Gene Page: HPRT1

Summary
GeneID  3251
Symbol  HPRT1
Synonyms  HGPRT|HPRT
Description  hypoxanthine phosphoribosyltransferase 1
See related  HGNC:5157|MIM:308000|Ensembl:ENSG00000165704|HPRD:02388|
Locus tag  -
Gene type  protein-coding
Map location  Xq26.1
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0044 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000287magnesium ion bindingIDA10360366 
GO:0005515protein bindingIPI17353931 
GO:0004422hypoxanthine phosphoribosyltransferase activityEXP6300847 
GO:0004422hypoxanthine phosphoribosyltransferase activityIDA6300847 |9521733 
GO:0016757transferase activity, transferring glycosyl groupsIEA-
GO:0042803protein homodimerization activityIPI8044844 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0045964positive regulation of dopamine metabolic processIMPdopamine (GO term level: 10)8643611 
GO:0009116nucleoside metabolic processIEA-
GO:0006166purine ribonucleoside salvageIMP9824441 
GO:0006164purine nucleotide biosynthetic processIMP9824441 
GO:0007610behaviorIMP16138897 
GO:0051289protein homotetramerizationIDA9521733 
GO:0046100hypoxanthine metabolic processIMP9824441 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP6300847 
GO:0005737cytoplasmIDA6300847 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
EIF1BGC20eukaryotic translation initiation factor 1BAffinity Capture-MSBioGRID17353931 
FANCAFA | FA-H | FA1 | FAA | FACA | FAH | FANCH | MGC75158Fanconi anemia, complementation group ATwo-hybridBioGRID14499622 
HPRT1HGPRT | HPRThypoxanthine phosphoribosyltransferase 1-HPRD,BioGRID8044844 
HUS1-HUS1 checkpoint homolog (S. pombe)Affinity Capture-MSBioGRID17353931 
MCCDKFZp762O1615 | FLJ38893 | FLJ46755 | MCC1mutated in colorectal cancersAffinity Capture-MSBioGRID17353931 
PRTFDC1FLJ11888 | HHGPphosphoribosyl transferase domain containing 1Two-hybridBioGRID16189514 
WDYHV1C8orf32 | FLJ10204WDYHV motif containing 1Two-hybridBioGRID16189514 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PURINE_METABOLISM 15996All SZGR genes in this pathway
KEGG_DRUG_METABOLISM_OTHER_ENZYMES 5127All SZGR genes in this pathway
WNT_SIGNALING 8971All SZGR genes in this pathway
REACTOME_METABOLISM_OF_NUCLEOTIDES 7245All SZGR genes in this pathway
REACTOME_PURINE_SALVAGE 1311All SZGR genes in this pathway
REACTOME_PURINE_METABOLISM 3324All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_UP 332228All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
BORCZUK_MALIGNANT_MESOTHELIOMA_UP 305185All SZGR genes in this pathway
RHEIN_ALL_GLUCOCORTICOID_THERAPY_DN 362238All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_KRAS_UP 12672All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
SCHLOSSER_MYC_TARGETS_REPRESSED_BY_SERUM 15993All SZGR genes in this pathway
AIYAR_COBRA1_TARGETS_DN 2918All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_UP 227137All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_UP 380213All SZGR genes in this pathway
KIM_MYC_AMPLIFICATION_TARGETS_UP 201127All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
PUJANA_CHEK2_PCC_NETWORK 779480All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_UP 176115All SZGR genes in this pathway
MORI_EMU_MYC_LYMPHOMA_BY_ONSET_TIME_UP 11069All SZGR genes in this pathway
BASSO_B_LYMPHOCYTE_NETWORK 14396All SZGR genes in this pathway
KIM_GERMINAL_CENTER_T_HELPER_UP 6642All SZGR genes in this pathway
PENG_LEUCINE_DEPRIVATION_DN 187122All SZGR genes in this pathway
CHEN_LUNG_CANCER_SURVIVAL 2822All SZGR genes in this pathway
TARTE_PLASMA_CELL_VS_PLASMABLAST_DN 309206All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_DN 337230All SZGR genes in this pathway
FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_DN 8757All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_SCC_UP 12375All SZGR genes in this pathway
ZHONG_SECRETOME_OF_LUNG_CANCER_AND_FIBROBLAST 13293All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
FERRANDO_HOX11_NEIGHBORS 2313All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_NEURAL 12985All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
CHICAS_RB1_TARGETS_GROWING 243155All SZGR genes in this pathway
LU_EZH2_TARGETS_DN 414237All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP 324193All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_UP 11265All SZGR genes in this pathway
JUBAN_TARGETS_OF_SPI1_AND_FLI1_DN 9260All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_BOUND_8D 658397All SZGR genes in this pathway
KRIEG_KDM3A_TARGETS_NOT_HYPOXIA 208107All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-4103453511Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-4944844901Ahsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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