SZGR2

Summary ?

GeneID	3776
Symbol	KCNK2
Synonyms	K2p2.1\|TPKC1\|TREK\|TREK-1\|TREK1\|hTREK-1c\|hTREK-1e
Description	potassium two pore domain channel subfamily K member 2
Reference	MIM:603219\|HGNC:HGNC:6277\|Ensembl:ENSG00000082482\|Vega:OTTHUMG00000037017
Gene type	protein-coding
Map location	1q41
Fetal beta	2.599
DMG	1 (# studies)

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1
Expression	Meta-analysis of gene expression	P value: 1.399

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg04976337	1	215256745	KCNK2	4.02E-8	-0.013	1.13E-5	DMG:Jaffe_2016

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MAST1	0.92	0.92
TRIM46	0.91	0.91
TNRC4	0.91	0.90
KIAA1543	0.91	0.91
DTX1	0.90	0.92
C7orf51	0.90	0.92
GNAZ	0.90	0.89
SPIRE2	0.90	0.92
BRF1	0.90	0.92
PIK3R2	0.90	0.88

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.72	-0.79
AF347015.27	-0.71	-0.79
MT-CO2	-0.70	-0.78
AF347015.33	-0.69	-0.76
AC021016.1	-0.68	-0.81
S100B	-0.68	-0.76
COPZ2	-0.68	-0.75
AF347015.21	-0.67	-0.82
AF347015.8	-0.67	-0.77
MT-CYB	-0.66	-0.74

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005244	voltage-gated ion channel activity	IEA		-
GO:0005267	potassium channel activity	IEA		-
GO:0005216	ion channel activity	IEA		-
GO:0015271	outward rectifier potassium channel activity	NAS		-
GO:0030955	potassium ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007186	G-protein coupled receptor protein signaling pathway	IEA		-
GO:0006811	ion transport	IEA		-
GO:0006813	potassium ion transport	IEA		-
GO:0006813	potassium ion transport	NAS		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0016020	membrane	IEA		-
GO:0016020	membrane	NAS		-
GO:0016021	integral to membrane	IEA		-
GO:0008076	voltage-gated potassium channel complex	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
REACTOME NEURONAL SYSTEM	279	221	All SZGR 2.0 genes in this pathway
REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	12	7	All SZGR 2.0 genes in this pathway
REACTOME POTASSIUM CHANNELS	98	68	All SZGR 2.0 genes in this pathway
NEWMAN ERCC6 TARGETS DN	39	24	All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN	232	154	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP	1142	669	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK DN	196	131	All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM DN	25	18	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS	1038	678	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3	1118	744	All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS	652	441	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR DN	178	121	All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS DN	142	94	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 12HR DN	101	64	All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR DN	191	123	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K27ME3 UP	295	149	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER WITH H3K9ME3 UP	141	75	All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN	940	425	All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP	425	298	All SZGR 2.0 genes in this pathway
TAYLOR METHYLATED IN ACUTE LYMPHOBLASTIC LEUKEMIA	77	52	All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2	491	319	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 1	68	50	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS GROWING	243	155	All SZGR 2.0 genes in this pathway
QI HYPOXIA	140	96	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE	317	190	All SZGR 2.0 genes in this pathway
LE NEURONAL DIFFERENTIATION UP	18	13	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	474	480	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	473	480	1A,m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	473	480	1A,m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-128	1904	1910	1A	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	1904	1910	1A	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-132/212	257	263	m8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	257	263	m8	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-183	284	291	1A,m8	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-19	1279	1286	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	1279	1286	1A,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-200bc/429	842	848	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-218	1345	1351	1A	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-24	374	380	m8	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-27	1904	1911	1A,m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	1904	1911	1A,m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-338	597	603	1A	hsa-miR-338^brain	UCCAGCAUCAGUGAUUUUGUUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: KCNK2