SZGR2

Summary ?

GeneID	351
Symbol	APP
Synonyms	AAA\|ABETA\|ABPP\|AD1\|APPI\|CTFgamma\|CVAP\|PN-II\|PN2
Description	amyloid beta precursor protein
Reference	MIM:104760\|HGNC:HGNC:620\|Ensembl:ENSG00000142192\|HPRD:00100\|Vega:OTTHUMG00000078438
Gene type	protein-coding
Map location	21q21.3
Pascal p-value	0.079
Sherlock p-value	0.726
Fetal beta	-1.23
DMG	1 (# studies)
Support	CompositeSet Darnell FMRP targets Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Nishioka_2013	Genome-wide DNA methylation analysis	The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls.	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 8.0457

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg13169373	21	27542843	APP		-0.027	0.32	DMG:Nishioka_2013

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004867	serine-type endopeptidase inhibitor activity	IDA		10652580
GO:0004867	serine-type endopeptidase inhibitor activity	NAS		11279603
GO:0005506	iron ion binding	IEA		-
GO:0005507	copper ion binding	IEA		-
GO:0008201	heparin binding	IEA		-
GO:0008270	zinc ion binding	IEA		-
GO:0033130	acetylcholine receptor binding	IPI		10681545
GO:0042802	identical protein binding	IPI		16286452
GO:0046872	metal ion binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007155	cell adhesion	IEA		-
GO:0007219	Notch signaling pathway	IEA		-
GO:0006915	apoptosis	IEA		-
GO:0006878	cellular copper ion homeostasis	TAS		15910549
GO:0006897	endocytosis	IEA		-
GO:0050905	neuromuscular process	NAS		7593229
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005794	Golgi apparatus	IDA		18029348
GO:0005576	extracellular region	EXP		2110384
GO:0005576	extracellular region	TAS		10806211
GO:0005737	cytoplasm	IDA		18029348
GO:0009986	cell surface	IDA		7593229
GO:0005905	coated pit	IEA		-
GO:0005886	plasma membrane	IDA		18029348
GO:0005887	integral to plasma membrane	TAS		10806211
GO:0031093	platelet alpha granule lumen	EXP		2110384

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ABL1	ABL \| JTK7 \| bcr/abl \| c-ABL \| p150 \| v-abl	c-abl oncogene 1, receptor tyrosine kinase	-	HPRD	11279131
ACHE	ARACHE \| N-ACHE \| YT	acetylcholinesterase (Yt blood group)	-	HPRD,BioGRID	12427014
APBA1	D9S411E \| MINT1 \| X11 \| X11A \| X11ALPHA	amyloid beta (A4) precursor protein-binding, family A, member 1	-	HPRD,BioGRID	8887653
APBA1	D9S411E \| MINT1 \| X11 \| X11A \| X11ALPHA	amyloid beta (A4) precursor protein-binding, family A, member 1	APPswe interacts with X11-alpha.	BIND	12849748 \|14756819
APBA1	D9S411E \| MINT1 \| X11 \| X11A \| X11ALPHA	amyloid beta (A4) precursor protein-binding, family A, member 1	Beta-APP interacts with X11.	BIND	8887653
APBA2	D15S1518E \| HsT16821 \| LIN-10 \| MGC99508 \| MGC:14091 \| MINT2 \| X11L	amyloid beta (A4) precursor protein-binding, family A, member 2	-	HPRD,BioGRID	9890987
APBA3	MGC:15815 \| X11L2 \| mint3	amyloid beta (A4) precursor protein-binding, family A, member 3	-	HPRD,BioGRID	10049767
APBB1	FE65 \| MGC:9072 \| RIR	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	8855266 \|8887653 \|9045663 \|9837937 \|10081969
APBB1	FE65 \| MGC:9072 \| RIR	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	-	HPRD	8887653 \|8955346 \|9045663 \|9799084 \|9837937 \|11085987
APBB2	DKFZp434E033 \| FE65L \| FE65L1 \| MGC35575	amyloid beta (A4) precursor protein-binding, family B, member 2	-	HPRD,BioGRID	8855266 \|14527950
APBB3	FE65L2 \| MGC150555 \| MGC87674 \| SRA	amyloid beta (A4) precursor protein-binding, family B, member 3	-	HPRD,BioGRID	10081969\|14527950
APOE	AD2 \| LPG \| MGC1571 \| apoprotein	apolipoprotein E	-	HPRD	10559559
APP	AAA \| ABETA \| ABPP \| AD1 \| APPI \| CTFgamma \| CVAP \| PN2	amyloid beta (A4) precursor protein	APP (Abeta) isoform b forms homodimers, homotrimers and oligomers.	BIND	15834427
APPBP2	HS.84084 \| KIAA0228 \| PAT1	amyloid beta precursor protein (cytoplasmic tail) binding protein 2	-	HPRD,BioGRID	9843960
BCAP31	6C6-AG \| BAP31 \| CDM \| DXS1357E	B-cell receptor-associated protein 31	-	HPRD,BioGRID	12529377
BGN	DSPG1 \| PG-S1 \| PGI \| SLRR1A	biglycan	-	HPRD,BioGRID	7793988
BLMH	BH \| BMH	bleomycin hydrolase	-	HPRD,BioGRID	10973933
CALR	CRT \| FLJ26680 \| RO \| SSA \| cC1qR	calreticulin	-	HPRD,BioGRID	11378243
CASP4	ICE(rel)II \| ICEREL-II \| ICH-2 \| Mih1/TX \| TX	caspase 4, apoptosis-related cysteine peptidase	-	HPRD	15123740
CASP8	ALPS2B \| CAP4 \| FLICE \| FLJ17672 \| MACH \| MCH5 \| MGC78473	caspase 8, apoptosis-related cysteine peptidase	-	HPRD	10911620
CAV1	CAV \| MSTP085 \| VIP21	caveolin 1, caveolae protein, 22kDa	-	HPRD,BioGRID	9553108
CLSTN1	ALC-ALPHA \| CSTN1 \| FLJ32258 \| KIAA0911 \| PIK3CD \| XB31alpha \| alcalpha1 \| alcalpha2	calsyntenin 1	-	HPRD,BioGRID	15037614
COL1A2	OI4	collagen, type I, alpha 2	-	HPRD	7688497
COL25A1	CLAC \| CLACP	collagen, type XXV, alpha 1	-	HPRD,BioGRID	11927537
COL4A1	arresten	collagen, type IV, alpha 1	-	HPRD	9136074
COL4A2	DKFZp686I14213 \| FLJ22259	collagen, type IV, alpha 2	-	HPRD	9136074
COL4A3	-	collagen, type IV, alpha 3 (Goodpasture antigen)	-	HPRD	9136074
COL4A5	ASLN \| ATS \| CA54 \| MGC167109 \| MGC42377	collagen, type IV, alpha 5	-	HPRD	9136074
COL4A6	MGC88184	collagen, type IV, alpha 6	-	HPRD	9136074
DAB1	-	disabled homolog 1 (Drosophila)	-	HPRD,BioGRID	10460257
DAB1	-	disabled homolog 1 (Drosophila)	-	HPRD	9837937 \|10460257
DAB2	DOC-2 \| DOC2 \| FLJ26626	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	Reconstituted Complex	BioGRID	11247302
F12	HAE3 \| HAEX \| HAF	coagulation factor XII (Hageman factor)	-	HPRD	11589915
FBLN1	FBLN	fibulin 1	-	HPRD,BioGRID	11238726
GAPDH	G3PD \| GAPD \| MGC88685	glyceraldehyde-3-phosphate dehydrogenase	-	HPRD	8473906
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD	12485888
GSN	DKFZp313L0718	gelsolin (amyloidosis, Finnish type)	-	HPRD,BioGRID	10329371
HADHB	ECHB \| MGC87480 \| MSTP029 \| TP-BETA	hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit	-	HPRD	11430884
HMOX2	HO-2	heme oxygenase (decycling) 2	-	HPRD	12057765
HSD17B10	17b-HSD10 \| ABAD \| CAMR \| ERAB \| HADH2 \| HCD2 \| MHBD \| MRX17 \| MRX31 \| MRXS10 \| SCHAD	hydroxysteroid (17-beta) dehydrogenase 10	-	HPRD,BioGRID	9338779 \|10371197
HSPG2	PLC \| PRCAN \| SJA \| SJS \| SJS1	heparan sulfate proteoglycan 2	-	HPRD	9136074
HTRA2	OMI \| PARK13 \| PRSS25	HtrA serine peptidase 2	HtrA2 interacts with APP.	BIND	15036614
IDE	FLJ35968 \| INSULYSIN	insulin-degrading enzyme	-	HPRD	9830016
KAT5	ESA1 \| HTATIP \| HTATIP1 \| PLIP \| TIP \| TIP60 \| cPLA2	K(lysine) acetyltransferase 5	-	HPRD	12888553
KLC1	KLC \| KNS2 \| KNS2A \| MGC15245	kinesin light chain 1	-	HPRD,BioGRID	11144355
KNG1	BDK \| KNG	kininogen 1	-	HPRD	12090937
LAMA1	LAMA	laminin, alpha 1	-	HPRD	9136074
LRP1	A2MR \| APOER \| APR \| CD91 \| FLJ16451 \| IGFBP3R \| LRP \| MGC88725 \| TGFBR5	low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)	-	HPRD	7543026 \|12212791
LRP1B	LRP-DIT \| LRPDIT	low density lipoprotein-related protein 1B (deleted in tumors)	-	HPRD	15126508
MAPK8IP1	IB1 \| JIP-1 \| JIP1 \| PRKM8IP	mitogen-activated protein kinase 8 interacting protein 1	JIP1 interacts with APP.	BIND	11724784
MAPK8IP1	IB1 \| JIP-1 \| JIP1 \| PRKM8IP	mitogen-activated protein kinase 8 interacting protein 1	-	HPRD	11517249 \|11724784
NAE1	A-116A10.1 \| APPBP1 \| HPP1 \| ula-1	NEDD8 activating enzyme E1 subunit 1	The carboxy terminus of Amyloid Precursor Protein (APP) mediates an interaction with APP-BP1.	BIND	8626687
NAE1	A-116A10.1 \| APPBP1 \| HPP1 \| ula-1	NEDD8 activating enzyme E1 subunit 1	-	HPRD,BioGRID	8626687
NCSTN	APH2 \| KIAA0253	nicastrin	-	HPRD,BioGRID	10993067
NID1	NID	nidogen 1	-	HPRD	11376898
NUMB	S171	numb homolog (Drosophila)	-	HPRD	12011466
PRSS2	MGC111183 \| MGC120174 \| TRY2 \| TRY8 \| TRYP2	protease, serine, 2 (trypsin 2)	-	HPRD	8478942
PRSS3	MTG \| PRSS4 \| TRY3 \| TRY4	protease, serine, 3	-	HPRD	11827488
PSEN1	AD3 \| FAD \| PS1 \| S182	presenilin 1	-	HPRD	10593990
PSEN1	AD3 \| FAD \| PS1 \| S182	presenilin 1	APPswe interacts with PS-1delta-9.	BIND	14756819
PSEN1	AD3 \| FAD \| PS1 \| S182	presenilin 1	PS1 interacts with APP via the APP-C100 fragment.	BIND	10801777
PSEN1	AD3 \| FAD \| PS1 \| S182	presenilin 1	PS1 interacts with APP751.	BIND	9223340
PSEN1	AD3 \| FAD \| PS1 \| S182	presenilin 1	PS1 interacts with APP695.	BIND	9223340
PSEN1	AD3 \| FAD \| PS1 \| S182	presenilin 1	PS1 interacts with APP.	BIND	15448688
PSEN2	AD3L \| AD4 \| PS2 \| STM2	presenilin 2 (Alzheimer disease 4)	PS2 interacts with APP.	BIND	9223340
SERPINA3	AACT \| ACT \| GIG24 \| GIG25 \| MGC88254	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	-	HPRD	2190106\|10048303
SHC1	FLJ26504 \| SHC \| SHCA	SHC (Src homology 2 domain containing) transforming protein 1	-	HPRD,BioGRID	9045663 \|11877420
SHC3	N-Shc \| NSHC \| RAI \| SHCC	SHC (Src homology 2 domain containing) transforming protein 3	-	HPRD	11877420
SNCA	MGC110988 \| NACP \| PARK1 \| PARK4 \| PD1	synuclein, alpha (non A4 component of amyloid precursor)	-	HPRD,BioGRID	9163350
SNCB	-	synuclein, beta	-	HPRD,BioGRID	9163350
SPON1	KIAA0762 \| MGC10724 \| f-spondin	spondin 1, extracellular matrix protein	-	HPRD	14983046
TGFB1	CED \| DPD1 \| TGFB \| TGFbeta	transforming growth factor, beta 1	TGF-beta-1 interacts with Amyloid-beta. This interaction was modelled on a demonstrated interaction between TGF-beta-1 from an unspecified species and consensus Amyloid-beta peptides.	BIND	12867422
TGFB2	MGC116892 \| TGF-beta2	transforming growth factor, beta 2	TGF-beta-2 interacts with Amyloid-beta. This interaction was modelled on a demonstrated interaction between TGF-beta-2 from an unspecified species and consensus Amyloid-beta peptides.	BIND	12867422
TM2D1	BBP	TM2 domain containing 1	-	HPRD	11278849
TP53BP2	53BP2 \| ASPP2 \| BBP \| PPP1R13A \| p53BP2	tumor protein p53 binding protein, 2	-	HPRD	11278849

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG ALZHEIMERS DISEASE	169	110	All SZGR 2.0 genes in this pathway
BIOCARTA P35ALZHEIMERS PATHWAY	11	9	All SZGR 2.0 genes in this pathway
BIOCARTA PLATELETAPP PATHWAY	14	10	All SZGR 2.0 genes in this pathway
PID GLYPICAN 1PATHWAY	27	20	All SZGR 2.0 genes in this pathway
PID P75 NTR PATHWAY	69	51	All SZGR 2.0 genes in this pathway
PID CASPASE PATHWAY	52	39	All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING	74	54	All SZGR 2.0 genes in this pathway
REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	18	15	All SZGR 2.0 genes in this pathway
REACTOME GASTRIN CREB SIGNALLING PATHWAY VIA PKC AND MAPK	205	136	All SZGR 2.0 genes in this pathway
REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	89	56	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR	920	449	All SZGR 2.0 genes in this pathway
REACTOME PEPTIDE LIGAND BINDING RECEPTORS	188	108	All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS	305	177	All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Q SIGNALLING EVENTS	184	116	All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING	805	368	All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS	195	114	All SZGR 2.0 genes in this pathway
REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	23	17	All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING	408	246	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED NFKB ACTIVATION	21	17	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION	77	57	All SZGR 2.0 genes in this pathway
REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	13	11	All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE	72	53	All SZGR 2.0 genes in this pathway
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	73	57	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE	83	63	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING	93	69	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES	118	84	All SZGR 2.0 genes in this pathway
REACTOME THE NLRP3 INFLAMMASOME	12	9	All SZGR 2.0 genes in this pathway
REACTOME INFLAMMASOMES	17	12	All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	46	33	All SZGR 2.0 genes in this pathway
REACTOME AMYLOIDS	83	63	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN	275	168	All SZGR 2.0 genes in this pathway
AKL HTLV1 INFECTION UP	27	16	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 DN	242	165	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN	281	186	All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP	157	104	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP	214	155	All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL QUIESCENT DN	47	32	All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN	142	95	All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP	215	137	All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS G UP	238	135	All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER DN	185	115	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW UP	162	104	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN	180	110	All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA DN	181	107	All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS REPRESSED BY SERUM	159	93	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
SASAI RESISTANCE TO NEOPLASTIC TRANSFROMATION	50	31	All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM2	153	102	All SZGR 2.0 genes in this pathway
KHETCHOUMIAN TRIM24 TARGETS UP	47	38	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN	514	330	All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS	734	436	All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX	230	156	All SZGR 2.0 genes in this pathway
SWEET KRAS TARGETS DN	66	39	All SZGR 2.0 genes in this pathway
GOLDRATH HOMEOSTATIC PROLIFERATION	171	102	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA UP	61	40	All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC	182	116	All SZGR 2.0 genes in this pathway
ABRAHAM ALPC VS MULTIPLE MYELOMA UP	26	22	All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN	246	180	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C8	72	56	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP	390	242	All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM DN	141	99	All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS RESPONSE	35	28	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS LATE PROGENITOR	544	307	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS UP	175	116	All SZGR 2.0 genes in this pathway
SIMBULAN PARP1 TARGETS UP	31	23	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
APRELIKOVA BRCA1 TARGETS	49	33	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 8	86	57	All SZGR 2.0 genes in this pathway
KAYO CALORIE RESTRICTION MUSCLE UP	95	64	All SZGR 2.0 genes in this pathway
CHENG RESPONSE TO NICKEL ACETATE	45	29	All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN	96	71	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND MACROPHAGE	77	50	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST	132	93	All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P7	90	52	All SZGR 2.0 genes in this pathway
KONDO EZH2 TARGETS	245	148	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP	673	430	All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP	602	364	All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN	591	366	All SZGR 2.0 genes in this pathway
CAMPS COLON CANCER COPY NUMBER DN	74	34	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN	564	326	All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS	425	261	All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA	447	277	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN	252	155	All SZGR 2.0 genes in this pathway
PARK APL PATHOGENESIS DN	50	35	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN	366	257	All SZGR 2.0 genes in this pathway
CHANG CORE SERUM RESPONSE DN	209	137	All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN	457	302	All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 11	36	24	All SZGR 2.0 genes in this pathway
VALK AML WITH FLT3 ITD	40	22	All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION	368	247	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA1 UP	101	66	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
DANG MYC TARGETS DN	31	25	All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC	1103	714	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
RAGHAVACHARI PLATELET SPECIFIC GENES	70	46	All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS UP	387	225	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B	549	316	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE	1137	655	All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN	315	215	All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS UP	266	142	All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL DN	146	88	All SZGR 2.0 genes in this pathway
WARTERS IR RESPONSE 5GY	47	23	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	243	250	1A,m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-101	243	250	1A,m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-144	532	538	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-144	532	538	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-15/16/195/424/497	544	550	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-153	458	464	m8	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-17-5p/20/93.mr/106/519.d	710	716	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-185	288	294	m8	hsa-miR-185^brain	UGGAGAGAAAGGCAGUUC
miR-324-5p	393	399	m8	hsa-miR-324-5p	CGCAUCCCCUAGGGCAUUGGUGU
miR-381	325	331	1A	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-383	451	457	1A	hsa-miR-383^brain	AGAUCAGAAGGUGAUUGUGGCU
miR-93.hd/291-3p/294/295/302/372/373/520	709	715	m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: APP