Gene Page: EIF3E

Summary ?
GeneID3646
SymbolEIF3E
SynonymsEIF3-P48|EIF3S6|INT6|eIF3-p46
Descriptioneukaryotic translation initiation factor 3 subunit E
ReferenceMIM:602210|HGNC:HGNC:3277|Ensembl:ENSG00000104408|HPRD:03734|Vega:OTTHUMG00000164858
Gene typeprotein-coding
Map location8q22-q23
Pascal p-value0.003
Sherlock p-value0.105
Fetal beta2.122
DMG1 (# studies)
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0018 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg071681488109260989EIF3E1.97E-9-0.0141.63E-6DMG:Jaffe_2016
cg180447238109261011EIF3E3.27E-8-0.0119.82E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs7911247chr1049724799EIF3E36460.11trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
COL3A10.780.27
LUM0.780.69
C70.760.83
ITIH20.760.71
OGN0.750.83
OSR10.750.66
COL1A10.740.50
OLFML30.740.54
CYP1B10.740.81
COL6A30.730.80
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AC007216.4-0.24-0.20
AF347015.21-0.240.05
SNHG12-0.24-0.47
CHMP4A-0.23-0.33
AC098691.2-0.22-0.04
AC010300.1-0.22-0.27
AF347015.18-0.22-0.03
AC005921.3-0.21-0.45
MT-CO2-0.210.06
AF347015.26-0.210.09

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003743translation initiation factor activityTAS9295280 
GO:0005515protein bindingIPI14667819 |17220478 |17324924 
|17353931 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006446regulation of translational initiationTAS9295280 
GO:0006412translationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP12588972 
GO:0005852eukaryotic translation initiation factor 3 complexTAS9295280 
GO:0005737cytoplasmIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BAT2D6S51 | D6S51E | DKFZp686D09175 | G2HLA-B associated transcript 2-HPRD,BioGRID14667819 
CNTFHCNTFciliary neurotrophic factorAffinity Capture-MSBioGRID17353931 
COPS6CSN6 | MOV34-34KDCOP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)-HPRD,BioGRID12220626 
COPS7AMGC110877COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)-HPRD12220626 
COPS7BFLJ12612 | MGC111077COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis)-HPRD12220626 
COPS8COP9 | CSN8 | MGC1297 | MGC43256 | SGN8COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis)-HPRD12220626 
CSN3CSN10 | CSNK | KCAcasein kappaAffinity Capture-Western
Two-hybrid		BioGRID12220626 
DDX24-DEAD (Asp-Glu-Ala-Asp) box polypeptide 24Two-hybridBioGRID16169070 
EIF1BGC20eukaryotic translation initiation factor 1BAffinity Capture-MSBioGRID17353931 
EIF3AEIF3 | EIF3S10 | KIAA0139 | P167 | TIF32 | eIF3-p170 | eIF3-theta | p180 | p185eukaryotic translation initiation factor 3, subunit AAffinity Capture-MS
Affinity Capture-Western
Co-purification		BioGRID11590142 |14519125 
|17353931 
EIF3CEIF3S8 | FLJ78287 | MGC189744 | eIF3-p110eukaryotic translation initiation factor 3, subunit C-HPRD,BioGRID10504338 
EIF3EIPEIF3S11 | EIF3S6IP | HSPC021 | HSPC025 | MSTP005eukaryotic translation initiation factor 3, subunit E interacting protein-HPRD,BioGRID11590142 
GPAA1GAA1 | hGAA1glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)Two-hybridBioGRID16169070 
GPBP1L1RP11-767N6.1 | SP192GC-rich promoter binding protein 1-like 1Two-hybridBioGRID16189514 
HAP1HAP2 | HIP5 | HLP | hHLP1huntingtin-associated protein 1Two-hybridBioGRID16169070 
IFIT1G10P1 | GARG-16 | IFI-56 | IFI56 | IFNAI1 | ISG56 | RNM561interferon-induced protein with tetratricopeptide repeats 1-HPRD,BioGRID10644362 
MAGED1DLXIN-1 | NRAGEmelanoma antigen family D, 1Affinity Capture-MSBioGRID17353931 
NSFSKD2N-ethylmaleimide-sensitive factorTwo-hybridBioGRID16169070 
RGS2G0S8regulator of G-protein signaling 2, 24kDaAffinity Capture-MSBioGRID17353931 
RUNDC3ARAP2IP | RPIP8RUN domain containing 3ATwo-hybridBioGRID16189514 
SAP182HOR0202 | MGC27131 | SAP18pSin3A-associated protein, 18kDaAffinity Capture-MSBioGRID17353931 
TRIM27RFP | RNF76tripartite motif-containing 27-HPRD10504338 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID HIF2PATHWAY 3429All SZGR 2.0 genes in this pathway
REACTOME TRANSLATION 22275All SZGR 2.0 genes in this pathway
REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX 7424All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S 8430All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518242All SZGR 2.0 genes in this pathway
REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION 17651All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN 229142All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747453All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
DER IFN GAMMA RESPONSE DN 119All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405264All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS DN 14192All SZGR 2.0 genes in this pathway
KIM LRRC3B TARGETS 3024All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543317All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593372All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591366All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270181All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285167All SZGR 2.0 genes in this pathway
NUTT GBM VS AO GLIOMA DN 4522All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491316All SZGR 2.0 genes in this pathway
SWEET KRAS ONCOGENIC SIGNATURE 8956All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA 4327All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS UP 7445All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518299All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442263All SZGR 2.0 genes in this pathway
JISON SICKLE CELL DISEASE DN 18197All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 9 7645All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682440All SZGR 2.0 genes in this pathway
BILANGES SERUM SENSITIVE GENES 9054All SZGR 2.0 genes in this pathway
BILANGES RAPAMYCIN SENSITIVE VIA TSC1 AND TSC2 7337All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway