Gene Page: LGALS3BP

Summary ?
GeneID3959
SymbolLGALS3BP
Synonyms90K|BTBD17B|CyCAP|M2BP|MAC-2-BP|TANGO10B|gp90
Descriptionlectin, galactoside-binding, soluble, 3 binding protein
ReferenceMIM:600626|HGNC:HGNC:6564|Ensembl:ENSG00000108679|HPRD:02796|Vega:OTTHUMG00000177572
Gene typeprotein-coding
Map location17q25
Pascal p-value0.152
Sherlock p-value0.351
Fetal beta-1.368
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 2

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
LGALS3BPchr1776967715GANM_005567.silentSchizophreniaDNM:Fromer_2014

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg111056101776976352LGALS3BP0.003-3.528DMG:vanEijk_2014
cg148702711776976010LGALS3BP2.261E-4-3.986DMG:vanEijk_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs4796798chr1776616546LGALS3BP39590.18cis
snp_a-22745050LGALS3BP39590.01trans
rs4501739chrX35960848LGALS3BP39590.01trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GPI0.890.87
DENND4B0.870.87
KLC20.860.84
AARS0.860.83
WBP20.860.83
NFE2L10.850.84
CYFIP20.850.87
PDXK0.850.82
IFFO10.840.82
AC135048.10.840.82
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GNG11-0.53-0.51
AF347015.21-0.51-0.40
IL32-0.51-0.49
NOSTRIN-0.47-0.41
AF347015.18-0.46-0.31
FAM159B-0.46-0.67
AL050337.1-0.45-0.49
C1orf54-0.45-0.43
AP002478.3-0.44-0.40
CLEC3B-0.44-0.47

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD14-CD14 molecule-HPRD7583357 
COL5A1-collagen, type V, alpha 1-HPRD9501082 
COL6A1OPLLcollagen, type VI, alpha 1-HPRD9501082 
FN1CIG | DKFZp686F10164 | DKFZp686H0342 | DKFZp686I1370 | DKFZp686O13149 | ED-B | FINC | FN | FNZ | GFND | GFND2 | LETS | MSFfibronectin 1-HPRD9501082 
ITGB1CD29 | FNRB | GPIIA | MDF2 | MSK12 | VLA-BETA | VLABintegrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)-HPRD9501082 
LGALS1DKFZp686E23103 | GAL1 | GBPlectin, galactoside-binding, soluble, 1in vitro
in vivo		BioGRID11146440 
LGALS3CBP35 | GAL3 | GALBP | GALIG | LGALS2 | MAC2lectin, galactoside-binding, soluble, 3-HPRD,BioGRID1917996 |8390986 
|8813152 |9501082 
LGALS3BP90K | BTBD17B | MAC-2-BPlectin, galactoside-binding, soluble, 3 binding protein-HPRD9501082 
MAP3K7IP2FLJ21885 | KIAA0733 | TAB2mitogen-activated protein kinase kinase kinase 7 interacting protein 2-HPRD14743216 
NID1NIDnidogen 1-HPRD9501082 
PHB2BAP | BCAP37 | Bap37 | MGC117268 | PNAS-141 | REA | p22prohibitin 2Affinity Capture-MSBioGRID17353931 
TRADDHs.89862 | MGC11078TNFRSF1A-associated via death domain-HPRD14743216 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
HOLLMANN APOPTOSIS VIA CD40 DN 267178All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP 368234All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP 306188All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN 275168All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP 182110All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP 15791All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP 194122All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN 281186All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329219All SZGR 2.0 genes in this pathway
SCIBETTA KDM5B TARGETS DN 8155All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES SKIN DN 2720All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP 215137All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP 211136All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS F UP 185119All SZGR 2.0 genes in this pathway
LI AMPLIFIED IN LUNG CANCER 178108All SZGR 2.0 genes in this pathway
PATTERSON DOCETAXEL RESISTANCE 2920All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS UP 11071All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP 380213All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP 209139All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A DN 10371All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS UP 292168All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335181All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS UP 266171All SZGR 2.0 genes in this pathway
LAMB CCND1 TARGETS 1914All SZGR 2.0 genes in this pathway
BECKER TAMOXIFEN RESISTANCE UP 5036All SZGR 2.0 genes in this pathway
RADAEVA RESPONSE TO IFNA1 UP 5240All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 UP 6440All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG UP 7850All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING UP 8356All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA SPIKED 2213All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318215All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION UP 11484All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183111All SZGR 2.0 genes in this pathway
BENNETT SYSTEMIC LUPUS ERYTHEMATOSUS 3121All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405264All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408274All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371218All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
LINDVALL IMMORTALIZED BY TERT DN 8056All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504323All SZGR 2.0 genes in this pathway
LEE AGING NEOCORTEX UP 8959All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM UP 8458All SZGR 2.0 genes in this pathway
LIU SMARCA4 TARGETS 6439All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681420All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS DN 264168All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND MACROPHAGE 7750All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM 6647All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND FIBROBLAST 13293All SZGR 2.0 genes in this pathway
LEIN CHOROID PLEXUS MARKERS 10361All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN 220147All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING UP 7451All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593372All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
BRUECKNER TARGETS OF MIRLET7A3 DN 7849All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO RADIATION THERAPY 3220All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP 10767All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356214All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
VALK AML WITH FLT3 ITD 4022All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G56 DN 179All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 LCP WITH H3K4ME3 16280All SZGR 2.0 genes in this pathway
MIKKELSEN MEF LCP WITH H3K4ME3 12868All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA UP 7543All SZGR 2.0 genes in this pathway
FONTAINE PAPILLARY THYROID CARCINOMA UP 6638All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S1 237159All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 12 7954All SZGR 2.0 genes in this pathway
NIELSEN GIST VS SYNOVIAL SARCOMA DN 2017All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP 307182All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572352All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430288All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 36HR 2923All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
WANG MLL TARGETS 289188All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS UP 266142All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP 289184All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL DN 428246All SZGR 2.0 genes in this pathway
HECKER IFNB1 TARGETS 9554All SZGR 2.0 genes in this pathway