Gene Page: RUNX2

Summary
GeneID  860
Symbol  RUNX2
Synonyms  AML3|CBFA1|CCD|CCD1|MGC120022|MGC120023|OSF2|PEA2aA|PEBP2A1|PEBP2A2|PEBP2aA|PEBP2aA1
Description  runt-related transcription factor 2
See related  HGNC:10472|MIM:600211|Ensembl:ENSG00000124813|HPRD:02566|
Locus tag  RP1-166H4.1
Gene type  protein-coding
Map location  6p21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.04433 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TBX20.680.63
ITPKB0.670.57
CHDH0.660.54
TPCN10.650.56
GPR37L10.650.56
FAM38A0.640.58
NACC20.640.56
GPER0.640.60
PBXIP10.640.56
NFATC10.640.58
Top 10 negatively co-expressed genes
MED19-0.49-0.52
C18orf21-0.47-0.49
POLB-0.46-0.52
FRG1-0.46-0.52
COQ3-0.46-0.48
ING4-0.46-0.49
PAK1IP1-0.45-0.46
FARSB-0.45-0.47
ASNSD1-0.45-0.46
DUSP12-0.45-0.47
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003682chromatin bindingIEA-
GO:0003700transcription factor activityIEA-
GO:0003700transcription factor activityNAS9182765 
GO:0003702RNA polymerase II transcription factor activityTAS9182762 
GO:0005515protein bindingIPI11965546 |12145306 
GO:0005524ATP bindingIEA-
GO:0016563transcription activator activityIDA11965546 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001501skeletal system developmentIEA-
GO:0001649osteoblast differentiationIEA-
GO:0001649osteoblast differentiationTAS12217689 
GO:0002062chondrocyte differentiationIEA-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0008284positive regulation of cell proliferationIEA-
GO:0048469cell maturationIEA-
GO:0016481negative regulation of transcriptionIDA11965546 
GO:0040036regulation of fibroblast growth factor receptor signaling pathwayIEA-
GO:0042487regulation of odontogenesis of dentine-containing toothIEA-
GO:0045879negative regulation of smoothened signaling pathwayIEA-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CBFBPEBP2Bcore-binding factor, beta subunit-HPRD12434156 
CEBPBC/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5CCAAT/enhancer binding protein (C/EBP), beta-HPRD11668178 
ETS1ETS-1 | EWSR2 | FLJ10768v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)-HPRD,BioGRID9794229 
FOSAP-1 | C-FOSv-fos FBJ murine osteosarcoma viral oncogene homolog-HPRD,BioGRID11641401 
HDAC3HD3 | RPD3 | RPD3-2histone deacetylase 3Affinity Capture-Western
Reconstituted Complex		BioGRID15292260 
HDAC6FLJ16239 | HD6 | JM21histone deacetylase 6-HPRD,BioGRID12391164 
JUNAP-1 | AP1 | c-Junjun oncogene-HPRD,BioGRID11274169 |11641401 
LEF1DKFZp586H0919 | TCF1ALPHAlymphoid enhancer-binding factor 1Reconstituted ComplexBioGRID12551949 
MSX2CRS2 | FPP | HOX8 | MSH | PFM | PFM1msh homeobox 2-HPRD,BioGRID11683913 
MYST4DKFZp313G1618 | FLJ90335 | KAT6B | KIAA0383 | MORF | MOZ2 | qkf | querkopfMYST histone acetyltransferase (monocytic leukemia) 4-HPRD,BioGRID11965546 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1Runx2 interacts with pRb.BIND15583032 
SMAD1BSP1 | JV4-1 | JV41 | MADH1 | MADR1SMAD family member 1Affinity Capture-WesternBioGRID10531362 |10962029 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2-HPRD,BioGRID10531362 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3-HPRD,BioGRID10962029 
SMAD5DKFZp781C1895 | DKFZp781O1323 | Dwfc | JV5-1 | MADH5SMAD family member 5Affinity Capture-WesternBioGRID10531362 
THOC4ALY | BEFTHO complex 4Reconstituted ComplexBioGRID9119228 
YAP1YAP | YAP2 | YAP65 | YKIYes-associated protein 1, 65kDa-HPRD,BioGRID10228168 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_SMAD2_3NUCLEAR_PATHWAY 8263All SZGR genes in this pathway
PID_FGF_PATHWAY 5537All SZGR genes in this pathway
PID_RB_1PATHWAY 6546All SZGR genes in this pathway
PID_HES_HEY_PATHWAY 4839All SZGR genes in this pathway
REACTOME_YAP1_AND_WWTR1_TAZ_STIMULATED_GENE_EXPRESSION 2416All SZGR genes in this pathway
REACTOME_GENERIC_TRANSCRIPTION_PATHWAY 352181All SZGR genes in this pathway
HOOI_ST7_TARGETS_UP 9457All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
RODRIGUES_DCC_TARGETS_DN 12184All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_DN 260143All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_UP 316190All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
MARTIN_INTERACT_WITH_HDAC 4431All SZGR genes in this pathway
LINDGREN_BLADDER_CANCER_CLUSTER_2B 392251All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN 712443All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_NEUROEPITHELIUM_DN 164111All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2 153102All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN 357212All SZGR genes in this pathway
OKUMURA_INFLAMMATORY_RESPONSE_LPS 183115All SZGR genes in this pathway
SANSOM_APC_TARGETS_DN 366238All SZGR genes in this pathway
MATSUDA_NATURAL_KILLER_DIFFERENTIATION 475313All SZGR genes in this pathway
ABRAHAM_ALPC_VS_MULTIPLE_MYELOMA_UP 2622All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP 390242All SZGR genes in this pathway
SU_PANCREAS 5430All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_DN 8759All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
BILD_CTNNB1_ONCOGENIC_SIGNATURE 8252All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_DN 191123All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_UP 11170All SZGR genes in this pathway
NAKAMURA_METASTASIS_MODEL_DN 4328All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_D_DN 252155All SZGR genes in this pathway
ZAIDI_OSTEOBLAST_TRANSCRIPTION_FACTORS 1412All SZGR genes in this pathway
GOLDRATH_ANTIGEN_RESPONSE 346192All SZGR genes in this pathway
HOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_DN 7561All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
ONO_AML1_TARGETS_DN 4125All SZGR genes in this pathway
ONO_FOXP3_TARGETS_DN 4223All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN 254158All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_MESENCHYMAL 216130All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
DUAN_PRDM5_TARGETS 7952All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_1 4633All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124.115291535m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/506152915351Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-130/30127282734m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-135101510211Ahsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-13710361042m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-148/15227292735m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-1537417471Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-1927272733m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-203.1934940m8hsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-204/21136533659m8hsa-miR-204brainUUCCCUUUGUCAUCCUAUGCCU
hsa-miR-211UUCCCUUUGUCAUCCUUCGCCU
miR-205112411311A,m8hsa-miR-205UCCUUCAUUCCACCGGAGUCUG
miR-218130813151A,m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-221/222351235181Ahsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
miR-224623629m8hsa-miR-224CAAGUCACUAGUGGUUCCGUUUA
miR-2310611067m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-30-5p33483354m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-323106110671Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-324-5p24922498m8hsa-miR-324-5pCGCAUCCCCUAGGGCAUUGGUGU
miR-3303913981A,m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-338124212491A,m8hsa-miR-338brainUCCAGCAUCAGUGAUUUUGUUGA
miR-369-3p7687741Ahsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-374768774m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-3836396451Ahsa-miR-383brainAGAUCAGAAGGUGAUUGUGGCU
miR-4487417471Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-485-3p112111281A,m8hsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU
miR-495377137771Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-543251025161Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
miR-927642770m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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