Gene Page: NOV

Summary ?
GeneID4856
SymbolNOV
SynonymsCCN3|IBP-9|IGFBP-9|IGFBP9|NOVh
Descriptionnephroblastoma overexpressed
ReferenceMIM:164958|HGNC:HGNC:7885|Ensembl:ENSG00000136999|HPRD:01291|Vega:OTTHUMG00000164984
Gene typeprotein-coding
Map location8q24.1
Pascal p-value0.653
Fetal beta-0.95
eGeneCerebellar Hemisphere
Cerebellum
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophrenias,schizotypalClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17535450chr239900012NOV48560.01trans
rs11706314chr345309716NOV48563.461E-5trans
rs11706394chr345309907NOV48560trans
rs2922180chr3125280472NOV48560.05trans
rs2976809chr3125451738NOV48560.02trans
rs17090446chr462255221NOV48560.03trans
rs7668550chr4104384355NOV48560.07trans
rs17034860chr4135177933NOV48560.13trans
rs16894149chr561013724NOV48560.02trans
rs6449550chr561034312NOV48560.01trans
rs4489051chr5147954484NOV48560.04trans
rs17056435chr5158453782NOV48560.02trans
rs9313797chr5158465457NOV48560.01trans
rs17056474chr5158468105NOV48560.01trans
rs2294262chr616108966NOV48560.06trans
rs9321275chr6131493217NOV48560.07trans
rs6593322chr751048058NOV48560.17trans
rs2199402chr89201002NOV48560.04trans
rs7841407chr89243427NOV48560trans
rs9325776chr815817555NOV48560.19trans
rs16929424chr863608389NOV48560.15trans
rs16908622chr8139231604NOV48560.06trans
rs2066720chr9107554068NOV48560.02trans
rs9423711chr102574802NOV48560.04trans
rs4514358chr1043861923NOV48560.01trans
rs822083chr10108713231NOV48560.11trans
rs11820030chr1176133564NOV48560trans
rs17134872chr1176139845NOV48562.289E-4trans
rs107512550NOV48560.02trans
rs11236774chr1176234952NOV48562.289E-4trans
rs9532792chr1341912654NOV48560.05trans
rs9590586chr1341913130NOV48560.02trans
rs7358856chr1341931609NOV48560.02trans
rs7358853chr1341931685NOV48560.01trans
rs8002343chr1341952090NOV48560.02trans
rs9315839chr1341952872NOV48560.04trans
rs4349050chr1341958722NOV48560trans
rs7982172chr1341969697NOV48567.174E-4trans
rs4942043chr1341978218NOV48569.529E-4trans
rs4402447chr1341984741NOV48560trans
rs1750009chr1342657093NOV48560.09trans
rs9529974chr1372821935NOV48560.06trans
rs17720221chr1375182377NOV48560.05trans
rs10149864chr1486719683NOV48560.15trans
rs2093759chr1497171024NOV48560.13trans
rs17244419chr1497171074NOV48560.06trans
rs11073814chr1589378883NOV48560.1trans
rs7165622chr1593979910NOV48560.02trans
rs17294918chr1652717122NOV48560.09trans
rs16941390chr1745050984NOV48560.07trans
rs4987765chr1860905021NOV48560.01trans
rs11873703chr1861448702NOV48564.187E-4trans
rs17191809chr2136444778NOV48560.19trans
rs6000401chr2237149335NOV48560.03trans
rs5991662chrX43335796NOV48560.08trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TAPT10.600.58
C1QL10.600.66
CPNE80.590.69
FGF140.590.63
L3MBTL40.570.56
SYDE20.570.65
CBLN20.550.63
NECAB10.540.65
NDST30.540.57
PGBD50.530.59
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
IMPA2-0.27-0.36
RAB13-0.27-0.36
GNG5-0.27-0.34
AC098691.2-0.27-0.29
RFXANK-0.25-0.32
RAB34-0.25-0.24
C1orf61-0.25-0.25
H2AFJ-0.24-0.31
GRTP1-0.23-0.25
IRF7-0.23-0.32

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
WEST ADRENOCORTICAL TUMOR MARKERS DN 2014All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA MYELOID DN 3825All SZGR 2.0 genes in this pathway
IGARASHI ATF4 TARGETS DN 9065All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233161All SZGR 2.0 genes in this pathway
PAPASPYRIDONOS UNSTABLE ATEROSCLEROTIC PLAQUE DN 4329All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329219All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2A DN 14184All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS G UP 238135All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 2B 392251All SZGR 2.0 genes in this pathway
SEITZ NEOPLASTIC TRANSFORMATION BY 8P DELETION UP 7347All SZGR 2.0 genes in this pathway
YORDY RECIPROCAL REGULATION BY ETS1 AND SP100 DN 8748All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS UP 292168All SZGR 2.0 genes in this pathway
BALDWIN PRKCI TARGETS UP 3526All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP 223140All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8Q23 Q24 AMPLICON 15787All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS DN 3522All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 DN 7748All SZGR 2.0 genes in this pathway
BRUNO HEMATOPOIESIS 6648All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR DN 148102All SZGR 2.0 genes in this pathway
MCCLUNG DELTA FOSB TARGETS 2WK 4836All SZGR 2.0 genes in this pathway
SIMBULAN PARP1 TARGETS UP 3123All SZGR 2.0 genes in this pathway
KANG FLUOROURACIL RESISTANCE UP 2215All SZGR 2.0 genes in this pathway
MCCLUNG CREB1 TARGETS UP 10072All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD UP 222139All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487303All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 0HR 6348All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C3 3624All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720440All SZGR 2.0 genes in this pathway
STEARMAN TUMOR FIELD EFFECT UP 3622All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE DN 6139All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543317All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
TAYLOR METHYLATED IN ACUTE LYMPHOBLASTIC LEUKEMIA 7752All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
LIU VAV3 PROSTATE CARCINOGENESIS UP 8961All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION 368247All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS DN 306191All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 1 6850All SZGR 2.0 genes in this pathway
BAE BRCA1 TARGETS UP 7547All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549316All SZGR 2.0 genes in this pathway
PLASARI NFIC TARGETS BASAL DN 1813All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 1HR UP 3325All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway
NABA ECM GLYCOPROTEINS 19699All SZGR 2.0 genes in this pathway
NABA CORE MATRISOME 275148All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway