SZGR2

Summary ?

GeneID	10672
Symbol	GNA13
Synonyms	G13
Description	G protein subunit alpha 13
Reference	MIM:604406\|HGNC:HGNC:4381\|HPRD:05100\|
Gene type	protein-coding
Map location	17q24.3
Pascal p-value	1.378E-4
Sherlock p-value	0.407
Fetal beta	1.28
DMG	1 (# studies)
Support	G-PROTEIN RELAY CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.1115

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg23423852	17	63053202	GNA13	8.55E-9	0.005	3.98E-6	DMG:Jaffe_2016

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0004871	signal transducer activity	IEA		-
GO:0003924	GTPase activity	TAS		7791744
GO:0005515	protein binding	IPI		10026210
GO:0005525	GTP binding	IEA		-
GO:0019001	guanyl nucleotide binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0001569	patterning of blood vessels	IEA		-
GO:0001701	in utero embryonic development	IEA		-
GO:0007186	G-protein coupled receptor protein signaling pathway	IEA		-
GO:0007266	Rho protein signal transduction	IEA		-
GO:0007243	protein kinase cascade	IEA		-
GO:0007165	signal transduction	TAS		7791744
GO:0030168	platelet activation	IEA		-
GO:0008360	regulation of cell shape	IEA		-
GO:0006928	cell motion	TAS		8999798
GO:0030154	cell differentiation	IEA		-
GO:0030334	regulation of cell migration	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0016020	membrane	IEA		-
GO:0042470	melanosome	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AKAP3	AKAP110 \| FSP95 \| PRKA3 \| SOB1	A kinase (PRKA) anchor protein 3	-	HPRD,BioGRID	11696326
ARHGEF1	GEF1 \| LBCL2 \| LSC \| P115-RHOGEF \| SUB1.5	Rho guanine nucleotide exchange factor (GEF) 1	-	HPRD	9641916
ARHGEF1	GEF1 \| LBCL2 \| LSC \| P115-RHOGEF \| SUB1.5	Rho guanine nucleotide exchange factor (GEF) 1	GNA13 (alpha-13) interacts with ARHGEF1 (p115RhoGEF).	BIND	15735747
ARHGEF1	GEF1 \| LBCL2 \| LSC \| P115-RHOGEF \| SUB1.5	Rho guanine nucleotide exchange factor (GEF) 1	-	HPRD,BioGRID	9641916 \|12681510
ARHGEF11	DKFZp667F1223 \| GTRAP48 \| KIAA0380 \| PDZ-RHOGEF	Rho guanine nucleotide exchange factor (GEF) 11	-	HPRD,BioGRID	10026210
ARHGEF12	DKFZp686O2372 \| KIAA0382 \| LARG \| PRO2792	Rho guanine nucleotide exchange factor (GEF) 12	-	HPRD,BioGRID	11094164
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	-	HPRD,BioGRID	11136230
CDH2	CD325 \| CDHN \| CDw325 \| NCAD	cadherin 2, type 1, N-cadherin (neuronal)	-	HPRD,BioGRID	11136230
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	-	HPRD	11136230
DRD5	DBDR \| DRD1B \| DRD1L2 \| MGC10601	dopamine receptor D5	-	HPRD,BioGRID	12623966
EDNRB	ABCDS \| ETB \| ETBR \| ETRB \| HSCR \| HSCR2	endothelin receptor type B	-	HPRD	12135322
F2R	CF2R \| HTR \| PAR1 \| TR	coagulation factor II (thrombin) receptor	Affinity Capture-Western	BioGRID	8290554
MCF2	DBL	MCF.2 cell line derived transforming sequence	in vitro in vivo	BioGRID	11062019
MTNR1A	MEL-1A-R \| MT1	melatonin receptor 1A	-	HPRD	10598579
PPP5C	FLJ36922 \| PP5 \| PPP5	protein phosphatase 5, catalytic subunit	GNA13 (alpha-13) interacts with PPP5C (PP5).	BIND	15735747
PPP5C	FLJ36922 \| PP5 \| PPP5	protein phosphatase 5, catalytic subunit	-	HPRD,BioGRID	12176367
PRKAR2A	MGC3606 \| PKR2 \| PRKAR2	protein kinase, cAMP-dependent, regulatory, type II, alpha	Affinity Capture-Western	BioGRID	11696326
PRKCB	MGC41878 \| PKC-beta \| PKCB \| PRKCB1 \| PRKCB2	protein kinase C, beta	-	HPRD,BioGRID	8824244
PRKCD	MAY1 \| MGC49908 \| PKCD \| nPKC-delta	protein kinase C, delta	-	HPRD,BioGRID	8824244
PRKCE	MGC125656 \| MGC125657 \| PKCE \| nPKC-epsilon	protein kinase C, epsilon	-	HPRD,BioGRID	8824244
PTK2B	CADTK \| CAKB \| FADK2 \| FAK2 \| FRNK \| PKB \| PTK \| PYK2 \| RAFTK	PTK2B protein tyrosine kinase 2 beta	-	HPRD,BioGRID	10821841
RDX	DFNB24	radixin	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10816569
RGS16	A28-RGS14 \| A28-RGS14P \| RGS-R	regulator of G-protein signaling 16	-	HPRD,BioGRID	14634662
RIC8A	MGC104517 \| MGC131931 \| MGC148073 \| MGC148074 \| RIC8 \| synembryn	resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)	-	HPRD,BioGRID	12509430
S1PR2	AGR16 \| EDG-5 \| EDG5 \| Gpcr13 \| H218 \| LPB2 \| S1P2	sphingosine-1-phosphate receptor 2	-	HPRD	10488065
S1PR3	EDG-3 \| EDG3 \| FLJ37523 \| FLJ93220 \| LPB3 \| MGC71696 \| S1P3	sphingosine-1-phosphate receptor 3	-	HPRD	10488065
TBXA2R	TXA2-R	thromboxane A2 receptor	-	HPRD,BioGRID	8290554\|10395940
TEC	MGC126760 \| MGC126762 \| PSCTK4	tec protein tyrosine kinase	Phenotypic Enhancement	BioGRID	12515866
TSHR	CHNG1 \| LGR3 \| MGC75129 \| hTSHR-I	thyroid stimulating hormone receptor	-	HPRD	8552586

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION	115	81	All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION	70	53	All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON	216	144	All SZGR 2.0 genes in this pathway
BIOCARTA MYOSIN PATHWAY	31	22	All SZGR 2.0 genes in this pathway
BIOCARTA AKAP13 PATHWAY	12	11	All SZGR 2.0 genes in this pathway
BIOCARTA PAR1 PATHWAY	37	28	All SZGR 2.0 genes in this pathway
ST GA13 PATHWAY	37	32	All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY	66	53	All SZGR 2.0 genes in this pathway
PID ER NONGENOMIC PATHWAY	41	35	All SZGR 2.0 genes in this pathway
PID S1P S1P3 PATHWAY	29	24	All SZGR 2.0 genes in this pathway
PID S1P S1P4 PATHWAY	14	11	All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY	57	43	All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY	102	78	All SZGR 2.0 genes in this pathway
PID THROMBIN PAR4 PATHWAY	15	11	All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY	48	38	All SZGR 2.0 genes in this pathway
PID S1P META PATHWAY	21	14	All SZGR 2.0 genes in this pathway
PID THROMBIN PAR1 PATHWAY	43	32	All SZGR 2.0 genes in this pathway
PID S1P S1P2 PATHWAY	24	19	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME G ALPHA1213 SIGNALLING EVENTS	74	56	All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING	805	368	All SZGR 2.0 genes in this pathway
REACTOME SIGNAL AMPLIFICATION	31	19	All SZGR 2.0 genes in this pathway
REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	23	14	All SZGR 2.0 genes in this pathway
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	32	20	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS DUCTAL NORMAL UP	69	38	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL DN	74	42	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP	473	314	All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS DN	186	114	All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS LIGHTYELLOW UP	11	8	All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE UP	136	80	All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP	457	269	All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP	238	144	All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS UP	114	66	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP	501	327	All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA DN	146	94	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN	508	354	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP	1142	669	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2	127	92	All SZGR 2.0 genes in this pathway
SCHRAMM INHBA TARGETS DN	24	12	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION UP	195	138	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON	335	181	All SZGR 2.0 genes in this pathway
BROCKE APOPTOSIS REVERSED BY IL6	144	98	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
MA MYELOID DIFFERENTIATION DN	44	30	All SZGR 2.0 genes in this pathway
MENSE HYPOXIA UP	98	71	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP	240	152	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR UP	225	139	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP	314	201	All SZGR 2.0 genes in this pathway
JIANG VHL TARGETS	138	91	All SZGR 2.0 genes in this pathway
SU THYMUS	20	12	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP	105	73	All SZGR 2.0 genes in this pathway
JI RESPONSE TO FSH DN	58	43	All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL	311	205	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN	543	317	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN	593	372	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP	601	369	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
DE YY1 TARGETS DN	92	64	All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR UP	174	96	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
MOOTHA PGC	420	269	All SZGR 2.0 genes in this pathway
CROONQUIST STROMAL STIMULATION DN	13	7	All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN	414	237	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP	682	433	All SZGR 2.0 genes in this pathway
IKEDA MIR30 TARGETS UP	116	87	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D	658	397	All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A	770	480	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4	227	149	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	2681	2687	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	2681	2687	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	2681	2687	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-30-5p	615	621	1A	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
				hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: GNA13