Gene Page: SPHK2

Summary
GeneID  56848
Symbol  SPHK2
Synonyms  -
Description  sphingosine kinase 2
See related  HGNC:18859|MIM:607092|Ensembl:ENSG00000063176|HPRD:06157|
Locus tag  -
Gene type  protein-coding
Map location  19q13.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004143diacylglycerol kinase activityIEA-
GO:0005515protein bindingIPI11777919 
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
GO:0008481sphinganine kinase activityNAS10751414 
GO:0017016Ras GTPase bindingNAS12391145 
GO:0017050D-erythro-sphingosine kinase activityIEA-
GO:0016301kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentIEABrain (GO term level: 7)-
GO:0001568blood vessel developmentIEA-
GO:0007205activation of protein kinase C activityIEA-
GO:0008283cell proliferationNAS10751414 
GO:0008284positive regulation of cell proliferationIEA-
GO:0006669sphinganine-1-phosphate biosynthetic processNAS10751414 
GO:0006670sphingosine metabolic processIEA-
GO:0006916anti-apoptosisNAS10751414 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolIDA10751414 
GO:0005829cytosolIEA-
GO:0005624membrane fractionIDA10751414 
GO:0005624membrane fractionIEA-
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_SPHINGOLIPID_METABOLISM 4026All SZGR genes in this pathway
KEGG_CALCIUM_SIGNALING_PATHWAY 178134All SZGR genes in this pathway
KEGG_VEGF_SIGNALING_PATHWAY 7653All SZGR genes in this pathway
KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS 9771All SZGR genes in this pathway
PID_IL12_2PATHWAY 6354All SZGR genes in this pathway
PID_CERAMIDE_PATHWAY 4837All SZGR genes in this pathway
PID_S1P_META_PATHWAY 2114All SZGR genes in this pathway
REACTOME_SPHINGOLIPID_DE_NOVO_BIOSYNTHESIS 3118All SZGR genes in this pathway
REACTOME_PHOSPHOLIPID_METABOLISM 198112All SZGR genes in this pathway
REACTOME_SPHINGOLIPID_METABOLISM 6940All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_UP 2518All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 335193All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
FERREIRA_EWINGS_SARCOMA_UNSTABLE_VS_STABLE_DN 9859All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
JAIN_NFKB_SIGNALING 7544All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_2D_UP 6946All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN 841431All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_4_UP 11264All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_6_UP 14081All SZGR genes in this pathway
FIGUEROA_AML_METHYLATION_CLUSTER_7_UP 11868All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-130/3014945011A,m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-137583589m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-1535996061A,m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-19493499m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-25/32/92/363/3676026081Ahsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-4486006061Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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