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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: PURA

Summary

GeneID

5813

Symbol

PURA

Synonyms

PUR-ALPHA|PUR1|PURALPHA

Description

purine-rich element binding protein A

Locus tag

Gene type

protein-coding

Map location

5q31

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.0032

Literature

High-throughput literature-search

Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]

Click to show detail

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 1

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0003691

double-stranded telomeric DNA binding

IDA

15777841

GO:0003697

single-stranded DNA binding

ISS

GO:0003705

RNA polymerase II transcription factor activity, enhancer binding

TAS

9334258

GO:0008134

transcription factor binding

ISS

GO:0046332

SMAD binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007399

nervous system development

IEA

neurite (GO term level: 5)

GO:0006350

transcription

IEA

GO:0006270

DNA replication initiation

TAS

1545807

GO:0006268

DNA unwinding during replication

IDA

15777841

GO:0008284

positive regulation of cell proliferation

IEA

GO:0045892

negative regulation of transcription, DNA-dependent

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0000784

nuclear chromosome, telomeric region

15777841

GO:0005634

nucleus

IDA

9716182

GO:0005662

DNA replication factor A complex

ISS

GO:0005737

cytoplasm

IEA

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ADAP1	CENTA1 \| GCS1L \| p42IP4	ArfGAP with dual PH domains 1	-	HPRD	12565890
CCNT1	CCNT \| CYCT1	cyclin T1	-	HPRD,BioGRID	11730934
CNBP	CNBP1 \| DM2 \| FLJ11631 \| PROMM \| RNF163 \| ZCCHC22 \| ZNF9	CCHC-type zinc finger, nucleic acid binding protein	Affinity Capture-MS	BioGRID	17353931
E2F1	E2F-1 \| RBAP1 \| RBBP3 \| RBP3	E2F transcription factor 1	-	HPRD,BioGRID	10597240
PURB	MGC126784 \| MGC126786 \| PURBETA	purine-rich element binding protein B	-	HPRD	10318844
SP1	-	Sp1 transcription factor	-	HPRD,BioGRID	10457364
YBX1	BP-8 \| CSDA2 \| CSDB \| DBPB \| MDR-NF1 \| MGC104858 \| MGC110976 \| MGC117250 \| NSEP-1 \| NSEP1 \| YB-1 \| YB1	Y box binding protein 1	-	HPRD,BioGRID	7862639
YBX1		Y box binding protein 1	YB-1 interacts with Pur-alpha.	BIND	10082537

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
GAZDA_DIAMOND_BLACKFAN_ANEMIA_ERYTHROID_DN	493	298	All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP	276	165	All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP	341	197	All SZGR genes in this pathway
KIM_WT1_TARGETS_8HR_UP	164	122	All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN	485	334	All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN	1781	1082	All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_AUGMENTED_BY_MYC	108	74	All SZGR genes in this pathway
SCHLOSSER_SERUM_RESPONSE_DN	712	443	All SZGR genes in this pathway
CALVET_IRINOTECAN_SENSITIVE_VS_REVERTED_UP	5	5	All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN	206	136	All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN	517	309	All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215	893	528	All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP	424	268	All SZGR genes in this pathway
KAUFFMANN_DNA_REPLICATION_GENES	147	87	All SZGR genes in this pathway
ROSS_ACUTE_MYELOID_LEUKEMIA_CBF	82	57	All SZGR genes in this pathway
KANNAN_TP53_TARGETS_DN	21	15	All SZGR genes in this pathway
GUO_HEX_TARGETS_UP	81	54	All SZGR genes in this pathway
LEI_MYB_TARGETS	318	215	All SZGR genes in this pathway
ZHAN_MULTIPLE_MYELOMA_UP	64	46	All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_NEOCORTEX_UP	83	66	All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN	830	547	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP	1691	1088	All SZGR genes in this pathway
KAAB_FAILED_HEART_ATRIUM_UP	38	30	All SZGR genes in this pathway
BACOLOD_RESISTANCE_TO_ALKYLATING_AGENTS_DN	60	45	All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_2	473	224	All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP	973	570	All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP	863	514	All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE	721	492	All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_DN	841	431	All SZGR genes in this pathway
LU_EZH2_TARGETS_DN	414	237	All SZGR genes in this pathway
GABRIELY_MIR21_TARGETS	289	187	All SZGR genes in this pathway
LINSLEY_MIR16_TARGETS	206	127	All SZGR genes in this pathway
PASINI_SUZ12_TARGETS_UP	112	65	All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_UP	344	215	All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_B	517	302	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	73	79	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-103/107	1571	1577	1A	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	1571	1577	1A	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-129-5p	474	480	1A	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
				hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
				hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
				hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-142-5p	217	223	m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-144	72	79	1A,m8	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-15/16/195/424/497	246	252	1A	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
				hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d	216	222	1A	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
				hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-21	371	377	1A	hsa-miR-21^brain	UAGCUUAUCAGACUGAUGUUGA
miR-21	371	377	1A	hsa-miR-590	GAGCUUAUUCAUAAAAGUGCAG
miR-218	470	476	1A	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-221/222	1276	1282	m8	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
miR-221/222	1276	1282	m8	hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-223	168	175	1A,m8	hsa-miR-223	UGUCAGUUUGUCAAAUACCCC
miR-24	1210	1217	1A,m8	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-26	302	308	m8	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	302	308	m8	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-27	782	788	1A	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	782	788	1A	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-29	1285	1292	1A,m8	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-30-3p	1447	1453	m8	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
miR-30-3p	1447	1453	m8	hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC
miR-31	190	196	1A	hsa-miR-31	AGGCAAGAUGCUGGCAUAGCUG
miR-330	928	935	1A,m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-369-3p	559	565	1A	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	411	417	1A	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-374	411	417	1A	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-410	428	434	1A	hsa-miR-410	AAUAUAACACAGAUGGCCUGU
miR-448	732	738	m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-485-3p	1395	1401	1A	hsa-miR-485-3p	GUCAUACACGGCUCUCCUCUCU
miR-488	743	749	1A	hsa-miR-488	CCCAGAUAAUGGCACUCUCAA
miR-495	526	532	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-503	246	252	1A	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG
miR-539	518	524	1A	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-543	650	656	1A	hsa-miR-543	AAACAUUCGCGGUGCACUUCU
miR-544	657	663	m8	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU
miR-9	854	860	m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-93.hd/291-3p/294/295/302/372/373/520	1419	1425	m8	hsa-miR-93^brain	AAAGUGCUGUUCGUGCAGGUAG
				hsa-miR-302a	UAAGUGCUUCCAUGUUUUGGUGA
				hsa-miR-302b	UAAGUGCUUCCAUGUUUUAGUAG
				hsa-miR-302c	UAAGUGCUUCCAUGUUUCAGUGG
				hsa-miR-302d	UAAGUGCUUCCAUGUUUGAGUGU
				hsa-miR-372	AAAGUGCUGCGACAUUUGAGCGU
				hsa-miR-373	GAAGUGCUUCGAUUUUGGGGUGU
				hsa-miR-520e	AAAGUGCUUCCUUUUUGAGGG
				hsa-miR-520a	AAAGUGCUUCCCUUUGGACUGU
				hsa-miR-520b	AAAGUGCUUCCUUUUAGAGGG
				hsa-miR-520c	AAAGUGCUUCCUUUUAGAGGGUU
				hsa-miR-520d	AAAGUGCUUCUCUUUGGUGGGUU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.