Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
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Found 82 literature records
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Entrez ID
Description
9940
"Molecular cloning of a candidate tumor suppressor gene, DLC1, from chromosome 3p21.3."
634
"C-CAM1, a candidate tumor suppressor gene, is abnormally expressed in primary lung cancers."
10641
The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium.
11186
The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium.
11334
The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium.
51364
The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium.
7869
The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium.
199731
"Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins."
11334
Overexpression of candidate tumor suppressor geneFUS1 isolated from the 3p21.3 homozygous deletionregion leads to G1 arrest and growth inhibition oflung cancer cells.
1050
may function as a tumor suppressor that is mutated during tumorigenesis. Abnormalties in C/EBPalpha function contribute to the development of malignancies in a variety of tisues.
23136
"TSLC1 and DAL-1, two distinct tumor suppressor proteins, directly associate in lung cancer."
9353
"SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers."
6595
This report provides supportive evidence that BRG1 and BRM act as tumor suppressor proteins and implicates a role for their loss in the development of non-small cell lung cancers.
6597
This report provides supportive evidence that BRG1 and BRM act as tumor suppressor proteins and implicates a role for their loss in the development of non-small cell lung cancers.
11186
RASSF1 is a putative tumor suppressor in non-small cell lung cancer
26524
"Lats2, a putative tumor suppressor, inhibits G1/S transition."
23705
"Lung tumor suppressor gene,TSLC1, associates with MPP3, a human homologue of Drosophila tumor suppressor Dlg."
23705
The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer.
1803
"DPPIV functions as a tumor suppressor, and its downregulation may contribute to the loss of growth control in NSCLC cells"
53353
Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.
5071
Parkin is a tumor suppressor gene whose inactivation may play an important role in non-small cell lung cancer tumorigenesis
4830
"Co-downregulation of PTEN, KAI-1, and nm23-H1 tumor/metastasis suppressor proteins in non-small cell lung cancer."
5728
a role of these tumor suppressor and metastasis suppressor genes in the evolution and progression of NSCLC
857
"Results suggest different roles for CAV1 in SCLC, where CAV1 acts like a tumor suppressor gene, and NSCLC, where it appears required for survival and growth."
11186
Hypermethylation of RASSF1A and BLU tumor suppressor genes in non-small cell lung cancer: implications for tobacco smoking during adolescence.
51364
Hypermethylation of RASSF1A and BLU tumor suppressor genes in non-small cell lung cancer: implications for tobacco smoking during adolescence.
5268
Prognostic significance of the tumor suppressor gene maspin in non-small cell lung cancer.
10210
"topors mediates p53-dependent cellular responses induced by DNA damage, suggesting its physiological role as a tumor suppressor"
1620
likely tumor suppressor for NSCLC;silencing through homozygous deletion or methylation of its promoter promotes progression
23705
Tumor suppressor in lung cancer 1 (TSLC1) alters tumorigenic growth properties and gene expression.
11186
Involvement of the RASSF1A tumor suppressor gene in controlling cell migration.
10181
3p21.3 tumor suppressor gene H37/Luca15/RBM5 inhibits growth of human lung cancer cells through cell cycle arrest and apoptosis.
1490
"CTGF may behave as a secreted tumor suppressor protein in the normal lung, and its expression is suppressed in many NSCLCs."
23705
Involvement of tumor suppressor in lung cancer 1 gene expression in cervical carcinogenesis.
11334
Oncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: inhibition of c-Abl by the tumor suppressor gene product Fus1.
10253
Spry2 plays a role as tumor suppressor in NSCLC by antagonizing receptor tyrosine kinase-induced signaling at different levels.
317
These data point to a role for Apaf-1 as a bona fide tumor suppressor.
6794
The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity.
7157
"Polymorphism Arg72Pro in tumor suppressor gene TP53 increases the risk of lung cancer, especially for small cell lung cancer and heavy smokers."
5371
CK2 mediates phosphorylation and ubiquitin-mediated degradation of the PML tumor suppressor.
8994
"The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development."
1316
Our results demonstrate the induction of the tumor suppressor KLF6 following PKC activation and its importance for PMA-mediated cancer cell growth arrest.
4851
"Notch1 signal activation can inhibit the proliferation and neuroendocrine marker expression in small cell lung cancer cells, and may behave as a tumor suppressor."
5728
"show that miR-221&222, by targeting PTEN and TIMP3 tumor suppressors, induce TRAIL resistance and enhance cellular migration through the activation of the AKT pathway and metallopeptidases"
7078
"show that miR-221&222, by targeting PTEN and TIMP3 tumor suppressors, induce TRAIL resistance and enhance cellular migration through the activation of the AKT pathway and metallopeptidases"
3622
Expression of candidate tumor suppressor gene ING2 is lost in non-small cell lung carcinoma.
11080
"HLJ1 switches the role of NPM1, which can act as tumor suppressor or oncogene, by modulating the oligomerization of NPM1 via HLJ1-NPM1 heterodimer formation and recruiting AP-2alpha to the MMP-2 promoter."
10217
"tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A are downregulated in primary non-small cell lung cancer"
10641
"tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A are downregulated in primary non-small cell lung cancer"
11186
"tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A are downregulated in primary non-small cell lung cancer"
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