Gene Page: GEMIN6

Summary ?
GeneID79833
SymbolGEMIN6
Synonyms-
Descriptiongem nuclear organelle associated protein 6
ReferenceMIM:607006|HGNC:HGNC:20044|HPRD:06110|
Gene typeprotein-coding
Map location2p22.1
Pascal p-value0.004
Sherlock p-value0.915
DMG1 (# studies)
eGeneFrontal Cortex BA9

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Nishioka_2013Genome-wide DNA methylation analysisThe authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg07959896239005451GEMIN6-0.0270.3DMG:Nishioka_2013


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
DDX20DKFZp434H052 | DP103 | GEMIN3DEAD (Asp-Glu-Ala-Asp) box polypeptide 20Affinity Capture-WesternBioGRID11748230 
GEMIN4DKFZp434B131 | DKFZp434D174 | HC56 | HCAP1 | HHRF-1 | p97gem (nuclear organelle) associated protein 4Affinity Capture-WesternBioGRID11748230 
GEMIN7SIP3gem (nuclear organelle) associated protein 7-HPRD,BioGRID12065586 
SIP1GEMIN2 | SIP1-deltasurvival of motor neuron protein interacting protein 1Affinity Capture-WesternBioGRID11748230 
SMN1BCD541 | SMA | SMA1 | SMA2 | SMA3 | SMA4 | SMA@ | SMN | SMNT | T-BCD541survival of motor neuron 1, telomericAffinity Capture-WesternBioGRID11748230 
SNRPBCOD | SNRPB1 | SmB/SmB' | snRNP-Bsmall nuclear ribonucleoprotein polypeptides B and B1Gemin6 interacts with SmB.BIND11748230 
SNRPBCOD | SNRPB1 | SmB/SmB' | snRNP-Bsmall nuclear ribonucleoprotein polypeptides B and B1Gemin6 interacts with SNRPB (SmB)BIND15939020 
SNRPD2SMD2 | SNRPD1small nuclear ribonucleoprotein D2 polypeptide 16.5kDaGemin6 interacts with SmD2BIND11748230 
SNRPD2SMD2 | SNRPD1small nuclear ribonucleoprotein D2 polypeptide 16.5kDaGemin6 interacts with SNRPD2 (SmD2)BIND15939020 
SNRPD2SMD2 | SNRPD1small nuclear ribonucleoprotein D2 polypeptide 16.5kDa-HPRD11748230 
SNRPD3SMD3small nuclear ribonucleoprotein D3 polypeptide 18kDaGemin6 interacts with SNRPD3 (SmD3)BIND15939020 
SNRPD3SMD3small nuclear ribonucleoprotein D3 polypeptide 18kDaGemin6 interacts with SmD3.BIND11748230 
SNRPEB-raf | SMEsmall nuclear ribonucleoprotein polypeptide EGemin6 interacts with SmE.BIND11748230 
SNRPEB-raf | SMEsmall nuclear ribonucleoprotein polypeptide E-HPRD11748230 
SNRPEB-raf | SMEsmall nuclear ribonucleoprotein polypeptide EGemin6 interacts with SNRPE (SmE)BIND15939020 
SNRPFSMFsmall nuclear ribonucleoprotein polypeptide FGemin6 interacts with SNRPF (SmF)BIND15939020 
SNRPGMGC117317 | SMGsmall nuclear ribonucleoprotein polypeptide GGemin6 interacts with SNRPG (SmG)BIND15939020 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME METABOLISM OF NON CODING RNA 4929All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA 330155All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP 285181All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783507All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431263All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE DN 384220All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL UP 13378All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE DN 5325All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA DN 284156All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES SKIN UP 177113All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770415All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637377All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795478All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN 289166All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911527All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011592All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728415All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863514All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425253All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285167All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299189All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277172All SZGR 2.0 genes in this pathway
WINNEPENNINCKX MELANOMA METASTASIS UP 16286All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335193All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718401All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445257All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS UP 12778All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570339All SZGR 2.0 genes in this pathway