Gene Page: KCNK2

Summary
GeneID  3776
Symbol  KCNK2
Synonyms  K2p2.1|MGC126742|MGC126744|TPKC1|TREK|TREK-1|TREK1|hTREK-1c|hTREK-1e
Description  potassium channel, subfamily K, member 2
See related  HGNC:6277|MIM:603219|Ensembl:ENSG00000082482|
Locus tag  -
Gene type  protein-coding
Map location  1q41
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.399 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MAST10.920.92
TRIM460.910.91
TNRC40.910.90
KIAA15430.910.91
DTX10.900.92
C7orf510.900.92
GNAZ0.900.89
SPIRE20.900.92
BRF10.900.92
PIK3R20.900.88
Top 10 negatively co-expressed genes
AF347015.31-0.72-0.79
AF347015.27-0.71-0.79
MT-CO2-0.70-0.78
AF347015.33-0.69-0.76
AC021016.1-0.68-0.81
S100B-0.68-0.76
COPZ2-0.68-0.75
AF347015.21-0.67-0.82
AF347015.8-0.67-0.77
MT-CYB-0.66-0.74
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005244voltage-gated ion channel activityIEA-
GO:0005267potassium channel activityIEA-
GO:0005216ion channel activityIEA-
GO:0015271outward rectifier potassium channel activityNAS-
GO:0030955potassium ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0006811ion transportIEA-
GO:0006813potassium ion transportIEA-
GO:0006813potassium ion transportNAS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016020membraneNAS-
GO:0016021integral to membraneIEA-
GO:0008076voltage-gated potassium channel complexIEA-
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS 127All SZGR genes in this pathway
REACTOME_POTASSIUM_CHANNELS 9868All SZGR genes in this pathway
NEWMAN_ERCC6_TARGETS_DN 3924All SZGR genes in this pathway
DELYS_THYROID_CANCER_DN 232154All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_DN 196131All SZGR genes in this pathway
HERNANDEZ_ABERRANT_MITOSIS_BY_DOCETACEL_2NM_DN 2518All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_DN 178121All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_DN 14294All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_12HR_DN 10164All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_DN 191123All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP 295149All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_WITH_H3K9ME3_UP 14175All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP 425298All SZGR genes in this pathway
TAYLOR_METHYLATED_IN_ACUTE_LYMPHOBLASTIC_LEUKEMIA 7752All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_1 6850All SZGR genes in this pathway
CHICAS_RB1_TARGETS_GROWING 243155All SZGR genes in this pathway
QI_HYPOXIA 14096All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_EARLY_LATE 317190All SZGR genes in this pathway
LE_NEURONAL_DIFFERENTIATION_UP 1813All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.1474480m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5064734801A,m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-128190419101Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-132/212257263m8hsa-miR-212SZUAACAGUCUCCAGUCACGGCC
hsa-miR-132brainUAACAGUCUACAGCCAUGGUCG
miR-1832842911A,m8hsa-miR-183UAUGGCACUGGUAGAAUUCACUG
miR-19127912861A,m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-200bc/429842848m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-218134513511Ahsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-24374380m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-27190419111A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-3385976031Ahsa-miR-338brainUCCAGCAUCAGUGAUUUUGUUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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