Gene Page: MYD88

Summary
GeneID  4615
Symbol  MYD88
Synonyms  MYD88D
Description  myeloid differentiation primary response gene (88)
See related  HGNC:7562|MIM:602170|Ensembl:ENSG00000172936|HPRD:03703|
Locus tag  -
Gene type  protein-coding
Map location  3p22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.006 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SDC30.730.69
SLC7A50.720.69
TBC1D2B0.710.73
RAB3IL10.700.71
DENND2A0.690.66
ABLIM10.670.63
ITGA30.670.61
PCDHGB8P0.660.65
KIAA15390.660.61
CUEDC10.660.66
Top 10 negatively co-expressed genes
SCRG1-0.53-0.40
AL050337.1-0.51-0.42
COX7B-0.51-0.49
SYCP3-0.50-0.42
MT3-0.49-0.36
AL138743.2-0.49-0.37
C1orf54-0.49-0.42
UQCRB-0.49-0.48
MYL3-0.48-0.40
LY96-0.48-0.43
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004888transmembrane receptor activityIEA-
GO:0005123death receptor bindingTAS9374458 
GO:0005515protein bindingIPI10383454 |10880445 |11544529 
|16286016 |16365431 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002755MyD88-dependent toll-like receptor signaling pathwayIEA-
GO:0002238response to molecule of fungal originIEA-
GO:0016064immunoglobulin mediated immune responseIEA-
GO:0009615response to virusIEA-
GO:0006954inflammatory responseIEA-
GO:0051092positive regulation of NF-kappaB transcription factor activityIEA-
GO:0032496response to lipopolysaccharideIEA-
GO:0032760positive regulation of tumor necrosis factor productionIEA-
GO:0031663lipopolysaccharide-mediated signaling pathwayIEA-
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEP12761501 
GO:0045087innate immune responseIEA-
GO:0045080positive regulation of chemokine biosynthetic processIEA-
GO:0045351type I interferon biosynthetic processIEA-
GO:0046330positive regulation of JNK cascadeIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005874microtubuleIEA-
GO:0005737cytoplasmIEA-
GO:0031315extrinsic to mitochondrial outer membraneIEA-
GO:0031224intrinsic to membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
FADDGIG3 | MGC8528 | MORT1Fas (TNFRSF6)-associated via death domain-HPRD,BioGRID11828002 
IL1R1CD121A | D2S1473 | IL-1R-alpha | IL1R | IL1RA | P80interleukin 1 receptor, type IAffinity Capture-WesternBioGRID10854325 
IL1RAPC3orf13 | FLJ37788 | IL-1RAcP | IL1R3interleukin 1 receptor accessory protein-HPRD,BioGRID11880380 
IRAK1IRAK | pelleinterleukin-1 receptor-associated kinase 1IRAK does not interact with MyD88, whilst the kinase inactive mutant IRAK[Lys239Ser] does interact.BIND10383454 
-HPRD10854325 
Affinity Capture-WesternBioGRID10383454 |11976320 
IRAK2IRAK-2 | MGC150550interleukin-1 receptor-associated kinase 2IRAK-2 interacts with MyD88.BIND10383454 
-HPRD,BioGRID9374458 
IRAK3ASRT5 | IRAK-M | IRAKMinterleukin-1 receptor-associated kinase 3IRAK-M interacts with MyD88.BIND10383454 
Affinity Capture-WesternBioGRID10383454 
IRAK4IPD1 | NY-REN-64 | REN64interleukin-1 receptor-associated kinase 4-HPRD,BioGRID11960013 
IRF7IRF-7H | IRF7Ainterferon regulatory factor 7IRF7 interacts with MyD88.BIND15361868 
PELI2-pellino homolog 2 (Drosophila)-HPRD12860405 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)Affinity Capture-Western
Reconstituted Complex		BioGRID11416133 
SPOPTEF2speckle-type POZ proteinTwo-hybridBioGRID16189514 
TIRAPFLJ42305 | Mal | wyatttoll-interleukin 1 receptor (TIR) domain containing adaptor protein-HPRD,BioGRID11544529 
TLR2CD282 | TIL4toll-like receptor 2Two-hybridBioGRID15107846 
TLR3CD283toll-like receptor 3-HPRD,BioGRID12646618 
TLR4ARMD10 | CD284 | TOLL | hTolltoll-like receptor 4Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID10952994 |12646618 
|15107846 
-HPRD10952994 |11743586 
TLR5FLJ10052 | MGC126430 | MGC126431 | SLEB1 | TIL3toll-like receptor 5Two-hybridBioGRID15107846 
TLR9CD289toll-like receptor 9Two-hybridBioGRID15107846 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_APOPTOSIS 8862All SZGR genes in this pathway
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 10288All SZGR genes in this pathway
KEGG_LEISHMANIA_INFECTION 7256All SZGR genes in this pathway
BIOCARTA_GSK3_PATHWAY 2726All SZGR genes in this pathway
BIOCARTA_NTHI_PATHWAY 2420All SZGR genes in this pathway
BIOCARTA_NFKB_PATHWAY 2319All SZGR genes in this pathway
BIOCARTA_IL1R_PATHWAY 3329All SZGR genes in this pathway
BIOCARTA_TOLL_PATHWAY 3731All SZGR genes in this pathway
PID_IL1_PATHWAY 3428All SZGR genes in this pathway
PID_P75_NTR_PATHWAY 6951All SZGR genes in this pathway
PID_TOLL_ENDOGENOUS_PATHWAY 2519All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_P75NTR_RECRUITS_SIGNALLING_COMPLEXES 128All SZGR genes in this pathway
REACTOME_P75NTR_SIGNALS_VIA_NFKB 1410All SZGR genes in this pathway
REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 8161All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ILS 10786All SZGR genes in this pathway
REACTOME_IL1_SIGNALING 3930All SZGR genes in this pathway
REACTOME_TRAF6_MEDIATED_INDUCTION_OF_NFKB_AND_MAP_KINASES_UPON_TLR7_8_OR_9_ACTIVATION 7757All SZGR genes in this pathway
REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING 109All SZGR genes in this pathway
REACTOME_MYD88_MAL_CASCADE_INITIATED_ON_PLASMA_MEMBRANE 8363All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_ACTIVATED_TLR4_SIGNALLING 9369All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_TOLL_RECEPTOR_CASCADES 11884All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
HOLLMANN_APOPTOSIS_VIA_CD40_DN 267178All SZGR genes in this pathway
FULCHER_INFLAMMATORY_RESPONSE_LECTIN_VS_LPS_DN 463290All SZGR genes in this pathway
PRAMOONJAGO_SOX4_TARGETS_UP 5238All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
KLEIN_TARGETS_OF_BCR_ABL1_FUSION 4534All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN 382224All SZGR genes in this pathway
RICKMAN_METASTASIS_DN 261155All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 151100All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 5135All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_DN 337230All SZGR genes in this pathway
BROWNE_INTERFERON_RESPONSIVE_GENES 6844All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_48HR_DN 161105All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C3 2015All SZGR genes in this pathway
BILD_HRAS_ONCOGENIC_SIGNATURE 261166All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_4NQO_OR_UV 6344All SZGR genes in this pathway
KYNG_DNA_DAMAGE_DN 195135All SZGR genes in this pathway
LABBE_TGFB1_TARGETS_DN 10864All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_DN 315201All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_DN 235144All SZGR genes in this pathway
RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_UP 408276All SZGR genes in this pathway
KYNG_WERNER_SYNDROM_AND_NORMAL_AGING_UP 9362All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_8 4936All SZGR genes in this pathway
HIRSCH_CELLULAR_TRANSFORMATION_SIGNATURE_UP 242159All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B 549316All SZGR genes in this pathway
DUAN_PRDM5_TARGETS 7952All SZGR genes in this pathway
VANLOO_SP3_TARGETS_DN 8947All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_36HR 15288All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D 882506All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_DN 418245All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway
FOSTER_KDM1A_TARGETS_DN 211119All SZGR genes in this pathway
ROESSLER_LIVER_CANCER_METASTASIS_UP 10772All SZGR genes in this pathway
ZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF 516308All SZGR genes in this pathway


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