Gene Page: BRCA2

Summary ?
GeneID675
SymbolBRCA2
SynonymsBRCC2|BROVCA2|FACD|FAD|FAD1|FANCD|FANCD1|GLM3|PNCA2|XRCC11
Descriptionbreast cancer 2
ReferenceMIM:600185|HGNC:HGNC:1101|Ensembl:ENSG00000139618|HPRD:02554|Vega:OTTHUMG00000017411
Gene typeprotein-coding
Map location13q12.3
Pascal p-value0.808
Fetal beta2.008

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0542 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003697single-stranded DNA bindingIEA-
GO:0005515protein bindingIPI9774970 |10373512 |11597317 
|12242698 |15930293 
|15967112 |16099937 
|16275750 |17515903 
GO:0004402histone acetyltransferase activityIDA9824164 
GO:0016563transcription activator activityIDA9619837 
GO:0043015gamma-tubulin bindingIPI17286961 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentIEABrain (GO term level: 7)-
GO:0001556oocyte maturationIEA-
GO:0000724double-strand break repair via homologous recombinationIEA-
GO:0001833inner cell mass cell proliferationIEA-
GO:0006355regulation of transcription, DNA-dependentIC9619837 
GO:0007141male meiosis IIEA-
GO:0006310DNA recombinationIEA-
GO:0008585female gonad developmentIEA-
GO:0006289nucleotide-excision repairIMP16845393 
GO:0007283spermatogenesisIEA-
GO:0007090regulation of S phase of mitotic cell cycleNAS9774970 
GO:0010225response to UV-CIEA-
GO:0010165response to X-rayIEA-
GO:0010332response to gamma radiationIEA-
GO:0048478replication fork protectionIEA-
GO:0007569cell agingIEA-
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorIEA-
GO:0033595response to genisteinIDA16434996 
GO:0033600negative regulation of mammary gland epithelial cell proliferationIDA15930293 
GO:0033205cytokinesis during cell cycleIDA17286961 
GO:0042771DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosisIEA-
GO:0043009chordate embryonic developmentIEA-
GO:0051298centrosome duplicationIDA17286961 
GO:0051276chromosome organizationIEA-
GO:0045931positive regulation of mitotic cell cycleIEA-
GO:0043627response to estrogen stimulusIDA8895509 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005813centrosomeIDA17286961 
GO:0005634nucleusIDA9560268 |9774970 |17286961 
GO:0005654nucleoplasmEXP12606939 
GO:0005737cytoplasmIEA-
GO:0033593BRCA2-MAGE-D1 complexIDA15930293 
GO:0030141secretory granuleIDA8589722 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATMAT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1ataxia telangiectasia mutatedReconstituted ComplexBioGRID15199141 
ATRFRP1 | MEC1 | SCKL | SCKL1ataxia telangiectasia and Rad3 relatedProtein-peptideBioGRID10608806 
BARD1-BRCA1 associated RING domain 1Co-purification
Reconstituted Complex		BioGRID14636569 
BCCIPTOK-1 | TOK1BRCA2 and CDKN1A interacting protein-HPRD,BioGRID11313963 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD,BioGRID9774970 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetBRCA1 interacts with BRCA2.BIND9774970 
BRCC3BRCC36 | C6.1A | CXorf53BRCA1/BRCA2-containing complex, subunit 3Affinity Capture-MS
Affinity Capture-Western
Co-purification		BioGRID14636569 
BREBRCC4 | BRCC45brain and reproductive organ-expressed (TNFRSF1A modulator)Affinity Capture-MS
Affinity Capture-Western
Co-purification		BioGRID14636569 
BUB1BBUB1beta | BUBR1 | Bub1A | MAD3L | SSK1 | hBUBR1budding uninhibited by benzimidazoles 1 homolog beta (yeast)-HPRD,BioGRID10749118 
C11orf30EMSY | FLJ90741 | GL002chromosome 11 open reading frame 30-HPRD,BioGRID14651845 
CHEK2CDS1 | CHK2 | HuCds1 | LFS2 | PP1425 | RAD53CHK2 checkpoint homolog (S. pombe)Affinity Capture-WesternBioGRID17525332 
FANCD2DKFZp762A223 | FA-D2 | FA4 | FACD | FAD | FAD2 | FANCD | FLJ23826Fanconi anemia, complementation group D2Affinity Capture-Western
Co-localization
Two-hybrid		BioGRID15115758 |15199141 
FANCD2DKFZp762A223 | FA-D2 | FA4 | FACD | FAD | FAD2 | FANCD | FLJ23826Fanconi anemia, complementation group D2FANCD2 interacts with BRCA2.BIND15115758 
FANCEFACE | FAEFanconi anemia, complementation group EAffinity Capture-WesternBioGRID15199141 
FANCGFAG | XRCC9Fanconi anemia, complementation group GAffinity Capture-Western
Two-hybrid		BioGRID12915460 
FANCGFAG | XRCC9Fanconi anemia, complementation group GFANCG interacts with BRCA2.BIND12915460 
FLNAABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2filamin A, alpha (actin binding protein 280)-HPRD,BioGRID11602572 
FLNAABP-280 | ABPX | DKFZp434P031 | FLN | FLN1 | FMD | MNS | NHBP | OPD | OPD1 | OPD2filamin A, alpha (actin binding protein 280)BRCA2 interacts with hsFLNa.BIND11602572 
HMG20BBRAF25 | BRAF35 | FLJ26127 | HMGX2 | PP7706 | SMARCE1r | SOXL | pp8857high-mobility group 20B-HPRD,BioGRID11207365 
KAT2BCAF | P | P/CAF | PCAFK(lysine) acetyltransferase 2B-HPRD,BioGRID9824164 
PLK1PLK | STPK13polo-like kinase 1 (Drosophila)Affinity Capture-Western
Reconstituted Complex		BioGRID12815053 |14647413 
RAD51BRCC5 | HRAD51 | HsRad51 | HsT16930 | RAD51A | RECARAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)Affinity Capture-MS
Affinity Capture-Western
Co-localization
Co-purification
Reconstituted Complex
Two-hybrid		BioGRID9126738 |9405383 
|9523196 |9560268 
|9774970 |9811893 
|11313963 |11477095 
|12408834 |12442171 
|12815053 |14580352 
|14636569 |15065660 
RAD51BRCC5 | HRAD51 | HsRad51 | HsT16930 | RAD51A | RECARAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)-HPRD9126738 |12619154 
RAD51BRCC5 | HRAD51 | HsRad51 | HsT16930 | RAD51A | RECARAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)BRCA2 interacts with RAD51.BIND9774970 
RAD51BRCC5 | HRAD51 | HsRad51 | HsT16930 | RAD51A | RECARAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)BRCA2 interacts with Rad51.BIND9774970 
RAD51BRCC5 | HRAD51 | HsRad51 | HsT16930 | RAD51A | RECARAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)BRCA2 interacts with an unspecified isoform of RAD51.BIND15800615 
RPA1HSSB | REPA1 | RF-A | RP-A | RPA70replication protein A1, 70kDaAffinity Capture-Western
Reconstituted Complex		BioGRID12527904 
SHFM1DSS1 | ECD | SEM1 | SHFD1 | SHSF1 | Shfdg1split hand/foot malformation (ectrodactyly) type 1-HPRD,BioGRID10373512 |12228710 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2Affinity Capture-WesternBioGRID12165866 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3SMAD3 interacts with BRCA2.BIND12165866 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3-HPRD,BioGRID12165866 
STAT5AMGF | STAT5signal transducer and activator of transcription 5A-HPRD,BioGRID12459499 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID9811893 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG HOMOLOGOUS RECOMBINATION 2817All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER 7056All SZGR 2.0 genes in this pathway
BIOCARTA ATRBRCA PATHWAY 2112All SZGR 2.0 genes in this pathway
PID FANCONI PATHWAY 4728All SZGR 2.0 genes in this pathway
PID P73PATHWAY 7959All SZGR 2.0 genes in this pathway
PID ATR PATHWAY 3925All SZGR 2.0 genes in this pathway
PID FOXM1 PATHWAY 4030All SZGR 2.0 genes in this pathway
PID DELTA NP63 PATHWAY 4734All SZGR 2.0 genes in this pathway
REACTOME MEIOSIS 11681All SZGR 2.0 genes in this pathway
REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS 1711All SZGR 2.0 genes in this pathway
REACTOME FANCONI ANEMIA PATHWAY 2511All SZGR 2.0 genes in this pathway
REACTOME DOUBLE STRAND BREAK REPAIR 2414All SZGR 2.0 genes in this pathway
REACTOME DNA REPAIR 11259All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC RECOMBINATION 8662All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493298All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA PROGENITOR DN 6642All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS DN 13976All SZGR 2.0 genes in this pathway
ODONNELL TARGETS OF MYC AND TFRC DN 4525All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431237All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722443All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF UP 11578All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228137All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
MATHEW FANCONI ANEMIA GENES 117All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE UP 13493All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855609All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 10173All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT NETWORK 168103All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
PUJANA BRCA CENTERED NETWORK 11772All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230156All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893528All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES 230137All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 DN 169102All SZGR 2.0 genes in this pathway
KUROKAWA LIVER CANCER CHEMOTHERAPY DN 4128All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC 182116All SZGR 2.0 genes in this pathway
YU MYC TARGETS UP 4226All SZGR 2.0 genes in this pathway
PARK HSC AND MULTIPOTENT PROGENITORS 5033All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP 12089All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA DN 2314All SZGR 2.0 genes in this pathway
ZHU CMV 8 HR UP 4739All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461298All SZGR 2.0 genes in this pathway
MATZUK SPERMATOCYTE 7255All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE UP 212128All SZGR 2.0 genes in this pathway
HOFFMANN LARGE TO SMALL PRE BII LYMPHOCYTE UP 163102All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456285All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605377All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE LITERATURE 4425All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN DN 15099All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324193All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553343All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN 321200All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570339All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 403240All SZGR 2.0 genes in this pathway