Gene Page: PRLR

Summary ?
GeneID5618
SymbolPRLR
SynonymsHPRL|MFAB|hPRLrI
Descriptionprolactin receptor
ReferenceMIM:176761|HGNC:HGNC:9446|Ensembl:ENSG00000113494|HPRD:01457|Vega:OTTHUMG00000090789
Gene typeprotein-coding
Map location5p13.2
Pascal p-value0.203
Fetal beta-0.582
eGeneCaudate basal ganglia
Nucleus accumbens basal ganglia
Putamen basal ganglia

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6897259535188444PRLRENSG00000113494.128.942E-70.0142350gtex_brain_putamen_basal
rs7721404535189624PRLRENSG00000113494.124.778E-70.0141170gtex_brain_putamen_basal
rs9292573535199433PRLRENSG00000113494.126.211E-70.0131361gtex_brain_putamen_basal
rs873456535199657PRLRENSG00000113494.123.666E-60.0131137gtex_brain_putamen_basal
rs875701535200656PRLRENSG00000113494.129.41E-70.0130138gtex_brain_putamen_basal
rs72456163535201798PRLRENSG00000113494.121.523E-60.0128996gtex_brain_putamen_basal
rs55902512535202270PRLRENSG00000113494.122.562E-60.0128524gtex_brain_putamen_basal
rs2047739535203338PRLRENSG00000113494.121.358E-60.0127456gtex_brain_putamen_basal
rs2047740535203392PRLRENSG00000113494.121.23E-60.0127402gtex_brain_putamen_basal
rs72734580535204923PRLRENSG00000113494.122.55E-60.0125871gtex_brain_putamen_basal
rs75915490535205592PRLRENSG00000113494.122.548E-60.0125202gtex_brain_putamen_basal
rs74383180535209548PRLRENSG00000113494.122.913E-60.0121246gtex_brain_putamen_basal
rs72734599535218764PRLRENSG00000113494.122.812E-60.0112030gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MAPK30.750.69
AC019206.30.710.66
LRMP0.700.69
PDK20.690.68
ANXA110.670.84
SLC25A450.660.76
ALDOA0.660.76
EXTL10.650.82
GJB30.640.70
CPEB10.640.81
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NKIRAS2-0.39-0.57
MMP25-0.39-0.61
PKN1-0.38-0.66
KIAA1949-0.38-0.65
TUBB2B-0.37-0.68
RP9-0.37-0.64
SH2B2-0.37-0.69
SH3BP2-0.37-0.70
YBX1-0.37-0.66
MARCKSL1-0.37-0.63

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CSH1CSA | CSMT | FLJ75407 | PLchorionic somatomammotropin hormone 1 (placental lactogen)-HPRD10966654 
GH1GH | GH-N | GHN | hGH-Ngrowth hormone 1-HPRD,BioGRID9556914 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)-HPRD,BioGRID10772872 
NEK3HSPK36 | MGC29949NIMA (never in mitosis gene a)-related kinase 3Nek3 interacts with PRLr.BIND15618286 
PPIACYPA | CYPH | MGC117158 | MGC12404 | MGC23397peptidylprolyl isomerase A (cyclophilin A)-HPRD,BioGRID12668872 
PRL-prolactin-HPRD9626554 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11Affinity Capture-WesternBioGRID10991949 
SOCS2CIS2 | Cish2 | SOCS-2 | SSI-2 | SSI2 | STATI2suppressor of cytokine signaling 2-HPRD,BioGRID9202403 |10455112 
SOCS3ATOD4 | CIS3 | Cish3 | MGC71791 | SOCS-3 | SSI-3 | SSI3suppressor of cytokine signaling 3-HPRD,BioGRID11713228 
TECMGC126760 | MGC126762 | PSCTK4tec protein tyrosine kinase-HPRD,BioGRID11328862 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD,BioGRID7768923 
VAV2-vav 2 guanine nucleotide exchange factorVav2 interacts with PRLr.BIND15618286 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267161All SZGR 2.0 genes in this pathway
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY 155105All SZGR 2.0 genes in this pathway
PID ERBB4 PATHWAY 3832All SZGR 2.0 genes in this pathway
PID PTP1B PATHWAY 5240All SZGR 2.0 genes in this pathway
REACTOME GROWTH HORMONE RECEPTOR SIGNALING 2419All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4 9067All SZGR 2.0 genes in this pathway
REACTOME PROLACTIN RECEPTOR SIGNALING 1411All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR SIGNALING BY ERBB4 3830All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270204All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276187All SZGR 2.0 genes in this pathway
LIU CMYB TARGETS UP 165106All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP 380215All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450256All SZGR 2.0 genes in this pathway
DOANE BREAST CANCER CLASSES UP 7238All SZGR 2.0 genes in this pathway
RODRIGUES NTN1 TARGETS DN 158102All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK UP 271175All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5 14789All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS BASAL 330217All SZGR 2.0 genes in this pathway
AIYAR COBRA1 TARGETS UP 3925All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP 414287All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261153All SZGR 2.0 genes in this pathway
KHETCHOUMIAN TRIM24 TARGETS DN 87All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
YAGI AML SURVIVAL 12987All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS DN 14294All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528324All SZGR 2.0 genes in this pathway
LEIN CHOROID PLEXUS MARKERS 10361All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA AND UV RADIATION 8865All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP 226164All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN 258160All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
BERNARD PPAPDC1B TARGETS DN 5839All SZGR 2.0 genes in this pathway
MATZUK LUTEAL GENES 85All SZGR 2.0 genes in this pathway
HUANG DASATINIB RESISTANCE DN 6944All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN 252155All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE D7 DN 4022All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D DN 4934All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA1 UP 10166All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN 253192All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP 221135All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN 157106All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745475All SZGR 2.0 genes in this pathway
SERVITJA ISLET HNF1A TARGETS DN 10971All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 403240All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517302All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL DN 428246All SZGR 2.0 genes in this pathway
LIM MAMMARY LUMINAL MATURE UP 11665All SZGR 2.0 genes in this pathway