SZGR2

Summary ?

GeneID	387
Symbol	RHOA
Synonyms	ARH12\|ARHA\|RHO12\|RHOH12
Description	ras homolog family member A
Reference	MIM:165390\|HGNC:HGNC:667\|Ensembl:ENSG00000067560\|HPRD:01323\|Vega:OTTHUMG00000156838
Gene type	protein-coding
Map location	3p21.3
Pascal p-value	0.026
Sherlock p-value	0.006
Fetal beta	-0.426
Support	INTRACELLULAR SIGNAL TRANSDUCTION Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 2
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0603

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg16951854	3	49449507	RHOA;TCTA	9.37E-5	0.351	0.027	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
H2AFY2	0.87	0.92
STAG1	0.86	0.89
PHF16	0.85	0.81
RNF122	0.85	0.72
LRCH2	0.84	0.92
KDM1	0.84	0.94
ZNF491	0.84	0.79
ZNF738	0.84	0.85
ZBTB5	0.84	0.90
PRIM1	0.84	0.85

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
HLA-F	-0.60	-0.84
TNFSF12	-0.59	-0.67
C5orf53	-0.59	-0.78
PTH1R	-0.58	-0.74
FBXO2	-0.58	-0.68
AIFM3	-0.58	-0.81
ALDOC	-0.58	-0.74
LHPP	-0.57	-0.64
LDHD	-0.56	-0.69
SLC9A3R2	-0.56	-0.57

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0000287	magnesium ion binding	IEA		-
GO:0003924	GTPase activity	TAS		10436159
GO:0005515	protein binding	IPI		15644318
GO:0005525	GTP binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007519	skeletal muscle development	IEA	neuron (GO term level: 8)	-
GO:0043524	negative regulation of neuron apoptosis	IEA	neuron (GO term level: 9)	-
GO:0000902	cell morphogenesis	IEA		-
GO:0007160	cell-matrix adhesion	IEA		-
GO:0007155	cell adhesion	IEA		-
GO:0007266	Rho protein signal transduction	TAS		10436159
GO:0007264	small GTPase mediated signal transduction	IEA		-
GO:0043149	stress fiber formation	IEA		-
GO:0042346	positive regulation of NF-kappaB import into nucleus	NAS		12761501
GO:0030154	cell differentiation	IEA		-
GO:0030036	actin cytoskeleton organization	TAS		10436159
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	IEP		12761501
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	IEA		-
GO:0005856	cytoskeleton	IEA		-
GO:0005622	intracellular	IEA		-
GO:0005634	nucleus	IEA		-
GO:0005737	cytoplasm	IEA		-
GO:0005886	plasma membrane	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AKAP13	AKAP-Lbc \| BRX \| FLJ11952 \| FLJ43341 \| HA-3 \| Ht31 \| LBC \| PROTO-LB \| PROTO-LBC \| c-lbc	A kinase (PRKA) anchor protein 13	-	HPRD,BioGRID	11696353 \|12423633
ARHGAP1	CDC42GAP \| RHOGAP \| RHOGAP1 \| p50rhoGAP	Rho GTPase activating protein 1	-	HPRD,BioGRID	9407060 \|9548756
ARHGAP10	FLJ20896 \| FLJ41791 \| GRAF2 \| PS-GAP	Rho GTPase activating protein 10	Biochemical Activity	BioGRID	11432776
ARHGAP21	ARHGAP10 \| DKFZp761L0424 \| FLJ33323 \| FLJ90108	Rho GTPase activating protein 21	ARHGAP21 interacts with RhoA-GTP, and acts as a GAP to increase RhoA GTPase activity.	BIND	15793564
ARHGAP26	FLJ42530 \| GRAF \| KIAA0621 \| OPHN1L \| OPHN1L1	Rho GTPase activating protein 26	Biochemical Activity	BioGRID	11432776
ARHGAP5	GFI2 \| RhoGAP5 \| p190-B	Rho GTPase activating protein 5	Affinity Capture-Western Reconstituted Complex	BioGRID	12842009
ARHGAP8	BPGAP1 \| FLJ20185 \| PP610	Rho GTPase activating protein 8	BPGAP1 interacts with RhoA.	BIND	12944407
ARHGDIA	GDIA1 \| MGC117248 \| RHOGDI \| RHOGDI-1	Rho GDP dissociation inhibitor (GDI) alpha	-	HPRD,BioGRID	11149925
ARHGDIB	D4 \| GDIA2 \| GDID4 \| LYGDI \| Ly-GDI \| RAP1GN1 \| RhoGDI2	Rho GDP dissociation inhibitor (GDI) beta	-	HPRD,BioGRID	9799233
ARHGDIG	RHOGDI-3	Rho GDP dissociation inhibitor (GDI) gamma	-	HPRD,BioGRID	9113980
ARHGEF1	GEF1 \| LBCL2 \| LSC \| P115-RHOGEF \| SUB1.5	Rho guanine nucleotide exchange factor (GEF) 1	Biochemical Activity	BioGRID	12748184
ARHGEF11	DKFZp667F1223 \| GTRAP48 \| KIAA0380 \| PDZ-RHOGEF	Rho guanine nucleotide exchange factor (GEF) 11	-	HPRD,BioGRID	10526156
ARHGEF12	DKFZp686O2372 \| KIAA0382 \| LARG \| PRO2792	Rho guanine nucleotide exchange factor (GEF) 12	-	HPRD,BioGRID	11373293
ARHGEF18	KIAA0521 \| MGC15913	rho/rac guanine nucleotide exchange factor (GEF) 18	-	HPRD,BioGRID	11085924
ARHGEF2	DKFZp547L106 \| DKFZp547P1516 \| GEF \| GEF-H1 \| GEFH1 \| KIAA0651 \| LFP40 \| P40	rho/rac guanine nucleotide exchange factor (GEF) 2	-	HPRD,BioGRID	9857026
ARHGEF3	DKFZp434F2429 \| FLJ98126 \| GEF3 \| MGC118905 \| STA3 \| XPLN	Rho guanine nucleotide exchange factor (GEF) 3	-	HPRD,BioGRID	12221096
ARHGEF4	ASEF \| ASEF1 \| GEF4 \| STM6	Rho guanine nucleotide exchange factor (GEF) 4	-	HPRD,BioGRID	10947987
BID	FP497 \| MGC15319 \| MGC42355	BH3 interacting domain death agonist	Co-purification	BioGRID	15659383
CASP10	ALPS2 \| FLICE2 \| MCH4	caspase 10, apoptosis-related cysteine peptidase	Co-purification	BioGRID	15659383
CASP8	ALPS2B \| CAP4 \| FLICE \| FLJ17672 \| MACH \| MCH5 \| MGC78473	caspase 8, apoptosis-related cysteine peptidase	Co-purification	BioGRID	15659383
CIT	CRIK \| KIAA0949 \| STK21	citron (rho-interacting, serine/threonine kinase 21)	Far Western Reconstituted Complex Two-hybrid	BioGRID	8543060 \|12773565
CNKSR1	CNK \| CNK1 \| KSR	connector enhancer of kinase suppressor of Ras 1	-	HPRD	14749388
CNKSR1	CNK \| CNK1 \| KSR	connector enhancer of kinase suppressor of Ras 1	hCNK1 interacts with RhoA. This interaction was modelled on a demonstrated interaction between human CNK1 and RhoA from an unspecified species.	BIND	14749388
CNTNAP1	CASPR \| CNTNAP \| NRXN4 \| P190	contactin associated protein 1	-	HPRD	9407060
CRMP1	DPYSL1 \| DRP-1 \| DRP1	collapsin response mediator protein 1	Phenotypic Suppression	BioGRID	12482610
DAAM1	FLJ41657 \| KIAA0666	dishevelled associated activator of morphogenesis 1	-	HPRD	11779461
DEF6	IBP \| SLAT	differentially expressed in FDCP 6 homolog (mouse)	-	HPRD,BioGRID	15023524
DEF6	IBP \| SLAT	differentially expressed in FDCP 6 homolog (mouse)	DEF6 interacts with RhoA. This interaction was modelled on a demonstrated interaction between human DEF6 and RhoA from an unspecified species.	BIND	15023524
DGKQ	DAGK \| DAGK4 \| DAGK7	diacylglycerol kinase, theta 110kDa	-	HPRD,BioGRID	10066731
DIAPH1	DFNA1 \| DIA1 \| DRF1 \| FLJ25265 \| LFHL1 \| hDIA1	diaphanous homolog 1 (Drosophila)	Reconstituted Complex Two-hybrid	BioGRID	12773565
DOCK7	KIAA1771 \| ZIR2	dedicator of cytokinesis 7	-	HPRD	12432077
DPYSL2	CRMP2 \| DHPRP2 \| DRP-2 \| DRP2	dihydropyrimidinase-like 2	Phenotypic Suppression	BioGRID	12482610
EZR	CVIL \| CVL \| DKFZp762H157 \| FLJ26216 \| MGC1584 \| VIL2	ezrin	Co-purification	BioGRID	15659383
FADD	GIG3 \| MGC8528 \| MORT1	Fas (TNFRSF6)-associated via death domain	Co-purification	BioGRID	15659383
FAS	ALPS1A \| APO-1 \| APT1 \| CD95 \| FAS1 \| FASTM \| TNFRSF6	Fas (TNF receptor superfamily, member 6)	Co-purification	BioGRID	15659383
FASLG	APT1LG1 \| CD178 \| CD95L \| FASL \| TNFSF6	Fas ligand (TNF superfamily, member 6)	Co-purification	BioGRID	15659383
FLNA	ABP-280 \| ABPX \| DKFZp434P031 \| FLN \| FLN1 \| FMD \| MNS \| NHBP \| OPD \| OPD1 \| OPD2	filamin A, alpha (actin binding protein 280)	-	HPRD	10051605
GEFT	p63RhoGEF	RhoA/RAC/CDC42 exchange factor	-	HPRD,BioGRID	15069594
GMIP	-	GEM interacting protein	-	HPRD	12093360
GNA12	MGC104623 \| MGC99644 \| NNX3 \| RMP \| gep	guanine nucleotide binding protein (G protein) alpha 12	Reconstituted Complex	BioGRID	12515866
GRLF1	GRF-1 \| KIAA1722 \| MGC10745 \| P190-A \| P190A \| p190RhoGAP	glucocorticoid receptor DNA binding factor 1	Reconstituted Complex	BioGRID	9548756
HSPA1A	FLJ54303 \| FLJ54370 \| FLJ54392 \| FLJ54408 \| FLJ75127 \| HSP70-1 \| HSP70-1A \| HSP70I \| HSP72 \| HSPA1 \| HSPA1B	heat shock 70kDa protein 1A	Affinity Capture-Western	BioGRID	12490434
ICMT	HSTE14 \| MGC39955 \| MST098 \| MSTP098 \| PCCMT \| PCMT \| PPMT	isoprenylcysteine carboxyl methyltransferase	-	HPRD,BioGRID	9614111
ITPR1	INSP3R1 \| IP3R \| IP3R1 \| SCA15 \| SCA16	inositol 1,4,5-triphosphate receptor, type 1	Affinity Capture-Western Reconstituted Complex	BioGRID	12766172
KCNA2	HBK5 \| HK4 \| HUKIV \| KV1.2 \| MGC50217 \| MK2 \| NGK1 \| RBK2	potassium voltage-gated channel, shaker-related subfamily, member 2	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	9635436
KTN1	CG1 \| KIAA0004 \| KNT \| MGC133337 \| MU-RMS-40.19	kinectin 1 (kinesin receptor)	-	HPRD	8769096 \|11689693
KTN1	CG1 \| KIAA0004 \| KNT \| MGC133337 \| MU-RMS-40.19	kinectin 1 (kinesin receptor)	Two-hybrid	BioGRID	8769096 \|11162552 \|11689693 \|12773565
MAPK8	JNK \| JNK1 \| JNK1A2 \| JNK21B1/2 \| PRKM8 \| SAPK1	mitogen-activated protein kinase 8	Co-purification	BioGRID	15659383
MCF2	DBL	MCF.2 cell line derived transforming sequence	-	HPRD,BioGRID	10854437
MCF2L	ARHGEF14 \| DBS \| FLJ12122 \| KIAA0362 \| OST	MCF.2 cell line derived transforming sequence-like	RhoA specifically interacts with Dbl-homology and pleckstrin-homology domains of the nucleotide exchange factor Dbs. This interaction is modelled on a demonstrated interaction between mouse Dbs and human RhoA.	BIND	12006984
MCF2L	ARHGEF14 \| DBS \| FLJ12122 \| KIAA0362 \| OST	MCF.2 cell line derived transforming sequence-like	-	HPRD,BioGRID	12006984
MPRIP	KIAA0864 \| M-RIP \| RHOIP3 \| p116Rip	myosin phosphatase Rho interacting protein	-	HPRD	14506264
MPRIP	KIAA0864 \| M-RIP \| RHOIP3 \| p116Rip	myosin phosphatase Rho interacting protein	-	HPRD,BioGRID	9199174
MSN	-	moesin	Co-purification	BioGRID	15659383
NET1	ARHGEF8 \| NET1A	neuroepithelial cell transforming 1	Two-hybrid	BioGRID	9535835
OPHN1	MRX60 \| OPN1	oligophrenin 1	-	HPRD,BioGRID	9582072 \|11998687
PDE6D	PDED	phosphodiesterase 6D, cGMP-specific, rod, delta	-	HPRD,BioGRID	11786539
PITPNM1	DRES9 \| FLJ44997 \| NIR2 \| PITPNM \| RDGB \| RDGB1 \| RDGBA \| RDGBA1 \| Rd9	phosphatidylinositol transfer protein, membrane-associated 1	Nir2 interacts with RhoA.	BIND	15125835
PKN1	DBK \| MGC46204 \| PAK1 \| PKN \| PKN-ALPHA \| PRK1 \| PRKCL1	protein kinase N1	-	HPRD,BioGRID	9446575
PKN2	MGC150606 \| MGC71074 \| PAK2 \| PRK2 \| PRKCL2 \| PRO2042 \| Pak-2	protein kinase N2	-	HPRD,BioGRID	8910519
PLCG1	PLC-II \| PLC1 \| PLC148 \| PLCgamma1	phospholipase C, gamma 1	-	HPRD,BioGRID	12071848
PLD1	-	phospholipase D1, phosphatidylcholine-specific	-	HPRD,BioGRID	11311142 \|12593858
PLEKHG2	CLG \| DKFZp667J2325 \| FLJ00018 \| FLJ22458 \| FLJ38638	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	-	HPRD,BioGRID	11839748
PPP1R12A	MBS \| MGC133042 \| MYPT1	protein phosphatase 1, regulatory (inhibitor) subunit 12A	-	HPRD	9354661
PRKCA	AAG6 \| MGC129900 \| MGC129901 \| PKC-alpha \| PKCA \| PRKACA	protein kinase C, alpha	in vivo	BioGRID	11284700
RABAC1	PRA1 \| PRAF1 \| YIP3	Rab acceptor 1 (prenylated)	-	HPRD	11335720
RAP1GDS1	GDS1 \| MGC118859 \| MGC118861 \| SmgGDS	RAP1, GTP-GDP dissociation stimulator 1	-	HPRD,BioGRID	11948427
RHPN1	KIAA1929 \| ODF5 \| RHOPHILIN \| RHPN	rhophilin, Rho GTPase binding protein 1	-	HPRD	12221077
RHPN2	RhoBP \| p76RBE	rhophilin, Rho GTPase binding protein 2	-	HPRD	12221077
RHPN2	RhoBP \| p76RBE	rhophilin, Rho GTPase binding protein 2	Two-hybrid	BioGRID	12773565
RICS	GC-GAP \| GRIT \| KIAA0712 \| MGC1892 \| p200RhoGAP \| p250GAP	Rho GTPase-activating protein	Biochemical Activity	BioGRID	12446789 \|12454018 \|12857875
RIPK4	ANKK2 \| ANKRD3 \| DIK \| MGC129992 \| MGC129993 \| PKK \| RIP4	receptor-interacting serine-threonine kinase 4	Two-hybrid	BioGRID	9199174
ROCK1	MGC131603 \| MGC43611 \| P160ROCK \| PRO0435	Rho-associated, coiled-coil containing protein kinase 1	-	HPRD,BioGRID	8798490
ROCK2	KIAA0619	Rho-associated, coiled-coil containing protein kinase 2	Affinity Capture-Western	BioGRID	11350930
RTKN	-	rhotekin	RhoA interacts with RTKN (Rhotekin). This interaction was modeled on a demonstrated interaction between RhoA and RTKN from an unspecified species.	BIND	15652748
RTKN	-	rhotekin	Rhotekin interacts with RhoA-GTP. This interaction was modeled on a demonstrated interaction between Rhotekin from an unspecified species and human Rho-GTP.	BIND	15467718
RTKN	-	rhotekin	-	HPRD	8662891
RTKN	-	rhotekin	RTKN (rhotekin) interacts with RhoA. This interaction was modeled on a demonstrated interaction between mouse RTKN and human RhoA.	BIND	15766663
RTKN	-	rhotekin	Reconstituted Complex	BioGRID	12593858
RTKN	-	rhotekin	RhoA interacts with Rhotekin. This interaction was modeled on a demonstrated interaction between human RhoA and Rhotekin from an unspecified species.	BIND	15834426
RTKN	-	rhotekin	Active, GTP-bound RhoA interacts with the RTKN (Rhotekin) Rho binding domain. This interaction was modelled on a demonstrated interaction between human RhoA and Rhotekin from an unspecified species.	BIND	15889147
SH3BP1	-	SH3-domain binding protein 1	-	HPRD	9548756
SPRED2	FLJ21897 \| FLJ31917 \| MGC163164 \| Spred-2	sprouty-related, EVH1 domain containing 2	-	HPRD	15184877
SRGAP1	ARHGAP13 \| FLJ22166 \| KIAA1304	SLIT-ROBO Rho GTPase activating protein 1	-	HPRD	11672528
TEC	MGC126760 \| MGC126762 \| PSCTK4	tec protein tyrosine kinase	Reconstituted Complex	BioGRID	12515866
TGM2	G-ALPHA-h \| GNAH \| TG2 \| TGC	transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)	-	HPRD	11350930
TNFRSF10B	CD262 \| DR5 \| KILLER \| KILLER/DR5 \| TRAIL-R2 \| TRAILR2 \| TRICK2 \| TRICK2A \| TRICK2B \| TRICKB \| ZTNFR9	tumor necrosis factor receptor superfamily, member 10b	Co-purification	BioGRID	15659383
TNFRSF1A	CD120a \| FPF \| MGC19588 \| TBP1 \| TNF-R \| TNF-R-I \| TNF-R55 \| TNFAR \| TNFR1 \| TNFR55 \| TNFR60 \| p55 \| p55-R \| p60	tumor necrosis factor receptor superfamily, member 1A	Co-purification	BioGRID	15659383
TRIO	FLJ42780 \| tgat	triple functional domain (PTPRF interacting)	-	HPRD,BioGRID	10948190
TRPC1	HTRP-1 \| MGC133334 \| MGC133335 \| TRP1	transient receptor potential cation channel, subfamily C, member 1	-	HPRD,BioGRID	12766172
VAV2	-	vav 2 guanine nucleotide exchange factor	-	HPRD	11909943
VAV3	FLJ40431	vav 3 guanine nucleotide exchange factor	-	HPRD,BioGRID	10523675

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CHEMOKINE SIGNALING PATHWAY	190	128	All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION	115	81	All SZGR 2.0 genes in this pathway
KEGG WNT SIGNALING PATHWAY	151	112	All SZGR 2.0 genes in this pathway
KEGG TGF BETA SIGNALING PATHWAY	86	64	All SZGR 2.0 genes in this pathway
KEGG AXON GUIDANCE	129	103	All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION	201	138	All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION	75	53	All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION	134	86	All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY	108	89	All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION	118	78	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON	216	144	All SZGR 2.0 genes in this pathway
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION	59	36	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG COLORECTAL CANCER	62	47	All SZGR 2.0 genes in this pathway
BIOCARTA CCR3 PATHWAY	23	21	All SZGR 2.0 genes in this pathway
BIOCARTA ECM PATHWAY	24	17	All SZGR 2.0 genes in this pathway
BIOCARTA RACCYCD PATHWAY	26	23	All SZGR 2.0 genes in this pathway
BIOCARTA INTEGRIN PATHWAY	38	29	All SZGR 2.0 genes in this pathway
BIOCARTA EDG1 PATHWAY	27	24	All SZGR 2.0 genes in this pathway
BIOCARTA AKAPCENTROSOME PATHWAY	15	14	All SZGR 2.0 genes in this pathway
BIOCARTA RAS PATHWAY	23	20	All SZGR 2.0 genes in this pathway
BIOCARTA RHO PATHWAY	32	23	All SZGR 2.0 genes in this pathway
BIOCARTA AKAP13 PATHWAY	12	11	All SZGR 2.0 genes in this pathway
BIOCARTA CARDIACEGF PATHWAY	18	16	All SZGR 2.0 genes in this pathway
BIOCARTA MAL PATHWAY	19	17	All SZGR 2.0 genes in this pathway
BIOCARTA CDC42RAC PATHWAY	16	13	All SZGR 2.0 genes in this pathway
BIOCARTA PAR1 PATHWAY	37	28	All SZGR 2.0 genes in this pathway
BIOCARTA TFF PATHWAY	21	15	All SZGR 2.0 genes in this pathway
BIOCARTA UCALPAIN PATHWAY	18	11	All SZGR 2.0 genes in this pathway
SA TRKA RECEPTOR	17	15	All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY	63	52	All SZGR 2.0 genes in this pathway
PID PRL SIGNALING EVENTS PATHWAY	23	17	All SZGR 2.0 genes in this pathway
PID RHOA PATHWAY	45	33	All SZGR 2.0 genes in this pathway
PID AURORA B PATHWAY	39	24	All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY	66	53	All SZGR 2.0 genes in this pathway
PID WNT NONCANONICAL PATHWAY	32	26	All SZGR 2.0 genes in this pathway
PID ER NONGENOMIC PATHWAY	41	35	All SZGR 2.0 genes in this pathway
PID MET PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID PTP1B PATHWAY	52	40	All SZGR 2.0 genes in this pathway
PID S1P S1P3 PATHWAY	29	24	All SZGR 2.0 genes in this pathway
PID AVB3 OPN PATHWAY	31	29	All SZGR 2.0 genes in this pathway
PID S1P S1P4 PATHWAY	14	11	All SZGR 2.0 genes in this pathway
PID RHOA REG PATHWAY	46	30	All SZGR 2.0 genes in this pathway
PID RET PATHWAY	39	29	All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY	57	43	All SZGR 2.0 genes in this pathway
PID SHP2 PATHWAY	58	46	All SZGR 2.0 genes in this pathway
PID S1P S1P1 PATHWAY	21	18	All SZGR 2.0 genes in this pathway
PID NETRIN PATHWAY	32	27	All SZGR 2.0 genes in this pathway
PID ARF6 DOWNSTREAM PATHWAY	15	14	All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY	69	55	All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY	55	43	All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY	102	78	All SZGR 2.0 genes in this pathway
PID PLK1 PATHWAY	46	25	All SZGR 2.0 genes in this pathway
PID THROMBIN PAR4 PATHWAY	15	11	All SZGR 2.0 genes in this pathway
PID PI3KCI PATHWAY	49	40	All SZGR 2.0 genes in this pathway
PID P75 NTR PATHWAY	69	51	All SZGR 2.0 genes in this pathway
PID ECADHERIN NASCENT AJ PATHWAY	39	33	All SZGR 2.0 genes in this pathway
PID AMB2 NEUTROPHILS PATHWAY	41	32	All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY	75	53	All SZGR 2.0 genes in this pathway
PID LIS1 PATHWAY	28	22	All SZGR 2.0 genes in this pathway
PID SYNDECAN 4 PATHWAY	32	25	All SZGR 2.0 genes in this pathway
PID EPHA FWDPATHWAY	34	29	All SZGR 2.0 genes in this pathway
PID ECADHERIN KERATINOCYTE PATHWAY	21	19	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY	62	48	All SZGR 2.0 genes in this pathway
PID ECADHERIN STABILIZATION PATHWAY	42	34	All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY	69	57	All SZGR 2.0 genes in this pathway
PID THROMBIN PAR1 PATHWAY	43	32	All SZGR 2.0 genes in this pathway
PID SYNDECAN 2 PATHWAY	33	27	All SZGR 2.0 genes in this pathway
PID TOLL ENDOGENOUS PATHWAY	25	19	All SZGR 2.0 genes in this pathway
PID NCADHERIN PATHWAY	33	32	All SZGR 2.0 genes in this pathway
PID S1P S1P2 PATHWAY	24	19	All SZGR 2.0 genes in this pathway
PID EPHA2 FWD PATHWAY	19	16	All SZGR 2.0 genes in this pathway
PID FAK PATHWAY	59	45	All SZGR 2.0 genes in this pathway
PID TGFBR PATHWAY	55	38	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY RHO GTPASES	113	81	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	16	7	All SZGR 2.0 genes in this pathway
REACTOME PI3K AKT ACTIVATION	38	29	All SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	81	61	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME GPVI MEDIATED ACTIVATION CASCADE	31	25	All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE	251	188	All SZGR 2.0 genes in this pathway
REACTOME G ALPHA1213 SIGNALLING EVENTS	74	56	All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING	805	368	All SZGR 2.0 genes in this pathway
REACTOME SEMA4D IN SEMAPHORIN SIGNALING	32	22	All SZGR 2.0 genes in this pathway
REACTOME SEMAPHORIN INTERACTIONS	68	53	All SZGR 2.0 genes in this pathway
REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	27	21	All SZGR 2.0 genes in this pathway
REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA	25	15	All SZGR 2.0 genes in this pathway
REACTOME G PROTEIN BETA GAMMA SIGNALLING	28	18	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX	63	42	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN	526	357	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN	362	238	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 DN	153	100	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN	800	473	All SZGR 2.0 genes in this pathway
LI LUNG CANCER	41	30	All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP	358	245	All SZGR 2.0 genes in this pathway
ALCALA APOPTOSIS	88	60	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN	261	155	All SZGR 2.0 genes in this pathway
ZUCCHI METASTASIS DN	44	29	All SZGR 2.0 genes in this pathway
IIZUKA LIVER CANCER PROGRESSION L0 L1 DN	21	14	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN	408	274	All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP	69	41	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR	544	307	All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA	50	31	All SZGR 2.0 genes in this pathway
MACLACHLAN BRCA1 TARGETS UP	21	16	All SZGR 2.0 genes in this pathway
ZHANG PROLIFERATING VS QUIESCENT	51	41	All SZGR 2.0 genes in this pathway
DELLA RESPONSE TO TSA AND BUTYRATE	21	17	All SZGR 2.0 genes in this pathway
VERRECCHIA EARLY RESPONSE TO TGFB1	58	43	All SZGR 2.0 genes in this pathway
RAMPON ENRICHED LEARNING ENVIRONMENT EARLY UP	15	12	All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C3	14	10	All SZGR 2.0 genes in this pathway
JOSEPH RESPONSE TO SODIUM BUTYRATE UP	31	21	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST	132	93	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5	482	296	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN	940	425	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN	193	112	All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION	422	277	All SZGR 2.0 genes in this pathway
YAGI AML WITH T 9 11 TRANSLOCATION	130	87	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1	237	159	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
ABDELMOHSEN ELAVL4 TARGETS	16	13	All SZGR 2.0 genes in this pathway
HOLLEMAN DAUNORUBICIN B ALL DN	12	10	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-142-5p	330	337	1A,m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-185	987	994	1A,m8	hsa-miR-185^brain	UGGAGAGAAAGGCAGUUC
miR-200bc/429	133	139	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-361	742	749	1A,m8	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC
miR-381	614	620	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-485-3p	62	68	m8	hsa-miR-485-3p	GUCAUACACGGCUCUCCUCUCU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: RHOA