Summary ?
GeneID10425
SymbolARIH2
SynonymsARI2|TRIAD1
Descriptionariadne RBR E3 ubiquitin protein ligase 2
ReferenceMIM:605615|HGNC:HGNC:690|Ensembl:ENSG00000177479|HPRD:09286|Vega:OTTHUMG00000133547
Gene typeprotein-coding
Map location3p21
Pascal p-value0.029
Sherlock p-value0.275
eGeneFrontal Cortex BA9
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.125 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
MPG0.880.82
CHCHD50.880.76
YIF1A0.880.81
ZNF5110.880.76
NDUFA110.870.77
C11orf590.860.79
COX8A0.860.78
C17orf610.860.81
TMEM2230.850.76
TRPT10.850.78
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
Z83840.4-0.44-0.51
ZNHIT6-0.42-0.42
TRAF3IP1-0.42-0.40
TRIM44-0.40-0.40
CCDC55-0.39-0.42
RBM25-0.39-0.42
KIF16B-0.38-0.32
AP000769.2-0.37-0.45
SDCCAG1-0.37-0.31
DST-0.37-0.37

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003676nucleic acid bindingIEA-
GO:0005515protein bindingIEA-
GO:0008270zinc ion bindingIEA-
GO:0008270zinc ion bindingTAS10422847 
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0007275multicellular organismal developmentTAS10422847 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusTAS10422847 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAP1CENTD2 | KIAA0782ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1Two-hybridBioGRID16169070 
BUB1BUB1A | BUB1L | hBUB1budding uninhibited by benzimidazoles 1 homolog (yeast)Two-hybridBioGRID16189514 
CBR3hCBR3carbonyl reductase 3Two-hybridBioGRID16169070 
DLSTDLTSdihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)Two-hybridBioGRID16169070 
EEF1A1CCS-3 | CCS3 | EEF-1 | EEF1A | EF-Tu | EF1A | FLJ25721 | GRAF-1EF | HNGC:16303 | LENG7 | MGC102687 | MGC131894 | MGC16224 | PTI1 | eEF1A-1eukaryotic translation elongation factor 1 alpha 1Two-hybridBioGRID16169070 
EEF1GEF1G | GIG35eukaryotic translation elongation factor 1 gammaTwo-hybridBioGRID16169070 
EML4C2orf2 | DKFZp686P18118 | ELP120 | FLJ10942 | FLJ32318 | ROPP120echinoderm microtubule associated protein like 4Two-hybridBioGRID16169070 
ENSAMGC4319 | MGC78563 | MGC8394endosulfine alphaTwo-hybridBioGRID16169070 
IL4RCD124 | IL4RAinterleukin 4 receptorTwo-hybridBioGRID16169070 
KAT5ESA1 | HTATIP | HTATIP1 | PLIP | TIP | TIP60 | cPLA2K(lysine) acetyltransferase 5Two-hybridBioGRID16169070 
KCNQ2BFNC | EBN | EBN1 | ENB1 | HNSPC | KCNA11 | KV7.2 | KVEBN1potassium voltage-gated channel, KQT-like subfamily, member 2Two-hybridBioGRID16169070 
KIAA1377-KIAA1377Two-hybridBioGRID16169070 
LOC147791-hypothetical protein LOC147791Two-hybridBioGRID16169070 
PPP2R1AMGC786 | PR65Aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoformTwo-hybridBioGRID16169070 
PTNHARP | HBGF8 | HBNF | NEGF1pleiotrophinTwo-hybridBioGRID16169070 
RPL8-ribosomal protein L8Two-hybridBioGRID16169070 
SCAMP2-secretory carrier membrane protein 2Two-hybridBioGRID16169070 
SGCEDYT11 | ESGsarcoglycan, epsilonTwo-hybridBioGRID16169070 
SLC1A6EAAT4 | MGC33092 | MGC43671solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6Two-hybridBioGRID16169070 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53Two-hybridBioGRID16169070 
UBE2L3E2-F1 | L-UBC | UBCH7 | UbcM4ubiquitin-conjugating enzyme E2L 3Two-hybridBioGRID16169070 
UBE2L3E2-F1 | L-UBC | UBCH7 | UbcM4ubiquitin-conjugating enzyme E2L 3An unspecified isoform of UbcH7 interacts with hAri-2.BIND12234920 
UGP2UDPG | UDPGP2 | UGPP2 | pHC379UDP-glucose pyrophosphorylase 2Two-hybridBioGRID16189514 
UTP14AKIAA0266 | NY-CO-16 | SDCCAG16 | dJ537K23.3UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)Two-hybridBioGRID16169070 
WDR91HSPC049WD repeat domain 91Two-hybridBioGRID16169070 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251156All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 212129All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN 309191All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493298All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA MYELOID DN 3825All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL UP 13378All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS UP 269146All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406230All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 UP 276165All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 2 UP 13983All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 UP 341197All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536332All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID WITH 7Q DELETION DN 3623All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION UP 8858All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
MANTOVANI VIRAL GPCR SIGNALING DN 4937All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN 261183All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311205All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN 202132All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA UP 7543All SZGR 2.0 genes in this pathway
FONTAINE THYROID TUMOR UNCERTAIN MALIGNANCY UP 3623All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-101851911Ahsa-miR-10aUACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10bUACCCUGUAGAACCGAAUUUGU
miR-1814314371Ahsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-19106210691A,m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-199125131m8hsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-200bc/4292862921Ahsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-3791801861Ahsa-miR-379brainUGGUAGACUAUGGAACGUA
miR-3823003071A,m8hsa-miR-382brainGAAGUUGUUCGUGGUGGAUUCG