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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Gene Page: PTN

Summary

GeneID

5764

Symbol

PTN

Synonyms

HARP|HBGF8|HBNF|NEGF1

Description

pleiotrophin

Locus tag

Gene type

protein-coding

Map location

7q33-q34

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 1.7318

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

LGALS8

0.86

0.81

AC079061.1

0.86

0.81

PTPN13

0.85

DOCK9

0.85

0.88

RNF19A

0.82

0.81

RP11-791G16.2

0.82

MEF2C

0.81

0.77

ACTN2

0.80

0.77

KLHL4

0.80

0.84

RBM24

0.80

0.82

Top 10 negatively co-expressed genes

DCXR

-0.52

-0.56

METRN

-0.52

-0.62

ENHO

-0.52

-0.64

HSD17B14

-0.52

-0.56

REEP6

-0.51

-0.46

AF347015.31

-0.51

-0.54

ACSF2

-0.51

-0.56

MT-CO2

-0.50

-0.54

FXYD1

-0.50

-0.52

TLCD1

-0.49

-0.55

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0004864

protein phosphatase inhibitor activity

TAS

10706604

GO:0008201

heparin binding

IEA

GO:0008083

growth factor activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007399

nervous system development

TAS

neurite (GO term level: 5)

2270483

GO:0007185

transmembrane receptor protein tyrosine phosphatase signaling pathway

TAS

10706604

GO:0008284

positive regulation of cell proliferation

TAS

2270483

GO:0007612

learning

IEA

GO:0030282

bone mineralization

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005576

extracellular region

IEA

GO:0005615

extracellular space

TAS

10706604

GO:0005783

endoplasmic reticulum

IDA

11256614

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTB	PS1TP5BP1	actin, beta	-	HPRD	9739080
ALK	CD246 \| Ki-1 \| TFG/ALK	anaplastic lymphoma receptor tyrosine kinase	-	HPRD,BioGRID	11278720
APOBEC3G	ARP9 \| CEM15 \| FLJ12740 \| MDS019 \| bK150C2.7 \| dJ494G10.1	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G	Two-hybrid	BioGRID	16169070
ARIH2	ARI2 \| FLJ10938 \| FLJ33921 \| TRIAD1	ariadne homolog 2 (Drosophila)	Two-hybrid	BioGRID	16169070
ARL15	ARFRP2 \| FLJ20051	ADP-ribosylation factor-like 15	Two-hybrid	BioGRID	16169070
ATP5C1	ATP5C \| ATP5CL1	ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1	Two-hybrid	BioGRID	16169070
ATRX	ATR2 \| MGC2094 \| MRXHF1 \| RAD54 \| RAD54L \| SFM1 \| SHS \| XH2 \| XNP \| ZNF-HX	alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)	Two-hybrid	BioGRID	16169070
BCCIP	TOK-1 \| TOK1	BRCA2 and CDKN1A interacting protein	Two-hybrid	BioGRID	16169070
BLOC1S1	BLOS1 \| FLJ39337 \| FLJ97089 \| GCN5L1 \| MGC87455 \| MICoA \| RT14	biogenesis of lysosomal organelles complex-1, subunit 1	Two-hybrid	BioGRID	16169070
BMI1	MGC12685 \| PCGF4 \| RNF51	BMI1 polycomb ring finger oncogene	Two-hybrid	BioGRID	16169070
BTBD2	-	BTB (POZ) domain containing 2	Two-hybrid	BioGRID	16169070
C8orf30A	FLJ40907	chromosome 8 open reading frame 30A	Two-hybrid	BioGRID	16169070
C9orf82	FLJ13657 \| RP11-337A23.1	chromosome 9 open reading frame 82	Two-hybrid	BioGRID	16169070
CACNB4	CAB4 \| CACNLB4 \| EA5 \| EJM	calcium channel, voltage-dependent, beta 4 subunit	Two-hybrid	BioGRID	16169070
CAPZB	CAPB \| CAPPB \| CAPZ \| MGC104401 \| MGC129749 \| MGC129750	capping protein (actin filament) muscle Z-line, beta	Two-hybrid	BioGRID	16169070
CCDC53	CGI-116	coiled-coil domain containing 53	Two-hybrid	BioGRID	16169070
CDH10	-	cadherin 10, type 2 (T2-cadherin)	Two-hybrid	BioGRID	16169070
CDK5RAP2	C48 \| Cep215 \| DKFZp686B1070 \| DKFZp686D1070 \| KIAA1633 \| MCPH3	CDK5 regulatory subunit associated protein 2	Two-hybrid	BioGRID	16169070
CGA	CG-ALPHA \| FSHA \| GPHA1 \| GPHa \| HCG \| LHA \| TSHA	glycoprotein hormones, alpha polypeptide	Two-hybrid	BioGRID	16169070
CHD3	Mi-2a \| Mi2-ALPHA \| ZFH	chromodomain helicase DNA binding protein 3	Two-hybrid	BioGRID	16169070
COX6C	-	cytochrome c oxidase subunit VIc	Two-hybrid	BioGRID	16169070
CRCT1	C1orf42 \| NICE-1	cysteine-rich C-terminal 1	Two-hybrid	BioGRID	16169070
CRELD1	AVSD2 \| CIRRIN \| DKFZp566D213	cysteine-rich with EGF-like domains 1	Two-hybrid	BioGRID	16169070
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	Affinity Capture-Western	BioGRID	10706604
DFNA5	ICERE-1	deafness, autosomal dominant 5	Two-hybrid	BioGRID	16169070
DNAJB11	ABBP-2 \| ABBP2 \| DJ9 \| EDJ \| ERdj3 \| ERj3 \| HEDJ \| PRO1080 \| UNQ537 \| hDj9	DnaJ (Hsp40) homolog, subfamily B, member 11	Two-hybrid	BioGRID	16169070
DUSP12	DUSP1 \| YVH1	dual specificity phosphatase 12	Two-hybrid	BioGRID	16169070
EIF3F	EIF3S5 \| eIF3-p47	eukaryotic translation initiation factor 3, subunit F	Two-hybrid	BioGRID	16169070
FAM176A	FLJ13391 \| TMEM166	family with sequence similarity 176, member A	Two-hybrid	BioGRID	16169070
FTL	MGC71996	ferritin, light polypeptide	Two-hybrid	BioGRID	16169070
GIPC2	FLJ20075 \| SEMCAP-2 \| SEMCAP2	GIPC PDZ domain containing family, member 2	Two-hybrid	BioGRID	16169070
GLYAT	ACGNAT \| CAT \| GAT	glycine-N-acyltransferase	Two-hybrid	BioGRID	16169070
GNB2L1	Gnb2-rs1 \| H12.3 \| HLC-7 \| PIG21 \| RACK1	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	Two-hybrid	BioGRID	16169070
GPD1	FLJ26652	glycerol-3-phosphate dehydrogenase 1 (soluble)	Two-hybrid	BioGRID	16169070
GSTP1	DFN7 \| FAEES3 \| GST3 \| PI	glutathione S-transferase pi 1	Two-hybrid	BioGRID	16169070
GTF2F1	BTF4 \| RAP74 \| TF2F1 \| TFIIF	general transcription factor IIF, polypeptide 1, 74kDa	Two-hybrid	BioGRID	16169070
HSPBAP1	FLJ22623 \| FLJ39386 \| PASS1	HSPB (heat shock 27kDa) associated protein 1	Two-hybrid	BioGRID	16169070
ITSN2	KIAA1256 \| PRO2015 \| SH3D1B \| SH3P18 \| SWA \| SWAP	intersectin 2	Two-hybrid	BioGRID	16169070
LAMA4	DKFZp686D23145 \| LAMA3 \| LAMA4*-1	laminin, alpha 4	Two-hybrid	BioGRID	16169070
LUC7L2	CGI-59 \| CGI-74 \| FLJ10657 \| LUC7B2	LUC7-like 2 (S. cerevisiae)	Two-hybrid	BioGRID	16169070
MAD2L1BP	CMT2 \| KIAA0110 \| MGC11282 \| RP1-261G23.6	MAD2L1 binding protein	Two-hybrid	BioGRID	16169070
MKKS	BBS6 \| HMCS \| KMS \| MKS	McKusick-Kaufman syndrome	Two-hybrid	BioGRID	16169070
MLLT3	AF9 \| FLJ2035 \| YEATS3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	Two-hybrid	BioGRID	16169070
MYCBP	AMY-1	c-myc binding protein	Two-hybrid	BioGRID	16169070
NAP1L5	DRLM	nucleosome assembly protein 1-like 5	Two-hybrid	BioGRID	16169070
NCAN	CSPG3 \| FLJ44681	neurocan	-	HPRD	9507007
P4HB	DSI \| ERBA2L \| GIT \| PDI \| PDIA1 \| PHDB \| PO4DB \| PO4HB \| PROHB	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide	Two-hybrid	BioGRID	16169070
PLXNB2	KIAA0315 \| MM1 \| Nbla00445 \| PLEXB2 \| dJ402G11.3	plexin B2	Two-hybrid	BioGRID	16169070
PMF1	-	polyamine-modulated factor 1	Two-hybrid	BioGRID	16169070
PPP2CA	PP2Ac \| PP2CA \| RP-C	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Two-hybrid	BioGRID	16169070
PSMB10	LMP10 \| MECL1 \| MGC1665 \| beta2i	proteasome (prosome, macropain) subunit, beta type, 10	Two-hybrid	BioGRID	16169070
PSMD11	MGC3844 \| Rpn6 \| S9 \| p44.5	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	Two-hybrid	BioGRID	16169070
PSMD2	MGC14274 \| P97 \| Rpn1 \| S2 \| TRAP2	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	Two-hybrid	BioGRID	16169070
PTPRB	DKFZp686E2262 \| DKFZp686H15164 \| FLJ44133 \| HPTP-BETA \| HPTPB \| MGC142023 \| MGC59935 \| PTPB \| R-PTP-BETA \| VEPTP	protein tyrosine phosphatase, receptor type, B	-	HPRD	10706604
PTPRS	PTPSIGMA	protein tyrosine phosphatase, receptor type, S	Two-hybrid	BioGRID	16169070
PTPRZ1	HPTPZ \| HPTPzeta \| PTP-ZETA \| PTP18 \| PTPRZ \| PTPZ \| RPTPB \| RPTPbeta \| phosphacan	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	-	HPRD,BioGRID	10706604
RBM23	CAPERbeta \| FLJ10482 \| MGC4458 \| PP239 \| RNPC4	RNA binding motif protein 23	Two-hybrid	BioGRID	16169070
RIT1	MGC125864 \| MGC125865 \| RIBB \| RIT \| ROC1	Ras-like without CAAX 1	Two-hybrid	BioGRID	16169070
RPLP1	FLJ27448 \| MGC5215 \| P1 \| RPP1	ribosomal protein, large, P1	Two-hybrid	BioGRID	16169070
SAT1	DC21 \| KFSD \| SAT \| SSAT \| SSAT-1	spermidine/spermine N1-acetyltransferase 1	Two-hybrid	BioGRID	16169070
SDC1	CD138 \| SDC \| SYND1 \| syndecan	syndecan 1	-	HPRD	7592855
SDC1	CD138 \| SDC \| SYND1 \| syndecan	syndecan 1	Reconstituted Complex	BioGRID	8175719
SDC3	N-syndecan \| SDCN \| SYND3	syndecan 3	-	HPRD	8175719
SGSM2	KIAA0397 \| RUTBC1	small G protein signaling modulator 2	Two-hybrid	BioGRID	16169070
SGTA	SGT \| alphaSGT \| hSGT	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	Two-hybrid	BioGRID	16169070
SLC25A36	DKFZp564C053 \| FLJ10618	solute carrier family 25, member 36	Two-hybrid	BioGRID	16169070
SNCAIP	MGC39814 \| SYPH1	synuclein, alpha interacting protein	Two-hybrid	BioGRID	16169070
SSR1	DKFZp781N23103 \| FLJ14232 \| FLJ22100 \| FLJ23034 \| FLJ78242 \| FLJ93042 \| TRAPA	signal sequence receptor, alpha	Two-hybrid	BioGRID	16169070
STC2	STC-2 \| STCRP	stanniocalcin 2	Two-hybrid	BioGRID	16169070
SUPT7L	ART1 \| KIAA0764 \| MGC90306 \| SPT7L \| STAF65 \| STAF65(gamma)	suppressor of Ty 7 (S. cerevisiae)-like	Two-hybrid	BioGRID	16169070
TAC3	NKB \| NKNB \| PRO1155 \| ZNEUROK1	tachykinin 3	Two-hybrid	BioGRID	16169070
TAF1D	JOSD3 \| MGC5306 \| TAF(I)41	TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa	Two-hybrid	BioGRID	16169070
TBRG4	CPR2 \| FASTKD4 \| KIAA0948	transforming growth factor beta regulator 4	Two-hybrid	BioGRID	16169070
TOMM20	KIAA0016 \| MAS20 \| MGC117367 \| MOM19 \| TOM20	translocase of outer mitochondrial membrane 20 homolog (yeast)	Two-hybrid	BioGRID	16169070
TP53BP2	53BP2 \| ASPP2 \| BBP \| PPP1R13A \| p53BP2	tumor protein p53 binding protein, 2	Two-hybrid	BioGRID	16169070
TXNDC9	APACD	thioredoxin domain containing 9	Two-hybrid	BioGRID	16169070
UBQLN4	A1U \| C1orf6 \| CIP75 \| UBIN	ubiquilin 4	Two-hybrid	BioGRID	16169070
UTP3	CRL1 \| CRLZ1 \| FLJ23256 \| SAS10	UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)	Two-hybrid	BioGRID	16169070
WFDC2	HE4 \| MGC57529 \| WAP5 \| dJ461P17.6	WAP four-disulfide core domain 2	Two-hybrid	BioGRID	16169070

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
PID_SYNDECAN_3_PATHWAY	17	15	All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_DN	182	111	All SZGR genes in this pathway
TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_DUCTAL_NORMAL_DN	198	110	All SZGR genes in this pathway
TURASHVILI_BREAST_DUCTAL_CARCINOMA_VS_LOBULAR_NORMAL_DN	69	43	All SZGR genes in this pathway
PEPPER_CHRONIC_LYMPHOCYTIC_LEUKEMIA_UP	33	28	All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN	291	176	All SZGR genes in this pathway
DELYS_THYROID_CANCER_DN	232	154	All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_E_UP	97	60	All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_3_4WK_UP	214	144	All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_UP	271	175	All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_DN	62	44	All SZGR genes in this pathway
KAN_RESPONSE_TO_ARSENIC_TRIOXIDE	123	80	All SZGR genes in this pathway
PATTERSON_DOCETAXEL_RESISTANCE	29	20	All SZGR genes in this pathway
SEITZ_NEOPLASTIC_TRANSFORMATION_BY_8P_DELETION_UP	73	47	All SZGR genes in this pathway
DACOSTA_ERCC3_ALLELE_XPCS_VS_TTD_DN	36	27	All SZGR genes in this pathway
TSAI_RESPONSE_TO_IONIZING_RADIATION	149	101	All SZGR genes in this pathway
HOWLIN_PUBERTAL_MAMMARY_GLAND	69	40	All SZGR genes in this pathway
CALVET_IRINOTECAN_SENSITIVE_VS_RESISTANT_UP	5	5	All SZGR genes in this pathway
CALVET_IRINOTECAN_SENSITIVE_VS_REVERTED_DN	5	5	All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN	848	527	All SZGR genes in this pathway
INGRAM_SHH_TARGETS_DN	64	41	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_UP	487	286	All SZGR genes in this pathway
HE_PTEN_TARGETS_DN	7	6	All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS	988	594	All SZGR genes in this pathway
BENPORATH_SOX2_TARGETS	734	436	All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_DN	357	212	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN	1237	837	All SZGR genes in this pathway
CUI_TCF21_TARGETS_UP	37	27	All SZGR genes in this pathway
PAL_PRMT5_TARGETS_UP	203	135	All SZGR genes in this pathway
RAMASWAMY_METASTASIS_DN	61	47	All SZGR genes in this pathway
LINDVALL_IMMORTALIZED_BY_TERT_UP	78	48	All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_UP	428	266	All SZGR genes in this pathway
RIZKI_TUMOR_INVASIVENESS_3D_UP	210	124	All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_DN	191	123	All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_DN	564	326	All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_A_UP	84	52	All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP	476	285	All SZGR genes in this pathway
IZADPANAH_STEM_CELL_ADIPOSE_VS_BONE_UP	126	92	All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_6HR_UP	10	8	All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_9HR_UP	223	132	All SZGR genes in this pathway
CROMER_TUMORIGENESIS_DN	51	29	All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP	165	118	All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_DN	138	92	All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP	395	249	All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_DN	134	83	All SZGR genes in this pathway
MIKKELSEN_IPS_ICP_WITH_H3K4ME3_AND_H327ME3	126	83	All SZGR genes in this pathway
CAIRO_LIVER_DEVELOPMENT_UP	166	105	All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE	721	492	All SZGR genes in this pathway
CHANDRAN_METASTASIS_DN	306	191	All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3_AND_H3K27ME3	137	85	All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3	445	257	All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT	572	352	All SZGR genes in this pathway
CHICAS_RB1_TARGETS_LOW_SERUM	100	51	All SZGR genes in this pathway
CHICAS_RB1_TARGETS_GROWING	243	155	All SZGR genes in this pathway
CHICAS_RB1_TARGETS_CONFLUENT	567	365	All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_1_DN	63	39	All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE	1137	655	All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN	882	538	All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_UP	570	339	All SZGR genes in this pathway
SERVITJA_ISLET_HNF1A_TARGETS_UP	163	111	All SZGR genes in this pathway
YANG_BCL3_TARGETS_UP	364	236	All SZGR genes in this pathway
ACEVEDO_FGFR1_TARGETS_IN_PROSTATE_CANCER_MODEL_DN	308	187	All SZGR genes in this pathway
DURAND_STROMA_S_UP	297	194	All SZGR genes in this pathway
NABA_SECRETED_FACTORS	344	197	All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED	753	411	All SZGR genes in this pathway
NABA_MATRISOME	1028	559	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-137	419	425	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-384	644	651	1A,m8	hsa-miR-384	AUUCCUAGAAAUUGUUCAUA
miR-496	338	344	1A	hsa-miR-496	AUUACAUGGCCAAUCUC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.