Gene Page: SREBF1

Summary
GeneID  6720
Symbol  SREBF1
Synonyms  SREBP-1c|SREBP1|bHLHd1
Description  sterol regulatory element binding transcription factor 1
See related  HGNC:11289|MIM:184756|Ensembl:ENSG00000072310|HPRD:01701|
Locus tag  -
Gene type  protein-coding
Map location  17p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0033 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SP10.890.91
TCF120.880.87
ZFAND30.880.84
TOB20.880.86
PARP10.870.84
REST0.870.86
FUBP30.870.84
PHF80.860.86
CTDSP20.860.85
DHTKD10.860.83
Top 10 negatively co-expressed genes
AF347015.21-0.60-0.68
IFI27-0.57-0.61
IL32-0.54-0.63
AF347015.31-0.54-0.60
MT-CO2-0.54-0.59
C1orf54-0.53-0.59
CXCL14-0.53-0.60
MYL3-0.53-0.56
SYCP3-0.52-0.55
AC044839.2-0.51-0.60
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityIDA16407292 
GO:0003702RNA polymerase II transcription factor activityTAS8156598 
GO:0005515protein bindingIPI16799563 
GO:0032810sterol response element bindingIDA16407292 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006357regulation of transcription from RNA polymerase II promoterTAS8156598 
GO:0008202steroid metabolic processIEA-
GO:0008203cholesterol metabolic processIEA-
GO:0009267cellular response to starvationISS16407292 
GO:0006629lipid metabolic processTAS8156598 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000139Golgi membraneIEA-
GO:0005794Golgi apparatusIEA-
GO:0005789endoplasmic reticulum membraneTAS8156598 
GO:0005634nucleusTAS8156598 
GO:0005635nuclear envelopeTAS8156598 
GO:0005783endoplasmic reticulumIEA-
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0031410cytoplasmic vesicleIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CREBBPCBP | KAT3A | RSTSCREB binding proteinAffinity Capture-Western
Far Western		BioGRID8918891 
ID3HEIR-1 | bHLHb25inhibitor of DNA binding 3, dominant negative helix-loop-helix protein-HPRD10585876 
LMNACDCD1 | CDDC | CMD1A | CMT2B1 | EMD2 | FPL | FPLD | HGPS | IDC | LDP1 | LFP | LGMD1B | LMN1 | LMNC | PRO1lamin A/C-HPRD,BioGRID11929849 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1Biochemical ActivityBioGRID10627507 
MAPK3ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3mitogen-activated protein kinase 3Biochemical ActivityBioGRID10627507 
NR0B1AHC | AHCH | AHX | DAX-1 | DAX1 | DSS | GTD | HHG | NROB1nuclear receptor subfamily 0, group B, member 1Reconstituted Complex
Two-hybrid		BioGRID11713202 
SP1-Sp1 transcription factor-HPRD,BioGRID10224053 
TWIST2DERMO1 | MGC117334 | bHLHa39twist homolog 2 (Drosophila)-HPRD,BioGRID14654692 
UBE2IC358B7.1 | P18 | UBC9ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)-HPRD,BioGRID12615929 
YY1DELTA | INO80S | NF-E1 | UCRBP | YIN-YANG-1YY1 transcription factorReconstituted ComplexBioGRID10224053 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
SA_CASPASE_CASCADE 1913All SZGR genes in this pathway
PID_MTOR_4PATHWAY 6955All SZGR genes in this pathway
PID_RXR_VDR_PATHWAY 2624All SZGR genes in this pathway
PID_CASPASE_PATHWAY 5239All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 10472All SZGR genes in this pathway
REACTOME_RORA_ACTIVATES_CIRCADIAN_EXPRESSION 2417All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 168115All SZGR genes in this pathway
REACTOME_CIRCADIAN_CLOCK 5340All SZGR genes in this pathway
REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 7253All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
FARMER_BREAST_CANCER_CLUSTER_7 2011All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
PENG_RAPAMYCIN_RESPONSE_DN 245154All SZGR genes in this pathway
NADLER_OBESITY_DN 4834All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
DASU_IL6_SIGNALING_SCAR_UP 3021All SZGR genes in this pathway
BURTON_ADIPOGENESIS_4 4832All SZGR genes in this pathway
SESTO_RESPONSE_TO_UV_C5 4636All SZGR genes in this pathway
BILD_E2F3_ONCOGENIC_SIGNATURE 246153All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_UP 172109All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_ESR1_UP 16799All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_DN 668419All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S3 266180All SZGR genes in this pathway
DANG_REGULATED_BY_MYC_UP 7253All SZGR genes in this pathway
SENGUPTA_EBNA1_ANTICORRELATED 17385All SZGR genes in this pathway
DASU_IL6_SIGNALING_UP 5944All SZGR genes in this pathway
MARTENS_BOUND_BY_PML_RARA_FUSION 456287All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
ZWANG_EGF_INTERVAL_DN 214124All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-142-5p486492m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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