SZGR2

Summary ?

GeneID	5581
Symbol	PRKCE
Synonyms	PKCE\|nPKC-epsilon
Description	protein kinase C epsilon
Reference	MIM:176975\|HGNC:HGNC:9401\|Ensembl:ENSG00000171132\|HPRD:01500\|Vega:OTTHUMG00000128817
Gene type	protein-coding
Map location	2p21
Pascal p-value	0.002
Fetal beta	-1.365
DMG	1 (# studies)
eGene	Myers' cis & trans Meta
Support	CANABINOID INTRACELLULAR SIGNAL TRANSDUCTION METABOTROPIC GLUTAMATE RECEPTOR SEROTONIN G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.humanNRC G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Darnell FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Nishioka_2013	Genome-wide DNA methylation analysis	The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls.	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 6.2183

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg11476211	2	45879284	PRKCE		-0.026	0.43	DMG:Nishioka_2013

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs3851333	chr2	45545406	PRKCE	5581	0.18	cis
rs12473388	chr2	45549304	PRKCE	5581	0.06	cis
rs11681887	chr2	45549659	PRKCE	5581	0.02	cis
rs17211786	chr4	182548238	PRKCE	5581	0.09	trans
rs16930362	chr10	74890320	PRKCE	5581	0.17	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MYT1	0.93	0.82
PHF21B	0.91	0.84
VANGL2	0.91	0.89
MED12	0.91	0.87
CTBP2	0.90	0.87
SERINC2	0.90	0.82
NUP188	0.90	0.89
PLAGL2	0.90	0.84
FANCC	0.89	0.85
ABL1	0.89	0.87

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
C5orf53	-0.58	-0.79
HLA-F	-0.55	-0.71
FBXO2	-0.55	-0.64
PTH1R	-0.54	-0.66
AIFM3	-0.54	-0.69
SLC16A11	-0.54	-0.61
LHPP	-0.54	-0.58
TNFSF12	-0.53	-0.61
ALDOC	-0.53	-0.63
TMEM54	-0.53	-0.57

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0004871	signal transducer activity	TAS		1382605 \|10438519
GO:0004699	calcium-independent protein kinase C activity	IEA		-
GO:0005515	protein binding	IPI		10801826 \|17668322
GO:0005524	ATP binding	IEA		-
GO:0004674	protein serine/threonine kinase activity	IEA		-
GO:0016740	transferase activity	IEA		-
GO:0008270	zinc ion binding	IEA		-
GO:0019992	diacylglycerol binding	IEA		-
GO:0046872	metal ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006468	protein amino acid phosphorylation	IEA		-
GO:0006468	protein amino acid phosphorylation	TAS		1382605
GO:0007242	intracellular signaling cascade	IEA		-
GO:0006917	induction of apoptosis	TAS		10438519
GO:0050730	regulation of peptidyl-tyrosine phosphorylation	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005624	membrane fraction	TAS		7935319
GO:0005634	nucleus	IEA		-
GO:0005737	cytoplasm	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTA1	ACTA \| ASMA \| CFTD \| CFTD1 \| CFTDM \| MPFD \| NEM1 \| NEM2 \| NEM3	actin, alpha 1, skeletal muscle	Affinity Capture-MS Affinity Capture-Western	BioGRID	11897493
ACTC1	ACTC \| CMD1R \| CMH11	actin, alpha, cardiac muscle 1	-	HPRD	11968018
ADAP1	CENTA1 \| GCS1L \| p42IP4	ArfGAP with dual PH domains 1	Biochemical Activity	BioGRID	12893243
AFAP1	AFAP \| AFAP-110 \| FLJ56849	actin filament associated protein 1	-	HPRD,BioGRID	12134071
AKAP9	AKAP350 \| AKAP450 \| CG-NAP \| HYPERION \| KIAA0803 \| MU-RMS-40.16A \| PRKA9 \| YOTIAO	A kinase (PRKA) anchor protein (yotiao) 9	-	HPRD	10945988
CFTR	ABC35 \| ABCC7 \| CF \| CFTR/MRP \| MRP7 \| TNR-CFTR \| dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	-	HPRD,BioGRID	11956211
CNN1	SMCC \| Sm-Calp	calponin 1, basic, smooth muscle	-	HPRD	9312127
COPB1	COPB \| DKFZp761K102 \| FLJ10341	coatomer protein complex, subunit beta 1	-	HPRD	11897493
COPB2	beta'-COP	coatomer protein complex, subunit beta 2 (beta prime)	Affinity Capture-MS Affinity Capture-Western	BioGRID	11897493
COPB2	beta'-COP	coatomer protein complex, subunit beta 2 (beta prime)	-	HPRD	9360998
GAD1	FLJ45882 \| GAD \| SCP	glutamate decarboxylase 1 (brain, 67kDa)	Biochemical Activity	BioGRID	15147202
GAD2	GAD65 \| MGC161605 \| MGC161607	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	-	HPRD,BioGRID	15147202
GJA1	CX43 \| DFNB38 \| GJAL \| ODDD	gap junction protein, alpha 1, 43kDa	-	HPRD,BioGRID	10679481
GNA12	MGC104623 \| MGC99644 \| NNX3 \| RMP \| gep	guanine nucleotide binding protein (G protein) alpha 12	Biochemical Activity	BioGRID	8824244
GNA13	G13 \| MGC46138	guanine nucleotide binding protein (G protein), alpha 13	-	HPRD,BioGRID	8824244
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	Affinity Capture-Western Far Western Reconstituted Complex	BioGRID	11956211
GRIN1	NMDA1 \| NMDAR1 \| NR1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	-	HPRD	10862698
HK2	DKFZp686M1669 \| HKII \| HXK2	hexokinase 2	Affinity Capture-Western	BioGRID	12663490
KRT1	CK1 \| EHK1 \| K1 \| KRT1A	keratin 1	-	HPRD,BioGRID	11897493
KRT18	CYK18 \| K18	keratin 18	-	HPRD,BioGRID	1374067
MAPK1	ERK \| ERK2 \| ERT1 \| MAPK2 \| P42MAPK \| PRKM1 \| PRKM2 \| p38 \| p40 \| p41 \| p41mapk	mitogen-activated protein kinase 1	Affinity Capture-Western	BioGRID	11350735
MYH2	MYH2A \| MYHSA2 \| MYHas8 \| MyHC-2A \| MyHC-IIa	myosin, heavy chain 2, skeletal muscle, adult	-	HPRD	11897493
MYH9	DFNA17 \| EPSTS \| FTNS \| MGC104539 \| MHA \| NMHC-II-A \| NMMHCA	myosin, heavy chain 9, non-muscle	Affinity Capture-MS Affinity Capture-Western	BioGRID	11897493
PDLIM5	ENH \| ENH1 \| L9 \| LIM	PDZ and LIM domain 5	-	HPRD,BioGRID	8940095
PDPK1	MGC20087 \| MGC35290 \| PDK1 \| PRO0461	3-phosphoinositide dependent protein kinase-1	An unspecified isoform of PDPK1 (PDK1) phosphorylates PRKCE (PKC-epsilon). This interaction was modeled on a demonstrated interaction between PDPK1 from an unspecified species and PRKCE from an unspecified species.	BIND	12223477
PIK3CB	DKFZp779K1237 \| MGC133043 \| PI3K \| PI3KCB \| PI3Kbeta \| PIK3C1 \| p110-BETA	phosphoinositide-3-kinase, catalytic, beta polypeptide	-	HPRD,BioGRID	9822674
PPP1R14A	CPI-17 \| CPI17 \| PPP1INL	protein phosphatase 1, regulatory (inhibitor) subunit 14A	-	HPRD	15003508
PRKCE	MGC125656 \| MGC125657 \| PKCE \| nPKC-epsilon	protein kinase C, epsilon	PRKCE (PKC-epsilon) autophosphorylates. This interaction was modeled on a demonstrated interaction using PRKCE from an unspecified species.	BIND	12223477
PRKD1	PKC-MU \| PKCM \| PKD \| PRKCM	protein kinase D1	PRKCE (PKC-epsilon) phosphorylates PRKD1 (PKC-mu). This interaction was modeled on a demonstrated interaction between PRKCE from an unspecified species and human PRKD1.	BIND	12223477
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	-	HPRD,BioGRID	11350735
RASGRP3	GRP3 \| KIAA0846	RAS guanyl releasing protein 3 (calcium and DAG-regulated)	Biochemical Activity	BioGRID	15213298
SLC25A4	AAC1 \| ANT \| ANT1 \| PEO2 \| PEO3 \| T1	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4	Affinity Capture-Western	BioGRID	12663490
SNCA	MGC110988 \| NACP \| PARK1 \| PARK4 \| PD1	synuclein, alpha (non A4 component of amyloid precursor)	-	HPRD	10407019
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD	11834516
TIAM1	FLJ36302	T-cell lymphoma invasion and metastasis 1	-	HPRD,BioGRID	10212259
VDAC1	MGC111064 \| PORIN \| PORIN-31-HL	voltage-dependent anion channel 1	-	HPRD,BioGRID	12663490
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	Affinity Capture-Western	BioGRID	11950841

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION	115	81	All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION	134	86	All SZGR 2.0 genes in this pathway
KEGG FC EPSILON RI SIGNALING PATHWAY	79	58	All SZGR 2.0 genes in this pathway
KEGG FC GAMMA R MEDIATED PHAGOCYTOSIS	97	71	All SZGR 2.0 genes in this pathway
KEGG TYPE II DIABETES MELLITUS	47	41	All SZGR 2.0 genes in this pathway
BIOCARTA KERATINOCYTE PATHWAY	46	38	All SZGR 2.0 genes in this pathway
BIOCARTA PTDINS PATHWAY	23	16	All SZGR 2.0 genes in this pathway
BIOCARTA AKAPCENTROSOME PATHWAY	15	14	All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY	63	52	All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY	66	53	All SZGR 2.0 genes in this pathway
PID TCR PATHWAY	66	51	All SZGR 2.0 genes in this pathway
PID LPA4 PATHWAY	15	10	All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY	70	51	All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY	53	42	All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY	57	43	All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY	54	47	All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY	55	43	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID IL8 CXCR1 PATHWAY	28	19	All SZGR 2.0 genes in this pathway
PID RAS PATHWAY	30	22	All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY	65	56	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME DAG AND IP3 SIGNALING	32	25	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER	109	80	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	205	136	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	95	76	All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS	184	116	All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING	805	368	All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Z SIGNALLING EVENTS	44	29	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	100	74	All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE	54	40	All SZGR 2.0 genes in this pathway
REACTOME EFFECTS OF PIP2 HYDROLYSIS	25	17	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR	112	80	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 3 4WK UP	214	144	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK DN	196	131	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
MANTOVANI NFKB TARGETS UP	43	33	All SZGR 2.0 genes in this pathway
MANTOVANI VIRAL GPCR SIGNALING UP	86	54	All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS	1038	678	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3	1118	744	All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS	652	441	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL CIS	65	38	All SZGR 2.0 genes in this pathway
CHESLER BRAIN HIGHEST EXPRESSION	40	29	All SZGR 2.0 genes in this pathway
GOLDRATH IMMUNE MEMORY	65	42	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN	298	200	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL	254	164	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 2	72	52	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR	681	420	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN	543	317	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN	120	81	All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN	264	159	All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN	435	289	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP	271	165	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D	658	397	All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS UP	221	120	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY	1839	928	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	3040	3047	1A,m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-103/107	1564	1570	1A	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	1564	1570	1A	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-141/200a	1289	1296	1A,m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	1289	1296	1A,m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-143	2180	2187	1A,m8	hsa-miR-143^brain	UGAGAUGAAGCACUGUAGCUCA
miR-144	3041	3047	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-181	3060	3066	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-182	3032	3038	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-182	3032	3038	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-205	2732	2739	1A,m8	hsa-miR-205	UCCUUCAUUCCACCGGAGUCUG
miR-216	1495	1501	m8	hsa-miR-216	UAAUCUCAGCUGGCAACUGUG
miR-218	2153	2159	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-23	3057	3063	1A	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	3057	3063	1A	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-25/32/92/363/367	1628	1635	1A,m8	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-362	2735	2741	1A	hsa-miR-362	AAUCCUUGGAACCUAGGUGUGAGU
miR-363	2879	2885	1A	hsa-miR-363	AUUGCACGGUAUCCAUCUGUAA
miR-381	1503	1509	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-500	1626	1633	1A,m8	hsa-miR-500	AUGCACCUGGGCAAGGAUUCUG
miR-543	1838	1844	m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-96	614	620	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC
miR-96	614	620	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: PRKCE