Gene Page: TAF11

Summary ?
GeneID6882
SymbolTAF11
SynonymsMGC:15243|PRO2134|TAF2I|TAFII28
DescriptionTATA-box binding protein associated factor 11
ReferenceMIM:600772|HGNC:HGNC:11544|Ensembl:ENSG00000064995|HPRD:15980|Vega:OTTHUMG00000014556
Gene typeprotein-coding
Map location6p21.31
Pascal p-value0.201
Sherlock p-value0.562
Fetal beta0.531
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 3
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3
GSMA_IGenome scan meta-analysisPsr: 0.033 
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.04433 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg13028789634856920ANKS1A;TAF115.64E-5-0.3720.022DMG:Wockner_2014
cg00215801634855797TAF11;ANKS1A6.94E-5-0.3320.024DMG:Wockner_2014
cg02691355634855834TAF119.21E-10-0.0131.11E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs802402chr790615513TAF1168820.05trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIEA-
GO:0005515protein bindingIPI9045704 
GO:0016251general RNA polymerase II transcription factor activityTAS9695952 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006367transcription initiation from RNA polymerase II promoterEXP8946909 
GO:0006368RNA elongation from RNA polymerase II promoterEXP9405375 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005654nucleoplasmEXP1939271 |2449431 |8946909 
GO:0005669transcription factor TFIID complexIDA14580349 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CPSF1CPSF160 | HSU37012 | P/cl.18cleavage and polyadenylation specific factor 1, 160kDain vitroBioGRID9311784 
GTF2BTF2B | TFIIBgeneral transcription factor IIBCo-purification
Reconstituted Complex		BioGRID9159119 
GTF2E1FE | TF2E1 | TFIIE-Ageneral transcription factor IIE, polypeptide 1, alpha 56kDaCo-purification
Reconstituted Complex		BioGRID9159119 
GTF2F1BTF4 | RAP74 | TF2F1 | TFIIFgeneral transcription factor IIF, polypeptide 1, 74kDaCo-purification
Reconstituted Complex		BioGRID9159119 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDaCo-purification
Reconstituted Complex		BioGRID9159119 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)-HPRD,BioGRID9584164 
TAF12TAF2J | TAFII20TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa-HPRD7729427 
TAF13MGC22425 | TAF2K | TAFII18TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa-HPRD,BioGRID7729427 |9695952 
TAF15Npl3 | RBP56 | TAF2N | TAFII68 | hTAFII68TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDaAffinity Capture-Western
Reconstituted Complex		BioGRID9488465 
TAF5TAF2D | TAFII100TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa-HPRD,BioGRID9045704 
TBPGTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIIDTATA box binding protein-HPRD,BioGRID7729427 
TRIM24PTC6 | RNF82 | TF1A | TIF1 | TIF1A | TIF1ALPHA | hTIF1tripartite motif-containing 24-HPRD,BioGRID9632676 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG BASAL TRANSCRIPTION FACTORS 3624All SZGR 2.0 genes in this pathway
REACTOME RNA POL II TRANSCRIPTION 10554All SZGR 2.0 genes in this pathway
REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING 4121All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTION 210127All SZGR 2.0 genes in this pathway
REACTOME RNA POL II PRE TRANSCRIPTION EVENTS 6132All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION 207122All SZGR 2.0 genes in this pathway
REACTOME HIV LIFE CYCLE 12569All SZGR 2.0 genes in this pathway
REACTOME LATE PHASE OF HIV LIFE CYCLE 10461All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305185All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557331All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329196All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT NETWORK 168103All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
PUJANA BRCA CENTERED NETWORK 11772All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160110All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC DN 228146All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN 312203All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198132All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318220All SZGR 2.0 genes in this pathway
GENTILE RESPONSE CLUSTER D3 6139All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN 336211All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080713All SZGR 2.0 genes in this pathway