SZGR2

Summary ?

GeneID	142
Symbol	PARP1
Synonyms	ADPRT\|ADPRT 1\|ADPRT1\|ARTD1\|PARP\|PARP-1\|PPOL\|pADPRT-1
Description	poly(ADP-ribose) polymerase 1
Reference	MIM:173870\|HGNC:HGNC:270\|Ensembl:ENSG00000143799\|HPRD:01435\|Vega:OTTHUMG00000037556
Gene type	protein-coding
Map location	1q41-q42
Sherlock p-value	0.664
Fetal beta	-0.497
DMG	1 (# studies)
eGene	Cerebellar Hemisphere Cerebellum
Support	G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0455

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg17127702	1	226594323	PARP1	5.818E-4	0.444	0.049	DMG:Wockner_2014

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003950	NAD+ ADP-ribosyltransferase activity	IDA		16107709
GO:0003677	DNA binding	IEA		-
GO:0003677	DNA binding	TAS		2513174
GO:0016757	transferase activity, transferring glycosyl groups	IEA		-
GO:0008270	zinc ion binding	IEA		-
GO:0042802	identical protein binding	IPI		14734561
GO:0051287	NAD binding	IEA		-
GO:0046872	metal ion binding	IEA		-
GO:0047485	protein N-terminus binding	IPI		16107709
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006471	protein amino acid ADP-ribosylation	TAS		2513174
GO:0006366	transcription from RNA polymerase II promoter	TAS		10944198
GO:0006281	DNA repair	TAS		10958667
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005622	intracellular	IEA		-
GO:0005634	nucleus	IEA		-
GO:0005634	nucleus	TAS		2513174
GO:0005635	nuclear envelope	IDA		9518481
GO:0005730	nucleolus	IDA		9518481 \|16107709

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
APTX	AOA \| AOA1 \| AXA1 \| EAOH \| EOAHA \| FHA-HIT \| FLJ20157 \| MGC1072	aprataxin	-	HPRD,BioGRID	15044383
BCL2	Bcl-2	B-cell CLL/lymphoma 2	-	HPRD,BioGRID	11790116
BUB3	BUB3L \| hBUB3	budding uninhibited by benzimidazoles 3 homolog (yeast)	-	HPRD,BioGRID	12011073
CASP3	CPP32 \| CPP32B \| SCA-1	caspase 3, apoptosis-related cysteine peptidase	PARP interacts with Caspase-3. This interaction was modeled on a demonstrated interaction between human PARP and caspase-3 from an unspecified source.	BIND	15186778
CASP7	CMH-1 \| ICE-LAP3 \| MCH3	caspase 7, apoptosis-related cysteine peptidase	PARP interacts with caspase-7. This interaction was modelled on a demonstrated interaction between human PARP and fly drICE.	BIND	15580265
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	-	HPRD,BioGRID	12930846
CENPA	CENP-A	centromere protein A	-	HPRD,BioGRID	12011073
CENPB	-	centromere protein B, 80kDa	-	HPRD,BioGRID	12011073
MED6	NY-REN-28	mediator complex subunit 6	PARP-1 interacts with Med6.	BIND	15808511
MYBL2	B-MYB \| BMYB \| MGC15600	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	-	HPRD,BioGRID	10744766
NCOA6	AIB3 \| ANTP \| ASC2 \| HOX1.1 \| HOXA7 \| KIAA0181 \| NRC \| PRIP \| RAP250 \| TRBP	nuclear receptor coactivator 6	Affinity Capture-MS	BioGRID	12519782
NFKB1	DKFZp686C01211 \| EBP-1 \| KBF1 \| MGC54151 \| NF-kappa-B \| NFKB-p105 \| NFKB-p50 \| p105	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	-	HPRD	11590148
PARP2	ADPRT2 \| ADPRTL2 \| ADPRTL3 \| PARP-2 \| pADPRT-2	poly (ADP-ribose) polymerase 2	-	HPRD,BioGRID	12217960
PARP3	ADPRT3 \| ADPRTL2 \| ADPRTL3 \| IRT1 \| hPARP-3 \| pADPRT-3	poly (ADP-ribose) polymerase family, member 3	-	HPRD,BioGRID	12640039
PCNA	MGC8367	proliferating cell nuclear antigen	Affinity Capture-Western	BioGRID	12930846
POLA1	DKFZp686K1672 \| POLA \| p180	polymerase (DNA directed), alpha 1, catalytic subunit	-	HPRD,BioGRID	9518481 \|9563011
POLA2	FLJ21662 \| FLJ37250	polymerase (DNA directed), alpha 2 (70kD subunit)	-	HPRD,BioGRID	9518481
POU2F1	OCT1 \| OTF1	POU class 2 homeobox 1	-	HPRD	9537509
PRKDC	DNA-PKcs \| DNAPK \| DNPK1 \| HYRC \| HYRC1 \| XRCC7 \| p350	protein kinase, DNA-activated, catalytic polypeptide	-	HPRD	9398855
RARA	NR1B1 \| RAR	retinoic acid receptor, alpha	PARP-1 interacts with RAR-alpha.	BIND	15808511
RBM14	COAA \| DKFZp779J0927 \| MGC15912 \| MGC31756 \| PSP2 \| SIP \| SYTIP1 \| TMEM137	RNA binding motif protein 14	-	HPRD,BioGRID	11443112
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	-	HPRD,BioGRID	11590148
RPS3A	FTE1 \| MFTL \| MGC23240	ribosomal protein S3A	-	HPRD,BioGRID	11790116
RXRA	FLJ00280 \| FLJ00318 \| FLJ16020 \| FLJ16733 \| MGC102720 \| NR2B1	retinoid X receptor, alpha	-	HPRD	10082530
SFRS12	DKFZp564B176 \| MGC133045 \| SRrp508 \| SRrp86	splicing factor, arginine/serine-rich 12	-	HPRD	14559993
SWAP70	FLJ39540 \| HSPC321 \| KIAA0640 \| SWAP-70	SWAP-70 protein	-	HPRD,BioGRID	9642267
TAL1	SCL \| TCL5 \| bHLHa17 \| tal-1	T-cell acute lymphocytic leukemia 1	Affinity Capture-MS	BioGRID	16407974
TERF2IP	DRIP5 \| RAP1	telomeric repeat binding factor 2, interacting protein	Affinity Capture-MS	BioGRID	15100233
THRA	AR7 \| EAR7 \| ERB-T-1 \| ERBA \| ERBA1 \| MGC000261 \| MGC43240 \| NR1A1 \| THRA1 \| THRA2 \| c-ERBA-1	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	PARP-1 interacts with TR-alpha. This interaction was modeled on a demonstrated interaction between human PARP-1 and TR-alpha from an unspecified species.	BIND	15808511
TOP1	TOPI	topoisomerase (DNA) I	PARP-1 interacts with Topo I	BIND	15247263
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	-	HPRD,BioGRID	9565608
WRN	DKFZp686C2056 \| RECQ3 \| RECQL2 \| RECQL3	Werner syndrome	WRN interacts with PARP1.	BIND	14734561
XRCC1	RCC	X-ray repair complementing defective repair in Chinese hamster cells 1	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	9584196 \|15044383
XRCC1	RCC	X-ray repair complementing defective repair in Chinese hamster cells 1	-	HPRD	9584196 \|14500814
ZNF423	Ebfaz \| KIAA0760 \| MGC138520 \| MGC138522 \| OAZ \| Roaz \| ZFP423 \| Zfp104	zinc finger protein 423	-	HPRD,BioGRID	14623329

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG BASE EXCISION REPAIR	35	22	All SZGR 2.0 genes in this pathway
BIOCARTA CHEMICAL PATHWAY	22	15	All SZGR 2.0 genes in this pathway
BIOCARTA CASPASE PATHWAY	23	15	All SZGR 2.0 genes in this pathway
BIOCARTA D4GDI PATHWAY	13	8	All SZGR 2.0 genes in this pathway
BIOCARTA FAS PATHWAY	30	22	All SZGR 2.0 genes in this pathway
BIOCARTA HIVNEF PATHWAY	58	43	All SZGR 2.0 genes in this pathway
BIOCARTA TNFR1 PATHWAY	29	21	All SZGR 2.0 genes in this pathway
SA CASPASE CASCADE	19	13	All SZGR 2.0 genes in this pathway
ST GRANULE CELL SURVIVAL PATHWAY	27	23	All SZGR 2.0 genes in this pathway
ST FAS SIGNALING PATHWAY	65	54	All SZGR 2.0 genes in this pathway
PID ILK PATHWAY	45	32	All SZGR 2.0 genes in this pathway
PID CASPASE PATHWAY	52	39	All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY	48	39	All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	38	26	All SZGR 2.0 genes in this pathway
REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	20	14	All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY	352	181	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX	63	42	All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 UP	201	125	All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS UP	332	228	All SZGR 2.0 genes in this pathway
PRAMOONJAGO SOX4 TARGETS DN	51	35	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN	485	334	All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN	228	137	All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP UP	117	85	All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL	116	62	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP	479	299	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY UP	236	139	All SZGR 2.0 genes in this pathway
BENPORATH ES 1	379	235	All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX	230	156	All SZGR 2.0 genes in this pathway
BENPORATH PROLIFERATION	147	80	All SZGR 2.0 genes in this pathway
COLLIS PRKDC SUBSTRATES	20	15	All SZGR 2.0 genes in this pathway
COLLIS PRKDC REGULATORS	15	10	All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES	230	137	All SZGR 2.0 genes in this pathway
DER IFN BETA RESPONSE UP	102	67	All SZGR 2.0 genes in this pathway
MANALO HYPOXIA DN	289	166	All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA	176	122	All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK UP	63	48	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
DER IFN GAMMA RESPONSE UP	71	45	All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS UP	126	84	All SZGR 2.0 genes in this pathway
CROMER METASTASIS UP	79	46	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN	163	115	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR	532	309	All SZGR 2.0 genes in this pathway
LY AGING PREMATURE DN	30	17	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE DN	261	183	All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP	77	57	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN	165	106	All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRCA1 VS BRCA2	163	113	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
LY AGING OLD DN	56	35	All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D8	40	29	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1	528	324	All SZGR 2.0 genes in this pathway
SANSOM WNT PATHWAY REQUIRE MYC	58	43	All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS DN	120	81	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP	863	514	All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN	249	165	All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP	425	253	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN	342	220	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN	277	166	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
ONO AML1 TARGETS DN	41	25	All SZGR 2.0 genes in this pathway
ONO FOXP3 TARGETS DN	42	23	All SZGR 2.0 genes in this pathway
SYED ESTRADIOL RESPONSE	19	15	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE	335	193	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS DURATION CORR DN	146	90	All SZGR 2.0 genes in this pathway
GABRIELY MIR21 TARGETS	289	187	All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS UP	84	51	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
ABDELMOHSEN ELAVL4 TARGETS	16	13	All SZGR 2.0 genes in this pathway
ABRAMSON INTERACT WITH AIRE	45	33	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	326	332	m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	326	332	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	326	332	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: PARP1