SZGR2

Summary ?

GeneID	1027
Symbol	CDKN1B
Synonyms	CDKN4\|KIP1\|MEN1B\|MEN4\|P27KIP1
Description	cyclin-dependent kinase inhibitor 1B
Reference	MIM:600778\|HGNC:HGNC:1785\|Ensembl:ENSG00000111276\|HPRD:02867\|Vega:OTTHUMG00000149914
Gene type	protein-coding
Map location	12p13.1-p12
Pascal p-value	0.249
Sherlock p-value	8.849E-6
Fetal beta	0.697

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0925

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MAD2L1	0.90	0.72
CCNB1	0.90	0.72
CENPN	0.89	0.74
CKS2	0.87	0.59
CHEK2	0.87	0.65
PBK	0.86	0.32
KIAA0101	0.86	0.31
HMGB2	0.86	0.55
RAD51AP1	0.86	0.46
AURKA	0.86	0.52

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.26	-0.34	-0.28
AF347015.15	-0.33	-0.26
AF347015.8	-0.33	-0.25
MT-CYB	-0.33	-0.26
APOL1	-0.32	-0.27
AF347015.2	-0.32	-0.24
AF347015.33	-0.31	-0.24
MT-CO2	-0.31	-0.22
SLC9A3R2	-0.31	-0.23
AF347015.18	-0.31	-0.31

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity	TAS		8033212
GO:0005515	protein binding	IPI		8756624 \|9106657 \|9840943 \|12082530 \|15057270 \|15652749 \|15890360 \|17254966 \|17254967
GO:0004861	cyclin-dependent protein kinase inhibitor activity	TAS		10918569
GO:0004860	protein kinase inhibitor activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000079	regulation of cyclin-dependent protein kinase activity	TAS		8033212
GO:0000082	G1/S transition of mitotic cell cycle	IDA		10208428
GO:0006917	induction of apoptosis	IDA		10208428
GO:0007049	cell cycle	IEA		-
GO:0007050	cell cycle arrest	IMP		12093740
GO:0008285	negative regulation of cell proliferation	TAS		8033212
GO:0048102	autophagic cell death	IDA		12698196
GO:0042326	negative regulation of phosphorylation	IDA		10208428
GO:0030308	negative regulation of cell growth	IDA		10208428
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		12244303
GO:0005634	nucleus	IDA		12093740
GO:0005737	cytoplasm	IDA		12093740

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1	Affinity Capture-Western Biochemical Activity	BioGRID	12042314
ARHGDIA	GDIA1 \| MGC117248 \| RHOGDI \| RHOGDI-1	Rho GDP dissociation inhibitor (GDI) alpha	Two-hybrid	BioGRID	16169070
CCNA1	-	cyclin A1	cyclin A1 interacts with p27.	BIND	10022926
CCNA2	CCN1 \| CCNA	cyclin A2	p27 interacts with Cyc A.	BIND	15469821
CCNA2	CCN1 \| CCNA	cyclin A2	p27 interacts with cyclin A.	BIND	9632134
CCNA2	CCN1 \| CCNA	cyclin A2	-	HPRD,BioGRID	12501191
CCNA2	CCN1 \| CCNA	cyclin A2	p27 interacts with cyclin A.	BIND	15652749
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	in vitro Reconstituted Complex	BioGRID	10908655 \|11360184
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	p27 interacts with cyclin D.	BIND	9632134
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	-	HPRD	7478582 \|10908655
CCND2	KIAK0002 \| MGC102758	cyclin D2	Two-hybrid	BioGRID	16189514
CCND3	-	cyclin D3	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10342870 \|11360184 \|16189514
CCNE1	CCNE	cyclin E1	p27 interacts with cyclin E.	BIND	9632134
CCNE1	CCNE	cyclin E1	p27 interacts with Cyc E.	BIND	15469821
CCNE1	CCNE	cyclin E1	Affinity Capture-Western	BioGRID	9891079 \|12529437
CCNE2	CYCE2	cyclin E2	-	HPRD	9858585
CDK2	p33(CDK2)	cyclin-dependent kinase 2	p27 interacts with an unspecified isoform of CDK2.	BIND	15652749
CDK2	p33(CDK2)	cyclin-dependent kinase 2	Cdk2 interacts with p27kip1.	BIND	15619620
CDK2	p33(CDK2)	cyclin-dependent kinase 2	-	HPRD,BioGRID	12972555
CDK2	p33(CDK2)	cyclin-dependent kinase 2	Cdk2 interacts with p27.	BIND	15469821
CDK4	CMM3 \| MGC14458 \| PSK-J3	cyclin-dependent kinase 4	-	HPRD,BioGRID	10908655
CDK6	MGC59692 \| PLSTIRE \| STQTL11	cyclin-dependent kinase 6	Affinity Capture-Western	BioGRID	11360184
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	-	HPRD	9858585
CKS1B	CKS1 \| PNAS-16 \| PNAS-18 \| ckshs1	CDC28 protein kinase regulatory subunit 1B	Biochemical Activity Reconstituted Complex	BioGRID	12140288 \|12813041
COPS5	CSN5 \| JAB1 \| MGC3149 \| MOV-34 \| SGN5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	Affinity Capture-Western	BioGRID	12082530
COPS5	CSN5 \| JAB1 \| MGC3149 \| MOV-34 \| SGN5	COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)	COPS5 (CSN5) interacts with CDKN1B (p27).	BIND	15688030
FOXO3	AF6q21 \| DKFZp781A0677 \| FKHRL1 \| FKHRL1P2 \| FOXO2 \| FOXO3A \| MGC12739 \| MGC31925	forkhead box O3	FOXO3a interacts with p27Kip1 promoter.	BIND	15084260
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	11278754
KPNA2	IPOA1 \| QIP2 \| RCH1 \| SRP1alpha	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	p27 interacts with importin-alpha.	BIND	15579463
NUP50	MGC39961 \| NPAP60 \| NPAP60L	nucleoporin 50kDa	-	HPRD,BioGRID	10891500
SKP2	FBL1 \| FBXL1 \| FLB1 \| MGC1366	S-phase kinase-associated protein 2 (p45)	-	HPRD	10559916
SKP2	FBL1 \| FBXL1 \| FLB1 \| MGC1366	S-phase kinase-associated protein 2 (p45)	Affinity Capture-Western Biochemical Activity Reconstituted Complex	BioGRID	12042314 \|12140288 \|12813041
SKP2	FBL1 \| FBXL1 \| FLB1 \| MGC1366	S-phase kinase-associated protein 2 (p45)	CDKN1B (p27Kip1) interacts with SKP2 (p45Skp2).	BIND	15735731
SKP2	FBL1 \| FBXL1 \| FLB1 \| MGC1366	S-phase kinase-associated protein 2 (p45)	Skp2 interacts with p27.	BIND	15469821
SPDYA	MGC110856 \| MGC57218 \| Ringo3 \| SPDY1 \| SPY1	speedy homolog A (Drosophila)	Affinity Capture-Western Reconstituted Complex	BioGRID	12972555
STMN1	LAP18 \| Lag \| OP18 \| PP17 \| PP19 \| PR22 \| SMN	stathmin 1/oncoprotein 18	p27 interacts with stathmin.	BIND	15652749
TRAF2	MGC:45012 \| TRAP \| TRAP3	TNF receptor-associated factor 2	Two-hybrid	BioGRID	16189514
TSC1	KIAA0243 \| LAM \| MGC86987 \| TSC	tuberous sclerosis 1	Affinity Capture-Western	BioGRID	15355997
TSC2	FLJ43106 \| LAM \| TSC4	tuberous sclerosis 2	Affinity Capture-Western	BioGRID	15355997
UBB	FLJ25987 \| MGC8385	ubiquitin B	Ub interacts with p27.	BIND	15469821
UCHL1	PARK5 \| PGP9.5 \| Uch-L1	ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)	-	HPRD,BioGRID	12082530
XPO1	CRM1 \| DKFZp686B1823	exportin 1 (CRM1 homolog, yeast)	p27Kip1 interacts with CRM1.	BIND	11889117
XPO1	CRM1 \| DKFZp686B1823	exportin 1 (CRM1 homolog, yeast)	-	HPRD,BioGRID	11889117 \|12529437
YWHAE	14-3-3E \| FLJ45465 \| KCIP-1 \| MDCR \| MDS	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	-	HPRD	12042314
YWHAH	YWHA1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	-	HPRD	12042314
YWHAQ	14-3-3 \| 1C5 \| HS1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide	-	HPRD,BioGRID	12042314

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG ERBB SIGNALING PATHWAY	87	71	All SZGR 2.0 genes in this pathway
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER	89	75	All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA	73	59	All SZGR 2.0 genes in this pathway
KEGG SMALL CELL LUNG CANCER	84	67	All SZGR 2.0 genes in this pathway
BIOCARTA MCM PATHWAY	18	8	All SZGR 2.0 genes in this pathway
BIOCARTA G1 PATHWAY	28	21	All SZGR 2.0 genes in this pathway
BIOCARTA CTCF PATHWAY	23	18	All SZGR 2.0 genes in this pathway
BIOCARTA CELLCYCLE PATHWAY	23	15	All SZGR 2.0 genes in this pathway
BIOCARTA RACCYCD PATHWAY	26	23	All SZGR 2.0 genes in this pathway
BIOCARTA PTEN PATHWAY	18	14	All SZGR 2.0 genes in this pathway
BIOCARTA P27 PATHWAY	13	10	All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN CARDIAC MYOCTES	67	54	All SZGR 2.0 genes in this pathway
SA G1 AND S PHASES	15	10	All SZGR 2.0 genes in this pathway
SA REG CASCADE OF CYCLIN EXPR	13	7	All SZGR 2.0 genes in this pathway
PID RHOA PATHWAY	45	33	All SZGR 2.0 genes in this pathway
PID E2F PATHWAY	74	48	All SZGR 2.0 genes in this pathway
PID RHOA REG PATHWAY	46	30	All SZGR 2.0 genes in this pathway
PID TELOMERASE PATHWAY	68	48	All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY	49	43	All SZGR 2.0 genes in this pathway
PID AVB3 INTEGRIN PATHWAY	75	53	All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY	70	60	All SZGR 2.0 genes in this pathway
PID CMYB PATHWAY	84	61	All SZGR 2.0 genes in this pathway
PID PI3KCI AKT PATHWAY	35	30	All SZGR 2.0 genes in this pathway
PID MYC REPRESS PATHWAY	63	52	All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY	65	46	All SZGR 2.0 genes in this pathway
PID HNF3A PATHWAY	44	29	All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY	48	39	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT	78	59	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4	90	67	All SZGR 2.0 genes in this pathway
REACTOME ORC1 REMOVAL FROM CHROMATIN	67	37	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB2	101	78	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER	109	80	All SZGR 2.0 genes in this pathway
REACTOME PI3K EVENTS IN ERBB4 SIGNALING	38	28	All SZGR 2.0 genes in this pathway
REACTOME PI3K EVENTS IN ERBB2 SIGNALING	44	34	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR	97	66	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY THE B CELL RECEPTOR BCR	126	90	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME PI3K AKT ACTIVATION	38	29	All SZGR 2.0 genes in this pathway
REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	12	10	All SZGR 2.0 genes in this pathway
REACTOME GAB1 SIGNALOSOME	38	29	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE CHECKPOINTS	124	70	All SZGR 2.0 genes in this pathway
REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION	65	40	All SZGR 2.0 genes in this pathway
REACTOME G1 PHASE	38	23	All SZGR 2.0 genes in this pathway
REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE	57	35	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF	122	93	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION	95	76	All SZGR 2.0 genes in this pathway
REACTOME G1 S TRANSITION	112	63	All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF DNA	92	53	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G1 G1 S PHASES	137	79	All SZGR 2.0 genes in this pathway
REACTOME PI 3K CASCADE	56	39	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	100	74	All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION	192	110	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME PIP3 ACTIVATES AKT SIGNALING	29	20	All SZGR 2.0 genes in this pathway
REACTOME S PHASE	109	66	All SZGR 2.0 genes in this pathway
REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	56	34	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR	112	80	All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 DN	267	178	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN	459	276	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP	128	95	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP	117	84	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
LAU APOPTOSIS CDKN2A UP	55	40	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
CAIRO PML TARGETS BOUND BY MYC DN	14	12	All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS	1174	695	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL	326	213	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC UP	33	20	All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC 8HR 5 UP	16	7	All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS	775	494	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP	424	268	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 UP	140	85	All SZGR 2.0 genes in this pathway
RADAEVA RESPONSE TO IFNA1 UP	52	40	All SZGR 2.0 genes in this pathway
TENEDINI MEGAKARYOCYTE MARKERS	66	48	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK DN	51	35	All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR	293	193	All SZGR 2.0 genes in this pathway
ABRAHAM ALPC VS MULTIPLE MYELOMA UP	26	22	All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH3 21 DN	49	29	All SZGR 2.0 genes in this pathway
HARRIS HYPOXIA	81	64	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS UP	37	27	All SZGR 2.0 genes in this pathway
LEONARD HYPOXIA	47	35	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP	428	266	All SZGR 2.0 genes in this pathway
SARTIPY BLUNTED BY INSULIN RESISTANCE DN	18	14	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 6HR DN	160	101	All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3	491	310	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN	292	189	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN	281	179	All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING DN	36	24	All SZGR 2.0 genes in this pathway
MATZUK LUTEAL GENES	8	5	All SZGR 2.0 genes in this pathway
LIN NPAS4 TARGETS UP	163	100	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE	242	168	All SZGR 2.0 genes in this pathway
BOHN PRIMARY IMMUNODEFICIENCY SYNDROM UP	47	30	All SZGR 2.0 genes in this pathway
SCHRAETS MLL TARGETS DN	33	24	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 MULTIPLE MYELOMA PROGRAM	36	25	All SZGR 2.0 genes in this pathway
SCHOEN NFKB SIGNALING	34	26	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
DANG MYC TARGETS DN	31	25	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN	222	147	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 2HR DN	49	33	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G2	182	102	All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA PRONEURAL	177	132	All SZGR 2.0 genes in this pathway
BAKKER FOXO3 TARGETS UP	61	41	All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS UP	149	96	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38	337	236	All SZGR 2.0 genes in this pathway
ZWANG DOWN BY 2ND EGF PULSE	293	119	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-148/152	128	134	1A	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-186	427	433	1A	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-190	90	96	m8	hsa-miR-190	UGAUAUGUUUGAUAUAUUAGGU
miR-194	1301	1307	1A	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-196	245	251	m8	hsa-miR-196a	UAGGUAGUUUCAUGUUGUUGG
miR-196	245	251	m8	hsa-miR-196b	UAGGUAGUUUCCUGUUGUUGG
miR-221/222	201	208	1A,m8	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
				hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
				hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
				hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-24	1253	1260	1A,m8	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-323	1275	1281	m8	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-377	1278	1285	1A,m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-455	279	285	1A	hsa-miR-455	UAUGUGCCUUUGGACUACAUCG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: CDKN1B