Gene Page: CXCL10

Summary ?
GeneID3627
SymbolCXCL10
SynonymsC7|IFI10|INP10|IP-10|SCYB10|crg-2|gIP-10|mob-1
DescriptionC-X-C motif chemokine ligand 10
ReferenceMIM:147310|HGNC:HGNC:10637|Ensembl:ENSG00000169245|HPRD:00930|Vega:OTTHUMG00000160887
Gene typeprotein-coding
Map location4q21
Pascal p-value0.067
Fetal beta-0.622
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10915489chr14321466CXCL1036270.09trans
rs12036740chr158432174CXCL1036270.04trans
rs10789056chr158457827CXCL1036270.18trans
rs12041093chr158462509CXCL1036270.01trans
rs12023109chr158482942CXCL1036270.01trans
rs473019chr172296394CXCL1036273.789E-4trans
rs17359517chr1115381897CXCL1036270.11trans
rs1342707chr1147264296CXCL1036279.186E-9trans
rs12076447chr1159552549CXCL1036275.311E-5trans
rs10752920chr1183783202CXCL1036270.13trans
rs10494571chr1183930700CXCL1036279.805E-6trans
rs6656512chr1223644438CXCL1036270.08trans
rs4027083chr1234452908CXCL1036270.05trans
rs2907143chr1243147434CXCL1036270.05trans
rs10495652chr217139288CXCL1036270.09trans
rs6531271chr217139932CXCL1036270.09trans
rs12620194chr217148003CXCL1036270.09trans
rs16987384chr220328893CXCL1036270.09trans
rs17042744chr221824821CXCL1036270trans
rs918897chr221825859CXCL1036270.08trans
rs2113625chr221828617CXCL1036270trans
rs17680142chr221849670CXCL1036270trans
rs6547745chr221852551CXCL1036270trans
rs6758775chr221887142CXCL1036270.02trans
rs17042868chr221895688CXCL1036270trans
rs11893111chr221910980CXCL1036270trans
rs4488633chr235142820CXCL1036270.16trans
rs6760426chr266175535CXCL1036270.15trans
rs17546660chr266218021CXCL1036270.12trans
rs2218030chr2184261431CXCL1036270.07trans
rs16824418chr2184275364CXCL1036270.19trans
rs17033273chr310676696CXCL1036270.01trans
rs277655chr3100044586CXCL1036270.14trans
rs16847252chr3163481290CXCL1036272.588E-5trans
rs2215847chr425067686CXCL1036270.12trans
rs591585chr443424979CXCL1036270.07trans
rs6551878chr465690588CXCL1036270.11trans
rs17622486chr4115785097CXCL1036270.05trans
rs298465chr4139260859CXCL1036270.19trans
rs11953760chr59842943CXCL1036270.09trans
rs7380779chr534436068CXCL1036270trans
rs7380792chr534436187CXCL1036270trans
rs10074060chr534437321CXCL1036270.05trans
rs7442700chr534493693CXCL1036270.06trans
rs4516856chr543889206CXCL1036270.05trans
rs31304chr552942082CXCL1036270.01trans
rs10514893chr559657694CXCL1036270.11trans
rs10514894chr559658797CXCL1036270.18trans
rs10515260chr597076547CXCL1036272.687E-12trans
rs10515267chr5100128201CXCL1036270.03trans
rs17780121chr5100168511CXCL1036270.05trans
rs17780992chr5100195770CXCL1036270.05trans
rs9313842chr5159690030CXCL1036270.05trans
rs6920921chr68884160CXCL1036270.11trans
rs2327748chr614082533CXCL1036270.01trans
rs121959840CXCL1036270.14trans
rs10498827chr665470694CXCL1036270.08trans
rs16869716chr671743471CXCL1036279.782E-8trans
rs2093506chr6154232014CXCL1036270.06trans
rs6455821chr6162825101CXCL1036270.06trans
rs6956395chr728072244CXCL1036270.01trans
rs6462122chr729137630CXCL1036270.01trans
rs7776597chr751015581CXCL1036270.08trans
rs3937454chr7152676939CXCL1036270.19trans
rs7790094chr7152786528CXCL1036270.02trans
rs4410820chr7152853659CXCL1036270.05trans
rs17075051chr85761144CXCL1036270.02trans
rs17075079chr85765448CXCL1036270.05trans
rs10503341chr85775097CXCL1036270.18trans
rs9325708chr812402940CXCL1036277.414E-4trans
rs7817084chr843242956CXCL1036270.14trans
rs10959381chr910936134CXCL1036270.11trans
rs12344698chr916750142CXCL1036270.07trans
rs17376956chr1011179948CXCL1036270.17trans
rs3802522chr1028341865CXCL1036274.127E-7trans
rs10508730chr1028403391CXCL1036274.127E-7trans
rs16936983chr1037871050CXCL1036270.14trans
rs1344342chr1037958911CXCL1036270.14trans
rs1108733chr1037993286CXCL1036270.14trans
rs4917410chr1095872539CXCL1036270.17trans
rs7089703chr10119182182CXCL1036270.06trans
rs11246002chr11211446CXCL1036270.16trans
rs10743139chr1110425326CXCL1036270.02trans
rs2508654chr11120405519CXCL1036270.02trans
rs1944608chr11123091803CXCL1036270.09trans
rs17127157chr11123092323CXCL1036270.09trans
rs10893162chr11124076268CXCL1036270.09trans
rs11219545chr11124136438CXCL1036270.09trans
rs11219646chr11124279239CXCL1036270.04trans
rs7102988chr11130134440CXCL1036270.16trans
rs7972594chr1211724913CXCL1036270.06trans
rs10491979chr1211727969CXCL1036270.06trans
rs11171083chr1255192688CXCL1036270.08trans
rs1542363chr1255213677CXCL1036270.08trans
rs1542364chr1255213700CXCL1036270.08trans
rs7298952chr1255216414CXCL1036270.08trans
rs921723chr1255221358CXCL1036270.08trans
rs2219716chr1286139883CXCL1036270.04trans
rs11107750chr1295241256CXCL1036270.11trans
rs7304048chr1295292947CXCL1036270.11trans
rs4762419chr1295771835CXCL1036270.09trans
rs3751152chr12121442063CXCL1036270.01trans
rs9645995chr1347246048CXCL1036270.01trans
rs9598109chr1360878618CXCL1036270.13trans
rs17081091chr1366867486CXCL1036270.13trans
rs4328300chr13104315373CXCL1036270.12trans
rs9519133chr13104325831CXCL1036270.12trans
rs6491786chr13104328014CXCL1036270.12trans
rs9519135chr13104332307CXCL1036270.12trans
rs9519136chr13104332406CXCL1036270.12trans
rs17111522chr1441634403CXCL1036270.18trans
rs9989174chr1482663493CXCL1036270.02trans
rs1958669chr1482675761CXCL1036270.04trans
rs2219618chr1554109136CXCL1036270.11trans
rs6494052chr1559295924CXCL1036270.11trans
rs6497089chr1594163348CXCL1036273.036E-4trans
rs7170017chr1594179359CXCL1036270.06trans
rs6498459chr1613795898CXCL1036270.07trans
rs963303chr1673372497CXCL1036270.01trans
rs4303487chr1690033254CXCL1036272.809E-7trans
rs6587203chr1719671457CXCL1036270.03trans
rs205113chr1719673879CXCL1036270.03trans
rs205111chr1719675103CXCL1036270.03trans
rs205110chr1719675587CXCL1036270.03trans
rs205093chr1719685712CXCL1036270.03trans
rs157406chr1719710650CXCL1036270.03trans
rs157402chr1719720588CXCL1036270.03trans
rs157396chr1719726832CXCL1036270.03trans
rs157397chr1719729494CXCL1036270.03trans
rs80742580CXCL1036270.03trans
rs172186chr1719780658CXCL1036270.01trans
rs281334chr1719782079CXCL1036270.03trans
rs4586510chr1719783973CXCL1036270.03trans
rs2448755chr1865344801CXCL1036270.12trans
rs16966813chr1932698878CXCL1036274.503E-4trans
rs6076060chr2023345068CXCL1036270.12trans
rs965018chr2041531585CXCL1036270.18trans
rs9619990chr2242163258CXCL1036270.13trans
rs17342476chrX102243644CXCL1036274.175E-5trans
rs17342483chrX102250155CXCL1036279.008E-4trans
rs17342504chrX102272107CXCL1036274.175E-5trans
snp_a-21388510CXCL1036274.175E-5trans
snp_a-20599280CXCL1036274.175E-5trans
rs5957194chrX118769609CXCL1036274.136E-5trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RFC10.830.83
CLPX0.830.84
METT10D0.830.83
HOOK30.820.85
ZNF3970.820.85
ZNF4260.820.85
TPR0.820.81
XIAP0.810.84
PCM10.810.82
NEK40.810.81
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.65-0.66
AF347015.21-0.63-0.67
MT-CO2-0.61-0.63
AF347015.27-0.60-0.62
HIGD1B-0.60-0.62
IFI27-0.60-0.62
MT-CYB-0.58-0.60
AF347015.8-0.58-0.60
AF347015.15-0.55-0.58
AF347015.33-0.54-0.56

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267161All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY 190128All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 10288All SZGR 2.0 genes in this pathway
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY 7151All SZGR 2.0 genes in this pathway
KEGG CYTOSOLIC DNA SENSING PATHWAY 5644All SZGR 2.0 genes in this pathway
PID CXCR3 PATHWAY 4334All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS 188108All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES 5727All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195114All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
PICCALUGA ANGIOIMMUNOBLASTIC LYMPHOMA UP 205140All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP 294178All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP 485293All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233161All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP 182110All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP 194122All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP 204140All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501327All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP 544308All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431237All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL DIVIDING UP 5733All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP 6647All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
KOINUMA COLON CANCER MSI UP 1611All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP 215137All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP 211136All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS C UP 170114All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP 207128All SZGR 2.0 genes in this pathway
MAHADEVAN RESPONSE TO MP470 UP 2011All SZGR 2.0 genes in this pathway
EBAUER MYOGENIC TARGETS OF PAX3 FOXO1 FUSION 5026All SZGR 2.0 genes in this pathway
SEITZ NEOPLASTIC TRANSFORMATION BY 8P DELETION UP 7347All SZGR 2.0 genes in this pathway
KANG GIST WITH PDGFRA UP 5027All SZGR 2.0 genes in this pathway
YAN ESCAPE FROM ANOIKIS 2419All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION 149101All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN 156106All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
AMIT SERUM RESPONSE 120 MCF10A 6544All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP 223140All SZGR 2.0 genes in this pathway
LEI HOXC8 TARGETS DN 1713All SZGR 2.0 genes in this pathway
RADAEVA RESPONSE TO IFNA1 UP 5240All SZGR 2.0 genes in this pathway
WIELAND UP BY HBV INFECTION 10166All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG UP 7850All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING UP 8356All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 UP 6235All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183111All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway
BROWNE INTERFERON RESPONSIVE GENES 6844All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP 10573All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP 12089All SZGR 2.0 genes in this pathway
HAN JNK SINGALING UP 3521All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP 7757All SZGR 2.0 genes in this pathway
ZHU CMV 8 HR UP 4739All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS 9268All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282183All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317208All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648398All SZGR 2.0 genes in this pathway
MOSERLE IFNA RESPONSE 3119All SZGR 2.0 genes in this pathway
GAURNIER PSMD4 TARGETS 7355All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN DN 1816All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165118All SZGR 2.0 genes in this pathway
SEKI INFLAMMATORY RESPONSE LPS UP 7756All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP 10767All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION A 6752All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315201All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418282All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408276All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS KERATINOCYTE UP 9163All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE UP 181106All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288168All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE UP 10968All SZGR 2.0 genes in this pathway
MIKKELSEN IPS ICP WITH H3K27ME3 5432All SZGR 2.0 genes in this pathway
KUROZUMI RESPONSE TO ONCOCYTIC VIRUS 4430All SZGR 2.0 genes in this pathway
WORSCHECH TUMOR EVASION AND TOLEROGENICITY UP 3019All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253192All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP 7646All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572352All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS UP 217131All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS GROUP2 6038All SZGR 2.0 genes in this pathway
KIM GLIS2 TARGETS UP 8461All SZGR 2.0 genes in this pathway
WINZEN DEGRADED VIA KHSRP 10070All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364236All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337236All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE 11462All SZGR 2.0 genes in this pathway
ALTEMEIER RESPONSE TO LPS WITH MECHANICAL VENTILATION 12881All SZGR 2.0 genes in this pathway
GHANDHI BYSTANDER IRRADIATION UP 8654All SZGR 2.0 genes in this pathway
HECKER IFNB1 TARGETS 9554All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344197All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway