Gene Page: POLD1

Summary
GeneID  5424
Symbol  POLD1
Synonyms  CDC2|POLD
Description  polymerase (DNA directed), delta 1, catalytic subunit 125kDa
See related  HGNC:9175|MIM:174761|Ensembl:ENSG00000062822|HPRD:08882|
Locus tag  -
Gene type  protein-coding
Map location  19q13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 1.401 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
AC018470.30.920.67
SP90.920.67
DLX60.880.45
MEIS10.860.71
FOXP40.860.56
NTN10.830.63
BMF0.820.74
MEIS20.820.86
MAP3K10.820.75
SIX30.810.37
Top 10 negatively co-expressed genes
C5orf53-0.39-0.72
CA4-0.37-0.69
PTH1R-0.36-0.57
AF347015.31-0.35-0.71
HLA-F-0.35-0.60
AF347015.27-0.35-0.70
PPAP2A-0.35-0.46
S100B-0.35-0.64
MUSTN1-0.35-0.63
ALDOC-0.34-0.50
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003677DNA bindingIDA16762037 
GO:0003677DNA bindingIEA-
GO:0003682chromatin bindingIDA16762037 
GO:0003887DNA-directed DNA polymerase activityIEA-
GO:0003887DNA-directed DNA polymerase activityIMP16762037 
GO:0005515protein bindingIPI15670210 
GO:0004527exonuclease activityIEA-
GO:0016779nucleotidyltransferase activityIEA-
GO:0016787hydrolase activityIEA-
GO:0016740transferase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:00084083'-5' exonuclease activityIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000084S phase of mitotic cell cycleIDA16762037 
GO:0000731DNA synthesis during DNA repairIDA3335506 
GO:0000731DNA synthesis during DNA repairIMP1730053 
GO:0006297nucleotide-excision repair, DNA gap fillingEXP9111189 
GO:0006287base-excision repair, gap-fillingIEA-
GO:0006260DNA replicationIEA-
GO:0006139nucleobase, nucleoside, nucleotide and nucleic acid metabolic processIEA-
GO:0009411response to UVTAS3146346 
GO:0045004DNA replication proofreadingIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA16762037 
GO:0005634nucleusIEA-
GO:0005654nucleoplasmEXP10559261 |11473323 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATRFRP1 | MEC1 | SCKL | SCKL1ataxia telangiectasia and Rad3 relatedProtein-peptideBioGRID10608806 
CHGBSCG1chromogranin B (secretogranin 1)Two-hybridBioGRID16169070 
KIAA1377-KIAA1377Two-hybridBioGRID16169070 
PCNAMGC8367proliferating cell nuclear antigenPOLD1 is a PCNA-binding proteinBIND12171929 
-HPRD,BioGRID9563011 
POLA1DKFZp686K1672 | POLA | p180polymerase (DNA directed), alpha 1, catalytic subunit-HPRD,BioGRID9563011 
POLD2-polymerase (DNA directed), delta 2, regulatory subunit 50kDa-HPRD9286699 
POLD3KIAA0039 | MGC119642 | MGC119643 | P66 | P68polymerase (DNA-directed), delta 3, accessory subunit-HPRD10852724 
PTP4A3PRL-3 | PRL-R | PRL3protein tyrosine phosphatase type IVA, member 3Affinity Capture-MSBioGRID17353931 
RFC1A1 | MGC51786 | MHCBFB | PO-GA | RECC1 | RFC | RFC140replication factor C (activator 1) 1, 145kDa-HPRD,BioGRID9563011 
TREX2-three prime repair exonuclease 2in vitroBioGRID12806015 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_PURINE_METABOLISM 15996All SZGR genes in this pathway
KEGG_PYRIMIDINE_METABOLISM 9853All SZGR genes in this pathway
KEGG_DNA_REPLICATION 3621All SZGR genes in this pathway
KEGG_BASE_EXCISION_REPAIR 3522All SZGR genes in this pathway
KEGG_NUCLEOTIDE_EXCISION_REPAIR 4425All SZGR genes in this pathway
KEGG_MISMATCH_REPAIR 2314All SZGR genes in this pathway
KEGG_HOMOLOGOUS_RECOMBINATION 2817All SZGR genes in this pathway
REACTOME_BASE_EXCISION_REPAIR 1913All SZGR genes in this pathway
REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_MULTIPLE_NUCLEOTIDE_PATCH_REPLACEMENT_PATHWAY 1711All SZGR genes in this pathway
REACTOME_CELL_CYCLE 421253All SZGR genes in this pathway
REACTOME_PROCESSIVE_SYNTHESIS_ON_THE_LAGGING_STRAND 1510All SZGR genes in this pathway
REACTOME_CELL_CYCLE_MITOTIC 325185All SZGR genes in this pathway
REACTOME_TRANSCRIPTION_COUPLED_NER_TC_NER 4524All SZGR genes in this pathway
REACTOME_POL_SWITCHING 139All SZGR genes in this pathway
REACTOME_NUCLEOTIDE_EXCISION_REPAIR 5127All SZGR genes in this pathway
REACTOME_REPAIR_SYNTHESIS_FOR_GAP_FILLING_BY_DNA_POL_IN_TC_NER 1411All SZGR genes in this pathway
REACTOME_SYNTHESIS_OF_DNA 9253All SZGR genes in this pathway
REACTOME_DNA_REPAIR 11259All SZGR genes in this pathway
REACTOME_CHROMOSOME_MAINTENANCE 12280All SZGR genes in this pathway
REACTOME_GLOBAL_GENOMIC_NER_GG_NER 3520All SZGR genes in this pathway
REACTOME_LAGGING_STRAND_SYNTHESIS 1912All SZGR genes in this pathway
REACTOME_DNA_REPLICATION 192110All SZGR genes in this pathway
REACTOME_TELOMERE_MAINTENANCE 7557All SZGR genes in this pathway
REACTOME_REMOVAL_OF_THE_FLAP_INTERMEDIATE_FROM_THE_C_STRAND 108All SZGR genes in this pathway
REACTOME_EXTENSION_OF_TELOMERES 2717All SZGR genes in this pathway
REACTOME_S_PHASE 10966All SZGR genes in this pathway
REACTOME_DNA_STRAND_ELONGATION 3018All SZGR genes in this pathway
PRAMOONJAGO_SOX4_TARGETS_DN 5135All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_DN 310188All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP 293179All SZGR genes in this pathway
NADERI_BREAST_CANCER_PROGNOSIS_UP 5026All SZGR genes in this pathway
MARKEY_RB1_CHRONIC_LOF_UP 11578All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_DN 172112All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION 7751All SZGR genes in this pathway
WAKASUGI_HAVE_ZNF143_BINDING_SITES 5833All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
DAIRKEE_TERT_TARGETS_UP 380213All SZGR genes in this pathway
PUJANA_BRCA2_PCC_NETWORK 423265All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
KAUFFMANN_DNA_REPAIR_GENES 230137All SZGR genes in this pathway
KAUFFMANN_DNA_REPLICATION_GENES 14787All SZGR genes in this pathway
REN_BOUND_BY_E2F 6140All SZGR genes in this pathway
ALCALAY_AML_BY_NPM1_LOCALIZATION_DN 184132All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_RESPONSE 3528All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR 544307All SZGR genes in this pathway
JIANG_VHL_TARGETS 13891All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP 428266All SZGR genes in this pathway
JACKSON_DNMT1_TARGETS_DN 2521All SZGR genes in this pathway
KALMA_E2F1_TARGETS 117All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_UP 202115All SZGR genes in this pathway
WELCSH_BRCA1_TARGETS_DN 14192All SZGR genes in this pathway
BURTON_ADIPOGENESIS_PEAK_AT_16HR 4024All SZGR genes in this pathway
AMUNDSON_POOR_SURVIVAL_AFTER_GAMMA_RADIATION_2G 17196All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_UP 250168All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
FLOTHO_PEDIATRIC_ALL_THERAPY_RESPONSE_DN 2917All SZGR genes in this pathway
ZHANG_TLX_TARGETS_60HR_DN 277166All SZGR genes in this pathway
CROONQUIST_IL6_DEPRIVATION_DN 9869All SZGR genes in this pathway
CROONQUIST_NRAS_SIGNALING_DN 7247All SZGR genes in this pathway
IRITANI_MAD1_TARGETS_DN 4730All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
WONG_EMBRYONIC_STEM_CELL_CORE 335193All SZGR genes in this pathway
JIANG_HYPOXIA_VIA_VHL 3424All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_UP 324193All SZGR genes in this pathway
FEVR_CTNNB1_TARGETS_DN 553343All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP 570339All SZGR genes in this pathway
ZHOU_CELL_CYCLE_GENES_IN_IR_RESPONSE_24HR 12873All SZGR genes in this pathway


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