| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44018958 | HTLV-1 | ENSG00000196639.7 | protein_coding | HRH1 | No | No | 3269 | P35367 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | HRH1 |
|---|---|
| DrugBank ID | DB00370 |
| Drug Name | Mirtazapine |
| Target ID | BE0000442 |
| UniProt ID | P35367 |
| Regulation Type | antagonist |
| PubMed IDs | 23229983; 27593622; 23728612 |
| Citations | Vande Griend JP, Anderson SL: Histamine-1 receptor antagonism for treatment of insomnia. J Am Pharm Assoc (2003). 2012;52(6):e210-9. doi: 10.1331/JAPhA.2012.12051.@@Salvi V, Mencacci C, Barone-Adesi F: H1-histamine receptor affinity predicts weight gain with antidepressants. Eur Neuropsychopharmacol. 2016 Oct;26(10):1673-7. doi: 10.1016/j.euroneuro.2016.08.012. Epub 2016 Sep 1.@@Sato H, Ito C, Tashiro M, Hiraoka K, Shibuya K, Funaki Y, Iwata R, Matsuoka H, Yanai K: Histamine H(1) receptor occupancy by the new-generation antidepressants fluvoxamine and mirtazapine: a positron emission tomography study in healthy volunteers. Psychopharmacology (Berl). 2013 Nov;230(2):227-34. doi: 10.1007/s00213-013-3146-1. Epub 2013 Jun 1. |
| Groups | Approved |
| Direct Classification | Piperazinoazepines |
| SMILES | CN1CCN2C(C1)C1=CC=CC=C1CC1=C2N=CC=C1 |
| Pathways | Mirtazapine H1-Antihistamine Action |
| PharmGKB | PA450522 |
| ChEMBL | CHEMBL654 |
