SZGR2

Summary ?

GeneID	2033
Symbol	EP300
Synonyms	KAT3B\|RSTS2\|p300
Description	E1A binding protein p300
Reference	MIM:602700\|HGNC:HGNC:3373\|Ensembl:ENSG00000100393\|HPRD:04078\|Vega:OTTHUMG00000150937
Gene type	protein-coding
Map location	22q13.2
Pascal p-value	6.924E-6
Sherlock p-value	0.807
Fetal beta	0.728
eGene	Cerebellar Hemisphere Myers' cis & trans Meta
Support	CompositeSet Darnell FMRP targets Ascano FMRP targets Chromatin Remodeling Genes

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:PGCnp	Genome-wide Association Study	GWAS
DNM:Fromer_2014	Whole Exome Sequencing analysis	This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 2
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0862

Section I. Genetics and epigenetics annotation

DNM table

Gene	Chromosome	Position	Ref	Alt	Transcript	AA change	Mutation type	Sift	CG46	Trait	Study
EP300	chr22	41546041	C	G	NM_001429	p.886P>A	missense			Schizophrenia	DNM:Fromer_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs16829545	chr2	151977407	EP300	2033	1.229E-4	trans
rs9810143	chr3	5060209	EP300	2033	0.11	trans
rs11186601	chr10	93287199	EP300	2033	0.11	trans
rs16955618	chr15	29937543	EP300	2033	0	trans
rs16990575	chrX	32691327	EP300	2033	0.18	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
DLG5	0.96	0.95
EHMT1	0.95	0.90
ZXDC	0.95	0.94
NUP62	0.95	0.97
PFAS	0.95	0.97
RBM15B	0.95	0.97
CD276	0.95	0.93
DNMT1	0.95	0.97
GPR161	0.95	0.94
PHF2	0.94	0.93

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
C5orf53	-0.73	-0.80
AIFM3	-0.71	-0.79
HLA-F	-0.71	-0.78
AF347015.31	-0.70	-0.92
AF347015.27	-0.70	-0.92
S100B	-0.70	-0.87
ALDOC	-0.70	-0.73
MT-CO2	-0.69	-0.93
AF347015.33	-0.69	-0.90
TSC22D4	-0.68	-0.80

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003700	transcription factor activity	TAS		10893273
GO:0003713	transcription coactivator activity	IDA		12435739 \|12586840
GO:0004402	histone acetyltransferase activity	IDA		12040021
GO:0016740	transferase activity	IEA		-
GO:0008270	zinc ion binding	IEA		-
GO:0008022	protein C-terminus binding	TAS		10205054
GO:0016407	acetyltransferase activity	IMP		12435739
GO:0046872	metal ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007519	skeletal muscle development	IEA	neuron (GO term level: 8)	-
GO:0007399	nervous system development	TAS	neurite (GO term level: 5)	10205054
GO:0001756	somitogenesis	IEA		-
GO:0001666	response to hypoxia	IDA		15261140
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0009887	organ morphogenesis	IEA		-
GO:0007165	signal transduction	NAS		15261140
GO:0007049	cell cycle	IEA		-
GO:0007507	heart development	IEA		-
GO:0006915	apoptosis	IMP		9194565
GO:0018076	N-terminal peptidyl-lysine acetylation	IDA		12435739
GO:0051091	positive regulation of transcription factor activity	IDA		10518217
GO:0016573	histone acetylation	IEA		-
GO:0042592	homeostatic process	TAS		15261140
GO:0030324	lung development	IEA		-
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA		-
GO:0044419	interspecies interaction between organisms	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000123	histone acetyltransferase complex	IEA		-
GO:0005634	nucleus	IDA		9194565
GO:0005730	nucleolus	IDA		18029348
GO:0005737	cytoplasm	IDA		18029348

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ALX1	CART1	ALX homeobox 1	-	HPRD	12929931
ARNTL	BMAL1 \| BMAL1c \| JAP3 \| MGC47515 \| MOP3 \| PASD3 \| TIC \| bHLHe5	aryl hydrocarbon receptor nuclear translocator-like	Reconstituted Complex	BioGRID	14645221
ASCL1	ASH1 \| HASH1 \| MASH1 \| bHLHa46	achaete-scute complex homolog 1 (Drosophila)	Affinity Capture-Western	BioGRID	11564735
BCL3	BCL4 \| D19S37	B-cell CLL/lymphoma 3	Reconstituted Complex Two-hybrid	BioGRID	10497212
BIRC3	AIP1 \| API2 \| CIAP2 \| HAIP1 \| HIAP1 \| MALT2 \| MIHC \| RNF49	baculoviral IAP repeat-containing 3	The cIAP-2 promoter interacts with p300.	BIND	15494311
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	-	HPRD,BioGRID	10655477
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	p300 interacts with BRCA1.	BIND	10655477
CARM1	PRMT4	coactivator-associated arginine methyltransferase 1	CARM1 interacts with p300.	BIND	15616592
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	-	HPRD,BioGRID	11788592
CDX2	CDX-3 \| CDX3	caudal type homeobox 2	-	HPRD,BioGRID	10506141
CEBPB	C/EBP-beta \| CRP2 \| IL6DBP \| LAP \| MGC32080 \| NF-IL6 \| TCF5	CCAAT/enhancer binding protein (C/EBP), beta	-	HPRD,BioGRID	9343424
CITED1	MSG1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1	-	HPRD,BioGRID	10722728
CITED2	MRG1 \| P35SRJ	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	9887100 \|10593900 \|11744733 \|12586840
CITED2	MRG1 \| P35SRJ	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	-	HPRD	9887100 \|12586840
CITED4	-	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4	-	HPRD,BioGRID	11744733
CLOCK	KAT13D \| KIAA0334 \| bHLHe8	clock homolog (mouse)	Reconstituted Complex	BioGRID	14645221
CNTN2	AXT \| DKFZp781D102 \| FLJ42746 \| MGC157722 \| TAG-1 \| TAX \| TAX1	contactin 2 (axonal)	Phenotypic Suppression	BioGRID	11264182
COPS6	CSN6 \| MOV34-34KD	COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis)	Two-hybrid	BioGRID	16169070
CREB1	CREB \| MGC9284	cAMP responsive element binding protein 1	Affinity Capture-Western	BioGRID	10506141
CTBP1	BARS \| MGC104684	C-terminal binding protein 1	CTBP1 interacts with EP300 (p300)	BIND	15834423
CXCL10	C7 \| IFI10 \| INP10 \| IP-10 \| SCYB10 \| crg-2 \| gIP-10 \| mob-1	chemokine (C-X-C motif) ligand 10	p300 interacts with promoter IP-10.	BIND	15315758
DDX5	DKFZp686J01190 \| G17P1 \| HLR1 \| HUMP68 \| p68	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	Affinity Capture-Western	BioGRID	12527917
DTX1	hDx-1	deltex homolog 1 (Drosophila)	-	HPRD,BioGRID	11564735
EGR1	AT225 \| G0S30 \| KROX-24 \| NGFI-A \| TIS8 \| ZIF-268 \| ZNF225	early growth response 1	p300 interacts with Egr1 promoter.	BIND	15225550
EGR1	AT225 \| G0S30 \| KROX-24 \| NGFI-A \| TIS8 \| ZIF-268 \| ZNF225	early growth response 1	-	HPRD,BioGRID	9806899
EGR1	AT225 \| G0S30 \| KROX-24 \| NGFI-A \| TIS8 \| ZIF-268 \| ZNF225	early growth response 1	p300 interacts with Egr1.	BIND	15225550
EID1	C15orf3 \| CRI1 \| EID-1 \| IRO45620 \| MGC138883 \| MGC138884 \| PNAS-22 \| PTD014 \| RBP21	EP300 interacting inhibitor of differentiation 1	-	HPRD,BioGRID	11073989 \|11073990
EID2	CRI2 \| EID-2 \| MGC20452	EP300 interacting inhibitor of differentiation 2	-	HPRD	14585496
ELK1	-	ELK1, member of ETS oncogene family	Affinity Capture-Western Phenotypic Enhancement Reconstituted Complex	BioGRID	12514134
EP300	KAT3B \| p300	E1A binding protein p300	Biochemical Activity	BioGRID	10567538
EP300	KAT3B \| p300	E1A binding protein p300	EP300 (p300) autoacetylates. This interaction was modeled on a demonstrated interaction using EP300 from an unspecified species.	BIND	14761960
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	-	HPRD,BioGRID	11782371
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	EP300 (p300) acetylates ESR1 (ER-alpha). This interaction was modeled on a demonstrated interaction between EP300 from an unspecified species and ESR1 from an unspecified species.	BIND	14761960
ETS1	ETS-1 \| EWSR2 \| FLJ10768	v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)	-	HPRD,BioGRID	10942770
ETS2	ETS2IT1	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)	-	HPRD,BioGRID	10942770
FEN1	FEN-1 \| MF1 \| RAD2	flap structure-specific endonuclease 1	-	HPRD,BioGRID	11430825
GATA6	-	GATA binding protein 6	-	HPRD,BioGRID	10851229
GPS2	AMF-1 \| MGC104294 \| MGC119287 \| MGC119288 \| MGC119289	G protein pathway suppressor 2	-	HPRD,BioGRID	10846067
GTF2B	TF2B \| TFIIB	general transcription factor IIB	p300 interacts with TFIIB. This interaction is modelled on a demonstrated interaction between human p300 and TFIIB from an unspecified species.	BIND	8621548
H3F3A	H3.3A \| H3F3 \| MGC87782 \| MGC87783	H3 histone, family 3A	EP300 (p300) interacts with H3F3A (histone 3).	BIND	15834423
HAND2	DHAND2 \| FLJ16260 \| Hed \| MGC125303 \| MGC125304 \| Thing2 \| bHLHa26 \| dHand	heart and neural crest derivatives expressed 2	-	HPRD,BioGRID	11994297
HIF1A	HIF-1alpha \| HIF1 \| HIF1-ALPHA \| MOP1 \| PASD8	hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	-	HPRD,BioGRID	11823643
HIST4H4	H4/p \| MGC24116	histone cluster 4, H4	EP300 (p300) interacts with HIST4H4 (histone 4)	BIND	15834423
HNF1A	HNF1 \| LFB1 \| MODY3 \| TCF1	HNF1 homeobox A	-	HPRD,BioGRID	11978637
HNRNPU	HNRPU \| SAF-A \| U21.1	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)	-	HPRD,BioGRID	11909954
IL8	CXCL8 \| GCP-1 \| GCP1 \| LECT \| LUCT \| LYNAP \| MDNCF \| MONAP \| NAF \| NAP-1 \| NAP1	interleukin 8	The IL-8 promoter interacts with p300.	BIND	15494311
ING1	p24ING1c \| p33 \| p33ING1 \| p33ING1b \| p47 \| p47ING1a	inhibitor of growth family, member 1	-	HPRD,BioGRID	12015309
ING4	MGC12557 \| my036 \| p29ING4	inhibitor of growth family, member 4	p300 interacts with p29ING4.	BIND	12750254
ING4	MGC12557 \| my036 \| p29ING4	inhibitor of growth family, member 4	-	HPRD,BioGRID	12750254
ING5	FLJ23842 \| p28ING5	inhibitor of growth family, member 5	-	HPRD,BioGRID	12750254
ING5	FLJ23842 \| p28ING5	inhibitor of growth family, member 5	p300 interacts with p28ING5.	BIND	12750254
IRF2	DKFZp686F0244 \| IRF-2	interferon regulatory factor 2	Affinity Capture-Western Biochemical Activity Reconstituted Complex	BioGRID	11304541
JDP2	JUNDM2	Jun dimerization protein 2	-	HPRD	12101239
JMY	FLJ37870 \| MGC163496	junction-mediating and regulatory protein	-	HPRD,BioGRID	10518217
KAT2B	CAF \| P \| P/CAF \| PCAF	K(lysine) acetyltransferase 2B	Biochemical Activity	BioGRID	12419806
KLF5	BTEB2 \| CKLF \| IKLF	Kruppel-like factor 5 (intestinal)	Affinity Capture-Western	BioGRID	14612398
LEF1	DKFZp586H0919 \| TCF1ALPHA	lymphoid enhancer-binding factor 1	-	HPRD,BioGRID	12446687
MAF	MGC71685 \| c-MAF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)	p300 interacts with c-Maf. This interaction was modeled on a demonstrated interaction between c-Maf from an unspecified source and human p300.	BIND	11943779
MAF	MGC71685 \| c-MAF	v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)	-	HPRD,BioGRID	11943779
MAML1	KIAA0200 \| Mam-1 \| Mam1	mastermind-like 1 (Drosophila)	-	HPRD,BioGRID	12050117 \|12391150
MAML1	KIAA0200 \| Mam-1 \| Mam1	mastermind-like 1 (Drosophila)	p300 interacts with MAML1. This interaction was modeled on a demonstrated interaction between p300 from an unspecified species and human MAML1.	BIND	12391150
MDM2	HDMX \| MGC71221 \| hdm2	Mdm2 p53 binding protein homolog (mouse)	-	HPRD,BioGRID	9809062
MDM4	DKFZp781B1423 \| HDMX \| MDMX \| MGC132766 \| MRP1	Mdm4 p53 binding protein homolog (mouse)	-	HPRD,BioGRID	12483531
MEF2A	ADCAD1 \| RSRFC4 \| RSRFC9	myocyte enhancer factor 2A	-	HPRD,BioGRID	12371907
MEF2C	-	myocyte enhancer factor 2C	Phenotypic Enhancement Reconstituted Complex	BioGRID	9001254
MEF2D	DKFZp686I1536	myocyte enhancer factor 2D	Affinity Capture-Western	BioGRID	10825153 \|10933397
MGMT	-	O-6-methylguanine-DNA methyltransferase	-	HPRD,BioGRID	11564893
MPG	AAG \| APNG \| CRA36.1 \| MDG \| Mid1 \| PIG11 \| PIG16 \| anpg	N-methylpurine-DNA glycosylase	EP300 (p300) acetylates MPG. This interaction was modeled on a demonstrated interaction between EP300 from an unspecified species and MPG from an unspecified species.	BIND	14761960
MYB	Cmyb \| c-myb \| c-myb_CDS \| efg	v-myb myeloblastosis viral oncogene homolog (avian)	c-Myb interacts with p300.	BIND	15691758
MYBL2	B-MYB \| BMYB \| MGC15600	v-myb myeloblastosis viral oncogene homolog (avian)-like 2	-	HPRD,BioGRID	11733503
MYOD1	MYF3 \| MYOD \| PUM \| bHLHc1	myogenic differentiation 1	-	HPRD,BioGRID	9001254
MYOD1	MYF3 \| MYOD \| PUM \| bHLHc1	myogenic differentiation 1	p300 interacts with MyoD. This interaction is modelled on a demonstrated interaction between human and mouse p300 and MyoD from mouse and an unspecified species.	BIND	8621548
N4BP2	B3BP \| FLJ10680 \| KIAA1413	NEDD4 binding protein 2	-	HPRD,BioGRID	12730195
NCOA1	F-SRC-1 \| KAT13A \| MGC129719 \| MGC129720 \| NCoA-1 \| RIP160 \| SRC-1 \| SRC1 \| bHLHe42	nuclear receptor coactivator 1	-	HPRD	11113179
NCOA1	F-SRC-1 \| KAT13A \| MGC129719 \| MGC129720 \| NCoA-1 \| RIP160 \| SRC-1 \| SRC1 \| bHLHe42	nuclear receptor coactivator 1	NCOA1 (SRC-1) interacts with EP300 (p300).	BIND	15688032
NCOA2	GRIP1 \| KAT13C \| MGC138808 \| NCoA-2 \| TIF2	nuclear receptor coactivator 2	GRIP1 interacts with p300. This interaction was modeled on a demonstrated interaction between mouse GRIP1 and human p300.	BIND	9920895
NCOA3	ACTR \| AIB-1 \| AIB1 \| CAGH16 \| CTG26 \| KAT13B \| MGC141848 \| RAC3 \| SRC3 \| TNRC14 \| TNRC16 \| TRAM-1 \| pCIP	nuclear receptor coactivator 3	Affinity Capture-Western	BioGRID	10655477
NCOA6	AIB3 \| ANTP \| ASC2 \| HOX1.1 \| HOXA7 \| KIAA0181 \| NRC \| PRIP \| RAP250 \| TRBP	nuclear receptor coactivator 6	-	HPRD,BioGRID	10823961
NEIL2	FLJ31644 \| MGC2832 \| MGC4505 \| NEH2 \| NEI2	nei like 2 (E. coli)	-	HPRD	15175427
NEUROD1	BETA2 \| BHF-1 \| NEUROD \| bHLHa3	neurogenic differentiation 1	-	HPRD,BioGRID	10545951
NEUROG1	AKA \| Math4C \| NEUROD3 \| bHLHa6 \| ngn1	neurogenin 1	Phenotypic Enhancement	BioGRID	11239394
NFATC2	KIAA0611 \| NFAT1 \| NFATP	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	-	HPRD,BioGRID	9625762
NPAS2	FLJ23138 \| MGC71151 \| MOP4 \| PASD4 \| bHLHe9	neuronal PAS domain protein 2	Reconstituted Complex	BioGRID	14645221
NR4A1	GFRP1 \| HMR \| MGC9485 \| N10 \| NAK-1 \| NGFIB \| NP10 \| NUR77 \| TR3	nuclear receptor subfamily 4, group A, member 1	-	HPRD,BioGRID	12082103
NUP98	ADIR2 \| NUP196 \| NUP96	nucleoporin 98kDa	Affinity Capture-Western	BioGRID	9858599
NUPR1	COM1 \| P8	nuclear protein 1	p8 interacts with and is acetylated by p300.	BIND	11940591
P53AIP1	-	p53-regulated apoptosis-inducing protein 1	p300 interacts with p53AIP1 promoter.	BIND	15893728
PAX6	AN \| AN2 \| D11S812E \| MGC17209 \| MGDA \| WAGR	paired box 6	Affinity Capture-Western Reconstituted Complex	BioGRID	10506141
PCNA	MGC8367	proliferating cell nuclear antigen	-	HPRD,BioGRID	11268218
PELP1	HMX3 \| MNAR \| P160	proline, glutamate and leucine rich protein 1	-	HPRD,BioGRID	11481323
PIAS3	FLJ14651 \| ZMIZ5	protein inhibitor of activated STAT, 3	Affinity Capture-Western	BioGRID	14691252
POLR2A	MGC75453 \| POLR2 \| POLRA \| RPB1 \| RPBh1 \| RPO2 \| RPOL2 \| RpIILS \| hRPB220 \| hsRPB1	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	Affinity Capture-Western Co-purification	BioGRID	9443979 \|9710619
POU3F2	BRN2 \| OCT7 \| OTF7 \| POUF3	POU class 3 homeobox 2	Brn-2 interacts with p300.	BIND	11029584
PPARA	MGC2237 \| MGC2452 \| NR1C1 \| PPAR \| hPPAR	peroxisome proliferator-activated receptor alpha	-	HPRD,BioGRID	9407140
PPARD	FAAR \| MGC3931 \| NR1C2 \| NUC1 \| NUCI \| NUCII \| PPAR-beta \| PPARB	peroxisome proliferator-activated receptor delta	-	HPRD	10567538
PPARG	NR1C3 \| PPARG1 \| PPARG2 \| PPARgamma	peroxisome proliferator-activated receptor gamma	Reconstituted Complex Two-hybrid	BioGRID	10944516 \|12479814
PROX1	-	prospero homeobox 1	-	HPRD,BioGRID	11943779
PROX1	-	prospero homeobox 1	p300 interacts with Prox-1. This interaction was modeled on a demonstrated interaction between Prox-1 from an unspecified source and human p300.	BIND	11943779
PTMA	MGC104802 \| TMSA	prothymosin, alpha	-	HPRD,BioGRID	11967287
RAD23A	HHR23A \| MGC111083	RAD23 homolog A (S. cerevisiae)	hHR23A interacts with p300. This interaction was modelled on a demonstrated interaction between hHR23A from human and p300 from an unspecified species.	BIND	11196199
RBM14	COAA \| DKFZp779J0927 \| MGC15912 \| MGC31756 \| PSP2 \| SIP \| SYTIP1 \| TMEM137	RNA binding motif protein 14	-	HPRD,BioGRID	11443112
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	p300 interacts with p65.	BIND	9096323
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	p300 interacts with p65.	BIND	15616592
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	-	HPRD,BioGRID	9096323
RORA	DKFZp686M2414 \| MGC119326 \| MGC119329 \| NR1F1 \| ROR1 \| ROR2 \| ROR3 \| RZR-ALPHA \| RZRA	RAR-related orphan receptor A	-	HPRD,BioGRID	9862959
RUNX3	AML2 \| CBFA3 \| FLJ34510 \| MGC16070 \| PEBP2aC	runt-related transcription factor 3	-	HPRD	15138260
SMAD1	BSP1 \| JV4-1 \| JV41 \| MADH1 \| MADR1	SMAD family member 1	-	HPRD,BioGRID	10673036
SMAD2	JV18 \| JV18-1 \| MADH2 \| MADR2 \| MGC22139 \| MGC34440 \| hMAD-2 \| hSMAD2	SMAD family member 2	p300 interacts with Smad2. This interaction was modeled on a demonstrated interaction between p300 from an unspecified species and human Smad2.	BIND	9679056
SMAD2	JV18 \| JV18-1 \| MADH2 \| MADR2 \| MGC22139 \| MGC34440 \| hMAD-2 \| hSMAD2	SMAD family member 2	Affinity Capture-Western	BioGRID	10199400 \|11371641
SMAD2	JV18 \| JV18-1 \| MADH2 \| MADR2 \| MGC22139 \| MGC34440 \| hMAD-2 \| hSMAD2	SMAD family member 2	-	HPRD	11264182
SMAD3	DKFZp586N0721 \| DKFZp686J10186 \| HSPC193 \| HsT17436 \| JV15-2 \| MADH3 \| MGC60396	SMAD family member 3	Smad3 interacts with p300. This interaction was modeled on a demonstrated interaction between Smad3 and p300 from an unspecified sources.	BIND	10497242
SMAD3	DKFZp586N0721 \| DKFZp686J10186 \| HSPC193 \| HsT17436 \| JV15-2 \| MADH3 \| MGC60396	SMAD family member 3	SMAD3 interacts with EP300 (p300).	BIND	15688032
SMAD4	DPC4 \| JIP \| MADH4	SMAD family member 4	Affinity Capture-Western	BioGRID	10887155
SMAD4	DPC4 \| JIP \| MADH4	SMAD family member 4	p300 interacts with Smad4 fragment. p300 interacting with full-length Smad4 could not be demonstrated in vitro. This interaction was modeled on a demonstrated interaction between p300 from an unspecified species and human Smad4 fragment.	BIND	9679056
SMAD7	CRCS3 \| FLJ16482 \| MADH7 \| MADH8	SMAD family member 7	-	HPRD,BioGRID	12408818
SNIP1	FLJ12553 \| RP3-423B22.3 \| dJ423B22.2	Smad nuclear interacting protein 1	-	HPRD,BioGRID	10887155
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Reconstituted Complex	BioGRID	10973497
SREBF2	SREBP2 \| bHLHd2	sterol regulatory element binding transcription factor 2	-	HPRD,BioGRID	8918891
SS18	MGC116875 \| SSXT \| SYT \| SYT-SSX1 \| SYT-SSX2	synovial sarcoma translocation, chromosome 18	-	HPRD,BioGRID	11030627
SS18L1	CREST \| KIAA0693 \| LP2261 \| MGC26711 \| MGC78386	synovial sarcoma translocation gene on chromosome 18-like 1	-	HPRD,BioGRID	14716005
STAT1	DKFZp686B04100 \| ISGF-3 \| STAT91	signal transducer and activator of transcription 1, 91kDa	Affinity Capture-Western	BioGRID	10464260
STAT1	DKFZp686B04100 \| ISGF-3 \| STAT91	signal transducer and activator of transcription 1, 91kDa	Stat1-beta interacts with p300. This interaction is modelled on a demonstrated interaction between human Stat1-beta and p300 from an unspecified species.	BIND	8986769
STAT2	ISGF-3 \| MGC59816 \| P113 \| STAT113	signal transducer and activator of transcription 2, 113kDa	Reconstituted Complex	BioGRID	10464260
STAT2	ISGF-3 \| MGC59816 \| P113 \| STAT113	signal transducer and activator of transcription 2, 113kDa	Stat2 interacts with p300.	BIND	10464260
STAT3	APRF \| FLJ20882 \| HIES \| MGC16063	signal transducer and activator of transcription 3 (acute-phase response factor)	Stat3 interacts with p300.	BIND	15653507
STAT3	APRF \| FLJ20882 \| HIES \| MGC16063	signal transducer and activator of transcription 3 (acute-phase response factor)	-	HPRD,BioGRID	10205054
STAT6	D12S1644 \| IL-4-STAT \| STAT6B \| STAT6C	signal transducer and activator of transcription 6, interleukin-4 induced	-	HPRD,BioGRID	10454341
SUB1	MGC102747 \| P15 \| PC4 \| p14	SUB1 homolog (S. cerevisiae)	-	HPRD,BioGRID	11279157
TACC2	AZU-1 \| ECTACC	transforming, acidic coiled-coil containing protein 2	TACC2 interacts with p300.	BIND	14767476
TADA3L	ADA3 \| FLJ20221 \| FLJ21329 \| hADA3	transcriptional adaptor 3 (NGG1 homolog, yeast)-like	-	HPRD,BioGRID	11707411
TAL1	SCL \| TCL5 \| bHLHa17 \| tal-1	T-cell acute lymphocytic leukemia 1	Affinity Capture-Western Reconstituted Complex	BioGRID	10490830
TBP	GTF2D \| GTF2D1 \| MGC117320 \| MGC126054 \| MGC126055 \| SCA17 \| TFIID	TATA box binding protein	p300 interacts with TBP.	BIND	8621548
TCF12	HEB \| HTF4 \| HsT17266 \| bHLHb20	transcription factor 12	HEBb interacts with p300.	BIND	15333839
TCF12	HEB \| HTF4 \| HsT17266 \| bHLHb20	transcription factor 12	HEBa interacts with p300. This interaction was modeled on a demonstrated interaction between HEBb and p300.	BIND	15333839
TCF3	E2A \| ITF1 \| MGC129647 \| MGC129648 \| bHLHb21	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	-	HPRD,BioGRID	12435739
TDG	-	thymine-DNA glycosylase	-	HPRD,BioGRID	11864601
TFAP2A	AP-2 \| AP-2alpha \| AP2TF \| BOFS \| TFAP2	transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)	-	HPRD,BioGRID	12586840
TFF1	BCEI \| D21S21 \| HP1.A \| HPS2 \| pNR-2 \| pS2	trefoil factor 1	p300 interacts with pS2.	BIND	10490106
TGS1	DKFZp762A163 \| FLJ22995 \| NCOA6IP \| PIMT \| PIPMT	trimethylguanosine synthase homolog (S. cerevisiae)	-	HPRD,BioGRID	11912212
THRA	AR7 \| EAR7 \| ERB-T-1 \| ERBA \| ERBA1 \| MGC000261 \| MGC43240 \| NR1A1 \| THRA1 \| THRA2 \| c-ERBA-1	thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)	Affinity Capture-Western	BioGRID	12371907
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	p300 interacts with p53	BIND	15558054
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	p300 interacts with p53. This interaction was modeled on a demonstrated interaction between p300 from an unspecified species and human p53.	BIND	15186775
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	p300 interacts with and acetylates p53. This interaction was modeled on a demonstrated interaction between p300 from an unspecified species and human p53.	BIND	15933712
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	-	HPRD,BioGRID	10942770
TP73	P73	tumor protein p73	p73-alpha interacts with p300.This interaction was modeled on a demonstrated interaction between human p73-alpha and p300 from an unspecified species.	BIND	15175157
TRERF1	BCAR2 \| FLJ21198 \| HSA277276 \| RAPA \| RP1-139D8.5 \| TReP-132 \| dJ139D8.5	transcriptional regulating factor 1	-	HPRD,BioGRID	11349124
TRIP4	HsT17391	thyroid hormone receptor interactor 4	-	HPRD,BioGRID	10454579
TSG101	TSG10 \| VPS23	tumor susceptibility gene 101	-	HPRD,BioGRID	10440698
TWIST1	ACS3 \| BPES2 \| BPES3 \| SCS \| TWIST \| bHLHa38	twist homolog 1 (Drosophila)	-	HPRD,BioGRID	10025406
UBE2I	C358B7.1 \| P18 \| UBC9	ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)	-	HPRD	8824223
USF2	FIP \| bHLHb12	upstream transcription factor 2, c-fos interacting	-	HPRD,BioGRID	10434034
XPA	XP1 \| XPAC	xeroderma pigmentosum, complementation group A	Affinity Capture-Western	BioGRID	11268218
YY1	DELTA \| INO80S \| NF-E1 \| UCRBP \| YIN-YANG-1	YY1 transcription factor	Affinity Capture-Western Biochemical Activity Reconstituted Complex Two-hybrid	BioGRID	7758944 \|11486036
ZBTB17	MIZ-1 \| ZNF151 \| ZNF60 \| pHZ-67	zinc finger and BTB domain containing 17	Affinity Capture-Western	BioGRID	11283613
ZRANB2	DKFZp686J1831 \| DKFZp686N09117 \| FLJ41119 \| ZIS \| ZIS1 \| ZIS2 \| ZNF265	zinc finger, RAN-binding domain containing 2	-	HPRD	11448987

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
KEGG WNT SIGNALING PATHWAY	151	112	All SZGR 2.0 genes in this pathway
KEGG NOTCH SIGNALING PATHWAY	47	35	All SZGR 2.0 genes in this pathway
KEGG TGF BETA SIGNALING PATHWAY	86	64	All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION	75	53	All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY	155	105	All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION	70	57	All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS	102	80	All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE	185	109	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA	70	60	All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER	89	75	All SZGR 2.0 genes in this pathway
BIOCARTA RELA PATHWAY	16	12	All SZGR 2.0 genes in this pathway
BIOCARTA CARM ER PATHWAY	35	27	All SZGR 2.0 genes in this pathway
BIOCARTA G2 PATHWAY	24	20	All SZGR 2.0 genes in this pathway
BIOCARTA VDR PATHWAY	12	7	All SZGR 2.0 genes in this pathway
BIOCARTA P53HYPOXIA PATHWAY	23	21	All SZGR 2.0 genes in this pathway
BIOCARTA HIF PATHWAY	15	12	All SZGR 2.0 genes in this pathway
BIOCARTA IL7 PATHWAY	17	14	All SZGR 2.0 genes in this pathway
BIOCARTA PPARA PATHWAY	58	43	All SZGR 2.0 genes in this pathway
BIOCARTA PITX2 PATHWAY	15	15	All SZGR 2.0 genes in this pathway
BIOCARTA NTHI PATHWAY	24	20	All SZGR 2.0 genes in this pathway
BIOCARTA HER2 PATHWAY	22	17	All SZGR 2.0 genes in this pathway
BIOCARTA MEF2D PATHWAY	23	16	All SZGR 2.0 genes in this pathway
BIOCARTA TGFB PATHWAY	19	14	All SZGR 2.0 genes in this pathway
BIOCARTA CARM1 PATHWAY	13	11	All SZGR 2.0 genes in this pathway
WNT SIGNALING	89	71	All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY	82	63	All SZGR 2.0 genes in this pathway
PID NOTCH PATHWAY	59	49	All SZGR 2.0 genes in this pathway
PID P73PATHWAY	79	59	All SZGR 2.0 genes in this pathway
PID HDAC CLASSIII PATHWAY	25	20	All SZGR 2.0 genes in this pathway
PID E2F PATHWAY	74	48	All SZGR 2.0 genes in this pathway
PID HIF2PATHWAY	34	29	All SZGR 2.0 genes in this pathway
PID FRA PATHWAY	37	28	All SZGR 2.0 genes in this pathway
PID MYC ACTIV PATHWAY	79	62	All SZGR 2.0 genes in this pathway
PID HDAC CLASSI PATHWAY	66	50	All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY	54	47	All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY	82	60	All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY	49	43	All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY	137	94	All SZGR 2.0 genes in this pathway
PID AR TF PATHWAY	53	38	All SZGR 2.0 genes in this pathway
PID IFNG PATHWAY	40	34	All SZGR 2.0 genes in this pathway
PID ATF2 PATHWAY	59	43	All SZGR 2.0 genes in this pathway
PID AP1 PATHWAY	70	60	All SZGR 2.0 genes in this pathway
PID FOXM1 PATHWAY	40	30	All SZGR 2.0 genes in this pathway
PID CMYB PATHWAY	84	61	All SZGR 2.0 genes in this pathway
PID ERA GENOMIC PATHWAY	65	37	All SZGR 2.0 genes in this pathway
PID RETINOIC ACID PATHWAY	30	23	All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID MYC REPRESS PATHWAY	63	52	All SZGR 2.0 genes in this pathway
PID HIF1 TFPATHWAY	66	52	All SZGR 2.0 genes in this pathway
PID TAP63 PATHWAY	54	40	All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY	59	50	All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY	65	46	All SZGR 2.0 genes in this pathway
PID HNF3A PATHWAY	44	29	All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY	48	39	All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	36	27	All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION	104	72	All SZGR 2.0 genes in this pathway
REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	29	17	All SZGR 2.0 genes in this pathway
REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	24	17	All SZGR 2.0 genes in this pathway
REACTOME PRE NOTCH EXPRESSION AND PROCESSING	44	24	All SZGR 2.0 genes in this pathway
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	46	28	All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	23	16	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH1	70	46	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	25	17	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS	478	302	All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	168	115	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	30	26	All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN CLOCK	53	40	All SZGR 2.0 genes in this pathway
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	132	101	All SZGR 2.0 genes in this pathway
REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	14	10	All SZGR 2.0 genes in this pathway
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	73	57	All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	72	53	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH	103	64	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN	634	384	All SZGR 2.0 genes in this pathway
MYLLYKANGAS AMPLIFICATION HOT SPOT 22	13	9	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN	712	443	All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING VIA SMAD4 UP	108	66	All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION	149	101	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP	479	299	All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK	101	73	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN	160	110	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP	390	242	All SZGR 2.0 genes in this pathway
HEDENFALK BREAST CANCER BRACX DN	20	14	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 10HR UP	101	69	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN	287	208	All SZGR 2.0 genes in this pathway
LIN MELANOMA COPY NUMBER UP	73	53	All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION	175	125	All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP	323	240	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2	115	74	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-129-5p	989	995	m8	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
miR-129-5p	989	995	m8	hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-132/212	1065	1072	1A,m8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	1065	1072	1A,m8	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-142-5p	417	423	m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-148/152	259	265	m8	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-17-5p/20/93.mr/106/519.d	416	422	1A	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-182	733	739	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-186	559	565	m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-200bc/429	669	675	1A	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-203.1	436	442	m8	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-217	128	134	1A	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU
miR-22	727	733	m8	hsa-miR-22^brain	AAGCUGCCAGUUGAAGAACUGU
miR-26	978	984	1A	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	978	984	1A	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-30-3p	60	67	1A,m8	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
miR-30-3p	60	67	1A,m8	hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
miR-342	1108	1115	1A,m8	hsa-miR-342^brain	UCUCACACAGAAAUCGCACCCGUC
miR-363	545	551	1A	hsa-miR-363	AUUGCACGGUAUCCAUCUGUAA
miR-369-3p	745	752	1A,m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	746	752	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-377	1107	1113	m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-450	989	995	1A	hsa-miR-450	UUUUUGCGAUGUGUUCCUAAUA
miR-495	202	208	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-500	544	550	1A	hsa-miR-500	AUGCACCUGGGCAAGGAUUCUG
miR-543	466	472	1A	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-96	733	739	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: EP300