Gene Page: GAD2

Summary
GeneID  2572
Symbol  GAD2
Synonyms  GAD65|MGC161605|MGC161607
Description  glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
See related  HGNC:4093|MIM:138275|Ensembl:ENSG00000136750|HPRD:11817|
Locus tag  RP11-420F12.2
Gene type  protein-coding
Map location  10p11.23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0384 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CLCN70.800.86
DNAJB120.800.83
ATG2A0.780.83
RAB360.780.76
RNF1230.770.83
ZNF3350.770.86
C2orf180.770.82
DPP90.760.83
SPG70.760.80
FLRT10.760.84
Top 10 negatively co-expressed genes
AF347015.21-0.62-0.62
AF347015.31-0.56-0.55
MT-CO2-0.54-0.53
AF347015.8-0.53-0.52
MT-CYB-0.52-0.50
AF347015.27-0.52-0.53
C1orf54-0.50-0.55
CLEC2B-0.50-0.56
AF347015.33-0.49-0.47
AL139819.3-0.49-0.55
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004351glutamate decarboxylase activityIEAglutamate (GO term level: 6)-
GO:0005515protein bindingIPI10671565 
GO:0016829lyase activityIEA-
GO:0016831carboxy-lyase activityIEA-
GO:0030170pyridoxal phosphate bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)8954991 
GO:0006540glutamate decarboxylation to succinateTASGABA, glutamate, Brain, Neurotransmitter (GO term level: 10)1549570 
GO:0042136neurotransmitter biosynthetic processIEAneuron, axon, Synap, Neurotransmitter (GO term level: 9)-
GO:0019752carboxylic acid metabolic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030424axonIEAneuron, axon, Neurotransmitter (GO term level: 6)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0000139Golgi membraneIEA-
GO:0005794Golgi apparatusIEA-
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-
GO:0031410cytoplasmic vesicleIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
GAD1FLJ45882 | GAD | SCPglutamate decarboxylase 1 (brain, 67kDa)-HPRD,BioGRID7836456 
PRKACAMGC102831 | MGC48865 | PKACAprotein kinase, cAMP-dependent, catalytic, alphaBiochemical ActivityBioGRID15147202 
PRKCEMGC125656 | MGC125657 | PKCE | nPKC-epsilonprotein kinase C, epsilon-HPRD,BioGRID15147202 
ZDHHC17HIP14 | HIP3 | HSPC294 | HYPH | KIAA0946zinc finger, DHHC-type containing 17HIP14 catalyzes palmitoylation of GAD65. This interaction was modeled on a demonstrated interaction between human HIP14 and GAD65 from an unspecified species.BIND15603740 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM 3226All SZGR genes in this pathway
KEGG_BETA_ALANINE_METABOLISM 2216All SZGR genes in this pathway
KEGG_TAURINE_AND_HYPOTAURINE_METABOLISM 107All SZGR genes in this pathway
KEGG_BUTANOATE_METABOLISM 3420All SZGR genes in this pathway
KEGG_TYPE_I_DIABETES_MELLITUS 4438All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE 3430All SZGR genes in this pathway
REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION 1716All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_UP 544308All SZGR genes in this pathway
SCHLESINGER_H3K27ME3_IN_NORMAL_AND_METHYLATED_IN_CANCER 2821All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
MCCLUNG_DELTA_FOSB_TARGETS_8WK 4738All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_UP 244151All SZGR genes in this pathway
XU_GH1_EXOGENOUS_TARGETS_DN 12069All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_DN 315197All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN 564326All SZGR genes in this pathway
LABBE_TARGETS_OF_TGFB1_AND_WNT3A_UP 11170All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
LIU_VAV3_PROSTATE_CARCINOGENESIS_DN 1714All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
ALFANO_MYC_TARGETS 239156All SZGR genes in this pathway
PEDRIOLI_MIR31_TARGETS_DN 418245All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B 517302All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-128325331m8hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-485-3p493499m8hsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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