Gene Page: NFYA

Summary
GeneID  4800
Symbol  NFYA
Synonyms  CBF-A|CBF-B|FLJ11236|HAP2|NF-YA
Description  nuclear transcription factor Y, alpha
See related  HGNC:7804|MIM:189903|Ensembl:ENSG00000001167|HPRD:01793|
Locus tag  -
Gene type  protein-coding
Map location  6p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.033 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.04433 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NME1-NME20.980.98
C2orf790.890.91
MYL60.890.89
NME2P10.890.84
RPL120.890.83
COMMD60.860.84
RPL360.860.81
TCTEX1D20.850.84
RP11-544M22.10.850.83
UFC10.850.85
Top 10 negatively co-expressed genes
MYH14-0.53-0.65
AF347015.26-0.53-0.65
AF347015.33-0.51-0.61
EPAS1-0.51-0.61
KIF1C-0.51-0.65
ZBTB7B-0.51-0.62
AF347015.15-0.51-0.60
AF347015.27-0.50-0.59
FYCO1-0.50-0.61
AF347015.8-0.50-0.58
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003700transcription factor activityTAS1774067 |2000400 
GO:0005515protein bindingIPI10571058 |12659632 |12741956 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIDA15243141 
GO:0006350transcriptionIEA-
GO:0006366transcription from RNA polymerase II promoterTAS2000400 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA15243141 
GO:0016602CCAAT-binding factor complexIDA15243141 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APPBP2HS.84084 | KIAA0228 | PAT1amyloid beta precursor protein (cytoplasmic tail) binding protein 2Two-hybridBioGRID16189514 
ATF6ATF6Aactivating transcription factor 6Two-hybridBioGRID11158310 
ATF6BCREB-RP | CREBL1 | FLJ10066 | G13activating transcription factor 6 betaTwo-hybridBioGRID11158310 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD,BioGRID11777930 
BRCA1 interacts with NF-YABIND11777930 
ELF1-E74-like factor 1 (ets domain transcription factor)Reconstituted ComplexBioGRID9668064 
HMGA1HMG-R | HMGA1A | HMGIY | MGC12816 | MGC4242 | MGC4854high mobility group AT-hook 1-HPRD,BioGRID9388234 
JUNAP-1 | AP1 | c-Junjun oncogeneAffinity Capture-WesternBioGRID11903046 
NFYBCBF-A | CBF-B | HAP3 | NF-YBnuclear transcription factor Y, beta-HPRD,BioGRID8051128 
POU2F1OCT1 | OTF1POU class 2 homeobox 1-HPRD11777930 
Oct-1 interacts with NF-YABIND11777930 
SPI1OF | PU.1 | SFPI1 | SPI-1 | SPI-Aspleen focus forming virus (SFFV) proviral integration oncogene spi1Reconstituted ComplexBioGRID9668064 
SRFMCM1serum response factor (c-fos serum response element-binding transcription factor)NF-YA interacts with SRF. This interaction was modeled on a demonstrated interaction between NF-YA from an unspecified species and SRF from human.BIND10571058 
Reconstituted Complex
Two-hybrid		BioGRID10571058 
ZHX1-zinc fingers and homeoboxes 1NF-YA interacts with ZHX1. This interaction was modeled on a demonstrated interaction between NF-YA from an unspecified species and ZHX1 from human.BIND10571058 
-HPRD,BioGRID10441475 |10571058 
ZHX2AFR1 | KIAA0854 | RAFzinc fingers and homeoboxes 2-HPRD12741956 
ZHX3KIAA0395 | TIX1zinc fingers and homeoboxes 3-HPRD12659632 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 8965All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
PID_MYC_REPRESS_PATHWAY 6352All SZGR genes in this pathway
REACTOME_PPARA_ACTIVATES_GENE_EXPRESSION 10472All SZGR genes in this pathway
REACTOME_DIABETES_PATHWAYS 13391All SZGR genes in this pathway
REACTOME_PERK_REGULATED_GENE_EXPRESSION 2914All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_CHAPERONES_BY_ATF6_ALPHA 139All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_GENES_BY_ATF4 2612All SZGR genes in this pathway
REACTOME_UNFOLDED_PROTEIN_RESPONSE 8051All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_ATF6_ALPHA 118All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 168115All SZGR genes in this pathway
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN 493298All SZGR genes in this pathway
PUIFFE_INVASION_INHIBITED_BY_ASCITES_DN 14591All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_UP 177110All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_DN 406230All SZGR genes in this pathway
GARGALOVIC_RESPONSE_TO_OXIDIZED_PHOSPHOLIPIDS_GREEN_DN 2512All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
KIM_WT1_TARGETS_8HR_DN 12984All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
TANAKA_METHYLATED_IN_ESOPHAGEAL_CARCINOMA 10358All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_UP 236139All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN 514330All SZGR genes in this pathway
GEORGES_CELL_CYCLE_MIR192_TARGETS 6246All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_CIS 12877All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_DN 4130All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP 6348All SZGR genes in this pathway
ADDYA_ERYTHROID_DIFFERENTIATION_BY_HEMIN 7347All SZGR genes in this pathway
KANG_FLUOROURACIL_RESISTANCE_DN 1610All SZGR genes in this pathway
XU_GH1_EXOGENOUS_TARGETS_UP 8550All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_UP 8458All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
AMUNDSON_POOR_SURVIVAL_AFTER_GAMMA_RADIATION_2G 17196All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_CLUSTER_UP 3826All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_C_UP 4729All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_30MIN_DN 15099All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN 254158All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
JUBAN_TARGETS_OF_SPI1_AND_FLI1_DN 9260All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-132/212221227m8hsa-miR-212SZUAACAGUCUCCAGUCACGGCC
hsa-miR-132brainUAACAGUCUACAGCCAUGGUCG
miR-200bc/4291421491A,m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-2212741280m8hsa-miR-22brainAAGCUGCCAGUUGAAGAACUGU
miR-3306866921Ahsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-504139013971A,m8hsa-miR-504AGACCCUGGUCUGCACUCUAU
miR-93.hd/291-3p/294/295/302/372/373/5202943011A,m8hsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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