Gene Page: LIMK1

Summary
GeneID  3984
Symbol  LIMK1
Synonyms  LIMK
Description  LIM domain kinase 1
See related  HGNC:6613|MIM:601329|Ensembl:ENSG00000106683|HPRD:03210|
Locus tag  -
Gene type  protein-coding
Map location  7q11.23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 1.9241 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIEA-
GO:0005515protein bindingIPI12361576 |15220930 |16837009 
GO:0005524ATP bindingIEA-
GO:0004672protein kinase activityIEA-
GO:0004674protein serine/threonine kinase activityTAS8537403 
GO:0004713protein tyrosine kinase activityIEA-
GO:0016740transferase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
GO:0046982protein heterodimerization activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0045773positive regulation of axon extensionIEAaxon (GO term level: 15)-
GO:0007399nervous system developmentTASneurite (GO term level: 5)8689688 
GO:0006468protein amino acid phosphorylationIEA-
GO:0006468protein amino acid phosphorylationTAS8537403 
GO:0007266Rho protein signal transductionTAS10436159 
GO:0007165signal transductionTAS10428028 |10436159 
GO:0030036actin cytoskeleton organizationTAS10428028 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005737cytoplasmTAS8537403 
GO:0005925focal adhesionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BMPR2BMPR-II | BMPR3 | BMR2 | BRK-3 | FLJ41585 | FLJ76945 | PPH1 | T-ALKbone morphogenetic protein receptor, type II (serine/threonine kinase)-HPRD,BioGRID12963706 
CDKN1CBWCR | BWS | KIP2 | WBS | p57cyclin-dependent kinase inhibitor 1C (p57, Kip2)-HPRD,BioGRID14530263 
CFL1CFLcofilin 1 (non-muscle)-HPRD9655398 
Biochemical ActivityBioGRID10436159 |12963706 
LATS1WARTS | wtsLATS, large tumor suppressor, homolog 1 (Drosophila)LATS1 interacts with LIMK1.BIND15220930 
LIMK1LIMKLIM domain kinase 1-HPRD,BioGRID8980133 
LIMK2-LIM domain kinase 2-HPRD,BioGRID8980133 
NRG1ARIA | GGF | GGF2 | HGL | HRG | HRG1 | HRGA | NDF | SMDFneuregulin 1-HPRD,BioGRID9685409 
PAK1MGC130000 | MGC130001 | PAKalphap21 protein (Cdc42/Rac)-activated kinase 1-HPRD,BioGRID10559936 
PAK4-p21 protein (Cdc42/Rac)-activated kinase 4PAK4 interacts with and phosphorylates LIMK1.BIND15660133 
-HPRD,BioGRID11413130 
PXNFLJ16691paxillin-HPRD15023529 
RNF12MGC15161 | NY-REN-43 | RLIMring finger protein 12-HPRD10431247 
ROCK1MGC131603 | MGC43611 | P160ROCK | PRO0435Rho-associated, coiled-coil containing protein kinase 1-HPRD10436159 
SSH1FLJ38102 | KIAA1298 | SSH-1slingshot homolog 1 (Drosophila)SSH-1S interacts with LIMK1.BIND15660133 
SSH-1L interacts with and dephosphorylates LIMK1.BIND15660133 
SSH2KIAA1725 | MGC78588 | SSH-2slingshot homolog 2 (Drosophila)The shorter isoform, SSH-2S, interacts with LIMK1.BIND15660133 
SSH3FLJ10928 | FLJ20515 | SSH-3slingshot homolog 3 (Drosophila)SSH-3S interacts with LIMK1.BIND15660133 
YWHAZKCIP-1 | MGC111427 | MGC126532 | MGC138156tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide-HPRD,BioGRID12323073 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 9771All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
BIOCARTA_CCR3_PATHWAY 2321All SZGR genes in this pathway
BIOCARTA_RAC1_PATHWAY 2316All SZGR genes in this pathway
BIOCARTA_RHO_PATHWAY 3223All SZGR genes in this pathway
BIOCARTA_MAL_PATHWAY 1917All SZGR genes in this pathway
SIG_CHEMOTAXIS 4537All SZGR genes in this pathway
SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES 3525All SZGR genes in this pathway
PID_RHOA_PATHWAY 4533All SZGR genes in this pathway
PID_CDC42_PATHWAY 7051All SZGR genes in this pathway
PID_CXCR4_PATHWAY 10278All SZGR genes in this pathway
PID_CASPASE_PATHWAY 5239All SZGR genes in this pathway
PID_RAC1_PATHWAY 5437All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_AXON_GUIDANCE 251188All SZGR genes in this pathway
REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION 1514All SZGR genes in this pathway
REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING 3222All SZGR genes in this pathway
REACTOME_SEMAPHORIN_INTERACTIONS 6853All SZGR genes in this pathway
REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE 2721All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_UP 579346All SZGR genes in this pathway
RODRIGUES_NTN1_TARGETS_DN 158102All SZGR genes in this pathway
CASTELLANO_NRAS_TARGETS_DN 1414All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM1 229137All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
BURTON_ADIPOGENESIS_2 7252All SZGR genes in this pathway
LEE_AGING_NEOCORTEX_UP 8959All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_UP 9564All SZGR genes in this pathway
HILLION_HMGA1_TARGETS 9071All SZGR genes in this pathway
HILLION_HMGA1B_TARGETS 9268All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_DN 12081All SZGR genes in this pathway
BHATI_G2M_ARREST_BY_2METHOXYESTRADIOL_UP 12568All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SCHRAETS_MLL_TARGETS_DN 3324All SZGR genes in this pathway
CARD_MIR302A_TARGETS 7762All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_A 898516All SZGR genes in this pathway
IVANOVSKA_MIR106B_TARGETS 9056All SZGR genes in this pathway
LINSLEY_MIR16_TARGETS 206127All SZGR genes in this pathway
WANG_TNF_TARGETS 2417All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway
ROESSLER_LIVER_CANCER_METASTASIS_UP 10772All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-128105710631Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-1388018081A,m8hsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-1438248311A,m8hsa-miR-143brainUGAGAUGAAGCACUGUAGCUCA
miR-17-5p/20/93.mr/106/519.d10761082m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-27105710641A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-369-3p932938m8hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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