Gene Page: RAD51C
Summary ?
| GeneID | 5889 |
| Symbol | RAD51C |
| Synonyms | BROVCA3|FANCO|R51H3|RAD51L2 |
| Description | RAD51 paralog C |
| Reference | MIM:602774|HGNC:HGNC:9820|Ensembl:ENSG00000108384|HPRD:04143|Vega:OTTHUMG00000141292 |
| Gene type | protein-coding |
| Map location | 17q22 |
| Pascal p-value | 0.005 |
| Sherlock p-value | 0.878 |
| eGene | Anterior cingulate cortex BA24 Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hypothalamus Nucleus accumbens basal ganglia Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg19532212 | 17 | 56769430 | TEX14;RAD51C | 5.264E-4 | 0.392 | 0.048 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs2014835 | chr17 | 56417286 | RAD51C | 5889 | 0.19 | cis | ||
| rs4793952 | chr17 | 56608464 | RAD51C | 5889 | 0.16 | cis | ||
| rs8074016 | chr17 | 56840586 | RAD51C | 5889 | 0.13 | cis | ||
| rs2014835 | 17 | 56417287 | RAD51C | ENSG00000108384.10 | 1.926E-6 | 0 | -352647 | gtex_brain_ba24 |
| rs62084586 | 17 | 56419228 | RAD51C | ENSG00000108384.10 | 2.316E-6 | 0 | -350706 | gtex_brain_ba24 |
| rs71365878 | 17 | 56422603 | RAD51C | ENSG00000108384.10 | 7.96E-7 | 0 | -347331 | gtex_brain_ba24 |
| rs2070107 | 17 | 56423201 | RAD51C | ENSG00000108384.10 | 8.165E-7 | 0 | -346733 | gtex_brain_ba24 |
| rs13414 | 17 | 56431453 | RAD51C | ENSG00000108384.10 | 1.114E-6 | 0 | -338481 | gtex_brain_ba24 |
| rs2877877 | 17 | 56431530 | RAD51C | ENSG00000108384.10 | 1.175E-6 | 0 | -338404 | gtex_brain_ba24 |
| rs2158460 | 17 | 56432362 | RAD51C | ENSG00000108384.10 | 1.114E-6 | 0 | -337572 | gtex_brain_ba24 |
| rs2107547 | 17 | 56432743 | RAD51C | ENSG00000108384.10 | 1.114E-6 | 0 | -337191 | gtex_brain_ba24 |
| rs56133607 | 17 | 56432767 | RAD51C | ENSG00000108384.10 | 1.114E-6 | 0 | -337167 | gtex_brain_ba24 |
| rs10515157 | 17 | 56433448 | RAD51C | ENSG00000108384.10 | 1.114E-6 | 0 | -336486 | gtex_brain_ba24 |
| rs11079348 | 17 | 56438624 | RAD51C | ENSG00000108384.10 | 1.114E-6 | 0 | -331310 | gtex_brain_ba24 |
| rs2240259 | 17 | 56458129 | RAD51C | ENSG00000108384.10 | 1.415E-6 | 0 | -311805 | gtex_brain_ba24 |
| rs2240258 | 17 | 56458183 | RAD51C | ENSG00000108384.10 | 1.415E-6 | 0 | -311751 | gtex_brain_ba24 |
| rs3785493 | 17 | 56472119 | RAD51C | ENSG00000108384.10 | 1.415E-6 | 0 | -297815 | gtex_brain_ba24 |
| rs8078280 | 17 | 56473132 | RAD51C | ENSG00000108384.10 | 1.415E-6 | 0 | -296802 | gtex_brain_ba24 |
| rs35454383 | 17 | 56475599 | RAD51C | ENSG00000108384.10 | 1.41E-6 | 0 | -294335 | gtex_brain_ba24 |
| rs10515155 | 17 | 56481944 | RAD51C | ENSG00000108384.10 | 1.415E-6 | 0 | -287990 | gtex_brain_ba24 |
| rs3785492 | 17 | 56488063 | RAD51C | ENSG00000108384.10 | 1.4E-6 | 0 | -281871 | gtex_brain_ba24 |
| rs12603174 | 17 | 56489279 | RAD51C | ENSG00000108384.10 | 1.4E-6 | 0 | -280655 | gtex_brain_ba24 |
| rs68100606 | 17 | 56500898 | RAD51C | ENSG00000108384.10 | 2.887E-7 | 0 | -269036 | gtex_brain_ba24 |
| rs12950028 | 17 | 56510140 | RAD51C | ENSG00000108384.10 | 4.594E-7 | 0 | -259794 | gtex_brain_ba24 |
| rs35245220 | 17 | 56510305 | RAD51C | ENSG00000108384.10 | 4.594E-7 | 0 | -259629 | gtex_brain_ba24 |
| rs34683543 | 17 | 56520036 | RAD51C | ENSG00000108384.10 | 4.594E-7 | 0 | -249898 | gtex_brain_ba24 |
| rs71365890 | 17 | 56534409 | RAD51C | ENSG00000108384.10 | 5.467E-7 | 0 | -235525 | gtex_brain_ba24 |
| rs3887355 | 17 | 56538639 | RAD51C | ENSG00000108384.10 | 5.467E-7 | 0 | -231295 | gtex_brain_ba24 |
| rs3803753 | 17 | 56540110 | RAD51C | ENSG00000108384.10 | 5.467E-7 | 0 | -229824 | gtex_brain_ba24 |
| rs3803752 | 17 | 56540267 | RAD51C | ENSG00000108384.10 | 5.467E-7 | 0 | -229667 | gtex_brain_ba24 |
| rs17741087 | 17 | 56550300 | RAD51C | ENSG00000108384.10 | 5.467E-7 | 0 | -219634 | gtex_brain_ba24 |
| rs200253521 | 17 | 56560298 | RAD51C | ENSG00000108384.10 | 9.738E-7 | 0 | -209636 | gtex_brain_ba24 |
| rs34900851 | 17 | 56566399 | RAD51C | ENSG00000108384.10 | 5.482E-7 | 0 | -203535 | gtex_brain_ba24 |
| rs3087762 | 17 | 56568680 | RAD51C | ENSG00000108384.10 | 5.467E-7 | 0 | -201254 | gtex_brain_ba24 |
| rs62082149 | 17 | 56577042 | RAD51C | ENSG00000108384.10 | 4.468E-7 | 0 | -192892 | gtex_brain_ba24 |
| rs12603808 | 17 | 56578508 | RAD51C | ENSG00000108384.10 | 4.375E-7 | 0 | -191426 | gtex_brain_ba24 |
| rs12948536 | 17 | 56580413 | RAD51C | ENSG00000108384.10 | 2.843E-7 | 0 | -189521 | gtex_brain_ba24 |
| rs2240719 | 17 | 56582477 | RAD51C | ENSG00000108384.10 | 1.973E-7 | 0 | -187457 | gtex_brain_ba24 |
| rs34920953 | 17 | 56589406 | RAD51C | ENSG00000108384.10 | 9.677E-9 | 0 | -180528 | gtex_brain_ba24 |
| rs2007993 | 17 | 56590643 | RAD51C | ENSG00000108384.10 | 8.912E-8 | 0 | -179291 | gtex_brain_ba24 |
| rs12935851 | 17 | 56600244 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -169690 | gtex_brain_ba24 |
| rs35288118 | 17 | 56600748 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -169186 | gtex_brain_ba24 |
| rs2072316 | 17 | 56604813 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -165121 | gtex_brain_ba24 |
| rs17822735 | 17 | 56620167 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -149767 | gtex_brain_ba24 |
| rs17222523 | 17 | 56620501 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -149433 | gtex_brain_ba24 |
| rs35194610 | 17 | 56625260 | RAD51C | ENSG00000108384.10 | 7.928E-8 | 0 | -144674 | gtex_brain_ba24 |
| rs714959 | 17 | 56628601 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -141333 | gtex_brain_ba24 |
| rs7225896 | 17 | 56637337 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -132597 | gtex_brain_ba24 |
| rs2013166 | 17 | 56637630 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -132304 | gtex_brain_ba24 |
| rs66583824 | 17 | 56639853 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -130081 | gtex_brain_ba24 |
| rs113689249 | 17 | 56640270 | RAD51C | ENSG00000108384.10 | 6.566E-8 | 0 | -129664 | gtex_brain_ba24 |
| rs12150536 | 17 | 56640834 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -129100 | gtex_brain_ba24 |
| rs34818467 | 17 | 56643109 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -126825 | gtex_brain_ba24 |
| rs34382037 | 17 | 56643550 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -126384 | gtex_brain_ba24 |
| rs34468504 | 17 | 56648277 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -121657 | gtex_brain_ba24 |
| rs12948424 | 17 | 56653789 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -116145 | gtex_brain_ba24 |
| rs36109237 | 17 | 56653834 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -116100 | gtex_brain_ba24 |
| rs7215900 | 17 | 56654850 | RAD51C | ENSG00000108384.10 | 8.583E-8 | 0 | -115084 | gtex_brain_ba24 |
| rs62083525 | 17 | 56658088 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -111846 | gtex_brain_ba24 |
| rs35678735 | 17 | 56658444 | RAD51C | ENSG00000108384.10 | 7.72E-8 | 0 | -111490 | gtex_brain_ba24 |
| rs75922942 | 17 | 56663701 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -106233 | gtex_brain_ba24 |
| rs7210432 | 17 | 56668170 | RAD51C | ENSG00000108384.10 | 7.927E-8 | 0 | -101764 | gtex_brain_ba24 |
| rs7210700 | 17 | 56668186 | RAD51C | ENSG00000108384.10 | 7.927E-8 | 0 | -101748 | gtex_brain_ba24 |
| rs7211467 | 17 | 56668617 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -101317 | gtex_brain_ba24 |
| rs9303399 | 17 | 56672309 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -97625 | gtex_brain_ba24 |
| rs12948133 | 17 | 56673602 | RAD51C | ENSG00000108384.10 | 7.847E-8 | 0 | -96332 | gtex_brain_ba24 |
| rs12940212 | 17 | 56674474 | RAD51C | ENSG00000108384.10 | 3.257E-8 | 0 | -95460 | gtex_brain_ba24 |
| rs12601347 | 17 | 56680994 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -88940 | gtex_brain_ba24 |
| rs34426768 | 17 | 56683385 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -86549 | gtex_brain_ba24 |
| rs17822807 | 17 | 56687190 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -82744 | gtex_brain_ba24 |
| rs56162835 | 17 | 56687315 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -82619 | gtex_brain_ba24 |
| rs1864754 | 17 | 56688789 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -81145 | gtex_brain_ba24 |
| rs66508449 | 17 | 56691034 | RAD51C | ENSG00000108384.10 | 6.695E-8 | 0 | -78900 | gtex_brain_ba24 |
| rs34878689 | 17 | 56694330 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -75604 | gtex_brain_ba24 |
| rs34556735 | 17 | 56694447 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -75487 | gtex_brain_ba24 |
| rs17222621 | 17 | 56695923 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -74011 | gtex_brain_ba24 |
| rs12602808 | 17 | 56698420 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -71514 | gtex_brain_ba24 |
| rs35928756 | 17 | 56702652 | RAD51C | ENSG00000108384.10 | 7.267E-8 | 0 | -67282 | gtex_brain_ba24 |
| rs7219112 | 17 | 56703769 | RAD51C | ENSG00000108384.10 | 7.263E-8 | 0 | -66165 | gtex_brain_ba24 |
| rs34627216 | 17 | 56705755 | RAD51C | ENSG00000108384.10 | 7.263E-8 | 0 | -64179 | gtex_brain_ba24 |
| rs35448751 | 17 | 56709103 | RAD51C | ENSG00000108384.10 | 3.909E-6 | 0 | -60831 | gtex_brain_ba24 |
| rs66514313 | 17 | 56714057 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -55877 | gtex_brain_ba24 |
| rs35828828 | 17 | 56718205 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -51729 | gtex_brain_ba24 |
| rs35564417 | 17 | 56718286 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -51648 | gtex_brain_ba24 |
| rs144126341 | 17 | 56718829 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -51105 | gtex_brain_ba24 |
| rs12936771 | 17 | 56725052 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -44882 | gtex_brain_ba24 |
| rs35732484 | 17 | 56732744 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -37190 | gtex_brain_ba24 |
| rs35987270 | 17 | 56733545 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -36389 | gtex_brain_ba24 |
| rs35797125 | 17 | 56736547 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -33387 | gtex_brain_ba24 |
| rs34275691 | 17 | 56736640 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -33294 | gtex_brain_ba24 |
| rs67752533 | 17 | 56737553 | RAD51C | ENSG00000108384.10 | 7.956E-8 | 0 | -32381 | gtex_brain_ba24 |
| rs17822837 | 17 | 56737838 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -32096 | gtex_brain_ba24 |
| rs2116450 | 17 | 56745561 | RAD51C | ENSG00000108384.10 | 6.858E-7 | 0 | -24373 | gtex_brain_ba24 |
| rs7224468 | 17 | 56749943 | RAD51C | ENSG00000108384.10 | 6.858E-7 | 0 | -19991 | gtex_brain_ba24 |
| rs12939313 | 17 | 56755616 | RAD51C | ENSG00000108384.10 | 6.858E-7 | 0 | -14318 | gtex_brain_ba24 |
| rs12951104 | 17 | 56758379 | RAD51C | ENSG00000108384.10 | 4.237E-7 | 0 | -11555 | gtex_brain_ba24 |
| rs201924701 | 17 | 56761820 | RAD51C | ENSG00000108384.10 | 5.138E-7 | 0 | -8114 | gtex_brain_ba24 |
| rs113126189 | 17 | 56761824 | RAD51C | ENSG00000108384.10 | 4.346E-6 | 0 | -8110 | gtex_brain_ba24 |
| rs35574192 | 17 | 56763439 | RAD51C | ENSG00000108384.10 | 6.858E-7 | 0 | -6495 | gtex_brain_ba24 |
| rs34835800 | 17 | 56764990 | RAD51C | ENSG00000108384.10 | 1.323E-6 | 0 | -4944 | gtex_brain_ba24 |
| rs12946522 | 17 | 56768103 | RAD51C | ENSG00000108384.10 | 6.858E-7 | 0 | -1831 | gtex_brain_ba24 |
| rs16943176 | 17 | 56769887 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | -47 | gtex_brain_ba24 |
| rs12946397 | 17 | 56769979 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 45 | gtex_brain_ba24 |
| rs17222691 | 17 | 56771096 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 1162 | gtex_brain_ba24 |
| rs62081314 | 17 | 56778328 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 8394 | gtex_brain_ba24 |
| rs12602389 | 17 | 56779778 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 9844 | gtex_brain_ba24 |
| rs62081315 | 17 | 56781468 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 11534 | gtex_brain_ba24 |
| rs62081316 | 17 | 56781499 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 11565 | gtex_brain_ba24 |
| rs34351230 | 17 | 56782555 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 12621 | gtex_brain_ba24 |
| rs34170300 | 17 | 56789905 | RAD51C | ENSG00000108384.10 | 7.932E-8 | 0 | 19971 | gtex_brain_ba24 |
| rs7216648 | 17 | 56790858 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 20924 | gtex_brain_ba24 |
| rs17822908 | 17 | 56801778 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 31844 | gtex_brain_ba24 |
| rs10515159 | 17 | 56802693 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 32759 | gtex_brain_ba24 |
| rs62081322 | 17 | 56804230 | RAD51C | ENSG00000108384.10 | 7.351E-8 | 0 | 34296 | gtex_brain_ba24 |
| rs35047359 | 17 | 56816892 | RAD51C | ENSG00000108384.10 | 1.066E-8 | 0 | 46958 | gtex_brain_ba24 |
| rs62081326 | 17 | 56819417 | RAD51C | ENSG00000108384.10 | 7.927E-8 | 0 | 49483 | gtex_brain_ba24 |
| rs8074016 | 17 | 56840587 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 70653 | gtex_brain_ba24 |
| rs62083362 | 17 | 56846464 | RAD51C | ENSG00000108384.10 | 7.873E-8 | 0 | 76530 | gtex_brain_ba24 |
| rs35539277 | 17 | 56853833 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 83899 | gtex_brain_ba24 |
| rs62083368 | 17 | 56878062 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 108128 | gtex_brain_ba24 |
| rs34717648 | 17 | 56886624 | RAD51C | ENSG00000108384.10 | 4.52E-8 | 0 | 116690 | gtex_brain_ba24 |
| rs67346233 | 17 | 56893468 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 123534 | gtex_brain_ba24 |
| rs7223708 | 17 | 56896398 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 126464 | gtex_brain_ba24 |
| rs34913878 | 17 | 56897094 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 127160 | gtex_brain_ba24 |
| rs7224276 | 17 | 56897827 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 127893 | gtex_brain_ba24 |
| rs12952325 | 17 | 56899371 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 129437 | gtex_brain_ba24 |
| rs35103007 | 17 | 56900738 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 130804 | gtex_brain_ba24 |
| rs67014405 | 17 | 56901103 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 131169 | gtex_brain_ba24 |
| rs11079357 | 17 | 56902778 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 132844 | gtex_brain_ba24 |
| rs34504967 | 17 | 56904629 | RAD51C | ENSG00000108384.10 | 4.455E-8 | 0 | 134695 | gtex_brain_ba24 |
| rs61291849 | 17 | 56909867 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 139933 | gtex_brain_ba24 |
| rs143151705 | 17 | 56918881 | RAD51C | ENSG00000108384.10 | 2.548E-6 | 0 | 148947 | gtex_brain_ba24 |
| rs11495824 | 17 | 56918882 | RAD51C | ENSG00000108384.10 | 7.889E-8 | 0 | 148948 | gtex_brain_ba24 |
| rs11079358 | 17 | 56920949 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 151015 | gtex_brain_ba24 |
| rs7502342 | 17 | 56922629 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 152695 | gtex_brain_ba24 |
| rs139863951 | 17 | 56927552 | RAD51C | ENSG00000108384.10 | 1.243E-7 | 0 | 157618 | gtex_brain_ba24 |
| rs62083402 | 17 | 56928295 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 158361 | gtex_brain_ba24 |
| rs35082010 | 17 | 56936867 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 166933 | gtex_brain_ba24 |
| rs12150264 | 17 | 56939927 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 169993 | gtex_brain_ba24 |
| rs71367638 | 17 | 56950184 | RAD51C | ENSG00000108384.10 | 2.514E-7 | 0 | 180250 | gtex_brain_ba24 |
| rs72828726 | 17 | 56951217 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 181283 | gtex_brain_ba24 |
| rs36093395 | 17 | 56957357 | RAD51C | ENSG00000108384.10 | 7.873E-8 | 0 | 187423 | gtex_brain_ba24 |
| rs139731213 | 17 | 56958867 | RAD51C | ENSG00000108384.10 | 7.807E-8 | 0 | 188933 | gtex_brain_ba24 |
| rs62083410 | 17 | 56964386 | RAD51C | ENSG00000108384.10 | 7.819E-8 | 0 | 194452 | gtex_brain_ba24 |
| rs66896813 | 17 | 56964808 | RAD51C | ENSG00000108384.10 | 7.851E-8 | 0 | 194874 | gtex_brain_ba24 |
| rs4458062 | 17 | 56968532 | RAD51C | ENSG00000108384.10 | 1.643E-7 | 0 | 198598 | gtex_brain_ba24 |
| rs4426405 | 17 | 56968554 | RAD51C | ENSG00000108384.10 | 1.643E-7 | 0 | 198620 | gtex_brain_ba24 |
| rs34963822 | 17 | 56988424 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 218490 | gtex_brain_ba24 |
| rs12944971 | 17 | 56988801 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 218867 | gtex_brain_ba24 |
| rs12951141 | 17 | 57008642 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 238708 | gtex_brain_ba24 |
| rs12946852 | 17 | 57013337 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 243403 | gtex_brain_ba24 |
| rs61350506 | 17 | 57014709 | RAD51C | ENSG00000108384.10 | 1.383E-8 | 0 | 244775 | gtex_brain_ba24 |
| rs66506464 | 17 | 57024506 | RAD51C | ENSG00000108384.10 | 5.202E-7 | 0 | 254572 | gtex_brain_ba24 |
| rs62083436 | 17 | 57031742 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 261808 | gtex_brain_ba24 |
| rs34348776 | 17 | 57032475 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 262541 | gtex_brain_ba24 |
| rs202085059 | 17 | 57033815 | RAD51C | ENSG00000108384.10 | 1.225E-7 | 0 | 263881 | gtex_brain_ba24 |
| rs34713540 | 17 | 57033818 | RAD51C | ENSG00000108384.10 | 6.116E-7 | 0 | 263884 | gtex_brain_ba24 |
| rs16943326 | 17 | 57050365 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 280431 | gtex_brain_ba24 |
| rs12600349 | 17 | 57054245 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 284311 | gtex_brain_ba24 |
| rs16943333 | 17 | 57058710 | RAD51C | ENSG00000108384.10 | 3.293E-9 | 0 | 288776 | gtex_brain_ba24 |
| rs3809724 | 17 | 57061238 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 291304 | gtex_brain_ba24 |
| rs60868753 | 17 | 57068108 | RAD51C | ENSG00000108384.10 | 7.933E-8 | 0 | 298174 | gtex_brain_ba24 |
| rs28651036 | 17 | 57080471 | RAD51C | ENSG00000108384.10 | 3.206E-7 | 0 | 310537 | gtex_brain_ba24 |
| rs34607742 | 17 | 57085013 | RAD51C | ENSG00000108384.10 | 4.462E-6 | 0 | 315079 | gtex_brain_ba24 |
| rs34550282 | 17 | 57092788 | RAD51C | ENSG00000108384.10 | 4.415E-6 | 0 | 322854 | gtex_brain_ba24 |
| rs35057477 | 17 | 57097064 | RAD51C | ENSG00000108384.10 | 1.397E-7 | 0 | 327130 | gtex_brain_ba24 |
| rs66480139 | 17 | 57101538 | RAD51C | ENSG00000108384.10 | 3.253E-7 | 0 | 331604 | gtex_brain_ba24 |
| rs34941454 | 17 | 57102742 | RAD51C | ENSG00000108384.10 | 3.206E-7 | 0 | 332808 | gtex_brain_ba24 |
| rs34843288 | 17 | 57103140 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 333206 | gtex_brain_ba24 |
| rs66540071 | 17 | 57107348 | RAD51C | ENSG00000108384.10 | 5.267E-8 | 0 | 337414 | gtex_brain_ba24 |
| rs34741117 | 17 | 57107728 | RAD51C | ENSG00000108384.10 | 5.267E-8 | 0 | 337794 | gtex_brain_ba24 |
| rs17175663 | 17 | 57108437 | RAD51C | ENSG00000108384.10 | 7.942E-8 | 0 | 338503 | gtex_brain_ba24 |
| rs34076823 | 17 | 57114497 | RAD51C | ENSG00000108384.10 | 3.214E-7 | 0 | 344563 | gtex_brain_ba24 |
| rs62084381 | 17 | 57114788 | RAD51C | ENSG00000108384.10 | 7.952E-8 | 0 | 344854 | gtex_brain_ba24 |
| rs8082334 | 17 | 57116809 | RAD51C | ENSG00000108384.10 | 3.354E-7 | 0 | 346875 | gtex_brain_ba24 |
| rs34058624 | 17 | 57118121 | RAD51C | ENSG00000108384.10 | 3.354E-7 | 0 | 348187 | gtex_brain_ba24 |
| rs62084384 | 17 | 57126842 | RAD51C | ENSG00000108384.10 | 8.8E-8 | 0 | 356908 | gtex_brain_ba24 |
| rs66885215 | 17 | 57134124 | RAD51C | ENSG00000108384.10 | 8.813E-8 | 0 | 364190 | gtex_brain_ba24 |
| rs2333409 | 17 | 57139134 | RAD51C | ENSG00000108384.10 | 3.521E-7 | 0 | 369200 | gtex_brain_ba24 |
| rs12947982 | 17 | 57140301 | RAD51C | ENSG00000108384.10 | 1.985E-6 | 0 | 370367 | gtex_brain_ba24 |
| rs12949720 | 17 | 57140594 | RAD51C | ENSG00000108384.10 | 4.632E-7 | 0 | 370660 | gtex_brain_ba24 |
| rs12950373 | 17 | 57142291 | RAD51C | ENSG00000108384.10 | 3.75E-7 | 0 | 372357 | gtex_brain_ba24 |
| rs62084387 | 17 | 57148027 | RAD51C | ENSG00000108384.10 | 8.787E-8 | 0 | 378093 | gtex_brain_ba24 |
| rs8081058 | 17 | 57160513 | RAD51C | ENSG00000108384.10 | 3.21E-7 | 0 | 390579 | gtex_brain_ba24 |
| rs35308719 | 17 | 57163501 | RAD51C | ENSG00000108384.10 | 3.206E-7 | 0 | 393567 | gtex_brain_ba24 |
| rs12946396 | 17 | 57164195 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 394261 | gtex_brain_ba24 |
| rs34097494 | 17 | 57171917 | RAD51C | ENSG00000108384.10 | 3.218E-7 | 0 | 401983 | gtex_brain_ba24 |
| rs35165585 | 17 | 57173840 | RAD51C | ENSG00000108384.10 | 7.931E-8 | 0 | 403906 | gtex_brain_ba24 |
| rs34678056 | 17 | 57177549 | RAD51C | ENSG00000108384.10 | 3.206E-7 | 0 | 407615 | gtex_brain_ba24 |
| rs56284918 | 17 | 57178838 | RAD51C | ENSG00000108384.10 | 3.206E-7 | 0 | 408904 | gtex_brain_ba24 |
| rs35104446 | 17 | 57180234 | RAD51C | ENSG00000108384.10 | 1.989E-7 | 0 | 410300 | gtex_brain_ba24 |
| rs62081879 | 17 | 57181524 | RAD51C | ENSG00000108384.10 | 4.224E-8 | 0 | 411590 | gtex_brain_ba24 |
| rs397774004 | 17 | 57184270 | RAD51C | ENSG00000108384.10 | 2.704E-7 | 0 | 414336 | gtex_brain_ba24 |
| rs28687626 | 17 | 57191904 | RAD51C | ENSG00000108384.10 | 4.108E-8 | 0 | 421970 | gtex_brain_ba24 |
| rs67378767 | 17 | 57194237 | RAD51C | ENSG00000108384.10 | 2.67E-7 | 0 | 424303 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MORC3 | 0.92 | 0.94 |
| TRIP12 | 0.91 | 0.92 |
| NUP50 | 0.91 | 0.92 |
| UBP1 | 0.91 | 0.92 |
| ZRANB1 | 0.90 | 0.92 |
| ZC3H14 | 0.90 | 0.91 |
| C4orf41 | 0.90 | 0.91 |
| USP7 | 0.90 | 0.91 |
| DIAPH1 | 0.90 | 0.91 |
| RABGAP1 | 0.90 | 0.91 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.78 | -0.81 |
| MT-CO2 | -0.78 | -0.81 |
| FXYD1 | -0.77 | -0.80 |
| HIGD1B | -0.76 | -0.82 |
| IFI27 | -0.76 | -0.81 |
| AF347015.21 | -0.75 | -0.81 |
| CST3 | -0.74 | -0.80 |
| MT-CYB | -0.74 | -0.76 |
| AF347015.8 | -0.74 | -0.78 |
| METRN | -0.74 | -0.79 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG HOMOLOGOUS RECOMBINATION | 28 | 17 | All SZGR 2.0 genes in this pathway |
| REACTOME MEIOSIS | 116 | 81 | All SZGR 2.0 genes in this pathway |
| REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | 132 | 101 | All SZGR 2.0 genes in this pathway |
| REACTOME MEIOTIC RECOMBINATION | 86 | 62 | All SZGR 2.0 genes in this pathway |
| REACTOME HEMOSTASIS | 466 | 331 | All SZGR 2.0 genes in this pathway |
| NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP | 285 | 181 | All SZGR 2.0 genes in this pathway |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | All SZGR 2.0 genes in this pathway |
| KIM WT1 TARGETS DN | 459 | 276 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP | 633 | 376 | All SZGR 2.0 genes in this pathway |
| HAHTOLA SEZARY SYNDROM UP | 98 | 58 | All SZGR 2.0 genes in this pathway |
| LINDGREN BLADDER CANCER CLUSTER 3 UP | 329 | 196 | All SZGR 2.0 genes in this pathway |
| VANHARANTA UTERINE FIBROID WITH 7Q DELETION UP | 67 | 37 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN | 770 | 415 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER UP | 181 | 108 | All SZGR 2.0 genes in this pathway |
| DACOSTA UV RESPONSE VIA ERCC3 DN | 855 | 609 | All SZGR 2.0 genes in this pathway |
| MOHANKUMAR TLX1 TARGETS UP | 414 | 287 | All SZGR 2.0 genes in this pathway |
| PUJANA XPRSS INT NETWORK | 168 | 103 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA2 PCC NETWORK | 423 | 265 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| PUJANA CHEK2 PCC NETWORK | 779 | 480 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA CENTERED NETWORK | 117 | 72 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS DN | 848 | 527 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS DN | 1024 | 594 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS DN | 637 | 377 | All SZGR 2.0 genes in this pathway |
| WEI MYCN TARGETS WITH E BOX | 795 | 478 | All SZGR 2.0 genes in this pathway |
| BENPORATH OCT4 TARGETS | 290 | 172 | All SZGR 2.0 genes in this pathway |
| BENPORATH CYCLING GENES | 648 | 385 | All SZGR 2.0 genes in this pathway |
| SAKAI TUMOR INFILTRATING MONOCYTES DN | 81 | 51 | All SZGR 2.0 genes in this pathway |
| KAUFFMANN DNA REPAIR GENES | 230 | 137 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON | 335 | 181 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 16HR UP | 225 | 139 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS MATURE CELL | 293 | 160 | All SZGR 2.0 genes in this pathway |
| MARCHINI TRABECTEDIN RESISTANCE UP | 21 | 16 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE DN | 1237 | 837 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE INCIPIENT DN | 165 | 106 | All SZGR 2.0 genes in this pathway |
| SONG TARGETS OF IE86 CMV PROTEIN | 60 | 42 | All SZGR 2.0 genes in this pathway |
| DAZARD RESPONSE TO UV SCC UP | 123 | 75 | All SZGR 2.0 genes in this pathway |
| ZHENG BOUND BY FOXP3 | 491 | 310 | All SZGR 2.0 genes in this pathway |
| MATZUK SPERMATOCYTE | 72 | 55 | All SZGR 2.0 genes in this pathway |
| ZHANG TLX TARGETS 36HR DN | 185 | 116 | All SZGR 2.0 genes in this pathway |
| ZHANG TLX TARGETS 60HR DN | 277 | 166 | All SZGR 2.0 genes in this pathway |
| ZHANG TLX TARGETS DN | 89 | 50 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS UP | 395 | 249 | All SZGR 2.0 genes in this pathway |
| CROONQUIST NRAS SIGNALING DN | 72 | 47 | All SZGR 2.0 genes in this pathway |
| YAGI AML WITH INV 16 TRANSLOCATION | 422 | 277 | All SZGR 2.0 genes in this pathway |
| WHITFIELD CELL CYCLE G2 M | 216 | 124 | All SZGR 2.0 genes in this pathway |
| SMIRNOV RESPONSE TO IR 6HR UP | 166 | 97 | All SZGR 2.0 genes in this pathway |
| WARTERS RESPONSE TO IR SKIN | 83 | 44 | All SZGR 2.0 genes in this pathway |
| FARMER BREAST CANCER CLUSTER 5 | 18 | 11 | All SZGR 2.0 genes in this pathway |