Gene Page: PCSK5

Summary ?
GeneID5125
SymbolPCSK5
SynonymsPC5|PC6|PC6A|SPC6
Descriptionproprotein convertase subtilisin/kexin type 5
ReferenceMIM:600488|HGNC:HGNC:8747|Ensembl:ENSG00000099139|HPRD:08985|Vega:OTTHUMG00000020039
Gene typeprotein-coding
Map location9q21.3
Pascal p-value0.088
Sherlock p-value0.26
Fetal beta1.189
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Nishioka_2013Genome-wide DNA methylation analysisThe authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg16904306978506294PCSK5-0.0180.68DMG:Nishioka_2013

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs4549432chr4182350656PCSK551250.08trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TUBA80.600.63
DTNBP10.590.47
PCP40.580.49
ECE20.570.59
BSPRY0.570.62
IKBKE0.570.44
KCTD170.560.38
HRH30.560.57
TMEM1730.550.46
CYB5R10.550.46
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SH2B2-0.36-0.46
SOX12-0.35-0.39
PFN3-0.34-0.41
MEX3D-0.33-0.36
DSCC1-0.33-0.38
FOXO6-0.33-0.35
LENG9-0.32-0.31
AC018648.1-0.31-0.37
AIM2-0.31-0.39
ZNF775-0.31-0.33

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004252serine-type endopeptidase activityIEAglutamate (GO term level: 7)-
GO:0008233peptidase activityIEA-
GO:0042277peptide bindingISS8940009 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002001renin secretion into blood streamIEP8901832 
GO:0001822kidney developmentIMP18519639 
GO:0001822kidney developmentISS8940009 
GO:0006465signal peptide processingIDA16912035 
GO:0007267cell-cell signalingTAS8901832 
GO:0009952anterior/posterior pattern formationIMP18519639 
GO:0007507heart developmentISS8940009 
GO:0007566embryo implantationISS8940009 
GO:0051605protein maturation via proteolysisIDA8901832 
GO:0042089cytokine biosynthetic processISS8940009 
GO:0019067viral assembly, maturation, egress, and releaseIEP8940009 
GO:0019067viral assembly, maturation, egress, and releaseISS8940009 
GO:0030323respiratory tube developmentISS8940009 
GO:0032455nerve growth factor processingEXP12787574 
GO:0035108limb morphogenesisISS8940009 
GO:0043043peptide biosynthetic processIDA8901832 
GO:0048566embryonic gut developmentIMP18519639 
GO:0048566embryonic gut developmentISS8940009 
GO:0048706embryonic skeletal system developmentIMP18519639 
GO:0048706embryonic skeletal system developmentISS8940009 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusISS-
GO:0005796Golgi lumenEXP8615794 
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceISS8940009 
GO:0030141secretory granuleISS-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME SIGNALLING BY NGF 217167All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255177All SZGR 2.0 genes in this pathway
NEWMAN ERCC6 TARGETS UP 2618All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN 205127All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN 14290All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226132All SZGR 2.0 genes in this pathway
WATANABE ULCERATIVE COLITIS WITH CANCER UP 1810All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP 215137All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
PEREZ TP63 TARGETS 355243All SZGR 2.0 genes in this pathway
PEREZ TP53 AND TP63 TARGETS 205145All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5 14789All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539324All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 1 UP 11866All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA MS UP 4832All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA RADIATION 8159All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP 226164All SZGR 2.0 genes in this pathway
SMID BREAST CANCER LUMINAL A UP 8452All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN 701446All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING 246152All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE UP 14985All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442275All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL 162122All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
YANG BCL3 TARGETS UP 364236All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 1HR DN 10677All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 10HR UP 5438All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238125All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-13926321Ahsa-miR-139brainUCUACAGUGCACGUGUCU