Gene Page: TNFRSF11B

Summary ?
GeneID4982
SymbolTNFRSF11B
SynonymsOCIF|OPG|PDB5|TR1
Descriptiontumor necrosis factor receptor superfamily member 11b
ReferenceMIM:602643|HGNC:HGNC:11909|Ensembl:ENSG00000164761|HPRD:04032|Vega:OTTHUMG00000164969
Gene typeprotein-coding
Map location8q24
Pascal p-value0.197
Fetal beta-0.652
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
CV:PheWASPhenome-wide association studies (PheWAS)157 SNPs associated with schizophrenia 3

Section I. Genetics and epigenetics annotation

@CV:PheWAS

SNP IDChromosomePositionAllelePFunctionGeneUp/Down Distance
rs69938138120052238null0.6515TNFRSF11Bnull
rs43558018119923873null0.6482TNFRSF11Bnull
rs64698048120044829null0.6666TNFRSF11Bnull

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17131472chr191962966TNFRSF11B49822.161E-4trans
rs546975chr191963738TNFRSF11B49820.02trans
rs17535450chr239900012TNFRSF11B49820.01trans
rs272110chr2131546319TNFRSF11B49820.18trans
rs9814206chr374573226TNFRSF11B49820.11trans
rs1691463chr384914366TNFRSF11B49820.01trans
rs394185chr384959076TNFRSF11B49820.09trans
rs9288980chr3112964991TNFRSF11B49820.16trans
rs3995908chr3112998529TNFRSF11B49820.16trans
rs7652801chr3113008605TNFRSF11B49820.16trans
rs2922180chr3125280472TNFRSF11B49827.331E-10trans
rs2971271chr3125450402TNFRSF11B49820.01trans
rs2976809chr3125451738TNFRSF11B49822.874E-6trans
rs9917710chr3176280218TNFRSF11B49820.18trans
rs16889842chr49872012TNFRSF11B49820.03trans
snp_a-19762280TNFRSF11B49820.13trans
snp_a-20657990TNFRSF11B49820.06trans
rs6856952chr474394402TNFRSF11B49820.06trans
rs17005214chr482845432TNFRSF11B49820.06trans
rs2732167chr488706292TNFRSF11B49820.17trans
rs313946chr4113975904TNFRSF11B49820.07trans
rs17034860chr4135177933TNFRSF11B49820.14trans
rs17636193chr53540160TNFRSF11B49820.09trans
rs1867710chr53576228TNFRSF11B49820.15trans
rs11747698chr53577007TNFRSF11B49820.15trans
rs13174189chr53579173TNFRSF11B49820.19trans
rs13187916chr53580498TNFRSF11B49820.15trans
rs13170862chr53582215TNFRSF11B49820.15trans
rs10050805chr530805352TNFRSF11B49820trans
rs837115chr540736290TNFRSF11B49820.03trans
rs16894149chr561013724TNFRSF11B49820.1trans
rs17143695chr5117520843TNFRSF11B49820.06trans
rs11954814chr5155088338TNFRSF11B49820.2trans
rs17056435chr5158453782TNFRSF11B49820.02trans
rs17135501chr62704474TNFRSF11B49820.04trans
rs17135521chr62707631TNFRSF11B49820.04trans
snp_a-17879260TNFRSF11B49820.04trans
rs6920042chr667907570TNFRSF11B49820.14trans
rs6939897chr667913123TNFRSF11B49820.14trans
rs6455226chr667930295TNFRSF11B49826.269E-4trans
rs2064428chr685067126TNFRSF11B49820.01trans
rs9451867chr692659609TNFRSF11B49820.01trans
rs283058chr6118625224TNFRSF11B49820.14trans
rs2398707chr72113428TNFRSF11B49820.03trans
rs3778948chr72123290TNFRSF11B49820.09trans
rs3778951chr72125319TNFRSF11B49820.03trans
rs3778957chr72127710TNFRSF11B49820.03trans
rs3778958chr72127794TNFRSF11B49820.09trans
rs3778968chr72139903TNFRSF11B49820.09trans
rs2286089chr738789903TNFRSF11B49820.11trans
rs10085487chr738870379TNFRSF11B49820.06trans
rs7782277chr738938053TNFRSF11B49820.16trans
rs2430483chr7104548631TNFRSF11B49820.02trans
rs1960369chr86379235TNFRSF11B49820.1trans
rs2199402chr89201002TNFRSF11B49820.02trans
rs2169384chr89216985TNFRSF11B49820.06trans
rs1381350chr89217194TNFRSF11B49820.17trans
rs7841407chr89243427TNFRSF11B49820trans
rs2739708chr817992280TNFRSF11B49820.01trans
rs714131chr817992832TNFRSF11B49820.02trans
rs2739726chr817998576TNFRSF11B49820.02trans
rs2919377chr832573740TNFRSF11B49820.04trans
rs9410375chr991444622TNFRSF11B49820.06trans
rs2253777chr993467893TNFRSF11B49820.02trans
rs4743989chr997859191TNFRSF11B49820.13trans
rs998410chr9117622673TNFRSF11B49820.06trans
rs9423711chr102574802TNFRSF11B49820.03trans
rs651134chr1027549960TNFRSF11B49820.17trans
rs748375chr1033440178TNFRSF11B49820.07trans
rs4514358chr1043861923TNFRSF11B49820.05trans
rs7081666chr1047673800TNFRSF11B49820.01trans
rs10886877chr1085425690TNFRSF11B49820.03trans
rs10488758chr11103493095TNFRSF11B49820.04trans
rs1905067chr11103493989TNFRSF11B49820.01trans
rs10895512chr11103553194TNFRSF11B49820.04trans
rs11604394chr11103554879TNFRSF11B49820.02trans
rs11603978chr11103555057TNFRSF11B49820.02trans
rs11225972chr11103555992TNFRSF11B49820.02trans
rs11225974chr11103560499TNFRSF11B49820.02trans
rs11225990chr11103608380TNFRSF11B49820.04trans
rs107479720TNFRSF11B49820.08trans
rs10879027chr1270237156TNFRSF11B49822.689E-4trans
rs11112163chr12105072508TNFRSF11B49820trans
rs9551590chr1329589464TNFRSF11B49820.05trans
rs17073665chr1381541961TNFRSF11B49820trans
rs11840833chr1394378306TNFRSF11B49820.02trans
rs16975617chr13110867407TNFRSF11B49820.09trans
rs10142086chr1435135892TNFRSF11B49820.02trans
rs1951867chr1454407191TNFRSF11B49820.01trans
rs2093759chr1497171024TNFRSF11B49820trans
rs17244419chr1497171074TNFRSF11B49825.97E-5trans
rs17629301chr1499467034TNFRSF11B49820.05trans
rs7177212chr1534425413TNFRSF11B49820.11trans
rs16976022chr1555454260TNFRSF11B49820.19trans
rs16976029chr1555455268TNFRSF11B49820.17trans
rs16976036chr1555456921TNFRSF11B49820.13trans
rs8034402chr1555480932TNFRSF11B49820.02trans
rs8043029chr1555486010TNFRSF11B49820.02trans
rs3809540chr1555489411TNFRSF11B49820.02trans
rs7165491chr1555500454TNFRSF11B49820.18trans
rs7165622chr1593979910TNFRSF11B49820.19trans
rs4984405chr1595260170TNFRSF11B49820.14trans
rs13380712chr1625601181TNFRSF11B49820.05trans
rs16977927chr1772154232TNFRSF11B49820.08trans
rs7236104chr1814032818TNFRSF11B49820.18trans
rs4987765chr1860905021TNFRSF11B49820.12trans
rs11873703chr1861448702TNFRSF11B49820trans
rs6017989chr2045329846TNFRSF11B49820.19trans
rs6095741chr2048666589TNFRSF11B49826E-7trans
rs5991662chrX43335796TNFRSF11B49820.01trans
rs2254586chrX117855503TNFRSF11B49820.14trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION 267161All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP 408247All SZGR 2.0 genes in this pathway
PIEPOLI LGI1 TARGETS UP 1511All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423283All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS UP 457269All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP 238144All SZGR 2.0 genes in this pathway
SENESE HDAC2 TARGETS UP 11466All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501327All SZGR 2.0 genes in this pathway
NAGASHIMA NRG1 SIGNALING UP 176123All SZGR 2.0 genes in this pathway
NAGASHIMA EGF SIGNALING UP 5840All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR UP 162116All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537339All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN 232154All SZGR 2.0 genes in this pathway
CHEBOTAEV GR TARGETS DN 12073All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS F UP 185119All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394258All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 4NM UP 2315All SZGR 2.0 genes in this pathway
HERNANDEZ MITOTIC ARREST BY DOCETAXEL 1 UP 3618All SZGR 2.0 genes in this pathway
FUNG IL2 SIGNALING 2 128All SZGR 2.0 genes in this pathway
FUNG IL2 TARGETS WITH STAT5 BINDING SITES T1 97All SZGR 2.0 genes in this pathway
LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL UP 8351All SZGR 2.0 genes in this pathway
SASAI RESISTANCE TO NEOPLASTIC TRANSFROMATION 5031All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER A 10063All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 8Q23 Q24 AMPLICON 15787All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS SUBSET 3320All SZGR 2.0 genes in this pathway
ROZANOV MMP14 TARGETS UP 266171All SZGR 2.0 genes in this pathway
WILLERT WNT SIGNALING 2413All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546351All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555346All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT UP 8961All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408274All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390242All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371218All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 24HR DN 3321All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262186All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR DN 178121All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD UP 222139All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487303All SZGR 2.0 genes in this pathway
LY AGING MIDDLE UP 1411All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS DN 10563All SZGR 2.0 genes in this pathway
DE YY1 TARGETS DN 9264All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315197All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL B DN 564326All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648398All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO RADIATION THERAPY 3220All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION C 6949All SZGR 2.0 genes in this pathway
COLINA TARGETS OF 4EBP1 AND 4EBP2 356214All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535325All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS EARLY DN 3827All SZGR 2.0 genes in this pathway
HOFFMAN CLOCK TARGETS UP 117All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS DN 8766All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN DN 8868All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP 307182All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549316All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN 229135All SZGR 2.0 genes in this pathway
PLASARI TGFB1 TARGETS 10HR UP 199143All SZGR 2.0 genes in this pathway
PLASARI NFIC TARGETS BASAL UP 2717All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367231All SZGR 2.0 genes in this pathway
DELACROIX RAR TARGETS UP 4833All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279155All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS UP 221120All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 COMPLETE 227151All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway