Summary ?
DescriptionEWS RNA binding protein 1
Gene typeprotein-coding
Map location22q12.2
Pascal p-value0.387
Sherlock p-value0.005
Fetal beta0.96
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.031 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.017 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003676nucleic acid bindingIEA-
GO:0003700transcription factor activityIEA-
GO:0003723RNA bindingTAS8084618 
GO:0005516calmodulin bindingIEA-
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0009986cell surfaceIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACTL6AACTL6 | Arp4 | BAF53A | INO80K | MGC5382actin-like 6ATwo-hybridBioGRID16189514 
AGTANHU | FLJ92595 | FLJ97926 | SERPINA8angiotensinogen (serpin peptidase inhibitor, clade A, member 8)Two-hybridBioGRID16189514 
ARHGDIAGDIA1 | MGC117248 | RHOGDI | RHOGDI-1Rho GDP dissociation inhibitor (GDI) alphaAffinity Capture-MSBioGRID17353931 
BADBBC2 | BCL2L8BCL2-associated agonist of cell deathTwo-hybridBioGRID16189514 
BARD1-BRCA1 associated RING domain 1-HPRD,BioGRID12183411 
BNIP3LBNIP3a | NIXBCL2/adenovirus E1B 19kDa interacting protein 3-likeTwo-hybridBioGRID16189514 
BTKAGMX1 | AT | ATK | BPK | IMD1 | MGC126261 | MGC126262 | PSCTK1 | XLABruton agammaglobulinemia tyrosine kinase-HPRD,BioGRID9201297 
C10orf12DKFZp564P1916 | FLJ13022chromosome 10 open reading frame 12Two-hybridBioGRID16189514 
C11orf16-chromosome 11 open reading frame 16Two-hybridBioGRID16189514 
C18orf10DKFZp586M1523 | HMFN0601 | HsT3006 | L17 | PGs2chromosome 18 open reading frame 10Two-hybridBioGRID16189514 
C19orf50FLJ25480 | MGC2749 | MST096 | MSTP096chromosome 19 open reading frame 50Two-hybridBioGRID16189514 
C19orf57MGC11271 | MGC149720chromosome 19 open reading frame 57Two-hybridBioGRID16189514 
C1orf71FLJ32001 | MGC18089chromosome 1 open reading frame 71Two-hybridBioGRID16189514 
CALM1CALML2 | CAMI | DD132 | PHKDcalmodulin 1 (phosphorylase kinase, delta)Reconstituted ComplexBioGRID9341188 
CCDC7BioT2-A | BioT2-B | BioT2-C | DKFZp686N0559 | FLJ32762 | RP11-479G22.1coiled-coil domain containing 7Two-hybridBioGRID16189514 
CCDC91DKFZp779L1558 | FLJ11088 | HSD8 | p56coiled-coil domain containing 91Two-hybridBioGRID16189514 
CD177HNA2A | NB1 | PRV1CD177 moleculeTwo-hybridBioGRID16189514 
CD2BP2FWP010 | LIN1 | Snu40 | U5-52KCD2 (cytoplasmic tail) binding protein 2Affinity Capture-MSBioGRID17353931 
CEACAM5CD66e | CEA | DKFZp781M2392carcinoembryonic antigen-related cell adhesion molecule 5Two-hybridBioGRID16189514 
CETPHDLCQ10cholesteryl ester transfer protein, plasmaTwo-hybridBioGRID16189514 
CFDP1BCNT | BUCENTAUR | CP27 | SWC5 | Yeti | p97craniofacial development protein 1Two-hybridBioGRID16189514 
CPSF6CFIM | CFIM68 | HPBRII-4 | HPBRII-7cleavage and polyadenylation specific factor 6, 68kDaTwo-hybridBioGRID16189514 
CREBBPCBP | KAT3A | RSTSCREB binding protein-HPRD,BioGRID12459554 
CUEDC2C10orf66 | MGC2491 | bA18I14.5CUE domain containing 2Two-hybridBioGRID16189514 
CXADRCAR | HCARcoxsackie virus and adenovirus receptorTwo-hybridBioGRID16189514 
DFFADFF-45 | DFF1 | ICADDNA fragmentation factor, 45kDa, alpha polypeptideTwo-hybridBioGRID16189514 
DMRTB1-DMRT-like family B with proline-rich C-terminal, 1Two-hybridBioGRID16189514 
DNAJB3HCG3 | MGC26879DnaJ (Hsp40) homolog, subfamily B, member 3Two-hybridBioGRID16189514 
DYNLL2DNCL1B | Dlc2 | MGC17810dynein, light chain, LC8-type 2Two-hybridBioGRID16189514 
ELAVL3DKFZp547J036 | HUC | HUCL | MGC20653 | PLE21ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)Two-hybridBioGRID16189514 
ELAVL4HUD | PNEMELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)Two-hybridBioGRID16189514 
ELK1-ELK1, member of ETS oncogene familyReconstituted ComplexBioGRID9010223 
FAM131CC1orf117 | FLJ36766 | RP11-5P18.9family with sequence similarity 131, member CTwo-hybridBioGRID16189514 
FASNFAS | MGC14367 | MGC15706 | OA-519fatty acid synthaseTwo-hybridBioGRID16189514 
FLJ12529FLJ39024 | MGC9315pre-mRNA cleavage factor I, 59 kDa subunitTwo-hybridBioGRID16189514 
GNPDA1GNPDA | GNPI | GPI | HLN | KIAA0060glucosamine-6-phosphate deaminase 1Two-hybridBioGRID16189514 
GPBP1L1RP11-767N6.1 | SP192GC-rich promoter binding protein 1-like 1Two-hybridBioGRID16189514 
GSK3B-glycogen synthase kinase 3 betaAffinity Capture-MSBioGRID17353931 
HERPUD1HERP | KIAA0025 | Mif1 | SUPhomocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1Two-hybridBioGRID16189514 
HMGA1HMG-R | HMGA1A | HMGIY | MGC12816 | MGC4242 | MGC4854high mobility group AT-hook 1Two-hybridBioGRID16189514 
ILKDKFZp686F1765 | P59integrin-linked kinaseAffinity Capture-MSBioGRID17353931 
KCNMB1K(VCA)beta | SLO-BETA | hslo-betapotassium large conductance calcium-activated channel, subfamily M, beta member 1Two-hybridBioGRID16189514 
KELCD238 | ECE3Kell blood group, metallo-endopeptidaseTwo-hybridBioGRID16189514 
KHDRBS2FLJ38664 | MGC26664 | SLM-1 | SLM1 | bA535F17.1KH domain containing, RNA binding, signal transduction associated 2Two-hybridBioGRID16189514 
KRR1HRB2 | RIP-1KRR1, small subunit (SSU) processome component, homolog (yeast)Two-hybridBioGRID16189514 
LILRA3CD85E | HM31 | HM43 | ILT6 | LIR-4 | LIR4 | e3leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3Two-hybridBioGRID16189514 
MAGEA11MAGE-11 | MAGE11 | MAGEA-11 | MGC10511melanoma antigen family A, 11Two-hybridBioGRID16189514 
MAPK1IP1LC14orf32 | MGC23138 | MISS | c14_5346mitogen-activated protein kinase 1 interacting protein 1-likeTwo-hybridBioGRID16189514 
MATKCHK | CTK | DKFZp434N1212 | HHYLTK | HYL | HYLTK | Lsk | MGC1708 | MGC2101megakaryocyte-associated tyrosine kinaseTwo-hybridBioGRID16189514 
MDFII-MF | I-mfaMyoD family inhibitorTwo-hybridBioGRID16189514 
MNS1FLJ11222 | FLJ26051meiosis-specific nuclear structural 1Two-hybridBioGRID16189514 
MRPS18BC6orf14 | DKFZp564H0223 | HSPC183 | HumanS18a | MRP-S18-2 | MRPS18-2 | PTD017 | S18amtmitochondrial ribosomal protein S18BTwo-hybridBioGRID16189514 
MSCABF-1 | ABF1 | MYOR | bHLHa22musculin (activated B-cell factor-1)Two-hybridBioGRID16189514 
MTCP1C6.1Bmature T-cell proliferation 1Two-hybridBioGRID16189514 
MTMR9C8orf9 | DKFZp434K171 | LIP-STYX | MGC126672 | MTMR8myotubularin related protein 9Two-hybridBioGRID16189514 
MVKFLJ96772 | LRBP | MK | MVLKmevalonate kinaseTwo-hybridBioGRID16189514 
MYL6ESMLC | LC17-GI | LC17-NM | LC17A | LC17B | MLC1SM | MLC3NM | MLC3SMmyosin, light chain 6, alkali, smooth muscle and non-muscleTwo-hybridBioGRID16189514 
MYO1F-myosin IFTwo-hybridBioGRID16189514 
MYOZ2C4orf5 | CS-1myozenin 2Two-hybridBioGRID16189514 
NBPF3AE2 | DKFZp434D177neuroblastoma breakpoint family, member 3Two-hybridBioGRID16189514 
NDUFB1CI-SGDH | MNLLNADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDaTwo-hybridBioGRID16189514 
NDUFV1CI-51kD | UQOR1NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDaTwo-hybridBioGRID16189514 
NLE1FLJ10458 | Nlenotchless homolog 1 (Drosophila)Two-hybridBioGRID16189514 
NPPBBNPnatriuretic peptide precursor BTwo-hybridBioGRID16189514 
NSUN4MGC22960 | RP4-603I14.2NOL1/NOP2/Sun domain family, member 4Two-hybridBioGRID16189514 
NTNG2KIAA0625 | KIAA1857 | LHLL9381 | Lmnt2 | MGC21884 | NTNG1 | bA479K20.1netrin G2Two-hybridBioGRID16189514 
PDHXDLDBP | E3BP | OPDX | PDX1 | proXpyruvate dehydrogenase complex, component XTwo-hybridBioGRID16189514 
PLSCR1MMTRA1Bphospholipid scramblase 1Two-hybridBioGRID16189514 
POLR2GMGC138367 | MGC138369 | RPB7 | hRPB19 | hsRPB7polymerase (RNA) II (DNA directed) polypeptide G-HPRD9704926 
POU4F1BRN3A | FLJ13449 | Oct-T1 | RDC-1POU class 4 homeobox 1-HPRD,BioGRID12432261 
PRTFDC1FLJ11888 | HHGPphosphoribosyl transferase domain containing 1Two-hybridBioGRID16189514 
PRUNE2A214N16.3 | BMCC1 | BNIPXL | C9orf65 | DKFZp762K117 | FLJ50060 | FLJ54876 | FLJ59118 | KIAA0367 | RP11-58J3.2 | bA214N16.3prune homolog 2 (Drosophila)Two-hybridBioGRID16189514 
PTK2BCADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTKPTK2B protein tyrosine kinase 2 beta-HPRD,BioGRID10322114 
PUF60FIR | FLJ31379 | RoBPI | SIAHBP1poly-U binding splicing factor 60KDaAffinity Capture-MSBioGRID17353931 
RAB37FLJ30284 | FLJ32507RAB37, member RAS oncogene familyTwo-hybridBioGRID16189514 
RAD23AHHR23A | MGC111083RAD23 homolog A (S. cerevisiae)Two-hybridBioGRID16189514 
RALYLHNRPCL3RALY RNA binding protein-likeTwo-hybridBioGRID16189514 
RASL11BMGC2827 | MGC4499RAS-like, family 11, member BTwo-hybridBioGRID16189514 
RBPMSHERMESRNA binding protein with multiple splicingTwo-hybridBioGRID16189514 
RHOXF2PEPP-2 | PEPP2 | THG1Rhox homeobox family, member 2Two-hybridBioGRID16189514 
RMND5BDKFZp434K0926 | FLJ22318required for meiotic nuclear division 5 homolog B (S. cerevisiae)Two-hybridBioGRID16189514 
RNF183FLJ31197 | MGC4734ring finger protein 183Two-hybridBioGRID16189514 
RP4-691N24.1FLJ11792 | KIAA0980 | NLP | dJ691N24.1ninein-likeTwo-hybridBioGRID16189514 
RPL31MGC88191ribosomal protein L31Two-hybridBioGRID16189514 
RPS15AFLJ27457 | MGC111208 | S15aribosomal protein S15aTwo-hybridBioGRID16189514 
SALL2FLJ10414 | FLJ55746 | HSAL2 | KIAA0360 | ZNF795 | p150(Sal2)sal-like 2 (Drosophila)Two-hybridBioGRID16189514 
SELIKIAA1724selenoprotein ITwo-hybridBioGRID16189514 
SERP2C13orf21 | MGC35505 | RP11-269C23.1 | bA269C23.1stress-associated endoplasmic reticulum protein family member 2Two-hybridBioGRID16189514 
SF1D11S636 | ZFM1 | ZNF162splicing factor 1-HPRD,BioGRID9660765 
SLC1A1EAAC1 | EAAT3solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1Two-hybridBioGRID16189514 
SLC22A24MGC34821solute carrier family 22, member 24Two-hybridBioGRID16189514 
SMAD4DPC4 | JIP | MADH4SMAD family member 4Two-hybridBioGRID16189514 
SMNDC1SMNR | SPF30survival motor neuron domain containing 1Affinity Capture-MSBioGRID17353931 
SNRPCFLJ20302small nuclear ribonucleoprotein polypeptide C-HPRD,BioGRID10827180 
SSBP2DKFZp686F03273 | HSPC116single-stranded DNA binding protein 2Two-hybridBioGRID16189514 
SUV39H2FLJ23414 | KMT1Bsuppressor of variegation 3-9 homolog 2 (Drosophila)Two-hybridBioGRID16189514 
TAF1BA2R | CCG1 | CCGS | DYT3 | KAT4 | N-TAF1 | NSCL2 | OF | P250 | TAF2A | TAFII250TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa-HPRD9488465 
TMSB4YMGC26307 | TB4Ythymosin beta 4, Y-linkedTwo-hybridBioGRID16189514 
TRIM37KIAA0898 | MUL | POB1 | TEF3tripartite motif-containing 37Two-hybridBioGRID16189514 
TRPV5CAT2 | ECAC1 | OTRPC3transient receptor potential cation channel, subfamily V, member 5Two-hybridBioGRID16189514 
TSPAN3TM4-A | TM4SF8 | TSPAN-3tetraspanin 3Two-hybridBioGRID16189514 
TULP2TUBL2tubby like protein 2Two-hybridBioGRID16189514 
VPS72CFL1 | Swc2 | TCFL1 | YL-1 | YL1vacuolar protein sorting 72 homolog (S. cerevisiae)Two-hybridBioGRID16189514 
WDR37FLJ40354 | KIAA0982 | RP11-529L18.2WD repeat domain 37Two-hybridBioGRID16189514 
WWP1AIP5 | DKFZp434D2111 | Tiul1 | hSDRP1WW domain containing E3 ubiquitin protein ligase 1Two-hybridBioGRID16189514 
WWP2AIP2 | WWp2-likeWW domain containing E3 ubiquitin protein ligase 2Two-hybridBioGRID16189514 
YY1AP1FLJ10875 | FLJ13914 | HCCA1 | HCCA2 | YAP | YY1APYY1 associated protein 1Two-hybridBioGRID16189514 
ZDHHC3DKFZp313D2314 | FLJ20209 | FLJ45940 | GODZ | ZNF373zinc finger, DHHC-type containing 3Two-hybridBioGRID16189514 
ZNF165LD65 | ZSCAN7zinc finger protein 165Affinity Capture-Western

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
PID BARD1 PATHWAY 2919All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404246All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN 180101All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
MYLLYKANGAS AMPLIFICATION HOT SPOT 22 139All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP 309199All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
MORI MATURE B LYMPHOCYTE DN 7543All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS UP 14591All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309206All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337230All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA SUBGROUPS 3020All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA UP 6446All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390242All SZGR 2.0 genes in this pathway
JIANG VHL TARGETS 13891All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911527All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011592All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425253All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342220All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299189All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE UP 14985All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP 442263All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 12HR DN 3325All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 24HR DN 4332All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 32HR DN 3928All SZGR 2.0 genes in this pathway
DORN ADENOVIRUS INFECTION 48HR DN 4029All SZGR 2.0 genes in this pathway
JIANG HYPOXIA VIA VHL 3424All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method