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Found 30 literature records

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Entrez ID	Description
4221	The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation.
4221	Differential expression of multiple alternative spliceforms of the Men1 tumor suppressor gene in mouse.
1031	"Here we show that treatment of p18 null and heterozygous mice with a chemical carcinogen resulted in tumor development at an accelerated rate.Hence, p18 is a haploinsufficient tumor suppressor in mice."
1871	"E2F3 loss leads to an increase in the rate of tumor initiation. Finally, analysis of Rb(+/-); E2f3(+/-) mice shows that this tumor-suppressive function of E2F3 is dose dependent."
4221	"the smad pathway and the tumor suppressor menin are key regulators of activin effects on PRL and Pit-1 expression, as well as on cell growth inhibition"
5933	Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130.
5934	Tissue-specific tumor suppressor activity of retinoblastoma gene homologs p107 and p130.
4221	that regulation of cyclin-dependent kinase inhibitor transcription by cooperative interaction between menin and MLL plays a central role in menin's activity as a tumor suppressor
11186	Inactivation of RASSF1A tumor suppressor gene by aberrant promoter hypermethylation in human pituitary adenomas.
1017	Cdk2 is not an essential target for p27(Kip1) and p21(Cip1) in cell cycle inhibition and tumor suppression.
5325	The candidate tumor suppressor gene ZAC is involved in keratinocyte differentiation and its expression is lost in basal cell carcinomas.
5925	"RB1 was not implicated, suggesting the participation of another tumor suppressor gene in this region."
5573	Reviews genetic aspects of hereditary GH-secreting tumors and data from animal models resulting from the inactivation of the PRKAR1A tumor suppressor gene.
4221	Phosphorylation of the menin tumor suppressor protein on serine 543 and serine 583.
7157	p53 is a direct transcriptional target gene of hPitx1. This observation is concordant with the recent identification of hPitx1 as a tumor suppressor gene.
8190	A potential tumor suppressor role of Mia/Cd-rap in pituitary cells.
4221	The expression changes associated with the loss of the tumor suppressor menin provide insights into the defective organogenesis observed during early embryonic development in Men1-null mouse embryos.
11197	"WIF1 may be a tumor suppressor, specifically in nonfunctioning pituitary tumors, and that the Wnt pathways are important in pituitary tumorigenesis."
9049	A tumor-suppressor role for AIP and its involvement in familial acromegaly.
406948	MicroRNAs (miRNAs) encoded by the miR-15/16 cluster are known to act as tumor suppressors
406950	MicroRNAs (miRNAs) encoded by the miR-15/16 cluster are known to act as tumor suppressors
7068	TRs could function as tumor suppressors in a mouse model of metastatic follicular thyroid cancer.
1316	"Pituitary tumor transforming gene 1 (PTTG1), an oncogene, was the most up-regulated transcript in KLF6+/- liver. PTTG1 downregulation represents a novel tumor suppressor pathway of KLF6."
4221	Concomitant deletions of tumor suppressor genes MEN1 and AIP are essential for the pathogenesis of the brown fat tumor hibernoma.
9049	Concomitant deletions of tumor suppressor genes MEN1 and AIP are essential for the pathogenesis of the brown fat tumor hibernoma.
4221	the menin tumor suppressor protein undergoes DNA damage induced phosphorylation and participates in the DNA damage transcriptional response.
8788	The DLK1-MEG3 locus plays a tumor suppressor role in human nonfunctioning adenomas.
89884	"data indicate that LHX4 may act as a potential tumor suppressor in hepatocarcinogenesis, suggesting that targeting LHX4 to downregulate AFP might have therapeutic implications"
406901	Data suggest that miR-107 is overexpressed in pituitary adenomas and acts as a tumor suppressor; pituitary tumor suppressor gene AIP (aryl hydrocarbon receptor-interacting protein) is a miR-107 target gene; both may have roles in tumorigenesis.
5925	Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse.