SZGR2

Summary ?

GeneID	7531
Symbol	YWHAE
Synonyms	14-3-3E\|HEL2\|KCIP-1\|MDCR\|MDS
Description	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
Reference	MIM:605066\|HGNC:HGNC:12851\|Ensembl:ENSG00000108953\|HPRD:05457\|Vega:OTTHUMG00000134316
Gene type	protein-coding
Map location	17p13.3
Pascal p-value	1.016E-4
Sherlock p-value	0.241
Fetal beta	0.345
Support	INTRACELLULAR SIGNAL TRANSDUCTION G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.human_TAP-PSD-95-CORE G2Cdb.humanNRC G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association	A combined odds ratio method (Sun et al. 2008), association studies	2	Link to SZGene
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.539

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ZNF131	0.94	0.95
DDX20	0.92	0.93
ZNF615	0.92	0.93
ZNF280D	0.92	0.93
ZNF567	0.91	0.92
TOPORS	0.91	0.92
WDR43	0.91	0.92
PHF20L1	0.91	0.92
ZNF175	0.91	0.91
C10orf137	0.91	0.93

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MT-CO2	-0.77	-0.86
AF347015.31	-0.77	-0.85
FXYD1	-0.76	-0.86
AF347015.33	-0.75	-0.83
AF347015.27	-0.75	-0.84
IFI27	-0.75	-0.85
MT-CYB	-0.74	-0.83
AF347015.8	-0.74	-0.85
HIGD1B	-0.74	-0.86
AIFM3	-0.73	-0.79

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0019904	protein domain specific binding	IEA		-
GO:0019899	enzyme binding	IPI		10788521
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007242	intracellular signaling cascade	TAS		7644510
GO:0006605	protein targeting	IEA		-
GO:0044419	interspecies interaction between organisms	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005737	cytoplasm	IEA		-
GO:0005739	mitochondrion	IEA		-
GO:0042470	melanosome	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ARHGEF2	DKFZp547L106 \| DKFZp547P1516 \| GEF \| GEF-H1 \| GEFH1 \| KIAA0651 \| LFP40 \| P40	rho/rac guanine nucleotide exchange factor (GEF) 2	-	HPRD	14970201
BAD	BBC2 \| BCL2L8	BCL2-associated agonist of cell death	-	HPRD,BioGRID	9369453
BIRC3	AIP1 \| API2 \| CIAP2 \| HAIP1 \| HIAP1 \| MALT2 \| MIHC \| RNF49	baculoviral IAP repeat-containing 3	The cIAP-2 promoter interacts with 14-3-3-epsilon.	BIND	15494311
CALM1	CALML2 \| CAMI \| DD132 \| PHKD	calmodulin 1 (phosphorylase kinase, delta)	-	HPRD	10088721
CDC25A	CDC25A2	cell division cycle 25 homolog A (S. pombe)	-	HPRD,BioGRID	7644510
CDC25A	CDC25A2	cell division cycle 25 homolog A (S. pombe)	-	HPRD	7644510 \|14559997
CDC25A	CDC25A2	cell division cycle 25 homolog A (S. pombe)	14-3-3-epsilon interacts with cdc25A.	BIND	7644510
CDC25B	-	cell division cycle 25 homolog B (S. pombe)	-	HPRD,BioGRID	7644510 \|10713667
CDC25B	-	cell division cycle 25 homolog B (S. pombe)	14-3-3-epsilon interacts with cdc25B.	BIND	7644510
CDC25C	CDC25	cell division cycle 25 homolog C (S. pombe)	Affinity Capture-Western	BioGRID	10330186
CDC2L1	CDC2L2 \| CDK11 \| CDK11-p110 \| CDK11-p46 \| CDK11-p58 \| CLK-1 \| FLJ59152 \| PK58 \| p58 \| p58CDC2L1 \| p58CLK-1	cell division cycle 2-like 1 (PITSLRE proteins)	CDK11-p110 interacts with 14-3-3-epsilon.	BIND	15883043
CDKN1B	CDKN4 \| KIP1 \| MEN1B \| MEN4 \| P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	-	HPRD	12042314
GPRIN2	GRIN2 \| KIAA0514 \| MGC15171	G protein regulated inducer of neurite outgrowth 2	Two-hybrid	BioGRID	16189514
GRAP2	GADS \| GRAP-2 \| GRB2L \| GRBLG \| GRID \| GRPL \| GrbX \| Grf40 \| Mona \| P38	GRB2-related adaptor protein 2	Two-hybrid	BioGRID	16189514
HDAC4	HA6116 \| HD4 \| HDAC-A \| HDACA \| KIAA0288	histone deacetylase 4	Affinity Capture-Western Reconstituted Complex	BioGRID	10869435 \|11504882
HDAC4	HA6116 \| HD4 \| HDAC-A \| HDACA \| KIAA0288	histone deacetylase 4	-	HPRD	11486037
HDAC5	FLJ90614 \| HD5 \| NY-CO-9	histone deacetylase 5	-	HPRD,BioGRID	10869435
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	-	HPRD,BioGRID	9111084
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	IGFIR interacts with 14-3-3-epsilon isoform. This interaction is modeled on a demonstrated interaction between human IGFIR and mouse 14-3-3-epsilon isoform	BIND	9111084
IRS1	HIRS-1	insulin receptor substrate 1	IRS-1 interacts with 14-3-3-epsilon isoform. This interaction was modeled on a demonstrated interaction between human IRS-1 and mouse 14-3-3-epsilon isoform.	BIND	9111084
IRS1	HIRS-1	insulin receptor substrate 1	-	HPRD,BioGRID	9111084 \|9312143
IRS2	-	insulin receptor substrate 2	-	HPRD,BioGRID	9312143
KCNH2	ERG1 \| HERG \| HERG1 \| Kv11.1 \| LQT2 \| SQT1	potassium voltage-gated channel, subfamily H (eag-related), member 2	-	HPRD,BioGRID	11953308
KIF1C	KIAA0706 \| LTXS1	kinesin family member 1C	-	HPRD	10559254
KRT18	CYK18 \| K18	keratin 18	-	HPRD	9524113
MAP3K1	MAPKKK1 \| MEKK \| MEKK1	mitogen-activated protein kinase kinase kinase 1	Reconstituted Complex	BioGRID	9452471
MAP3K10	MLK2 \| MST	mitogen-activated protein kinase kinase kinase 10	-	HPRD,BioGRID	9427749
MAP3K2	MEKK2 \| MEKK2B	mitogen-activated protein kinase kinase kinase 2	-	HPRD,BioGRID	9452471
MAP3K3	MAPKKK3 \| MEKK3	mitogen-activated protein kinase kinase kinase 3	-	HPRD,BioGRID	9452471
MAP3K7IP2	FLJ21885 \| KIAA0733 \| TAB2	mitogen-activated protein kinase kinase kinase 7 interacting protein 2	-	HPRD	14743216
MAPK7	BMK1 \| ERK4 \| ERK5 \| PRKM7	mitogen-activated protein kinase 7	Two-hybrid	BioGRID	14679215
NCOR2	CTG26 \| SMRT \| SMRTE \| SMRTE-tau \| TNRC14 \| TRAC-1 \| TRAC1	nuclear receptor co-repressor 2	14-3-3-epsilon interacts with SMRT.	BIND	15494311
NDEL1	DKFZp451M0318 \| EOPA \| MITAP1 \| NUDEL	nudE nuclear distribution gene E homolog (A. nidulans)-like 1	-	HPRD,BioGRID	12796778
NGFRAP1	BEX3 \| Bex \| DXS6984E \| HGR74 \| NADE	nerve growth factor receptor (TNFRSF16) associated protein 1	-	HPRD,BioGRID	11278287
PAPOLA	MGC5378 \| PAP	poly(A) polymerase alpha	-	HPRD	14517258
PCTK1	FLJ16665 \| PCTAIRE \| PCTAIRE1 \| PCTGAIRE	PCTAIRE protein kinase 1	-	HPRD	12154078
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	-	HPRD,BioGRID	7644510
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	14-3-3-epsilon interacts with Raf-1.	BIND	7644510
RASGRF1	CDC25 \| CDC25L \| GNRP \| GRF1 \| GRF55 \| H-GRF55 \| PP13187	Ras protein-specific guanine nucleotide-releasing factor 1	-	HPRD	11533041
REM1	GD:REM \| GES \| MGC48669 \| REM	RAS (RAD and GEM)-like GTP-binding 1	-	HPRD,BioGRID	10441394
RGNEF	DKFZp686P12164 \| FLJ21817 \| KIAA1998	Rho-guanine nucleotide exchange factor	-	HPRD	11533041
RGS3	C2PA \| FLJ20370 \| FLJ31516 \| FLJ90496 \| PDZ-RGS3 \| RGP3	regulator of G-protein signaling 3	-	HPRD	11985497
RIN1	-	Ras and Rab interactor 1	-	HPRD	9144171 \|11784866
SNCA	MGC110988 \| NACP \| PARK1 \| PARK4 \| PD1	synuclein, alpha (non A4 component of amyloid precursor)	-	HPRD	10407019
SORBS2	ARGBP2 \| FLJ93447 \| KIAA0777 \| PRO0618	sorbin and SH3 domain containing 2	Two-hybrid	BioGRID	16189514
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD	8702721
SYN2	SYNII \| SYNIIa \| SYNIIb	synapsin II	Two-hybrid	BioGRID	10358015
TGFB1	CED \| DPD1 \| TGFB \| TGFbeta	transforming growth factor, beta 1	-	HPRD,BioGRID	11172812
TNFAIP3	A20 \| MGC104522 \| MGC138687 \| MGC138688 \| OTUD7C \| TNFA1P2	tumor necrosis factor, alpha-induced protein 3	-	HPRD,BioGRID	8702721
TOP2A	TOP2 \| TP2A	topoisomerase (DNA) II alpha 170kDa	-	HPRD,BioGRID	10788521
TSC1	KIAA0243 \| LAM \| MGC86987 \| TSC	tuberous sclerosis 1	Hamartin interacts with 14-3-3-epsilon.	BIND	12176984
TSC2	FLJ43106 \| LAM \| TSC4	tuberous sclerosis 2	-	HPRD	12438239
TSC2	FLJ43106 \| LAM \| TSC4	tuberous sclerosis 2	Tumor suppressor protein tuberin interacts with 14-3-3-epsilon isoform. This interaction is modeled on demonstrated interaction between human tuberin and mouse 14-3-3-epsilon isoform.	BIND	12176984
WWTR1	DKFZp586I1419 \| TAZ	WW domain containing transcription regulator 1	-	HPRD	11118213

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS	114	79	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
BIOCARTA CHREBP2 PATHWAY	42	35	All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN CARDIAC MYOCTES	67	54	All SZGR 2.0 genes in this pathway
SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	51	41	All SZGR 2.0 genes in this pathway
ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	37	29	All SZGR 2.0 genes in this pathway
PID HDAC CLASSII PATHWAY	34	27	All SZGR 2.0 genes in this pathway
PID LKB1 PATHWAY	47	37	All SZGR 2.0 genes in this pathway
PID TELOMERASE PATHWAY	68	48	All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY	54	47	All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY	69	55	All SZGR 2.0 genes in this pathway
PID IGF1 PATHWAY	30	23	All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY	49	43	All SZGR 2.0 genes in this pathway
PID P75 NTR PATHWAY	69	51	All SZGR 2.0 genes in this pathway
PID LIS1 PATHWAY	28	22	All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY	105	78	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID P38 MK2 PATHWAY	21	19	All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID A6B1 A6B4 INTEGRIN PATHWAY	46	35	All SZGR 2.0 genes in this pathway
PID INSULIN GLUCOSE PATHWAY	26	24	All SZGR 2.0 genes in this pathway
PID PI3KCI AKT PATHWAY	35	30	All SZGR 2.0 genes in this pathway
PID PI3K PLC TRK PATHWAY	36	31	All SZGR 2.0 genes in this pathway
PID TGFBR PATHWAY	55	38	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY HIPPO	22	15	All SZGR 2.0 genes in this pathway
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE	60	43	All SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	81	61	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	66	43	All SZGR 2.0 genes in this pathway
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	59	38	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES	81	50	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN	526	357	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP	473	314	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP	404	246	All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 6HR UP	55	34	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
BIDUS METASTASIS UP	214	134	All SZGR 2.0 genes in this pathway
HAHTOLA SEZARY SYNDROM UP	98	58	All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES UP	19	15	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE AUGMENTED BY MYC	108	74	All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 UP	108	66	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX2 DN	7	6	All SZGR 2.0 genes in this pathway
DEN INTERACT WITH LCA5	26	21	All SZGR 2.0 genes in this pathway
ZUCCHI METASTASIS DN	44	29	All SZGR 2.0 genes in this pathway
MENSSEN MYC TARGETS	53	35	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM DN	141	99	All SZGR 2.0 genes in this pathway
LU AGING BRAIN DN	153	120	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
WU HBX TARGETS 1 DN	23	14	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
WU HBX TARGETS 2 UP	23	13	All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN DN	271	175	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM	66	47	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST	132	93	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN	315	197	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP	648	398	All SZGR 2.0 genes in this pathway
MALONEY RESPONSE TO 17AAG DN	79	45	All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA	447	277	All SZGR 2.0 genes in this pathway
SPIRA SMOKERS LUNG CANCER UP	38	24	All SZGR 2.0 genes in this pathway
HAHTOLA CTCL CUTANEOUS	26	19	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC UP	72	53	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 UP	140	94	All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 UP	87	52	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-155	266	272	m8	hsa-miR-155	UUAAUGCUAAUCGUGAUAGGGG
miR-186	227	233	1A	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-26	777	783	1A	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	777	783	1A	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-30-3p	560	566	1A	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
				hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
				hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
				hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
miR-31	608	614	m8	hsa-miR-31	AGGCAAGAUGCUGGCAUAGCUG
miR-320	216	222	m8	hsa-miR-320	AAAAGCUGGGUUGAGAGGGCGAA
miR-490	636	642	1A	hsa-miR-490	CAACCUGGAGGACUCCAUGCUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: YWHAE