Gene Page: MYD88

Summary ?
GeneID4615
SymbolMYD88
SynonymsMYD88D
Descriptionmyeloid differentiation primary response 88
ReferenceMIM:602170|HGNC:HGNC:7562|Ensembl:ENSG00000172936|HPRD:03703|Vega:OTTHUMG00000131083
Gene typeprotein-coding
Map location3p22
Pascal p-value0.205
Fetal beta2.387
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.006 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2070396chr2130878751MYD8846150.12trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SDC30.730.69
SLC7A50.720.69
TBC1D2B0.710.73
RAB3IL10.700.71
DENND2A0.690.66
ABLIM10.670.63
ITGA30.670.61
PCDHGB8P0.660.65
KIAA15390.660.61
CUEDC10.660.66
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SCRG1-0.53-0.40
AL050337.1-0.51-0.42
COX7B-0.51-0.49
SYCP3-0.50-0.42
MT3-0.49-0.36
AL138743.2-0.49-0.37
C1orf54-0.49-0.42
UQCRB-0.49-0.48
MYL3-0.48-0.40
LY96-0.48-0.43

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004888transmembrane receptor activityIEA-
GO:0005123death receptor bindingTAS9374458 
GO:0005515protein bindingIPI10383454 |10880445 |11544529 
|16286016 |16365431 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002755MyD88-dependent toll-like receptor signaling pathwayIEA-
GO:0002238response to molecule of fungal originIEA-
GO:0016064immunoglobulin mediated immune responseIEA-
GO:0009615response to virusIEA-
GO:0006954inflammatory responseIEA-
GO:0051092positive regulation of NF-kappaB transcription factor activityIEA-
GO:0032496response to lipopolysaccharideIEA-
GO:0032760positive regulation of tumor necrosis factor productionIEA-
GO:0031663lipopolysaccharide-mediated signaling pathwayIEA-
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEP12761501 
GO:0045087innate immune responseIEA-
GO:0045080positive regulation of chemokine biosynthetic processIEA-
GO:0045351type I interferon biosynthetic processIEA-
GO:0046330positive regulation of JNK cascadeIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005874microtubuleIEA-
GO:0005737cytoplasmIEA-
GO:0031315extrinsic to mitochondrial outer membraneIEA-
GO:0031224intrinsic to membraneIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
FADDGIG3 | MGC8528 | MORT1Fas (TNFRSF6)-associated via death domain-HPRD,BioGRID11828002 
IL1R1CD121A | D2S1473 | IL-1R-alpha | IL1R | IL1RA | P80interleukin 1 receptor, type IAffinity Capture-WesternBioGRID10854325 
IL1RAPC3orf13 | FLJ37788 | IL-1RAcP | IL1R3interleukin 1 receptor accessory protein-HPRD,BioGRID11880380 
IRAK1IRAK | pelleinterleukin-1 receptor-associated kinase 1IRAK does not interact with MyD88, whilst the kinase inactive mutant IRAK[Lys239Ser] does interact.BIND10383454 
IRAK1IRAK | pelleinterleukin-1 receptor-associated kinase 1-HPRD10854325 
IRAK1IRAK | pelleinterleukin-1 receptor-associated kinase 1Affinity Capture-WesternBioGRID10383454 |11976320 
IRAK2IRAK-2 | MGC150550interleukin-1 receptor-associated kinase 2IRAK-2 interacts with MyD88.BIND10383454 
IRAK2IRAK-2 | MGC150550interleukin-1 receptor-associated kinase 2-HPRD,BioGRID9374458 
IRAK3ASRT5 | IRAK-M | IRAKMinterleukin-1 receptor-associated kinase 3IRAK-M interacts with MyD88.BIND10383454 
IRAK3ASRT5 | IRAK-M | IRAKMinterleukin-1 receptor-associated kinase 3Affinity Capture-WesternBioGRID10383454 
IRAK4IPD1 | NY-REN-64 | REN64interleukin-1 receptor-associated kinase 4-HPRD,BioGRID11960013 
IRF7IRF-7H | IRF7Ainterferon regulatory factor 7IRF7 interacts with MyD88.BIND15361868 
PELI2-pellino homolog 2 (Drosophila)-HPRD12860405 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)Affinity Capture-Western
Reconstituted Complex		BioGRID11416133 
SPOPTEF2speckle-type POZ proteinTwo-hybridBioGRID16189514 
TIRAPFLJ42305 | Mal | wyatttoll-interleukin 1 receptor (TIR) domain containing adaptor protein-HPRD,BioGRID11544529 
TLR2CD282 | TIL4toll-like receptor 2Two-hybridBioGRID15107846 
TLR3CD283toll-like receptor 3-HPRD,BioGRID12646618 
TLR4ARMD10 | CD284 | TOLL | hTolltoll-like receptor 4Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID10952994 |12646618 
|15107846 
TLR4ARMD10 | CD284 | TOLL | hTolltoll-like receptor 4-HPRD10952994 |11743586 
TLR5FLJ10052 | MGC126430 | MGC126431 | SLEB1 | TIL3toll-like receptor 5Two-hybridBioGRID15107846 
TLR9CD289toll-like receptor 9Two-hybridBioGRID15107846 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG APOPTOSIS 8862All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 10288All SZGR 2.0 genes in this pathway
KEGG LEISHMANIA INFECTION 7256All SZGR 2.0 genes in this pathway
BIOCARTA GSK3 PATHWAY 2726All SZGR 2.0 genes in this pathway
BIOCARTA NTHI PATHWAY 2420All SZGR 2.0 genes in this pathway
BIOCARTA NFKB PATHWAY 2319All SZGR 2.0 genes in this pathway
BIOCARTA IL1R PATHWAY 3329All SZGR 2.0 genes in this pathway
BIOCARTA TOLL PATHWAY 3731All SZGR 2.0 genes in this pathway
PID IL1 PATHWAY 3428All SZGR 2.0 genes in this pathway
PID P75 NTR PATHWAY 6951All SZGR 2.0 genes in this pathway
PID TOLL ENDOGENOUS PATHWAY 2519All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217167All SZGR 2.0 genes in this pathway
REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES 128All SZGR 2.0 genes in this pathway
REACTOME P75NTR SIGNALS VIA NFKB 1410All SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING 8161All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS 10786All SZGR 2.0 genes in this pathway
REACTOME IL1 SIGNALING 3930All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 7757All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING 109All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE 8363All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279178All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING 9369All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES 11884All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270204All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 DN 267178All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
PRAMOONJAGO SOX4 TARGETS UP 5238All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP 12895All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 11784All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
KLEIN TARGETS OF BCR ABL1 FUSION 4534All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN 382224All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN 261155All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT OK VS DONOR UP 151100All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK DN 5135All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337230All SZGR 2.0 genes in this pathway
BROWNE INTERFERON RESPONSIVE GENES 6844All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN 161105All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C3 2015All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE 261166All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393244All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO OR UV 6344All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195135All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS DN 10864All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315201All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN 235144All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408276All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING UP 9362All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 8 4936All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP 242159All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549316All SZGR 2.0 genes in this pathway
DUAN PRDM5 TARGETS 7952All SZGR 2.0 genes in this pathway
VANLOO SP3 TARGETS DN 8947All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 36HR 15288All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN 418245All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467251All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS DN 211119All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS UP 10772All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516308All SZGR 2.0 genes in this pathway