Gene Page: RALGDS

Summary ?
GeneID5900
SymbolRALGDS
SynonymsRGDS|RGF|RalGEF
Descriptionral guanine nucleotide dissociation stimulator
ReferenceMIM:601619|HGNC:HGNC:9842|Ensembl:ENSG00000160271|HPRD:03371|Vega:OTTHUMG00000020858
Gene typeprotein-coding
Map location9q34.3
Pascal p-value0.195
Fetal beta0.799
DMG3 (# studies)
eGeneCerebellar Hemisphere
Cerebellum
Myers' cis & trans
SupportCompositeSet
Darnell FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 3
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 3
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3
DNM:Guipponi_2014Whole Exome Sequencing analysis49 DNMs were identified by comparing the exome of 53 individuals with sporadic SCZ and of their non-affected parents
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
RALGDSCTNM_001042368p.T482TsynonymousNANASchizophreniaDNM:Guipponi_2014

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg145410119135989682RALGDS4.18E-4-0.3590.044DMG:Wockner_2014
cg170143789136025100RALGDS1.44E-9-0.0211.39E-6DMG:Jaffe_2016
cg180890009136039706RALGDS9.898E-45.14DMG:vanEijk_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2407038chr83588530RALGDS59000.14trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SPC250.890.51
KIF110.890.54
EXO10.890.50
MELK0.890.50
SGOL10.890.46
SGOL20.890.64
DLGAP50.880.46
KIF18A0.880.48
PBK0.880.52
NDC800.880.46
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SLC9A3R2-0.36-0.40
HLA-F-0.32-0.34
AF347015.27-0.31-0.35
PTGDS-0.31-0.38
AF347015.15-0.31-0.36
FBXW4-0.31-0.37
TINAGL1-0.31-0.38
MT-CO2-0.30-0.34
FBXO2-0.30-0.32
AF347015.33-0.30-0.36

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARRB1ARB1 | ARR1arrestin, beta 1-HPRD,BioGRID12105416 
ARRB2ARB2 | ARR2 | BARR2 | DKFZp686L0365arrestin, beta 2-HPRD,BioGRID12105416 
CNKSR1CNK | CNK1 | KSRconnector enhancer of kinase suppressor of Ras 1-HPRD,BioGRID14749388 
HRASC-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1v-Ha-ras Harvey rat sarcoma viral oncogene homologRas interacts with the carboxy terminus of RalGDS. This interaction was modeled on a demonstrated interaction between human Ras and rat RalGDS.BIND9516482 
HRASC-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1v-Ha-ras Harvey rat sarcoma viral oncogene homologReconstituted Complex
Two-hybrid		BioGRID7809086 |7972015 
|9038168 |9150145 
|10783161 |10922060 
|15031288 
HRASC-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1v-Ha-ras Harvey rat sarcoma viral oncogene homolog-HPRD7972015|9038168 
KRASC-K-RAS | K-RAS2A | K-RAS2B | K-RAS4A | K-RAS4B | KI-RAS | KRAS1 | KRAS2 | NS3 | RASK2v-Ki-ras2 Kirsten rat sarcoma viral oncogene homologReconstituted Complex
Two-hybrid		BioGRID7809086 |10783161 
LRPAP1A2MRAP | A2RAP | HBP44 | MGC138272 | MRAP | RAPlow density lipoprotein receptor-related protein associated protein 1Two-hybridBioGRID10783161 
MAPK3ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3mitogen-activated protein kinase 3ERK1 interacts with and phosphorylates RalGDS.BIND9155018 
MRASFLJ42964 | M-RAs | R-RAS3 | RRAS3muscle RAS oncogene homologReconstituted Complex
Two-hybrid		BioGRID9400994 |10498616 
MRASFLJ42964 | M-RAs | R-RAS3 | RRAS3muscle RAS oncogene homolog-HPRD9400994|10498616 
PDK1-pyruvate dehydrogenase kinase, isozyme 1Affinity Capture-WesternBioGRID11889038 
PDPK1MGC20087 | MGC35290 | PDK1 | PRO04613-phosphoinositide dependent protein kinase-1-HPRD11889038 
RAP1AKREV-1 | KREV1 | RAP1 | SMGP21RAP1A, member of RAS oncogene family-HPRD,BioGRID10085114 
RAP1AKREV-1 | KREV1 | RAP1 | SMGP21RAP1A, member of RAS oncogene familyRap1A interacts with RalGDS. This interaction was modeled on a demonstrated interaction between human Rap1A and RalGDS from an unspecified species.BIND15856025 
RAP2AK-REV | KREV | RAP2 | RbBP-30RAP2A, member of RAS oncogene family-HPRD,BioGRID10085114 
RAP2BMGC20484RAP2B, member of RAS oncogene family-HPRD,BioGRID10085114 
RAPGEF2CNrasGEF | NRAPGEP | PDZ-GEF1 | PDZGEF1 | RA-GEF | Rap-GEPRap guanine nucleotide exchange factor (GEF) 2Reconstituted Complex
Two-hybrid		BioGRID7809086 
RIN1-Ras and Rab interactor 1Two-hybridBioGRID10545207 
RIT1MGC125864 | MGC125865 | RIBB | RIT | ROC1Ras-like without CAAX 1-HPRD,BioGRID10545207 
RIT2RIBA | RIN | ROC2Ras-like without CAAX 2-HPRD10545207 
RRAS-related RAS viral (r-ras) oncogene homolog-HPRD,BioGRID7809086 
RRAS2TC21related RAS viral (r-ras) oncogene homolog 2-HPRD,BioGRID11788587 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG COLORECTAL CANCER 6247All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER 7056All SZGR 2.0 genes in this pathway
BIOCARTA RAS PATHWAY 2320All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 10578All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217167All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO RAS 2723All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137105All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO ERKS 3630All SZGR 2.0 genes in this pathway
REACTOME P38MAPK EVENTS 1312All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634384All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN 281186All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394258All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217143All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN 261155All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428306All SZGR 2.0 genes in this pathway
POMEROY MEDULLOBLASTOMA PROGNOSIS UP 4730All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION UP 8767All SZGR 2.0 genes in this pathway
SCHLINGEMANN SKIN CARCINOGENESIS TPA UP 4224All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
ZHU CMV 8 HR DN 5340All SZGR 2.0 genes in this pathway
ZHU CMV ALL DN 12893All SZGR 2.0 genes in this pathway
SARTIPY BLUNTED BY INSULIN RESISTANCE DN 1814All SZGR 2.0 genes in this pathway
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN DN 5132All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 0HR 6348All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311205All SZGR 2.0 genes in this pathway
JIANG HYPOXIA CANCER 8352All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566371All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P3 160103All SZGR 2.0 genes in this pathway
AMBROSINI FLAVOPIRIDOL TREATMENT TP53 10963All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374247All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR UP 221150All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP 293203All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS UP 10878All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237159All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway
KUMAR PATHOGEN LOAD BY MACROPHAGES 275155All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR UP 16697All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway
ZWANG EGF INTERVAL DN 214124All SZGR 2.0 genes in this pathway