SZGR2

Summary ?

GeneID	4791
Symbol	NFKB2
Synonyms	CVID10\|H2TF1\|LYT-10\|LYT10\|NF-kB2\|p100\|p49/p100\|p52
Description	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
Reference	MIM:164012\|HGNC:HGNC:7795\|Ensembl:ENSG00000077150\|HPRD:01239\|Vega:OTTHUMG00000018962
Gene type	protein-coding
Map location	10q24
Pascal p-value	0.005
Fetal beta	-0.659
DMG	1 (# studies)
eGene	Meta

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Nishioka_2013	Genome-wide DNA methylation analysis	The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls.	1
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0233

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg23738770	10	104154605	NFKB2		-0.025	0.3	DMG:Nishioka_2013

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003700	transcription factor activity	TAS		1760839 \|1876189
GO:0003713	transcription coactivator activity	TAS		1876189
GO:0005515	protein binding	IPI		11526476 \|16108830
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0002268	follicular dendritic cell differentiation	IEA	dendrite (GO term level: 5)	-
GO:0002467	germinal center formation	IEA		-
GO:0006355	regulation of transcription, DNA-dependent	IDA		8360178
GO:0007165	signal transduction	IEA		-
GO:0030198	extracellular matrix organization	IEA		-
GO:0048536	spleen development	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		10723127
GO:0005634	nucleus	IDA		15677444
GO:0005654	nucleoplasm	EXP		10723127
GO:0005737	cytoplasm	IDA		15677444
GO:0033257	Bcl3/NF-kappaB2 complex	IDA		9407099

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AIFM1	AIF \| MGC111425 \| PDCD8	apoptosis-inducing factor, mitochondrion-associated, 1	-	HPRD	14743216
BCL3	BCL4 \| D19S37	B-cell CLL/lymphoma 3	p52 interacts with BCL-3. This interaction was modelled on a demonstrated interaction between p52 from an unspecified species and human BCL-3.	BIND	15469820
BCL3	BCL4 \| D19S37	B-cell CLL/lymphoma 3	-	HPRD	8453667 \|11707390
BCL3	BCL4 \| D19S37	B-cell CLL/lymphoma 3	Co-localization Reconstituted Complex	BioGRID	8453667 \|14678988
BTRC	BETA-TRCP \| FBW1A \| FBXW1 \| FBXW1A \| FWD1 \| MGC4643 \| bTrCP \| bTrCP1 \| betaTrCP	beta-transducin repeat containing	-	HPRD,BioGRID	11994270
DDX3X	DBX \| DDX14 \| DDX3 \| HLP2	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked	Affinity Capture-MS	BioGRID	14743216
DHX9	DDX9 \| LKP \| NDHII \| RHA	DEAH (Asp-Glu-Ala-His) box polypeptide 9	-	HPRD	14743216
DSP	DPI \| DPII	desmoplakin	-	HPRD	14743216
FBXW7	AGO \| CDC4 \| DKFZp686F23254 \| FBW6 \| FBW7 \| FBX30 \| FBXO30 \| FBXW6 \| FLJ16457 \| SEL-10 \| SEL10	F-box and WD repeat domain containing 7	Affinity Capture-MS	BioGRID	14743216
GLG1	CFR-1 \| ESL-1 \| FLJ23319 \| FLJ23967 \| MG-160 \| MG160	golgi apparatus protein 1	Affinity Capture-MS	BioGRID	14743216
GTF2I	BAP-135 \| BAP135 \| BTKAP1 \| DIWS \| FLJ38776 \| FLJ56355 \| IB291 \| SPIN \| TFII-I \| WBS \| WBSCR6	general transcription factor II, i	-	HPRD	14743216
HNRNPM	DKFZp547H118 \| HNRNPM4 \| HNRPM \| HNRPM4 \| HTGR1 \| NAGR1	heterogeneous nuclear ribonucleoprotein M	-	HPRD	14743216
HSPA8	HSC54 \| HSC70 \| HSC71 \| HSP71 \| HSP73 \| HSPA10 \| LAP1 \| MGC131511 \| MGC29929 \| NIP71	heat shock 70kDa protein 8	-	HPRD	14743216
IKBKG	AMCBX1 \| FIP-3 \| FIP3 \| Fip3p \| IKK-gamma \| IP \| IP1 \| IP2 \| IPD2 \| NEMO	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	Affinity Capture-MS	BioGRID	14743216
MAP3K14	FTDCR1B \| HS \| HSNIK \| NIK	mitogen-activated protein kinase kinase kinase 14	-	HPRD,BioGRID	11239468
MAP3K8	COT \| EST \| ESTF \| FLJ10486 \| TPL2 \| Tpl-2 \| c-COT	mitogen-activated protein kinase kinase kinase 8	Affinity Capture-MS	BioGRID	14743216
MEN1	MEAI \| SCG2	multiple endocrine neoplasia I	-	HPRD,BioGRID	11526476
NFKB1	DKFZp686C01211 \| EBP-1 \| KBF1 \| MGC54151 \| NF-kappa-B \| NFKB-p105 \| NFKB-p50 \| p105	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	Affinity Capture-MS	BioGRID	14743216
NFKB2	LYT-10 \| LYT10	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)	Affinity Capture-MS	BioGRID	14743216
NFKBIE	IKBE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	p52 interacts with I-kappa-B-epsilon. This interaction was modeled on a demonstrated interaction between p52 from an unspecified species and human I-kappa-B-epsilon.	BIND	9135156
NFKBIE	IKBE	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon	-	HPRD,BioGRID	9315679
NKRF	ITBA4 \| NRF	NFKB repressing factor	-	HPRD,BioGRID	10562553
NR3C1	GCCR \| GCR \| GR \| GRL	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	-	HPRD,BioGRID	7823959
PPP2R1A	MGC786 \| PR65A	protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform	-	HPRD	14743216
PSMD1	MGC133040 \| MGC133041 \| P112 \| Rpn2 \| S1	proteasome (prosome, macropain) 26S subunit, non-ATPase, 1	-	HPRD	14743216
PSMD3	P58 \| RPN3 \| S3	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	-	HPRD	14743216
REL	C-Rel	v-rel reticuloendotheliosis viral oncogene homolog (avian)	-	HPRD,BioGRID	8413211
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	-	HPRD,BioGRID	8413211
RELB	I-REL \| IREL	v-rel reticuloendotheliosis viral oncogene homolog B	Affinity Capture-MS Co-localization	BioGRID	14678988 \|14743216
RELB	I-REL \| IREL	v-rel reticuloendotheliosis viral oncogene homolog B	-	HPRD	12505990
RPL18	-	ribosomal protein L18	-	HPRD	14743216
RPL30	-	ribosomal protein L30	Affinity Capture-MS	BioGRID	14743216
RPL6	SHUJUN-2 \| TAXREB107 \| TXREB1	ribosomal protein L6	Affinity Capture-MS	BioGRID	14743216
RPS13	-	ribosomal protein S13	Affinity Capture-MS	BioGRID	14743216
RPS3	FLJ26283 \| FLJ27450 \| MGC87870	ribosomal protein S3	-	HPRD	14743216
RUVBL2	CGI-46 \| ECP51 \| INO80J \| REPTIN \| RVB2 \| TIH2 \| TIP48 \| TIP49B	RuvB-like 2 (E. coli)	-	HPRD	14743216
SEC16A	FLJ26737 \| KIAA0310 \| RP11-413M3.10 \| SEC16L \| p250	SEC16 homolog A (S. cerevisiae)	-	HPRD,BioGRID	14743216
SP1	-	Sp1 transcription factor	Reconstituted Complex	BioGRID	7933095
TBK1	FLJ11330 \| NAK \| T2K	TANK-binding kinase 1	Affinity Capture-MS	BioGRID	14743216
TIMM50	MGC102733 \| TIM50 \| TIM50L	translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)	-	HPRD	14743216
TNIP2	ABIN-2 \| ABIN2 \| FLIP1 \| KLIP \| MGC4289	TNFAIP3 interacting protein 2	-	HPRD,BioGRID	14743216
TSC22D3	DIP \| DKFZp313A1123 \| DSIPI \| GILZ \| TSC-22R \| hDIP	TSC22 domain family, member 3	-	HPRD,BioGRID	11468175
TUBA3C	TUBA2 \| bA408E5.3	tubulin, alpha 3c	-	HPRD	14743216
TUBB2B	DKFZp566F223 \| FLJ98847 \| MGC8685 \| TUBB-PARALOG \| bA506K6.1	tubulin, beta 2B	-	HPRD	14743216
TUBB6	HsT1601 \| MGC132410 \| MGC4083 \| TUBB-5	tubulin, beta 6	-	HPRD	14743216
TUBGCP2	GCP2 \| MGC138162 \| SPBC97 \| Spc97p	tubulin, gamma complex associated protein 2	-	HPRD	14743216
USP2	UBP41 \| USP9	ubiquitin specific peptidase 2	Affinity Capture-MS	BioGRID	14743216
USP9X	DFFRX \| FAF \| FAM	ubiquitin specific peptidase 9, X-linked	-	HPRD	14743216

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
ST TUMOR NECROSIS FACTOR PATHWAY	29	20	All SZGR 2.0 genes in this pathway
SIG CD40PATHWAYMAP	34	28	All SZGR 2.0 genes in this pathway
ST GAQ PATHWAY	28	22	All SZGR 2.0 genes in this pathway
ST GA13 PATHWAY	37	32	All SZGR 2.0 genes in this pathway
ST T CELL SIGNAL TRANSDUCTION	45	33	All SZGR 2.0 genes in this pathway
ST B CELL ANTIGEN RECEPTOR	40	32	All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY	65	54	All SZGR 2.0 genes in this pathway
PID IL12 2PATHWAY	63	54	All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING	74	54	All SZGR 2.0 genes in this pathway
REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	18	15	All SZGR 2.0 genes in this pathway
REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	23	17	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS	107	86	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED NFKB ACTIVATION	21	17	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION	77	57	All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE	72	53	All SZGR 2.0 genes in this pathway
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	73	57	All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE	83	63	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING	93	69	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES	118	84	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER UP	206	111	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP	473	314	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP	485	293	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC UP	185	126	All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP	457	269	All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP	238	144	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP	544	308	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP	431	237	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP	214	155	All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN	378	231	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 3 4WK DN	39	27	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK UP	271	175	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS DN	62	44	All SZGR 2.0 genes in this pathway
GILMORE CORE NFKB PATHWAY	14	10	All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK TARGETS	18	15	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2	127	92	All SZGR 2.0 genes in this pathway
RASHI NFKB1 TARGETS	19	18	All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE EARLY	66	48	All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE LATE UP	57	41	All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION	149	101	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
SCIAN INVERSED TARGETS OF TP53 AND TP73 DN	31	23	All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 480 HELA	164	118	All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 3	28	23	All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP	223	140	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP	398	262	All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO HD MTX UP	23	13	All SZGR 2.0 genes in this pathway
GALINDO IMMUNE RESPONSE TO ENTEROTOXIN	85	67	All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP	183	111	All SZGR 2.0 genes in this pathway
HOEGERKORP CD44 TARGETS TEMPORAL UP	13	8	All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING UP	101	76	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP	240	152	All SZGR 2.0 genes in this pathway
MARIADASON RESPONSE TO CURCUMIN SULINDAC 7	19	10	All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM DN	86	66	All SZGR 2.0 genes in this pathway
MEDINA SMARCA4 TARGETS	44	29	All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION DN	98	67	All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1	419	273	All SZGR 2.0 genes in this pathway
BILD MYC ONCOGENIC SIGNATURE	206	117	All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN	314	188	All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER T7	98	63	All SZGR 2.0 genes in this pathway
SANSOM APC MYC TARGETS	217	138	All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS REQUIRE MYC	210	123	All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6	469	239	All SZGR 2.0 genes in this pathway
GAURNIER PSMD4 TARGETS	73	55	All SZGR 2.0 genes in this pathway
LABBE WNT3A TARGETS UP	112	71	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE	242	168	All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP	323	240	All SZGR 2.0 genes in this pathway
VILIMAS NOTCH1 TARGETS UP	52	41	All SZGR 2.0 genes in this pathway
SEKI INFLAMMATORY RESPONSE LPS UP	77	56	All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION B	53	36	All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS FIBROBLAST UP	84	60	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR UP	221	150	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS UP	108	78	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN	668	419	All SZGR 2.0 genes in this pathway
CROONQUIST STROMAL STIMULATION DN	13	7	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SURVIVAL UP	73	49	All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 12HR UP	29	18	All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 24HR DN	43	32	All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 32HR DN	39	28	All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 48HR UP	14	9	All SZGR 2.0 genes in this pathway
TIAN TNF SIGNALING VIA NFKB	28	21	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP	397	206	All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN	157	106	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B	549	316	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS DN	418	245	All SZGR 2.0 genes in this pathway
PHONG TNF TARGETS UP	63	43	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL	160	106	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38	337	236	All SZGR 2.0 genes in this pathway
ZWANG CLASS 3 TRANSIENTLY INDUCED BY EGF	222	159	All SZGR 2.0 genes in this pathway

Gene Page: NFKB2