Gene Page: NGF

Summary ?
GeneID4803
SymbolNGF
SynonymsBeta-NGF|HSAN5|NGFB
Descriptionnerve growth factor
ReferenceMIM:162030|HGNC:HGNC:7808|Ensembl:ENSG00000134259|HPRD:08874|Vega:OTTHUMG00000011880
Gene typeprotein-coding
Map location1p13.1
Pascal p-value1.079E-5
Fetal beta-0.354
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWAScatGenome-wide Association StudiesThis data set includes 560 SNPs associated with schizophrenia. A total of 486 genes were mapped to these SNPs within 50kb.
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias,schizotypalClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs537914chr1182492679NGF48030.12trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005057receptor signaling protein activityIEA-
GO:0005163nerve growth factor receptor bindingIPI14985763 
GO:0008083growth factor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0046928regulation of neurotransmitter secretionIEASynap, Neurotransmitter (GO term level: 9)-
GO:0045773positive regulation of axon extensionIEAaxon (GO term level: 15)-
GO:0045664regulation of neuron differentiationIEAneuron, neurogenesis (GO term level: 9)-
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayEXP16939974 
GO:0007265Ras protein signal transductionEXP11520933 
GO:0007422peripheral nervous system developmentIEA-
GO:0019233sensory perception of painIEA-
GO:0032455nerve growth factor processingEXP12787574 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005796Golgi lumenEXP8615794 |12787574 
GO:0005576extracellular regionEXP11157096 |12787574 |16284401 
GO:0005576extracellular regionIEA-
GO:0005768endosomeEXP7806500 |9182757 |10629055 
|16284401 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG MAPK SIGNALING PATHWAY 267205All SZGR 2.0 genes in this pathway
KEGG APOPTOSIS 8862All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126103All SZGR 2.0 genes in this pathway
BIOCARTA ERK PATHWAY 2822All SZGR 2.0 genes in this pathway
BIOCARTA NGF PATHWAY 1813All SZGR 2.0 genes in this pathway
BIOCARTA CDK5 PATHWAY 1111All SZGR 2.0 genes in this pathway
BIOCARTA TRKA PATHWAY 1210All SZGR 2.0 genes in this pathway
SA TRKA RECEPTOR 1715All SZGR 2.0 genes in this pathway
PID SHP2 PATHWAY 5846All SZGR 2.0 genes in this pathway
PID P75 NTR PATHWAY 6951All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY 6248All SZGR 2.0 genes in this pathway
PID PI3K PLC TRK PATHWAY 3631All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217167All SZGR 2.0 genes in this pathway
REACTOME ARMS MEDIATED ACTIVATION 1717All SZGR 2.0 genes in this pathway
REACTOME PROLONGED ERK ACTIVATION EVENTS 1918All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO RAS 2723All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137105All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO ERKS 3630All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO P38 VIA RIT AND RIN 1514All SZGR 2.0 genes in this pathway
REACTOME RETROGRADE NEUROTROPHIN SIGNALLING 137All SZGR 2.0 genes in this pathway
REACTOME PI3K AKT ACTIVATION 3829All SZGR 2.0 genes in this pathway
REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES 128All SZGR 2.0 genes in this pathway
REACTOME P75NTR SIGNALS VIA NFKB 1410All SZGR 2.0 genes in this pathway
REACTOME NRAGE SIGNALS DEATH THROUGH JNK 4333All SZGR 2.0 genes in this pathway
REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS 1510All SZGR 2.0 genes in this pathway
REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL 118All SZGR 2.0 genes in this pathway
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 6043All SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING 8161All SZGR 2.0 genes in this pathway
NEWMAN ERCC6 TARGETS DN 3924All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF DN 11878All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP 536340All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2 12792All SZGR 2.0 genes in this pathway
FURUKAWA DUSP6 TARGETS PCI35 DN 7440All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637377All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS 12690All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408274All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP 6941All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504323All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE NOT BY GAMMA IN WS 3322All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195135All SZGR 2.0 genes in this pathway
KYNG ENVIRONMENTAL STRESS RESPONSE UP 5641All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP 245159All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE UP 10968All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE UP 6242All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221135All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN 222147All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254158All SZGR 2.0 genes in this pathway
QI HYPOXIA TARGETS OF HIF1A AND FOXA2 3727All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549316All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR UP 199143All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489314All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS 344197All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway