Gene Page: ATF1

Summary ?
GeneID466
SymbolATF1
SynonymsEWS-ATF1|FUS/ATF-1|TREB36
Descriptionactivating transcription factor 1
ReferenceMIM:123803|HGNC:HGNC:783|Ensembl:ENSG00000123268|HPRD:00440|Vega:OTTHUMG00000169482
Gene typeprotein-coding
Map location12q13
Pascal p-value5.016E-4
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16829545chr2151977407ATF14660.07trans
rs7584986chr2184111432ATF14660.07trans
rs16955618chr1529937543ATF14660.07trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD,BioGRID10945975 
CAMK2ACAMKA | KIAA0968calcium/calmodulin-dependent protein kinase II alphaBiochemical ActivityBioGRID8663317 
CREB1CREB | MGC9284cAMP responsive element binding protein 1-HPRD,BioGRID1655749 |8384217 
CREBBPCBP | KAT3A | RSTSCREB binding protein-HPRD,BioGRID8663317 
CSNK2A1CK2A1 | CKIIcasein kinase 2, alpha 1 polypeptide-HPRD,BioGRID9685505 
CSNK2A2CK2A2 | CSNK2A1 | FLJ43934casein kinase 2, alpha prime polypeptide-HPRD,BioGRID9685505 
CSNK2BCK2B | CK2N | CSK2B | G5A | MGC138222 | MGC138224casein kinase 2, beta polypeptideReconstituted ComplexBioGRID9685505 
EDF1EDF-1 | MBF1 | MGC9058endothelial differentiation-related factor 1-HPRD,BioGRID10567391 
FOSL1FRA | FRA1 | fra-1FOS-like antigen 1ATF1 interacts with the region of the FRA-1 promoter containing the SRE and ATF sites.BIND15806162 
GABPAE4TF1-60 | E4TF1A | NFT2 | NRF2 | NRF2AGA binding protein transcription factor, alpha subunit 60kDa-HPRD,BioGRID10585419 
GABPB1BABPB2 | E4TF1 | E4TF1-47 | E4TF1-53 | E4TF1B | GABPB | GABPB2 | NRF2B1 | NRF2B2GA binding protein transcription factor, beta subunit 1-HPRD10585419 
HNF1BFJHN | HNF1beta | HNF2 | HPC11 | LF-B3 | LFB3 | MODY5 | TCF2 | VHNF1HNF1 homeobox BTwo-hybridBioGRID9671480 
JUNAP-1 | AP1 | c-Junjun oncogene-HPRD,BioGRID8570175 
SPI1OF | PU.1 | SFPI1 | SPI-1 | SPI-Aspleen focus forming virus (SFFV) proviral integration oncogene spi1-HPRD,BioGRID7730336 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA STRESS PATHWAY 2518All SZGR 2.0 genes in this pathway
ST DIFFERENTIATION PATHWAY IN PC12 CELLS 4535All SZGR 2.0 genes in this pathway
ST ERK1 ERK2 MAPK PATHWAY 3225All SZGR 2.0 genes in this pathway
ST P38 MAPK PATHWAY 3728All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 10578All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA DOWNSTREAM PATHWAY 3829All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217167All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING 7454All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137105All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 2420All SZGR 2.0 genes in this pathway
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE 5037All SZGR 2.0 genes in this pathway
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 3024All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 7757All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE 7253All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE 8363All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279178All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING 9369All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES 11884All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR DN 209122All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP DN 199124All SZGR 2.0 genes in this pathway
BARIS THYROID CANCER DN 5945All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION 7751All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION CCNE1 4026All SZGR 2.0 genes in this pathway
MYLLYKANGAS AMPLIFICATION HOT SPOT 21 95All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380213All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 10173All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN 156106All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424268All SZGR 2.0 genes in this pathway
HOFMANN CELL LYMPHOMA UP 5035All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway
GERHOLD ADIPOGENESIS DN 6444All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 11 5740All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN 271175All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566371All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543317All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593372All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591366All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN 193112All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 10 6938All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN 222147All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN 336211All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467251All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516308All SZGR 2.0 genes in this pathway