Gene Page: IPO5

Summary
GeneID  3843
Symbol  IPO5
Synonyms  DKFZp686O1576|FLJ43041|IMB3|KPNB3|MGC2068|RANBP5
Description  importin 5
See related  HGNC:6402|MIM:602008|Ensembl:ENSG00000065150|HPRD:03597|
Locus tag  RP11-72J7.1
Gene type  protein-coding
Map location  13q32.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
ExpressionExpressionP value: 1.509 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.2023 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005095GTPase inhibitor activityTAS9271386 
GO:0005488bindingIEA-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI15282309 
GO:0008536Ran GTPase bindingTAS9114010 
GO:0008565protein transporter activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000059protein import into nucleus, dockingIEA-
GO:0006607NLS-bearing substrate import into nucleusTAS9114010 
GO:0006886intracellular protein transportIEA-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusTAS9114010 
GO:0005643nuclear poreTAS9271386 
GO:0005737cytoplasmTAS9114010 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
H1F0H10 | H1FV | MGC5241H1 histone family, member 0in vitroBioGRID10228156 
NUP153HNUP153 | N153nucleoporin 153kDa-HPRD,BioGRID9114010 
NUP214CAIN | CAN | D9S46E | MGC104525 | N214nucleoporin 214kDa-HPRD,BioGRID9114010 
NUP98ADIR2 | NUP196 | NUP96nucleoporin 98kDa-HPRD9114010 
RAG2RAG-2recombination activating gene 2-HPRD12861017 
RANARA24 | Gsp1 | TC4RAN, member RAS oncogene family-HPRD,BioGRID9114010 
RANBP2NUP358 | TRP1 | TRP2RAN binding protein 2-HPRD9114010 
RPL23AFLJ27455 | MDA20ribosomal protein L23aAffinity Capture-Western
in vitro		BioGRID9687515 |11682607 
RPL5MGC117339 | MSTP030ribosomal protein L5-HPRD,BioGRID9687515 
RPS7-ribosomal protein S7-HPRD,BioGRID9687515 
SRP19-signal recognition particle 19kDaAffinity Capture-Western
Reconstituted Complex		BioGRID11682607 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_INFLUENZA_LIFE_CYCLE 20372All SZGR genes in this pathway
REACTOME_INFLUENZA_VIRAL_RNA_TRANSCRIPTION_AND_REPLICATION 16947All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_DN 526357All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_UP 294178All SZGR genes in this pathway
GARY_CD5_TARGETS_DN 431263All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
PROVENZANI_METASTASIS_UP 194112All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
MARKEY_RB1_ACUTE_LOF_DN 228137All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
SCHLOSSER_MYC_TARGETS_REPRESSED_BY_SERUM 15993All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_MODERATELY_VS_POORLY_UP 12171All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
KAMMINGA_EZH2_TARGETS 4126All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
YAMAZAKI_TCEB3_TARGETS_DN 215132All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_SHORT_TERM 3215All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_24HR 4330All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
FUJII_YBX1_TARGETS_DN 202132All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_DN 249165All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
TOOKER_GEMCITABINE_RESISTANCE_DN 12284All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP 163102All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_POOR_SURVIVAL_A6 456285All SZGR genes in this pathway
IRITANI_MAD1_TARGETS_DN 4730All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP 188121All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_14 14386All SZGR genes in this pathway
KARLSSON_TGFB1_TARGETS_UP 12778All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.14101Ahsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-181588594m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-186124812541Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-235905971A,m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-3235905961Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-377105910661A,m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-505114511511Ahsa-miR-505GUCAACACUUGCUGGUUUCCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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