Gene Page: RBBP8

Summary ?
GeneID5932
SymbolRBBP8
SynonymsCOM1|CTIP|JWDS|RIM|SAE2|SCKL2
Descriptionretinoblastoma binding protein 8
ReferenceMIM:604124|HGNC:HGNC:9891|Ensembl:ENSG00000101773|HPRD:04990|Vega:OTTHUMG00000131769
Gene typeprotein-coding
Map location18q11.2
Pascal p-value0.053
Sherlock p-value0.433
Fetal beta0.351
DMG1 (# studies)
eGeneCerebellar Hemisphere
Cerebellum
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg157707281820513120RBBP87.93E-10-0.0131.04E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs4854166chr23297005RBBP859320.17trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AATFCHE-1 | CHE1 | DEDapoptosis antagonizing transcription factor-HPRD10783144 
ATMAT1 | ATA | ATC | ATD | ATDC | ATE | DKFZp781A0353 | MGC74674 | TEL1 | TELO1ataxia telangiectasia mutatedAffinity Capture-Western
Protein-peptide
Reconstituted Complex		BioGRID10608806 |10910365 
BARD1-BRCA1 associated RING domain 1-HPRD,BioGRID10764811 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD9738006 |10196224 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetAffinity Capture-Western
Protein-peptide
Reconstituted Complex
Two-hybrid		BioGRID9738006 |9811458 
|10196224 |10764811 
|10910365 |11689934 
|14578343 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetBRCA1 interacts with CtIP.BIND9811458 
C17orf28DMC1 | FLJ43526chromosome 17 open reading frame 28Two-hybridBioGRID16189514 
CTBP1BARS | MGC104684C-terminal binding protein 1-HPRD9535825 |11313276 
CTBP1BARS | MGC104684C-terminal binding protein 1Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex
Two-hybrid		BioGRID9535825 |10196224 
FXR2FMR1L2fragile X mental retardation, autosomal homolog 2Two-hybridBioGRID16189514 
IKZF1Hs.54452 | IK1 | IKAROS | LYF1 | PRO0758 | ZNFN1A1 | hIk-1IKAROS family zinc finger 1 (Ikaros)-HPRD,BioGRID11959865 
IKZF3AIO | AIOLOS | ZNFN1A3IKAROS family zinc finger 3 (Aiolos)-HPRD12015313 
LIMS1PINCH | PINCH1LIM and senescent cell antigen-like domains 1Two-hybridBioGRID16189514 
LMO2RBTN2 | RBTNL1 | RHOM2 | TTG2LIM domain only 2 (rhombotin-like 1)The LIM domain protein LMO2 interacts with the cofactor CtIP. This interaction was modeled on a demonstrated interaction between mouse LMO2 and humanCtIP proteinsBIND11751867 
LMO2RBTN2 | RBTNL1 | RHOM2 | TTG2LIM domain only 2 (rhombotin-like 1)-HPRD11751867 
LMO4-LIM domain only 4-HPRD,BioGRID11751867 
LMO4-LIM domain only 4LMO4 interacts with CtIP.BIND11751867 
PIN1DOD | UBL5peptidylprolyl cis/trans isomerase, NIMA-interacting 1Two-hybridBioGRID16189514 
PRKDCDNA-PKcs | DNAPK | DNPK1 | HYRC | HYRC1 | XRCC7 | p350protein kinase, DNA-activated, catalytic polypeptideProtein-peptideBioGRID10608806 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1-HPRD,BioGRID9721205 
RBBP8CTIP | RIMretinoblastoma binding protein 8Affinity Capture-Western
Reconstituted Complex		BioGRID15084581 
RBL1CP107 | MGC40006 | PRB1 | p107retinoblastoma-like 1 (p107)-HPRD,BioGRID9721205 
RBL2FLJ26459 | P130 | Rb2retinoblastoma-like 2 (p130)-HPRD,BioGRID9721205 
RBL2FLJ26459 | P130 | Rb2retinoblastoma-like 2 (p130)-HPRD9721205 |10449734 
SIAH1FLJ08065 | HUMSIAH | Siah-1 | Siah-1a | hSIAH1seven in absentia homolog 1 (Drosophila)Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID14654780 
SIAH2hSiah2seven in absentia homolog 2 (Drosophila)Reconstituted ComplexBioGRID14654780 
TGIF2-TGFB-induced factor homeobox 2-HPRD11427533 
WDYHV1C8orf32 | FLJ10204WDYHV motif containing 1Two-hybridBioGRID16189514 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA ATM PATHWAY 2016All SZGR 2.0 genes in this pathway
PID NOTCH PATHWAY 5949All SZGR 2.0 genes in this pathway
PID E2F PATHWAY 7448All SZGR 2.0 genes in this pathway
PID ATM PATHWAY 3425All SZGR 2.0 genes in this pathway
PID BARD1 PATHWAY 2919All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY 4839All SZGR 2.0 genes in this pathway
REACTOME MEIOSIS 11681All SZGR 2.0 genes in this pathway
REACTOME MEIOTIC RECOMBINATION 8662All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP 294178All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP 368234All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380236All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633376All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722443All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE DN 485334All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443294All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
KONG E2F3 TARGETS 9758All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL 326213All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS BASAL 330217All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 10173All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT NETWORK 168103All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442892All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
PUJANA BRCA CENTERED NETWORK 11772All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379235All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648385All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPAIR GENES 230137All SZGR 2.0 genes in this pathway
CHEOK RESPONSE TO MERCAPTOPURINE DN 2215All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION DN 9867All SZGR 2.0 genes in this pathway
CHENG RESPONSE TO NICKEL ACETATE 4529All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C5 4636All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528324All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 307185All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543317All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593372All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591366All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN 258160All SZGR 2.0 genes in this pathway
MASSARWEH RESPONSE TO ESTRADIOL 6147All SZGR 2.0 genes in this pathway
DE YY1 TARGETS DN 9264All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425253All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY UP 13484All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR DN 185116All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN 277166All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS DN 8950All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS UP 518299All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE S 16286All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456287All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572352All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS GROWING 243155All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP 229149All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324193All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 UP 344215All SZGR 2.0 genes in this pathway
ZHOU CELL CYCLE GENES IN IR RESPONSE 24HR 12873All SZGR 2.0 genes in this pathway