRD	8602529
DDX17	DKFZp761H2016 \| P72 \| RH70	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	-	HPRD,BioGRID	15298701
DDX5	DKFZp686J01190 \| G17P1 \| HLR1 \| HUMP68 \| p68	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	Affinity Capture-Western	BioGRID	15298701
DNMT1	AIM \| CXXC9 \| DNMT \| FLJ16293 \| MCMT \| MGC104992	DNA (cytosine-5-)-methyltransferase 1	Co-fractionation	BioGRID	10888886
DNMT1	AIM \| CXXC9 \| DNMT \| FLJ16293 \| MCMT \| MGC104992	DNA (cytosine-5-)-methyltransferase 1	-	HPRD	10615135
DNMT3A	DNMT3A2 \| M.HsaIIIA	DNA (cytosine-5-)-methyltransferase 3 alpha	-	HPRD,BioGRID	11350943
DNMT3B	ICF \| M.HsaIIIB	DNA (cytosine-5-)-methyltransferase 3 beta	Co-purification	BioGRID	15148359
DNMT3B	ICF \| M.HsaIIIB	DNA (cytosine-5-)-methyltransferase 3 beta	-	HPRD	12202768
DNMT3B	ICF \| M.HsaIIIB	DNA (cytosine-5-)-methyltransferase 3 beta	DNMT3B interacts with HDAC1.	BIND	15120635
DNMT3L	MGC1090	DNA (cytosine-5-)-methyltransferase 3-like	-	HPRD,BioGRID	12177302 \|12202768
E2F1	E2F-1 \| RBAP1 \| RBBP3 \| RBP3	E2F transcription factor 1	Affinity Capture-Western	BioGRID	10734134
E2F4	E2F-4	E2F transcription factor 4, p107/p130-binding	-	HPRD,BioGRID	9724731
EED	HEED \| WAIT1	embryonic ectoderm development	-	HPRD,BioGRID	10581039
EFCAB6	DJBP \| FLJ23588 \| HSCBCIP1 \| KIAA1672 \| dJ185D5.1	EF-hand calcium binding domain 6	Affinity Capture-Western	BioGRID	12612053
EID2	CRI2 \| EID-2 \| MGC20452	EP300 interacting inhibitor of differentiation 2	-	HPRD	12586827
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	ER-alpha interacts with HDAC1.	BIND	14506733
EVI1	AML1-EVI-1 \| EVI-1 \| MDS1-EVI1 \| MGC163392 \| PRDM3	ecotropic viral integration site 1	-	HPRD,BioGRID	11568182
EZH2	ENX-1 \| EZH1 \| KMT6 \| MGC9169	enhancer of zeste homolog 2 (Drosophila)	-	HPRD,BioGRID	10581039
FKBP3	FKBP-25 \| PPIase	FK506 binding protein 3, 25kDa	-	HPRD,BioGRID	11532945
FOXG1	BF1 \| BF2 \| FHKL3 \| FKH2 \| FKHL1 \| FKHL2 \| FKHL3 \| FKHL4 \| FOXG1A \| FOXG1B \| FOXG1C \| HBF-1 \| HBF-2 \| HBF-3 \| HBF-G2 \| HBF2 \| HFK1 \| HFK2 \| HFK3 \| KHL2 \| QIN	forkhead box G1	-	HPRD	11238932
GATA1	ERYF1 \| GF-1 \| GF1 \| NFE1	GATA binding protein 1 (globin transcription factor 1)	Affinity Capture-Western	BioGRID	14668799
GATAD2B	FLJ37346 \| KIAA1150 \| MGC138257 \| MGC138285 \| P66beta \| RP11-216N14.6	GATA zinc finger domain containing 2B	Affinity Capture-Western	BioGRID	11756549
GTF2I	BAP-135 \| BAP135 \| BTKAP1 \| DIWS \| FLJ38776 \| FLJ56355 \| IB291 \| SPIN \| TFII-I \| WBS \| WBSCR6	general transcription factor II, i	Affinity Capture-Western	BioGRID	12393887
HBP1	FLJ16340	HMG-box transcription factor 1	-	HPRD,BioGRID	15235594
HCFC1	CFF \| HCF-1 \| HCF1 \| HFC1 \| MGC70925 \| VCAF	host cell factor C1 (VP16-accessory protein)	Affinity Capture-MS Affinity Capture-Western	BioGRID	12670868
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	Affinity Capture-MS	BioGRID	12920132
HDAC2	RPD3 \| YAF1	histone deacetylase 2	-	HPRD,BioGRID	9520398
HDAC3	HD3 \| RPD3 \| RPD3-2	histone deacetylase 3	-	HPRD	10944117 \|11302704
HDAC9	DKFZp779K1053 \| HD7 \| HDAC \| HDAC7 \| HDAC7B \| HDAC9B \| HDAC9FL \| HDRP \| KIAA0744 \| MITR	histone deacetylase 9	Affinity Capture-Western	BioGRID	10655483
HDAC9	DKFZp779K1053 \| HD7 \| HDAC \| HDAC7 \| HDAC7B \| HDAC9B \| HDAC9FL \| HDRP \| KIAA0744 \| MITR	histone deacetylase 9	An unspecified isoform of HDAC9 (MITR) interacts with HDAC1. This interaction was modelled on a demonstrated interaction between an unspecified isoform of human HDAC9 and HDAC1 from an unspecified species.	BIND	15711539
HDAC9	DKFZp779K1053 \| HD7 \| HDAC \| HDAC7 \| HDAC7B \| HDAC9B \| HDAC9FL \| HDRP \| KIAA0744 \| MITR	histone deacetylase 9	-	HPRD	12590135
HEY2	CHF1 \| GRIDLOCK \| GRL \| HERP1 \| HESR2 \| HRT2 \| MGC10720 \| bHLHb32	hairy/enhancer-of-split related with YRPW motif 2	-	HPRD,BioGRID	11486045
HIC1	ZBTB29 \| hic-1	hypermethylated in cancer 1	-	HPRD	12052894
HIF1A	HIF-1alpha \| HIF1 \| HIF1-ALPHA \| MOP1 \| PASD8	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	Reconstituted Complex	BioGRID	11641274
HIF1AN	DKFZp762F1811 \| FIH1 \| FLJ20615 \| FLJ22027	hypoxia-inducible factor 1, alpha subunit inhibitor	-	HPRD,BioGRID	11641274
HMG20B	BRAF25 \| BRAF35 \| FLJ26127 \| HMGX2 \| PP7706 \| SMARCE1r \| SOXL \| pp8857	high-mobility group 20B	Affinity Capture-Western Co-purification	BioGRID	12032298
HR	ALUNC \| AU \| HSA277165	hairless homolog (mouse)	-	HPRD,BioGRID	11641275
HSPA4	APG-2 \| HS24/P52 \| MGC131852 \| RY \| hsp70 \| hsp70RY	heat shock 70kDa protein 4	Affinity Capture-Western	BioGRID	11777905
HSPD1	CPN60 \| GROEL \| HSP60 \| HSP65 \| HuCHA60 \| SPG13	heat shock 60kDa protein 1 (chaperonin)	Affinity Capture-Western	BioGRID	11777905
HUS1	-	HUS1 checkpoint homolog (S. pombe)	-	HPRD,BioGRID	10846170
IFRD1	PC4 \| TIS7	interferon-related developmental regulator 1	Affinity Capture-Western	BioGRID	12198164
IKZF1	Hs.54452 \| IK1 \| IKAROS \| LYF1 \| PRO0758 \| ZNFN1A1 \| hIk-1	IKAROS family zinc finger 1 (Ikaros)	Affinity Capture-Western	BioGRID	10357820 \|12015313
ING1	p24ING1c \| p33 \| p33ING1 \| p33ING1b \| p47 \| p47ING1a	inhibitor of growth family, member 1	Affinity Capture-MS Affinity Capture-Western	BioGRID	11784859 \|12015309
KAT5	ESA1 \| HTATIP \| HTATIP1 \| PLIP \| TIP \| TIP60 \| cPLA2	K(lysine) acetyltransferase 5	-	HPRD	11994312
KLF11	FKLF \| FKLF1 \| MODY7 \| TIEG2 \| Tieg3	Kruppel-like factor 11	-	HPRD,BioGRID	11438660
MAD1L1	HsMAD1 \| MAD1 \| PIG9 \| TP53I9 \| TXBP181	MAD1 mitotic arrest deficient-like 1 (yeast)	Affinity Capture-Western Co-purification	BioGRID	15388328
MAP3K7IP2	FLJ21885 \| KIAA0733 \| TAB2	mitogen-activated protein kinase kinase kinase 7 interacting protein 2	Reconstituted Complex	BioGRID	12150997
MBD2	DKFZp586O0821 \| DMTase \| NY-CO-41	methyl-CpG binding domain protein 2	-	HPRD,BioGRID	10471499
MBD3	-	methyl-CpG binding domain protein 3	-	HPRD,BioGRID	12124384
MBD3	-	methyl-CpG binding domain protein 3	MBD3 interacts with HDAC1.	BIND	12124384
MBD3L1	MBD3L \| MGC138263 \| MGC138269	methyl-CpG binding domain protein 3-like 1	Affinity Capture-Western	BioGRID	15456747
MDM2	HDMX \| MGC71221 \| hdm2	Mdm2 p53 binding protein homolog (mouse)	-	HPRD,BioGRID	12426395
MDS1	MDS1-EVI1 \| PRDM3	myelodysplasia syndrome 1	-	HPRD,BioGRID	11552981
MIER1	DKFZp781G0451 \| ER1 \| KIAA1610 \| MGC131940 \| MGC150640 \| MGC150641 \| MI-ER1 \| RP5-944N15.1 \| hMI-ER1	mesoderm induction early response 1 homolog (Xenopus laevis)	-	HPRD,BioGRID	12482978
MIZF	DKFZp434F162 \| HiNF-P \| ZNF743	MBD2-interacting zinc finger	Affinity Capture-Western	BioGRID	12665568
MLL	ALL-1 \| CXXC7 \| FLJ11783 \| HRX \| HTRX1 \| KMT2A \| MLL/GAS7 \| MLL1A \| TET1-MLL \| TRX1	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	Affinity Capture-Western Reconstituted Complex	BioGRID	12829790
MORF4L2	KIAA0026 \| MORFL2 \| MRGX	mortality factor 4 like 2	-	HPRD	14506250
MT1G	MGC12386 \| MT1 \| MT1K	metallothionein 1G	HDAC1 interacts with the MT1G promoter.	BIND	15735762
MTA1	-	metastasis associated 1	-	HPRD,BioGRID	10840944 \|11146623
MTA2	DKFZp686F2281 \| MTA1L1 \| PID	metastasis associated 1 family, member 2	Affinity Capture-MS Affinity Capture-Western Co-purification	BioGRID	10444591 \|11171972 \|12374985 \|12920132
MXD1	MAD \| MAD1 \| MGC104659	MAX dimerization protein 1	-	HPRD	9150133 \|9150134
MXD1	MAD \| MAD1 \| MGC104659	MAX dimerization protein 1	Reconstituted Complex	BioGRID	11101889
MYOD1	MYF3 \| MYOD \| PUM \| bHLHc1	myogenic differentiation 1	-	HPRD,BioGRID	11285237 \|11684023
NCOR2	CTG26 \| SMRT \| SMRTE \| SMRTE-tau \| TNRC14 \| TRAC-1 \| TRAC1	nuclear receptor co-repressor 2	Affinity Capture-Western Co-purification	BioGRID	11013263 \|11739383
NFIX	NF1A	nuclear factor I/X (CCAAT-binding transcription factor)	Affinity Capture-Western	BioGRID	11896613
NFKB1	DKFZp686C01211 \| EBP-1 \| KBF1 \| MGC54151 \| NF-kappa-B \| NFKB-p105 \| NFKB-p50 \| p105	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	-	HPRD,BioGRID	11931769
NFKBIA	IKBA \| MAD-3 \| NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	HDAC1 interacts with I-kappa-B-alpha.	BIND	12972430
NR2F2	ARP1 \| COUP-TFII \| COUPTFB \| MGC117452 \| SVP40 \| TFCOUP2	nuclear receptor subfamily 2, group F, member 2	-	HPRD,BioGRID	10704340
NRIP1	FLJ77253 \| RIP140	nuclear receptor interacting protein 1	-	HPRD	11006275\|11285237
PCNA	MGC8367	proliferating cell nuclear antigen	-	HPRD,BioGRID	11929879
PEX14	MGC12767 \| NAPP2 \| Pex14p \| dJ734G22.2	peroxisomal biogenesis factor 14	-	HPRD	11909966
PHB	PHB1	prohibitin	-	HPRD,BioGRID	12466959
PHF12	FLJ34122 \| KIAA1523 \| MGC131914 \| PF1	PHD finger protein 12	-	HPRD,BioGRID	11390640
PHF21A	BHC80 \| BM-006 \| KIAA1696	PHD finger protein 21A	-	HPRD,BioGRID	15325272
PIAS3	FLJ14651 \| ZMIZ5	protein inhibitor of activated STAT, 3	-	HPRD	14691252
PML	MYL \| PP8675 \| RNF71 \| TRIM19	promyelocytic leukemia	-	HPRD,BioGRID	11259576 \|11430826
PPARD	FAAR \| MGC3931 \| NR1C2 \| NUC1 \| NUCI \| NUCII \| PPAR-beta \| PPARB	peroxisome proliferator-activated receptor delta	-	HPRD,BioGRID	11867749
PTMA	MGC104802 \| TMSA	prothymosin, alpha	-	HPRD,BioGRID	12634383
RAD9A	RAD9	RAD9 homolog A (S. pombe)	-	HPRD,BioGRID	10846170
RARB	HAP \| NR1B2 \| RRB2	retinoic acid receptor, beta	HDAC1 interacts with RARB (RAR-beta-2) gene promoter sequences.	BIND	15688037
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	RB interacts with HDAC1.	BIND	11447271
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	-	HPRD	9491888 \|10888886 \|11896613 \|11909966
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	The Retinoblastoma protein interacts with Histone Deacetylase 1.	BIND	10734134
RB1	OSRC \| RB \| p105-Rb \| pRb \| pp110	retinoblastoma 1	Affinity Capture-Western Reconstituted Complex	BioGRID	9491888 \|9724731 \|10490602 \|10615135 \|10779361 \|11684023 \|12466959
RBBP4	NURF55 \| RBAP48	retinoblastoma binding protein 4	RbAp48 interacts with HDAC1	BIND	10734134
RBBP4	NURF55 \| RBAP48	retinoblastoma binding protein 4	-	HPRD	10734134 \|11302704 \|12091390 \|12943729
RBBP4	NURF55 \| RBAP48	retinoblastoma binding protein 4	Affinity Capture-Western Co-purification Reconstituted Complex	BioGRID	9150133 \|9150135 \|9520398 \|10220385 \|10444591 \|10471499 \|11171972 \|11470869 \|12091390 \|12920132 \|12943729
RBBP7	MGC138867 \| MGC138868 \| RbAp46	retinoblastoma binding protein 7	Affinity Capture-Western Co-purification	BioGRID	9150135 \|10444591 \|10471499 \|12920132
RBL1	CP107 \| MGC40006 \| PRB1 \| p107	retinoblastoma-like 1 (p107)	-	HPRD,BioGRID	9724731
RBL2	FLJ26459 \| P130 \| Rb2	retinoblastoma-like 2 (p130)	-	HPRD,BioGRID	10969803
RCOR1	COREST \| KIAA0071 \| RCOR	REST corepressor 1	Affinity Capture-MS Affinity Capture-Western Co-purification	BioGRID	11171972 \|12032298
RECQL4	RECQ4	RecQ protein-like 4	HDAC1 interacts with the RECQL4 (RECQ4) promoter.	BIND	15674334
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	-	HPRD,BioGRID	11564889
RFC1	A1 \| MGC51786 \| MHCBFB \| PO-GA \| RECC1 \| RFC \| RFC140	replication factor C (activator 1) 1, 145kDa	-	HPRD,BioGRID	12045192
RFC4	A1 \| MGC27291 \| RFC37	replication factor C (activator 1) 4, 37kDa	-	HPRD	12045192
RUNX1T1	AML1T1 \| CBFA2T1 \| CDR \| ETO \| MGC2796 \| MTG8 \| MTG8b \| ZMYND2	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	Affinity Capture-Western	BioGRID	11533236
RUNX1T1	AML1T1 \| CBFA2T1 \| CDR \| ETO \| MGC2796 \| MTG8 \| MTG8b \| ZMYND2	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	ETO interacts with HDAC1.	BIND	15333839
RUNX3	AML2 \| CBFA3 \| FLJ34510 \| MGC16070 \| PEBP2aC	runt-related transcription factor 3	-	HPRD	15138260
RUVBL2	CGI-46 \| ECP51 \| INO80J \| REPTIN \| RVB2 \| TIH2 \| TIP48 \| TIP49B	RuvB-like 2 (E. coli)	RUVBL2 (reptin) interacts with HDAC1.	BIND	15829968
SALL1	HSAL1 \| TBS \| ZNF794	sal-like 1 (Drosophila)	-	HPRD	11836251
SAP130	FLJ12761	Sin3A-associated protein, 130kDa	Affinity Capture-Western	BioGRID	12724404
SAP18	2HOR0202 \| MGC27131 \| SAP18p	Sin3A-associated protein, 18kDa	-	HPRD	9150135
SAP30	-	Sin3A-associated protein, 30kDa	-	HPRD,BioGRID	9651585
SATB1	-	SATB homeobox 1	-	HPRD,BioGRID	12374985
SETDB1	ESET \| KG1T \| KIAA0067 \| KMT1E	SET domain, bifurcated 1	-	HPRD	12398767
SIN3A	DKFZp434K2235 \| FLJ90319 \| KIAA0700	SIN3 homolog A, transcription regulator (yeast)	The transcriptional repressor mSin3A interacts with the histone deacetylase 1 protein.	BIND	9150133 \|9150134
SIN3A	DKFZp434K2235 \| FLJ90319 \| KIAA0700	SIN3 homolog A, transcription regulator (yeast)	Affinity Capture-MS Affinity Capture-Western Co-fractionation Co-purification	BioGRID	9520398 \|9804427 \|10220385 \|10444591 \|10640275 \|11171972 \|11784859 \|11931768 \|12091390 \|12374985 \|12398767 \|12724404 \|12920132 \|12943729
SIN3A	DKFZp434K2235 \| FLJ90319 \| KIAA0700	SIN3 homolog A, transcription regulator (yeast)	-	HPRD	11013263
SIN3B	KIAA0700	SIN3 homolog B, transcription regulator (yeast)	-	HPRD	11959842
SIN3B	KIAA0700	SIN3 homolog B, transcription regulator (yeast)	Affinity Capture-Western Co-purification	BioGRID	10357820 \|10444591
SMAD2	JV18 \| JV18-1 \| MADH2 \| MADR2 \| MGC22139 \| MGC34440 \| hMAD-2 \| hSMAD2	SMAD family member 2	-	HPRD,BioGRID	10199400
SMARCA2	BAF190 \| BRM \| FLJ36757 \| MGC74511 \| SNF2 \| SNF2L2 \| SNF2LA \| SWI2 \| Sth1p \| hBRM \| hSNF2a	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	Co-purification	BioGRID	11238380
SMARCB1	BAF47 \| INI1 \| RDT \| SNF5 \| SNF5L1 \| Sfh1p \| Snr1 \| hSNFS	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Co-purification	BioGRID	11238380
SP1	-	Sp1 transcription factor	Affinity Capture-Western	BioGRID	11896613 \|12091390 \|12176973 \|12847090
SP1	-	Sp1 transcription factor	-	HPRD	11896613 \|11909966
SP3	DKFZp686O1631 \| SPR-2	Sp3 transcription factor	-	HPRD,BioGRID	12176973
SPEN	KIAA0929 \| MINT \| RP1-134O19.1 \| SHARP	spen homolog, transcriptional regulator (Drosophila)	-	HPRD,BioGRID	11331609
STAT3	APRF \| FLJ20882 \| HIES \| MGC16063	signal transducer and activator of transcription 3 (acute-phase response factor)	Stat3 interacts with HDAC1.	BIND	15653507
SUDS3	FLJ00052 \| MGC104711 \| SAP45 \| SDS3	suppressor of defective silencing 3 homolog (S. cerevisiae)	Affinity Capture-Western	BioGRID	11909966 \|12724404
SUV39H1	KMT1A \| MG44 \| SUV39H	suppressor of variegation 3-9 homolog 1 (Drosophila)	-	HPRD,BioGRID	11788710
TAL1	SCL \| TCL5 \| bHLHa17 \| tal-1	T-cell acute lymphocytic leukemia 1	-	HPRD	10688671
TAL1	SCL \| TCL5 \| bHLHa17 \| tal-1	T-cell acute lymphocytic leukemia 1	Affinity Capture-MS	BioGRID	16407974
TGIF1	HPE4 \| MGC39747 \| MGC5066 \| TGIF	TGFB-induced factor homeobox 1	Affinity Capture-Western	BioGRID	10995736 \|11427533
TGIF2	-	TGFB-induced factor homeobox 2	-	HPRD,BioGRID	11427533
TLE4	BCE-1 \| BCE1 \| E(spI) \| ESG \| ESG4 \| GRG4	transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)	Affinity Capture-Western	BioGRID	11266540
TNFSF10	APO2L \| Apo-2L \| CD253 \| TL2 \| TRAIL	tumor necrosis factor (ligand) superfamily, member 10	HDAC1 interacts with the TNFSF10 promoter.	BIND	15619633
TOP2A	TOP2 \| TP2A	topoisomerase (DNA) II alpha 170kDa	-	HPRD,BioGRID	11136718
TOP2B	TOPIIB \| top2beta	topoisomerase (DNA) II beta 180kDa	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	11062478 \|11136718
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	Affinity Capture-Western	BioGRID	12426395
TPD52L1	D53 \| MGC8556 \| TPD52L2 \| hD53	tumor protein D52-like 1	Two-hybrid	BioGRID	16169070
TRIM27	RFP \| RNF76	tripartite motif-containing 27	-	HPRD	14530259
TXNIP	EST01027 \| HHCPA78 \| THIF \| VDUP1	thioredoxin interacting protein	-	HPRD,BioGRID	12821938
VHL	HRCA1 \| RCA1 \| VHL1	von Hippel-Lindau tumor suppressor	Reconstituted Complex	BioGRID	11641274
YY1	DELTA \| INO80S \| NF-E1 \| UCRBP \| YIN-YANG-1	YY1 transcription factor	Reconstituted Complex	BioGRID	9346952
ZBTB16	PLZF \| ZNF145	zinc finger and BTB domain containing 16	-	HPRD	9627120 \|15467736
ZBTB16	PLZF \| ZNF145	zinc finger and BTB domain containing 16	Affinity Capture-Western Reconstituted Complex	BioGRID	9627120 \|9765306 \|15467736
ZBTB16	PLZF \| ZNF145	zinc finger and BTB domain containing 16	HDAC1 interacts with PLZF. This interaction was modelled on a demonstrated interaction between HDAC1 and PLZF from unspecified species.	BIND	9486654

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
KEGG NOTCH SIGNALING PATHWAY	47	35	All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE	185	109	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA	73	59	All SZGR 2.0 genes in this pathway
BIOCARTA CARM ER PATHWAY	35	27	All SZGR 2.0 genes in this pathway
BIOCARTA G1 PATHWAY	28	21	All SZGR 2.0 genes in this pathway
BIOCARTA VDR PATHWAY	12	7	All SZGR 2.0 genes in this pathway
BIOCARTA MTA3 PATHWAY	19	10	All SZGR 2.0 genes in this pathway
BIOCARTA PITX2 PATHWAY	15	15	All SZGR 2.0 genes in this pathway
BIOCARTA MEF2D PATHWAY	23	16	All SZGR 2.0 genes in this pathway
BIOCARTA WNT PATHWAY	26	24	All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY	82	63	All SZGR 2.0 genes in this pathway
PID NOTCH PATHWAY	59	49	All SZGR 2.0 genes in this pathway
PID E2F PATHWAY	74	48	All SZGR 2.0 genes in this pathway
PID PS1 PATHWAY	46	39	All SZGR 2.0 genes in this pathway
PID HDAC CLASSI PATHWAY	66	50	All SZGR 2.0 genes in this pathway
PID TELOMERASE PATHWAY	68	48	All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY	82	60	All SZGR 2.0 genes in this pathway
PID RANBP2 PATHWAY	11	11	All SZGR 2.0 genes in this pathway
PID AR TF PATHWAY	53	38	All SZGR 2.0 genes in this pathway
PID IL3 PATHWAY	27	19	All SZGR 2.0 genes in this pathway
PID ERA GENOMIC PATHWAY	65	37	All SZGR 2.0 genes in this pathway
PID RETINOIC ACID PATHWAY	30	23	All SZGR 2.0 genes in this pathway
PID HEDGEHOG GLI PATHWAY	48	35	All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID MYC REPRESS PATHWAY	63	52	All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY	65	46	All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY	48	39	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME G0 AND EARLY G1	25	13	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	46	28	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH1	70	46	All SZGR 2.0 genes in this pathway
REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	27	17	All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	38	26	All SZGR 2.0 genes in this pathway
REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	20	14	All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY	352	181	All SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	81	61	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES	137	79	All SZGR 2.0 genes in this pathway
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	132	101	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH	103	64	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX	63	42	All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 UP	201	125	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS DN	260	143	All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS DN	232	139	All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP	265	158	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR DN	64	39	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR DN	75	50	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP	293	179	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP	479	299	All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK	101	73	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
LIAO METASTASIS	539	324	All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 8	36	28	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 UP	64	40	All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA	176	122	All SZGR 2.0 genes in this pathway
XU RESPONSE TO TRETINOIN AND NSC682994 UP	17	13	All SZGR 2.0 genes in this pathway
NGUYEN NOTCH1 TARGETS UP	29	23	All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY TBH AND H2O2	36	24	All SZGR 2.0 genes in this pathway
LEE AGING NEOCORTEX DN	80	49	All SZGR 2.0 genes in this pathway
RHODES CANCER META SIGNATURE	64	47	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP	198	132	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C1	72	45	All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP	294	199	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN	342	220	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE	242	168	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
GU PDEF TARGETS UP	71	49	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION	368	247	All SZGR 2.0 genes in this pathway
SETLUR PROSTATE CANCER TMPRSS2 ERG FUSION UP	67	48	All SZGR 2.0 genes in this pathway
KESHELAVA MULTIPLE DRUG RESISTANCE	88	56	All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE	335	193	All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP	295	155	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN	336	211	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-410	90	96	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: HDAC1