Summary ?
GeneID10971
SymbolYWHAQ
Synonyms14-3-3|1C5|HS1
Descriptiontyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
ReferenceMIM:609009|HGNC:HGNC:12854|Ensembl:ENSG00000134308|HPRD:00886|Vega:OTTHUMG00000013848
Gene typeprotein-coding
Map location2p25.1
Pascal p-value0.248
Sherlock p-value0.57
Fetal beta0.741
DMG1 (# studies)
eGeneMyers' cis & trans
SupportINTRACELLULAR SIGNAL TRANSDUCTION
G2Cdb.human_mGluR5
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.3547 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg0246693329770529YWHAQ1.85E-5-0.3330.016DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs36781chr5109289728YWHAQ109710.12trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
KIF2C0.970.69
TACC30.960.73
HJURP0.960.70
PRC10.960.77
RAD510.960.68
BUB1B0.960.79
GTSE10.960.73
NCAPH0.960.73
NUSAP10.960.71
KIF20A0.960.69
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.27-0.40-0.66
AF347015.33-0.40-0.67
AF347015.31-0.40-0.64
HLA-F-0.40-0.54
MT-CO2-0.40-0.65
MT-CYB-0.39-0.64
TINAGL1-0.39-0.56
C5orf53-0.39-0.48
PTH1R-0.39-0.51
AF347015.8-0.38-0.65

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0019904protein domain specific bindingIEA-
GO:0047485protein N-terminus bindingIPI11984006 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0045892negative regulation of transcription, DNA-dependentIDA15163635 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005813centrosomeIDA18029348 
GO:0005634nucleusIDA18029348 
GO:0005737cytoplasmIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorReconstituted ComplexBioGRID11266503 
ARHGEF2DKFZp547L106 | DKFZp547P1516 | GEF | GEF-H1 | GEFH1 | KIAA0651 | LFP40 | P40rho/rac guanine nucleotide exchange factor (GEF) 2Affinity Capture-WesternBioGRID14970201 
BADBBC2 | BCL2L8BCL2-associated agonist of cell death-HPRD,BioGRID9369453 
BAXBCL2L4BCL2-associated X protein-HPRD,BioGRID12426317 
BRAFB-RAF1 | BRAF1 | FLJ95109 | MGC126806 | MGC138284 | RAFB1v-raf murine sarcoma viral oncogene homolog B1-HPRD8668348 
BRAFB-RAF1 | BRAF1 | FLJ95109 | MGC126806 | MGC138284 | RAFB1v-raf murine sarcoma viral oncogene homolog B1Affinity Capture-MSBioGRID17353931 
C22orf9-chromosome 22 open reading frame 9Affinity Capture-MSBioGRID17353931 
CABIN1CAIN | KIAA0330 | PPP3INcalcineurin binding protein 1YWHAQ (14-3-3-theta) interacts with phosphorylated CABIN1. This interaction was modelled on a demonstrated interaction between mouse 14-3-3-theta and human CABIN1.BIND15902271 
CALML5CLSPcalmodulin-like 5Affinity Capture-MSBioGRID17353931 
CAPN3CANP3 | CANPL3 | LGMD2 | LGMD2A | MGC10767 | MGC11121 | MGC14344 | MGC4403 | nCL-1 | p94calpain 3, (p94)-HPRD15324660 
CBLC-CBL | CBL2 | RNF55Cas-Br-M (murine) ecotropic retroviral transforming sequence-HPRD,BioGRID8663231 |11024037 
CBWD2-COBW domain containing 2Affinity Capture-MSBioGRID17353931 
CCAR1CARP-1 | CARP1 | MGC44628 | RP11-437A18.1cell division cycle and apoptosis regulator 1Affinity Capture-WesternBioGRID12816952 
CDC25B-cell division cycle 25 homolog B (S. pombe)-HPRD,BioGRID10713667 
CDC2L1CDC2L2 | CDK11 | CDK11-p110 | CDK11-p46 | CDK11-p58 | CLK-1 | FLJ59152 | PK58 | p58 | p58CDC2L1 | p58CLK-1cell division cycle 2-like 1 (PITSLRE proteins)CDK11-p110 interacts with 14-3-3-theta.BIND15883043 
CDKN1BCDKN4 | KIP1 | MEN1B | MEN4 | P27KIP1cyclin-dependent kinase inhibitor 1B (p27, Kip1)-HPRD,BioGRID12042314 
CRTC2RP11-422P24.6 | TORC2CREB regulated transcription coactivator 2Affinity Capture-MS
Affinity Capture-Western
BioGRID15454081 |17353931 
DAPK1DAPK | DKFZp781I035death-associated protein kinase 1Affinity Capture-WesternBioGRID12911633 
DDX6FLJ36338 | HLR2 | P54 | RCKDEAD (Asp-Glu-Ala-Asp) box polypeptide 6Affinity Capture-MSBioGRID17353931 
DENND4AFLJ33949 | IRLB | KIAA0476 | MYCPBPDENN/MADD domain containing 4AAffinity Capture-MSBioGRID17353931 
EDC3FLJ21128 | FLJ31777 | LSM16 | YJDC | YJEFN2enhancer of mRNA decapping 3 homolog (S. cerevisiae)Affinity Capture-MSBioGRID17353931 
EML3ELP95 | FLJ35827 | MGC111422echinoderm microtubule associated protein like 3Affinity Capture-MSBioGRID17353931 
EPB41L24.1-G | DKFZp781D1972 | DKFZp781H1755erythrocyte membrane protein band 4.1-like 2Affinity Capture-MSBioGRID17353931 
EPB41L34.1B | DAL-1 | DAL1 | FLJ37633 | KIAA0987erythrocyte membrane protein band 4.1-like 3Affinity Capture-MSBioGRID17353931 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1Reconstituted ComplexBioGRID11266503 
ESR2ER-BETA | ESR-BETA | ESRB | ESTRB | Erb | NR3A2estrogen receptor 2 (ER beta)Reconstituted ComplexBioGRID11266503 
FAM83GFLJ41564family with sequence similarity 83, member GAffinity Capture-MSBioGRID17353931 
FGRFLJ43153 | MGC75096 | SRC2 | c-fgr | c-src2 | p55c-fgr | p58c-fgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog-HPRD10066823 
FSHRFSHRO | LGR1 | MGC141667 | MGC141668 | ODG1follicle stimulating hormone receptor-HPRD15196694 
FUSIP1FUSIP2 | NSSR | SFRS13 | SRp38 | SRrp40 | TASR | TASR1 | TASR2FUS interacting protein (serine/arginine-rich) 1Affinity Capture-MSBioGRID17353931 
FXYD1MGC44983 | PLMFXYD domain containing ion transport regulator 1Reconstituted ComplexBioGRID14597563 
HDAC5FLJ90614 | HD5 | NY-CO-9histone deacetylase 5Affinity Capture-Western
Two-hybrid
BioGRID15367659 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8-HPRD15324660 
IRS2-insulin receptor substrate 2Affinity Capture-MSBioGRID17353931 
KIAA1409FLJ43337KIAA1409Affinity Capture-MSBioGRID17353931 
KIF23CHO1 | KNSL5 | MKLP-1 | MKLP1kinesin family member 23Affinity Capture-MSBioGRID17353931 
KIF5BKINH | KNS | KNS1 | UKHCkinesin family member 5BAffinity Capture-MSBioGRID17353931 
KIF5CFLJ44735 | KIAA0531 | KINN | MGC111478 | NKHC | NKHC-2 | NKHC2kinesin family member 5CAffinity Capture-MSBioGRID17353931 
KLC2FLJ12387kinesin light chain 2Affinity Capture-MSBioGRID17353931 
KLC3KLC2 | KLC2L | KLCt | KNS2Bkinesin light chain 3-HPRD15324660 
KLC4KNSL8 | MGC111777 | bA387M24.3kinesin light chain 4Affinity Capture-MSBioGRID17353931 
KRT18CYK18 | K18keratin 18Affinity Capture-WesternBioGRID9524113 
LARP1KIAA0731 | LARP | MGC19556La ribonucleoprotein domain family, member 1Affinity Capture-MSBioGRID17353931 
LUC7L2CGI-59 | CGI-74 | FLJ10657 | LUC7B2LUC7-like 2 (S. cerevisiae)Affinity Capture-MSBioGRID17353931 
LYSTCHS | CHS1lysosomal trafficking regulator-HPRD,BioGRID11984006 
MARK2EMK1 | MGC99619 | PAR-1 | Par1bMAP/microtubule affinity-regulating kinase 2Affinity Capture-MSBioGRID17353931 
MARK3CTAK1 | KP78 | PAR1AMAP/microtubule affinity-regulating kinase 3Affinity Capture-MSBioGRID17353931 
MED1CRSP1 | CRSP200 | DRIP205 | DRIP230 | MGC71488 | PBP | PPARBP | PPARGBP | RB18A | TRAP220 | TRIP2mediator complex subunit 1Reconstituted ComplexBioGRID11266503 
MEF2DDKFZp686I1536myocyte enhancer factor 2DAffinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID11433030 
MLLT4AF-6 | AF6 | AFADIN | FLJ34371 | RP3-431P23.3myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4Affinity Capture-MSBioGRID17353931 
MPRIPKIAA0864 | M-RIP | RHOIP3 | p116Ripmyosin phosphatase Rho interacting proteinAffinity Capture-MSBioGRID17353931 
NCOA1F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42nuclear receptor coactivator 1Reconstituted ComplexBioGRID11266503 
NCOA3ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIPnuclear receptor coactivator 3Reconstituted ComplexBioGRID11266503 
NFATC2KIAA0611 | NFAT1 | NFATPnuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2-HPRD,BioGRID10611249 
NFATC4NF-ATc4 | NFAT3nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4-HPRD,BioGRID10611249 
NIF3L1ALS2CR1 | CALS-7 | MDS015NIF3 NGG1 interacting factor 3-like 1 (S. pombe)-HPRD,BioGRID15163635 
NRIP1FLJ77253 | RIP140nuclear receptor interacting protein 1Co-localization
Phenotypic Suppression
Reconstituted Complex
BioGRID11266503 
PAK4-p21 protein (Cdc42/Rac)-activated kinase 4Affinity Capture-MSBioGRID17353931 
PAK6PAK5p21 protein (Cdc42/Rac)-activated kinase 6Affinity Capture-MSBioGRID17353931 
PANK2C20orf48 | FLJ17232 | HARP | HSS | MGC15053 | NBIA1 | PKANpantothenate kinase 2Affinity Capture-MSBioGRID17353931 
PDPK1MGC20087 | MGC35290 | PDK1 | PRO04613-phosphoinositide dependent protein kinase-1-HPRD,BioGRID12177059 
PFKFB2DKFZp781D2217 | MGC138308 | MGC138310 | PFK-2/FBPase-26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2-HPRD,BioGRID12853467 
PI4KBPI4K-BETA | PI4KIIIbeta | PI4Kbeta | PIK4CB | pi4K92phosphatidylinositol 4-kinase, catalytic, betaAffinity Capture-MSBioGRID17353931 
PI4KBPI4K-BETA | PI4KIIIbeta | PI4Kbeta | PIK4CB | pi4K92phosphatidylinositol 4-kinase, catalytic, beta-HPRD15324660 
PIK3CAMGC142161 | MGC142163 | PI3K | p110-alphaphosphoinositide-3-kinase, catalytic, alpha polypeptideReconstituted ComplexBioGRID8663231 
PIK3CGPI3CG | PI3K | PI3Kgamma | PIK3phosphoinositide-3-kinase, catalytic, gamma polypeptideAffinity Capture-WesternBioGRID8663231 
PNKPPNKpolynucleotide kinase 3'-phosphataseAffinity Capture-MSBioGRID17353931 
PPFIBP1L2 | hSGT2 | hSgt2pPTPRF interacting protein, binding protein 1 (liprin beta 1)Affinity Capture-MSBioGRID17353931 
PRKCZPKC-ZETA | PKC2protein kinase C, zetaAffinity Capture-Western
Biochemical Activity
Reconstituted Complex
BioGRID10620507 
PRKD1PKC-MU | PKCM | PKD | PRKCMprotein kinase D1Affinity Capture-Western
Reconstituted Complex
BioGRID10092600 |10831594 
RABEP1RAB5EP | RABPT5rabaptin, RAB GTPase binding effector protein 1Affinity Capture-MSBioGRID17353931 
RAF1CRAF | NS5 | Raf-1 | c-Rafv-raf-1 murine leukemia viral oncogene homolog 1Affinity Capture-MS
Affinity Capture-Western
Far Western
Reconstituted Complex
BioGRID8663231 |10620507 
|10757792 |17353931 
RAI14DKFZp564G013 | KIAA1334 | NORPEG | RAI13retinoic acid induced 14Affinity Capture-MSBioGRID17353931 
RASGRP3GRP3 | KIAA0846RAS guanyl releasing protein 3 (calcium and DAG-regulated)Affinity Capture-MSBioGRID17353931 
REM1GD:REM | GES | MGC48669 | REMRAS (RAD and GEM)-like GTP-binding 1-HPRD,BioGRID10441394 
RPL21DKFZp686C06101 | FLJ27458 | L21 | MGC104274 | MGC104275 | MGC71252ribosomal protein L21Affinity Capture-MSBioGRID17353931 
SAMD4BFLJ10211 | MGC99832 | SMGBsterile alpha motif domain containing 4BAffinity Capture-MSBioGRID17353931 
SFRS1ASF | MGC5228 | SF2 | SF2p33 | SRp30asplicing factor, arginine/serine-rich 1Affinity Capture-MSBioGRID17353931 
SFRS3SRp20splicing factor, arginine/serine-rich 3Affinity Capture-MSBioGRID17353931 
SFRS6B52 | FLJ08061 | MGC5045 | SRP55splicing factor, arginine/serine-rich 6Affinity Capture-MSBioGRID17353931 
SH3BP4BOG25 | TTPSH3-domain binding protein 4Affinity Capture-MSBioGRID17353931 
SPIRE1MGC150621 | MGC150622 | Spir-1spire homolog 1 (Drosophila)Affinity Capture-MSBioGRID17353931 
SUV420H1CGI-85 | CGI85 | KMT5B | MGC118906 | MGC118909 | MGC21161 | MGC703suppressor of variegation 4-20 homolog 1 (Drosophila)Affinity Capture-MSBioGRID17353931 
TERTEST2 | TCS1 | TP2 | TRT | hEST2telomerase reverse transcriptaseReconstituted Complex
Two-hybrid
BioGRID10835362 
THRAAR7 | EAR7 | ERB-T-1 | ERBA | ERBA1 | MGC000261 | MGC43240 | NR1A1 | THRA1 | THRA2 | c-ERBA-1thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)Reconstituted ComplexBioGRID11266503 
TJP2MGC26306 | X104 | ZO-2 | ZO2tight junction protein 2 (zona occludens 2)Affinity Capture-MSBioGRID17353931 
TSC1KIAA0243 | LAM | MGC86987 | TSCtuberous sclerosis 1Hamartin interacts with 14-3-3-tau. This interaction is modeled on demonstrated interaction between human hamartin and mouse 14-3-3-tau isoform.BIND12176984 
TSC2FLJ43106 | LAM | TSC4tuberous sclerosis 2Affinity Capture-MSBioGRID17353931 
TSC2FLJ43106 | LAM | TSC4tuberous sclerosis 2Tumor suppressor protein tuberin interacts with 14-3-3-tau isoform. This interaction is modeled on demonstrated interaction between human tuberin and mouse 14-3-3-tau isoform.BIND12176984 
TSC2FLJ43106 | LAM | TSC4tuberous sclerosis 2-HPRD12438239 
TUBA3CTUBA2 | bA408E5.3tubulin, alpha 3c-HPRD15324660 
UCP2BMIQ4 | SLC25A8 | UCPHuncoupling protein 2 (mitochondrial, proton carrier)-HPRD,BioGRID10785390 
UCP2BMIQ4 | SLC25A8 | UCPHuncoupling protein 2 (mitochondrial, proton carrier)UCP2 interacts with 14.3.3-theta.BIND10785390 
UCP3SLC25A9uncoupling protein 3 (mitochondrial, proton carrier)UCP3 interacts with 14.3.3-theta.BIND10785390 
UCP3SLC25A9uncoupling protein 3 (mitochondrial, proton carrier)-HPRD,BioGRID10785390 
USP8FLJ34456 | HumORF8 | KIAA0055 | MGC129718 | UBPYubiquitin specific peptidase 8Affinity Capture-MSBioGRID17353931 
WDR77HKMT1069 | MEP50 | MGC2722 | Nbla10071 | RP11-552M11.3 | p44WD repeat domain 77-HPRD15324660 
YAP1YAP | YAP2 | YAP65 | YKIYes-associated protein 1, 65kDa-HPRD,BioGRID12535517 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CELL CYCLE 12884All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS 11479All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126103All SZGR 2.0 genes in this pathway
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION 5936All SZGR 2.0 genes in this pathway
BIOCARTA G2 PATHWAY 2420All SZGR 2.0 genes in this pathway
BIOCARTA CHREBP2 PATHWAY 4235All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN CARDIAC MYOCTES 6754All SZGR 2.0 genes in this pathway
SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES 5141All SZGR 2.0 genes in this pathway
ST PHOSPHOINOSITIDE 3 KINASE PATHWAY 3729All SZGR 2.0 genes in this pathway
PID LKB1 PATHWAY 4737All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY 5447All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY 6955All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY 4943All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 10578All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129103All SZGR 2.0 genes in this pathway
PID P38 MK2 PATHWAY 2119All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY 8060All SZGR 2.0 genes in this pathway
PID A6B1 A6B4 INTEGRIN PATHWAY 4635All SZGR 2.0 genes in this pathway
PID INSULIN GLUCOSE PATHWAY 2624All SZGR 2.0 genes in this pathway
PID PI3KCI AKT PATHWAY 3530All SZGR 2.0 genes in this pathway
PID TAP63 PATHWAY 5440All SZGR 2.0 genes in this pathway
PID PI3K PLC TRK PATHWAY 3631All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305185All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557331All SZGR 2.0 genes in this pathway
MAYBURD RESPONSE TO L663536 DN 5632All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP 12895All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 11784All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329196All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770415All SZGR 2.0 genes in this pathway
WANG ESOPHAGUS CANCER VS NORMAL DN 10166All SZGR 2.0 genes in this pathway
MARTIN INTERACT WITH HDAC 4431All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER 178108All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
KOMMAGANI TP63 GAMMA TARGETS 97All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024594All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
SCIAN INVERSED TARGETS OF TP53 AND TP73 DN 3123All SZGR 2.0 genes in this pathway
DEN INTERACT WITH LCA5 2621All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG DN 8556All SZGR 2.0 genes in this pathway
FAELT B CLL WITH VH REARRANGEMENTS DN 4826All SZGR 2.0 genes in this pathway
MARCHINI TRABECTEDIN RESISTANCE UP 2116All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA DN 5233All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN 9671All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST 13293All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER T4 9469All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342220All SZGR 2.0 genes in this pathway
ALONSO METASTASIS UP 198128All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL DN 175103All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338225All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418282All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245150All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES 389245All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442263All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682440All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548370All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/206400406m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-129-5p9449501Ahsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-139934940m8hsa-miR-139brainUCUACAGUGCACGUGUCU
hsa-miR-139brainUCUACAGUGCACGUGUCU
miR-15/16/195/424/497617623m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d6936991Ahsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-203.12252311Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-320138144m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-376c9729781Ahsa-miR-376cAACAUAGAGGAAAUUCCACG
miR-378*8118181A,m8hsa-miR-422bCUGGACUUGGAGUCAGAAGGCC
hsa-miR-422aCUGGACUUAGGGUCAGAAGGCC
miR-5439619671Ahsa-miR-543AAACAUUCGCGGUGCACUUCU