Gene Page: PI4KA

Summary ?
GeneID5297
SymbolPI4KA
SynonymsPI4K-ALPHA|PIK4CA|PMGYCHA|pi4K230
Descriptionphosphatidylinositol 4-kinase alpha
ReferenceMIM:600286|HGNC:HGNC:8983|Ensembl:ENSG00000241973|HPRD:08972|Vega:OTTHUMG00000167440
Gene typeprotein-coding
Map location22q11.21
Pascal p-value0.192
Sherlock p-value0.376
Fetal beta-0.93
eGeneCerebellum
SupportCELL METABOLISM
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet
Darnell FMRP targets
Ascano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CNV:YESCopy number variation studiesManual curation
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies1Link to SZGene
GSMA_IGenome scan meta-analysisPsr: 0.031 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
LTB4R20.610.59
LHX20.590.56
TMEM1450.590.64
TMCO60.580.64
MOGS0.570.64
TIRAP0.570.69
IL27RA0.570.58
OVCA20.560.60
RDH50.560.59
MACROD10.560.56
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.31-0.41-0.48
AF347015.27-0.40-0.47
AF347015.21-0.39-0.51
AF347015.2-0.39-0.48
AF347015.8-0.38-0.45
MT-ATP8-0.38-0.50
MT-CO2-0.38-0.44
MT-CYB-0.38-0.45
AF347015.33-0.35-0.43
AL139819.3-0.34-0.40

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI14676841 
GO:0004428inositol or phosphatidylinositol kinase activityIEA-
GO:00044301-phosphatidylinositol 4-kinase activityTAS8662589 
GO:0016740transferase activityIEA-
GO:0016491oxidoreductase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)8662589 
GO:0006661phosphatidylinositol biosynthetic processTAS7961848 
GO:0007165signal transductionNAS7961848 
GO:0048015phosphoinositide-mediated signalingIEA-
GO:0046854phosphoinositide phosphorylationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005798Golgi-associated vesicleTAS8662589 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG INOSITOL PHOSPHATE METABOLISM 5442All SZGR 2.0 genes in this pathway
KEGG PHOSPHATIDYLINOSITOL SIGNALING SYSTEM 7656All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY 7553All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE 1710All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPID METABOLISM 198112All SZGR 2.0 genes in this pathway
REACTOME PI METABOLISM 4834All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN 309191All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP 380215All SZGR 2.0 genes in this pathway
HOWLIN PUBERTAL MAMMARY GLAND 6940All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER 214139All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428306All SZGR 2.0 genes in this pathway
ROSS ACUTE MYELOID LEUKEMIA CBF 8257All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210124All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN 414237All SZGR 2.0 genes in this pathway
CERIBELLI PROMOTERS INACTIVE AND BOUND BY NFY 4420All SZGR 2.0 genes in this pathway