Summary ?
GeneID3643
SymbolINSR
SynonymsCD220|HHF5
Descriptioninsulin receptor
ReferenceMIM:147670|HGNC:HGNC:6091|Ensembl:ENSG00000171105|HPRD:00975|Vega:OTTHUMG00000181992
Gene typeprotein-coding
Map location19p13.3-p13.2
Pascal p-value0.009
Fetal beta0.407
DMG1 (# studies)
eGeneMyers' cis & trans
SupportAscano FMRP targets

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0449 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg13976219197197166INSR4.646E-4-0.2330.046DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2860173chr197129085INSR36430.13cis

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004714transmembrane receptor protein tyrosine kinase activityIEAneurite (GO term level: 8)-
GO:0000166nucleotide bindingIEA-
GO:0004872receptor activityIEA-
GO:0004716receptor signaling protein tyrosine kinase activityIDA6849137 
GO:0005159insulin-like growth factor receptor bindingIDA8452530 
GO:0005009insulin receptor activityIDA8440175 
GO:0005524ATP bindingIEA-
GO:0005525GTP bindingIDA9092559 
GO:0016740transferase activityIEA-
GO:0042169SH2 domain bindingIPI8276809 
GO:0031994insulin-like growth factor I bindingIPI8452530 
GO:0031995insulin-like growth factor II bindingIPI12138094 
GO:0043548phosphoinositide 3-kinase bindingIPI7537849 |8276809 
GO:0043559insulin bindingIDA8440175 
GO:0043560insulin receptor substrate bindingIPI7537849 |7559478 
GO:0051425PTB domain bindingIPI7559478 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000187activation of MAPK activityIMP17001305 
GO:0003007heart morphogenesisIMP7693131 
GO:0030238male sex determinationIEA-
GO:0007186G-protein coupled receptor protein signaling pathwayIDA9092559 
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayIEA-
GO:0006468protein amino acid phosphorylationIEA-
GO:0005975carbohydrate metabolic processIEA-
GO:0008286insulin receptor signaling pathwayIDA8440175 
GO:0042593glucose homeostasisIMP7693131 
GO:0032583regulation of gene-specific transcriptionIMP12881524 
GO:0019087transformation of host cell by virusIMP17001305 
GO:0051290protein heterotetramerizationIDA1898103 
GO:0030335positive regulation of cell migrationIMP12138094 
GO:0045740positive regulation of DNA replicationIMP12138094 
GO:0045821positive regulation of glycolysisIMP7693131 
GO:0045995regulation of embryonic developmentIMP7693131 
GO:0046777protein amino acid autophosphorylationIMP7537849 
GO:0048639positive regulation of developmental growthIMP7693131 
GO:0045429positive regulation of nitric oxide biosynthetic processIMP10747347 
GO:0060267positive regulation of respiratory burstIDA9092559 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005792microsomeIDA8452530 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0005901caveolaIDA15182363 
GO:0005886plasma membraneEXP2986535 
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneIDA9092559 
GO:0010008endosome membraneEXP2986535 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACP1HAAP | MGC111030 | MGC3499acid phosphatase 1, soluble-HPRD1304913 
AHSGA2HS | AHS | FETUA | HSGAalpha-2-HS-glycoprotein-HPRD,BioGRID7906861 
CAV1CAV | MSTP085 | VIP21caveolin 1, caveolae protein, 22kDa-HPRD,BioGRID10598578 
CSKMGC117393c-src tyrosine kinaseCSK interacts with IR.BIND10026153 
CSKMGC117393c-src tyrosine kinase-HPRD,BioGRID10026153 
DOK5C20orf180 | MGC16926docking protein 5-HPRD12730241 
ENPP1M6S1 | NPP1 | NPPS | PC-1 | PCA1 | PDNP1ectonucleotide pyrophosphatase/phosphodiesterase 1-HPRD,BioGRID10615944 
FRS2FRS2A | FRS2alpha | SNT | SNT-1 | SNT1fibroblast growth factor receptor substrate 2-HPRD,BioGRID10650943 
GAB1-GRB2-associated binding protein 1Two-hybridBioGRID9658397 
GRB10GRB-IR | Grb-10 | IRBP | KIAA0207 | MEG1 | RSSgrowth factor receptor-bound protein 10Grb10 interacts with IR.BIND9506989 
GRB10GRB-IR | Grb-10 | IRBP | KIAA0207 | MEG1 | RSSgrowth factor receptor-bound protein 10-HPRD,BioGRID7479769 |8621530 
GRB14-growth factor receptor-bound protein 14-HPRD,BioGRID9748281 |11726652 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Affinity Capture-WesternBioGRID9083103 
GRB7-growth factor receptor-bound protein 7-HPRD,BioGRID10803466 
HMGA1HMG-R | HMGA1A | HMGIY | MGC12816 | MGC4242 | MGC4854high mobility group AT-hook 1HMGA1 interacts with INSR locus.BIND15924147 
HRASC-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1v-Ha-ras Harvey rat sarcoma viral oncogene homolog-HPRD,BioGRID3109943 
IGF2C11orf43 | FLJ22066 | FLJ44734 | INSIGF | pp9974insulin-like growth factor 2 (somatomedin A)-HPRD,BioGRID9722981 
INPPL1SHIP2inositol polyphosphate phosphatase-like 1Affinity Capture-WesternBioGRID12504111 
INSILPR | IRDNinsulin-HPRD2550426 
INSRRIRRinsulin receptor-related receptor-HPRD,BioGRID8916919 
IRS1HIRS-1insulin receptor substrate 1IRS-1 interacts with IR. This interaction was modeled on a demonstrated interaction between rat IRS-1 and human IR.BIND10026153 
IRS1HIRS-1insulin receptor substrate 1Insulin Receptor Substrate-1 Binds to the Insulin Receptor. This interaction is modeled on demonstrated interaction between human IR and rat IRS-1BIND8626379 
IRS1HIRS-1insulin receptor substrate 1-HPRD,BioGRID11606564 
IRS2-insulin receptor substrate 2-HPRD,BioGRID8626379 
IRS2-insulin receptor substrate 2Insulin Receptor Substrate-2 Binds to the Insulin Receptor. This interaction is modeled on demonstrated interaction between human IR and murine IRS-2.BIND8626379 
JAK1JAK1A | JAK1B | JTK3Janus kinase 1 (a protein tyrosine kinase)Phosphorylated IR-beta interacts with JAK-1.BIND9492017 
KHDRBS1FLJ34027 | Sam68 | p62KH domain containing, RNA binding, signal transduction associated 1Affinity Capture-WesternBioGRID11604231 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1Affinity Capture-WesternBioGRID11409918 
MAPK3ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3mitogen-activated protein kinase 3-HPRD,BioGRID11409918 
NAMPT1110035O14Rik | DKFZp666B131 | MGC117256 | PBEF | PBEF1 | VF | VISFATINnicotinamide phosphoribosyltransferasePBEF interacts with IR.BIND15604363 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)INSR (IR) interacts with PIK3R1. This interaction was modeled on a demonstrated interaction between INSR and PIK3R1 from unspecified species.BIND15735664 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)The insulin receptor (IR) interacts with p85-alpha.BIND8603569 
PIK3R3DKFZp686P05226 | FLJ41892 | p55 | p55-GAMMAphosphoinositide-3-kinase, regulatory subunit 3 (gamma)-HPRD,BioGRID9524259 
PRKCDMAY1 | MGC49908 | PKCD | nPKC-deltaprotein kinase C, delta-HPRD,BioGRID11266508 
PTPN1PTP1Bprotein tyrosine phosphatase, non-receptor type 1-HPRD,BioGRID8826975 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11-HPRD,BioGRID7493946 |8135823 
PTPN12PTP-PEST | PTPG1protein tyrosine phosphatase, non-receptor type 12-HPRD,BioGRID8454633 
PTPN6HCP | HCPH | HPTP1C | PTP-1C | SH-PTP1 | SHP-1 | SHP-1L | SHP1protein tyrosine phosphatase, non-receptor type 6-HPRD,BioGRID7512963 
PTPRFFLJ43335 | FLJ45062 | FLJ45567 | LARprotein tyrosine phosphatase, receptor type, F-HPRD,BioGRID1321126 
RAF1CRAF | NS5 | Raf-1 | c-Rafv-raf-1 murine leukemia viral oncogene homolog 1-HPRD11409918 
RASA1CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAPRAS p21 protein activator (GTPase activating protein) 1-HPRD,BioGRID1331107 
SH2B1DKFZp547G1110 | FLJ30542 | KIAA1299 | SH2-B | SH2BSH2B adaptor protein 1-HPRD,BioGRID9742218 |10594240 
SH2B2APSSH2B adaptor protein 2-HPRD10196204 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD9083103 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1Tyrosine-phosphorylated IR interacts with Shc. This interaction was modeled on a demonstrated interaction between human IR and Shc from an unspecified species.BIND10340378 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2-HPRD,BioGRID9092546 
SNX1HsT17379 | MGC8664 | SNX1A | Vps5sorting nexin 1-HPRD,BioGRID9819414 
SNX2MGC5204 | TRG-9sorting nexin 2-HPRD,BioGRID9819414 
SNX4-sorting nexin 4-HPRD,BioGRID9819414 
SNX6MGC3157 | MSTP010 | TFAF2sorting nexin 6-HPRD,BioGRID11279102 
SOCS1CIS1 | CISH1 | JAB | SOCS-1 | SSI-1 | SSI1 | TIP3suppressor of cytokine signaling 1Suppressors of cytokine signaling-1 associates with and inhibits the insulin receptor.BIND11342531 
SOCS3ATOD4 | CIS3 | Cish3 | MGC71791 | SOCS-3 | SSI-3 | SSI3suppressor of cytokine signaling 3-HPRD,BioGRID11071852 |12560330 
SOCS6CIS4 | HSPC060 | SOCS4 | SSI4 | STAI4 | STATI4suppressor of cytokine signaling 6Suppressors of cytokine signaling-6 associates with and inhibits the insulin receptor. This interaction is modeled on demonstrated interaction between human IR and murine SOCS-6.BIND11342531 
SORBS1CAP | DKFZp451C066 | DKFZp586P1422 | FLAF2 | FLJ12406 | KIAA1296 | R85FL | SH3D5 | SH3P12 | SORB1sorbin and SH3 domain containing 1-HPRD,BioGRID11374898 
SYNCRIPGRY-RBP | HNRPQ1 | NSAP1 | RP1-3J17.2 | dJ3J17.2 | hnRNP-Q | pp68synaptotagmin binding, cytoplasmic RNA interacting protein-HPRD,BioGRID11994298 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD,BioGRID7535775 
VAV3FLJ40431vav 3 guanine nucleotide exchange factor-HPRD,BioGRID11094073 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ADHERENS JUNCTION 7553All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137103All SZGR 2.0 genes in this pathway
KEGG TYPE II DIABETES MELLITUS 4741All SZGR 2.0 genes in this pathway
KEGG ALDOSTERONE REGULATED SODIUM REABSORPTION 4229All SZGR 2.0 genes in this pathway
BIOCARTA HDAC PATHWAY 3225All SZGR 2.0 genes in this pathway
BIOCARTA GH PATHWAY 2822All SZGR 2.0 genes in this pathway
BIOCARTA INSULIN PATHWAY 2216All SZGR 2.0 genes in this pathway
PID INSULIN PATHWAY 4532All SZGR 2.0 genes in this pathway
PID PTP1B PATHWAY 5240All SZGR 2.0 genes in this pathway
PID TCPTP PATHWAY 4333All SZGR 2.0 genes in this pathway
PID INSULIN GLUCOSE PATHWAY 2624All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR RECYCLING 239All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE 8764All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR 10872All SZGR 2.0 genes in this pathway
REACTOME SIGNAL ATTENUATION 148All SZGR 2.0 genes in this pathway
REACTOME PI3K CASCADE 7151All SZGR 2.0 genes in this pathway
REACTOME SHC RELATED EVENTS 1713All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634384All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN 11679All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN 352225All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380236All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
WANG BARRETTS ESOPHAGUS AND ESOPHAGUS CANCER UP 2612All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS 355243All SZGR 2.0 genes in this pathway
PEREZ TP53 AND TP63 TARGETS 205145All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203134All SZGR 2.0 genes in this pathway
KIM MYCN AMPLIFICATION TARGETS DN 10359All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230156All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC 182116All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP 207145All SZGR 2.0 genes in this pathway
URS ADIPOCYTE DIFFERENTIATION UP 7451All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
CHEN LVAD SUPPORT OF FAILING HEART UP 10369All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262186All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
BILD E2F3 ONCOGENIC SIGNATURE 246153All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS 9071All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN 353226All SZGR 2.0 genes in this pathway
OUYANG PROSTATE CANCER MARKERS 1916All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A DN 10868All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL UP 185112All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351238All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266180All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN 225124All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE G1 S 14776All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS UP 504321All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 UP 344215All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658397All SZGR 2.0 genes in this pathway
GUO TARGETS OF IRS1 AND IRS2 9867All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279155All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/98239324001A,m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-1281942001Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-15/16/195/424/497577583m8hsa-miR-15abrainUAGCAGCACAUAAUGGUUUGUG
hsa-miR-16brainUAGCAGCACGUAAAUAUUGGCG
hsa-miR-15bbrainUAGCAGCACAUCAUGGUUUACA
hsa-miR-195SZUAGCAGCACAGAAAUAUUGGC
hsa-miR-424CAGCAGCAAUUCAUGUUUUGAA
hsa-miR-497CAGCAGCACACUGUGGUUUGU
miR-37923912397m8hsa-miR-379brainUGGUAGACUAUGGAACGUA
miR-496232323301A,m8hsa-miR-496AUUACAUGGCCAAUCUC