Gene Page: TNF

Summary
GeneID  7124
Symbol  TNF
Synonyms  DIF|TNF-alpha|TNFA|TNFSF2
Description  tumor necrosis factor (TNF superfamily, member 2)
See related  HGNC:11892|MIM:191160|Ensembl:ENSG00000204490|HPRD:01855|
Locus tag  DADB-70P7.1
Gene type  protein-coding
Map location  6p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
GSMA_Igenome scan meta-analysisPsr: 0.033 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenia, schizophrenias]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NUDT180.900.85
ACOT80.890.92
MECR0.890.91
PGP0.890.90
ALKBH60.890.88
TMEM1110.880.91
DHRS7B0.880.90
KLHDC30.870.88
SH3GLB20.870.87
FDX1L0.870.88
Top 10 negatively co-expressed genes
THOC2-0.53-0.51
EIF5B-0.52-0.62
UPF3A-0.51-0.55
MAP4K4-0.51-0.47
UPF3B-0.50-0.52
AC005035.1-0.50-0.47
AC005921.3-0.49-0.72
ZNF326-0.49-0.47
RBMX2-0.49-0.55
KIAA1949-0.48-0.37
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005125cytokine activityIEA-
GO:0005164tumor necrosis factor receptor bindingIEA-
GO:0042802identical protein bindingIDA14512626 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0032800receptor biosynthetic processIDANeurotransmitter (GO term level: 5)10443688 
GO:0000060protein import into nucleus, translocationIDA16280327 
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA-
GO:0000187activation of MAPK activityIDA10748004 
GO:0002740negative regulation of cytokine secretion during immune responseIDA10443688 
GO:0002439chronic inflammatory response to antigenic stimulusIMP14512626 
GO:0001934positive regulation of protein amino acid phosphorylationIDA10748004 
GO:0008625induction of apoptosis via death domain receptorsIEA-
GO:0006006glucose metabolic processIEA-
GO:0009887organ morphogenesisIEA-
GO:0006927transformed cell apoptosisIDA3883195 
GO:0009615response to virusIDA10490959 
GO:0006959humoral immune responseIEA-
GO:0006954inflammatory responseIDA10748004 
GO:0006919caspase activationIDA14512626 
GO:0006916anti-apoptosisIDA10748004 
GO:0007275multicellular organismal developmentIEA-
GO:0042346positive regulation of NF-kappaB import into nucleusIDA17922812 
GO:0016481negative regulation of transcriptionIDA16895791 
GO:0033209tumor necrosis factor-mediated signaling pathwayIMP10748004 
GO:0051092positive regulation of NF-kappaB transcription factor activityIDA16280327 
GO:0051023regulation of immunoglobulin secretionIEA-
GO:0042127regulation of cell proliferationIEA-
GO:0050901leukocyte tethering or rollingIDA10820279 
GO:0043193positive regulation of gene-specific transcriptionIDA14512626 
GO:0042742defense response to bacteriumIEA-
GO:0032722positive regulation of chemokine productionIDA10490959 
GO:0032715negative regulation of interleukin-6 productionIDA10443688 
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cascadeIEA-
GO:0045941positive regulation of transcriptionIEA-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
GO:0050715positive regulation of cytokine secretionIDA10443688 
GO:0045080positive regulation of chemokine biosynthetic processIDA10490959 
GO:0045071negative regulation of viral genome replicationIDA10490959 
GO:0045670regulation of osteoclast differentiationIEA-
GO:0045994positive regulation of translational initiation by ironIEA-
GO:0046325negative regulation of glucose importIEA-
GO:0046330positive regulation of JNK cascadeIEA-
GO:0048661positive regulation of smooth muscle cell proliferationIDA16518841 
GO:0045429positive regulation of nitric oxide biosynthetic processIDA8383325 
GO:0050796regulation of insulin secretionIDA8383325 
GO:0051384response to glucocorticoid stimulusIDA10443688 
GO:0051798positive regulation of hair follicle developmentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0055037recycling endosomeISS-
GO:0001891phagocytic cupISS-
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIEA-
GO:0016021integral to membraneIEA-
GO:0009897external side of plasma membraneISS-
GO:0005886plasma membraneEXP2848815 |7758105 |12887920 
GO:0005886plasma membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BGNDSPG1 | PG-S1 | PGI | SLRR1Abiglycan-HPRD,BioGRID12387878 
CSF1MCSF | MGC31930colony stimulating factor 1 (macrophage)-HPRD,BioGRID8336080 
DCNCSCD | DSPG2 | PG40 | PGII | PGS2 | SLRR1Bdecorin-HPRD,BioGRID12387878 
KHSRPFBP2 | FUBP2 | KSRP | MGC99676KH-type splicing regulatory proteinKSRP interacts with AREtnf. This interaction was modeled on a demonstrated interaction between KSRP from human and AREtnf from an unspecified species.BIND15175153 
POU2F1OCT1 | OTF1POU class 2 homeobox 1Reconstituted ComplexBioGRID12019209 
PRTN3ACPA | AGP7 | C-ANCA | MBT | P29 | PR-3proteinase 3-HPRD,BioGRID10339575 
RALBP1RIP1 | RLIP1 | RLIP76ralA binding protein 1Affinity Capture-WesternBioGRID12887920 
TNFDIF | TNF-alpha | TNFA | TNFSF2tumor necrosis factor (TNF superfamily, member 2)Interaction between TNF (PDB ID: 1A8M_C) and TNF (PDB ID: 1A8M_B).BIND8869635 |9488135 
Interaction between TNF (PDB ID: 1A8M_C) and TNF (PDB ID: 1A8M_A).BIND8869635 |9488135 
Interaction between TNF (PDB ID: 1A8M_B) and TNF (PDB ID: 1A8M_A).BIND8869635 |9488135 
-HPRD,BioGRID1331108 
TNFRSF1ACD120a | FPF | MGC19588 | TBP1 | TNF-R | TNF-R-I | TNF-R55 | TNFAR | TNFR1 | TNFR55 | TNFR60 | p55 | p55-R | p60tumor necrosis factor receptor superfamily, member 1A-HPRD1331108 |2158863 
Affinity Capture-MS
Affinity Capture-Western		BioGRID12887920 |14743216 
TNF-alpha interacts with TNFR1.BIND7852363 
TNFRSF1BCD120b | TBPII | TNF-R-II | TNF-R75 | TNFBR | TNFR1B | TNFR2 | TNFR80 | p75 | p75TNFRtumor necrosis factor receptor superfamily, member 1BAffinity Capture-MSBioGRID14743216 
-HPRD8590321 |9552007 
TNF-alpha interacts with TNFR-2.BIND7852363 
TRADDHs.89862 | MGC11078TNFRSF1A-associated via death domainAffinity Capture-WesternBioGRID12887920 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2Affinity Capture-WesternBioGRID12887920 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_APOPTOSIS 8862All SZGR genes in this pathway
KEGG_TGF_BETA_SIGNALING_PATHWAY 8664All SZGR genes in this pathway
KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY 10288All SZGR genes in this pathway
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 6247All SZGR genes in this pathway
KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 7151All SZGR genes in this pathway
KEGG_HEMATOPOIETIC_CELL_LINEAGE 8860All SZGR genes in this pathway
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 13792All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 7958All SZGR genes in this pathway
KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 6757All SZGR genes in this pathway
KEGG_TYPE_II_DIABETES_MELLITUS 4741All SZGR genes in this pathway
KEGG_TYPE_I_DIABETES_MELLITUS 4438All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS 5343All SZGR genes in this pathway
KEGG_LEISHMANIA_INFECTION 7256All SZGR genes in this pathway
KEGG_ASTHMA 3025All SZGR genes in this pathway
KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 140100All SZGR genes in this pathway
KEGG_ALLOGRAFT_REJECTION 3834All SZGR genes in this pathway
KEGG_GRAFT_VERSUS_HOST_DISEASE 4231All SZGR genes in this pathway
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 8565All SZGR genes in this pathway
KEGG_DILATED_CARDIOMYOPATHY 9268All SZGR genes in this pathway
BIOCARTA_RELA_PATHWAY 1612All SZGR genes in this pathway
BIOCARTA_GRANULOCYTES_PATHWAY 149All SZGR genes in this pathway
BIOCARTA_CDMAC_PATHWAY 1615All SZGR genes in this pathway
BIOCARTA_LAIR_PATHWAY 1712All SZGR genes in this pathway
BIOCARTA_TID_PATHWAY 1915All SZGR genes in this pathway
BIOCARTA_CYTOKINE_PATHWAY 2216All SZGR genes in this pathway
BIOCARTA_INFLAM_PATHWAY 2924All SZGR genes in this pathway
BIOCARTA_FREE_PATHWAY 107All SZGR genes in this pathway
BIOCARTA_HIVNEF_PATHWAY 5843All SZGR genes in this pathway
BIOCARTA_IL10_PATHWAY 1714All SZGR genes in this pathway
BIOCARTA_KERATINOCYTE_PATHWAY 4638All SZGR genes in this pathway
BIOCARTA_PPARA_PATHWAY 5843All SZGR genes in this pathway
BIOCARTA_NTHI_PATHWAY 2420All SZGR genes in this pathway
BIOCARTA_NFKB_PATHWAY 2319All SZGR genes in this pathway
BIOCARTA_PML_PATHWAY 1712All SZGR genes in this pathway
BIOCARTA_IL1R_PATHWAY 3329All SZGR genes in this pathway
BIOCARTA_SODD_PATHWAY 107All SZGR genes in this pathway
BIOCARTA_HSP27_PATHWAY 1511All SZGR genes in this pathway
BIOCARTA_STRESS_PATHWAY 2518All SZGR genes in this pathway
BIOCARTA_TNFR1_PATHWAY 2921All SZGR genes in this pathway
ST_TUMOR_NECROSIS_FACTOR_PATHWAY 2920All SZGR genes in this pathway
SA_MMP_CYTOKINE_CONNECTION 159All SZGR genes in this pathway
PID_IL27_PATHWAY 2620All SZGR genes in this pathway
PID_NFKAPPAB_CANONICAL_PATHWAY 2320All SZGR genes in this pathway
PID_NFAT_TFPATHWAY 4739All SZGR genes in this pathway
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 5041All SZGR genes in this pathway
PID_HDAC_CLASSI_PATHWAY 6650All SZGR genes in this pathway
PID_TNF_PATHWAY 4633All SZGR genes in this pathway
PID_CERAMIDE_PATHWAY 4837All SZGR genes in this pathway
PID_AMB2_NEUTROPHILS_PATHWAY 4132All SZGR genes in this pathway
PID_RXR_VDR_PATHWAY 2624All SZGR genes in this pathway
PID_IL23_PATHWAY 3730All SZGR genes in this pathway
PID_HIV_NEF_PATHWAY 3526All SZGR genes in this pathway
PID_CASPASE_PATHWAY 5239All SZGR genes in this pathway
PID_ANTHRAX_PATHWAY 1715All SZGR genes in this pathway
PID_CD8_TCR_DOWNSTREAM_PATHWAY 6556All SZGR genes in this pathway
REACTOME_EXTRINSIC_PATHWAY_FOR_APOPTOSIS 138All SZGR genes in this pathway
REACTOME_DEVELOPMENTAL_BIOLOGY 396292All SZGR genes in this pathway
REACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION 7253All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LIVE_UP 485293All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_LPS_UP 431237All SZGR genes in this pathway
NUNODA_RESPONSE_TO_DASATINIB_IMATINIB_DN 1310All SZGR genes in this pathway
MARKS_HDAC_TARGETS_DN 1511All SZGR genes in this pathway
DUTTA_APOPTOSIS_VIA_NFKB 3325All SZGR genes in this pathway
DEBOSSCHER_NFKB_TARGETS_REPRESSED_BY_GLUCOCORTICOIDS 2418All SZGR genes in this pathway
DIRMEIER_LMP1_RESPONSE_EARLY 6648All SZGR genes in this pathway
AMUNDSON_GENOTOXIC_SIGNATURE 10568All SZGR genes in this pathway
HOWLIN_PUBERTAL_MAMMARY_GLAND 6940All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
GOUYER_TATI_TARGETS_UP 107All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
SHIN_B_CELL_LYMPHOMA_CLUSTER_5 1811All SZGR genes in this pathway
BROWN_MYELOID_CELL_DEVELOPMENT_UP 165100All SZGR genes in this pathway
GALINDO_IMMUNE_RESPONSE_TO_ENTEROTOXIN 8567All SZGR genes in this pathway
NEMETH_INFLAMMATORY_RESPONSE_LPS_UP 8864All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_DN 12890All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP 7752All SZGR genes in this pathway
VERHAAK_AML_WITH_NPM1_MUTATED_UP 183111All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_DN 6341All SZGR genes in this pathway
BASSO_CD40_SIGNALING_UP 10176All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_2 5034All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_UP 12375All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
GAURNIER_PSMD4_TARGETS 7355All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
RAY_ALZHEIMERS_DISEASE 137All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_A 6752All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
VANTVEER_BREAST_CANCER_ESR1_DN 240153All SZGR genes in this pathway
HINATA_NFKB_TARGETS_KERATINOCYTE_UP 9163All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
ZHAN_EARLY_DIFFERENTIATION_GENES_DN 4229All SZGR genes in this pathway
BUDHU_LIVER_CANCER_METASTASIS_DN 77All SZGR genes in this pathway
MIKKELSEN_MCV6_ICP_WITH_H3K27ME3 7446All SZGR genes in this pathway
MIKKELSEN_MEF_ICP_WITH_H3K27ME3 206108All SZGR genes in this pathway
MIKKELSEN_IPS_ICP_WITH_H3K27ME3 5432All SZGR genes in this pathway
SEIKE_LUNG_CANCER_POOR_SURVIVAL 118All SZGR genes in this pathway
KUROZUMI_RESPONSE_TO_ONCOCYTIC_VIRUS 4430All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K27ME3 4227All SZGR genes in this pathway
LI_INDUCED_T_TO_NATURAL_KILLER_UP 307182All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_DN 8859All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN 374217All SZGR genes in this pathway
WINZEN_DEGRADED_VIA_KHSRP 10070All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP 364236All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_DN 428246All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_6HR_DN 11469All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway


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