Gene Page: MEF2A

Summary ?
GeneID4205
SymbolMEF2A
SynonymsADCAD1|RSRFC4|RSRFC9|mef2
Descriptionmyocyte enhancer factor 2A
ReferenceMIM:600660|HGNC:HGNC:6993|Ensembl:ENSG00000068305|HPRD:02807|Vega:OTTHUMG00000171937
Gene typeprotein-coding
Map location15q26
Pascal p-value0.156
Sherlock p-value0.898
Fetal beta-0.883
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs4951059chr1204258018MEF2A42050.18trans
rs17014160chr1206855799MEF2A42050.1trans
rs12093398chr1246113979MEF2A42050.04trans
rs12997903chr21952083MEF2A42050.11trans
rs6733654chr21963270MEF2A42050trans
rs891877chr22043348MEF2A42050.13trans
rs6754787chr230141949MEF2A42050.01trans
rs841285chr2129330728MEF2A42050.13trans
rs7595584chr2175652187MEF2A42058.135E-4trans
rs10191055chr2201316238MEF2A42050.18trans
rs1155107chr326843376MEF2A42050.14trans
rs1395163chr331028951MEF2A42050.14trans
rs6446109chr360076988MEF2A42050.06trans
rs2339917chr3179669447MEF2A42050.16trans
rs6848885chr421582684MEF2A42050.05trans
snp_a-41960490MEF2A42050.01trans
snp_a-18535270MEF2A42050trans
rs7677329chr421586153MEF2A42050.05trans
rs6813178chr471575238MEF2A42054.106E-4trans
rs6834662chr471605100MEF2A42050.15trans
rs12639667chr4140243821MEF2A42050.06trans
rs16870339chr52705169MEF2A42054.945E-5trans
rs17146240chr5119522933MEF2A42050.15trans
rs17146261chr5119534252MEF2A42050.15trans
rs6930572chr631428168MEF2A42050.18trans
rs320082chr729105404MEF2A42050.03trans
rs317720chr729110633MEF2A42050.13trans
rs317714chr729115553MEF2A42050.02trans
rs317724chr729120565MEF2A42050.13trans
rs1831517chr92513405MEF2A42053.203E-4trans
rs1020772chr976532511MEF2A42050.07trans
rs10992675chr995963315MEF2A42050.06trans
rs4607971chr1019407890MEF2A42050.01trans
rs7078127chr1074847633MEF2A42050.14trans
rs12569493chr1074886042MEF2A42050.14trans
rs16930362chr1074890320MEF2A42050.04trans
rs2271904chr1074894374MEF2A42050.14trans
rs16915029chr1075001994MEF2A42050.03trans
rs11000607chr1075089777MEF2A42050.19trans
rs6480700chr1075101689MEF2A42050.16trans
rs12571454chr1075208954MEF2A42050.05trans
rs1700369chr12127842232MEF2A42050.13trans
rs1817693chr12128395998MEF2A42050.19trans
rs2699067chr12128397197MEF2A42050.19trans
rs2699066chr12128397415MEF2A42050.19trans
rs10145685chr1422794892MEF2A42050.03trans
rs17793827chr1422797560MEF2A42050.01trans
rs10136383chr1422801078MEF2A42050.01trans
rs2455956chr1443524686MEF2A42050trans
rs2254834chr1443596184MEF2A42050trans
rs1954396chr1443601835MEF2A42051.569E-4trans
rs11158850chr1470757171MEF2A42050trans
rs2239335chr1622897794MEF2A42050.1trans
rs2369690chr1622920851MEF2A42050.03trans
rs10500572chr1673559356MEF2A42050.03trans
rs9965053chr183166191MEF2A42050.07trans
rs8087321chr183168615MEF2A42050.17trans
rs7239484chr1855443711MEF2A42050.04trans
rs1761450chr1954818034MEF2A42050.09trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ASCL1ASH1 | HASH1 | MASH1 | bHLHa46achaete-scute complex homolog 1 (Drosophila)-HPRD,BioGRID8662987 
EP300KAT3B | p300E1A binding protein p300-HPRD,BioGRID12371907 
HDAC4HA6116 | HD4 | HDAC-A | HDACA | KIAA0288histone deacetylase 4-HPRD,BioGRID10487761 
HDAC5FLJ90614 | HD5 | NY-CO-9histone deacetylase 5-HPRD,BioGRID10748098 
HDAC9DKFZp779K1053 | HD7 | HDAC | HDAC7 | HDAC7B | HDAC9B | HDAC9FL | HDRP | KIAA0744 | MITRhistone deacetylase 9Affinity Capture-Western
Reconstituted Complex		BioGRID10487761 |10748098 
HDAC9DKFZp779K1053 | HD7 | HDAC | HDAC7 | HDAC7B | HDAC9B | HDAC9FL | HDRP | KIAA0744 | MITRhistone deacetylase 9-HPRD10825153 
MAPK14CSBP1 | CSBP2 | CSPB1 | EXIP | Mxi2 | PRKM14 | PRKM15 | RK | SAPK2A | p38 | p38ALPHAmitogen-activated protein kinase 14-HPRD,BioGRID10330143 
MAPK7BMK1 | ERK4 | ERK5 | PRKM7mitogen-activated protein kinase 7-HPRD,BioGRID9753748 
MEF2AADCAD1 | RSRFC4 | RSRFC9myocyte enhancer factor 2A-HPRD8575763 
MEF2DDKFZp686I1536myocyte enhancer factor 2D-HPRD,BioGRID8798771 |9858528 
MYOD1MYF3 | MYOD | PUM | bHLHc1myogenic differentiation 1-HPRD8548800|9418854 
MYOGMYF4 | MYOGENIN | bHLHc3myogenin (myogenic factor 4)-HPRD,BioGRID1329097 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2-HPRD,BioGRID11160896 
SMAD4DPC4 | JIP | MADH4SMAD family member 4-HPRD11160896 
TEAD1AA | REF1 | TCF13 | TEF-1TEA domain family member 1 (SV40 transcriptional enhancer factor)-HPRD12061776 
THRAAR7 | EAR7 | ERB-T-1 | ERBA | ERBA1 | MGC000261 | MGC43240 | NR1A1 | THRA1 | THRA2 | c-ERBA-1thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)-HPRD,BioGRID12371907 
VGLL4KIAA0121 | VGL-4vestigial like 4 (Drosophila)Two-hybridBioGRID15140898 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA AT1R PATHWAY 3628All SZGR 2.0 genes in this pathway
BIOCARTA HDAC PATHWAY 3225All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY 8768All SZGR 2.0 genes in this pathway
BIOCARTA P38MAPK PATHWAY 4031All SZGR 2.0 genes in this pathway
BIOCARTA PGC1A PATHWAY 2620All SZGR 2.0 genes in this pathway
BIOCARTA ERK5 PATHWAY 1815All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA DOWNSTREAM PATHWAY 3829All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217167All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING 7454All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137105All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION 2420All SZGR 2.0 genes in this pathway
REACTOME ERK MAPK TARGETS 2117All SZGR 2.0 genes in this pathway
REACTOME MYOGENESIS 2820All SZGR 2.0 genes in this pathway
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE 5037All SZGR 2.0 genes in this pathway
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES 3024All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION 7757All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE 7253All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE 8363All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279178All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING 9369All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES 11884All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473314All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN 275168All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL UP 9564All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 1 DN 12686All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 MUTATED SIGNATURE 2 DN 7746All SZGR 2.0 genes in this pathway
MULLIGHAN NPM1 SIGNATURE 3 DN 162116All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174695All SZGR 2.0 genes in this pathway
TURJANSKI MAPK7 TARGETS 88All SZGR 2.0 genes in this pathway
TURJANSKI MAPK11 TARGETS 55All SZGR 2.0 genes in this pathway
TURJANSKI MAPK14 TARGETS 1010All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855609All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483336All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514319All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
BALDWIN PRKCI TARGETS UP 3526All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 15Q26 AMPLICON 2219All SZGR 2.0 genes in this pathway
ROSS AML WITH CBFB MYH11 FUSION 5232All SZGR 2.0 genes in this pathway
MANALO HYPOXIA UP 207145All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR 293193All SZGR 2.0 genes in this pathway
NGUYEN NOTCH1 TARGETS DN 8667All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246180All SZGR 2.0 genes in this pathway
HOEGERKORP CD44 TARGETS TEMPORAL DN 2516All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371218All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM DN 8666All SZGR 2.0 genes in this pathway
DELASERNA MYOD TARGETS UP 8951All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN 165106All SZGR 2.0 genes in this pathway
KEEN RESPONSE TO ROSIGLITAZONE DN 10668All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783442All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 5 482296All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578341All SZGR 2.0 genes in this pathway
WENDT COHESIN TARGETS UP 3319All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518299All SZGR 2.0 genes in this pathway
CHIARETTI T ALL RELAPSE PROGNOSIS 1915All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824528All SZGR 2.0 genes in this pathway